| Project/Area Number |
08838005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
老化(加齢)
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| Research Institution | Chiba Univesity |
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Principal Investigator |
SUGITA Katsuo Chiba University, Department of Education, Associate Professor, 教育学部, 助教授 (40211304)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Nobuo Chiba University, Department of Medicine, Professor, 医学部, 教授 (90111426)
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| Project Period (FY) |
1996 – 1997
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| Project Status |
Completed (Fiscal Year 1997)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1997: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1996: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Cockayne syndrome / Cytokine / Interferon / Progeroid syndrome / Xeroderma pigmentosum (XP) -G / Xanthin dehydrogenase / Differential display / xauthin dehydrogenase / Differeutial display法 / Cockayne syndorome / 老化遺伝子 |
|---|
| Research Abstract |
We searched for genes expressed specifically in human interferon (HuIFN) -beta-treated Cockayne syndrome (CS) fibroblast cells, using the PCR differential display method. Eighteen expressed genes induced by HuIFN-beta were identified, the sequences of seven of which were highly homologous to previously cloned sequences. The cDNAs of six of these seven clones were similar to expression tagged sequences from unknown genes in databases and the remaining one was identical to the cDNA of the xeroderma pigmentosum (XP) -G gene. These results, together with the previous finding of increased resistance to ultraviolet (UV) cell-killing of CS cells pretreated with HuIFN-beta prior to UV irradiation, suggest that XP-G might be one of the genes possibly involved in the HuIFN-beta-induced UV-refractoriness.
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