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生体部分肝移植における免疫学的低反応性の導入に関する研究(免疫抑制療法離脱の試み)

Research Project

Project/Area Number 08877186
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionShinshu University

Principal Investigator

川崎 誠治  信州大学, 医学部, 教授 (80177667)

Co-Investigator(Kenkyū-buntansha) 川崎 誠治  信州大学, 医学部, 教授 (80177667)
Project Period (FY) 1996 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1998: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1997: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1996: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords肝移植 / 免疫抑制剤 / 免疫抑制 / 免疫学的寛容
Research Abstract

肝移植のみならず臓器移植術後患者において免疫抑制剤を中止しうるか否かを事前に判断する手段は国内外で確立されていない。本研究では術前にドナーとレシピエントの間で行われたABO血液型、リンパ球クロスマッチ、mixed lymphocyte cultureによって得られる“免疫学的な相性"が、術後経過とりわけ拒絶反応の有無と免疫抑制剤減量の可否に関わる影響について検討した。
その結果、ABO血液型不適合例では、適合例に比べて難治性拒絶反応と胆道合併症の発生率が高く、リンパ球クロスマッチ陽性例では陰性例に比べて難治性拒絶反応の発生率が高いことが明らかとなった。一方、mixed lymphocyte cultureの結果は拒絶反応などの術後合併症に関連性がなく、腎移植におけるそれとは異なることが明らかとなった。

Report

(3 results)
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • 1996 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Ikegami T, et al: "Should all hepatic arterial branches be reconstructed in living-related liver transplantation?" Surgery. 119. 431-436 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawasaki S, et al: "Temporary shunt between right portal vein and vena gava in living related liver transplantation" J.Am.Coll Surg. 183. 74-76 (1996)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takayama T, et al: "Liver transplantation using living donors with aberrant hepatic artery" J Am Coll Surg. 184. 525-528 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miwa S, et al: "Effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejectior" Surgery. 121. 681-689 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda S, et al: "Peripneral nerves regenerated in familial amyloid polyneuropathy after liver transplantation" Ann Intern Med. 127. 618-620 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hashikura Y, Kawasaki: "Urgent living related liver transplantation using a graft with multiple intrahepatic arteroportal fistulae" Traplantation. 64. 1076-1078 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川崎 誠治: "成人肝疾患に対する生体部分肝移植・肝移植と肝病態" 日本人ディセルセンター 東京, 8 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 橋倉 恭彦 川崎 誠治 他: "成人 患者に対する生体部分肝移植" 新外科学体系(肝胆膵の外科と分子生物)中山書店, 7 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikegami T, et al: "Should all hepatic arterial branches be reconstructed in living-related liver transplantation?" Surgery. 119. 431-436 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawasaki S, et al: "Temporary shunt between right portal vein and vena eava in living related liver transplantation" J.Am.Coll Surg. 183. 74-76 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takayama T, et al: "Liver transplantation using living donors with aberrant hepatic artery" J Am Coll Surg. 184. 525-528 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Miwa S, et al: "Effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on rat-to-mouse cardiac xenograft rejection" Surgery. 121. 681-689 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikeda S, et al: "Peripheral nerves regenerated in familial amyloid polyneuropathy after liver transplantation" Ann Intern Med. 127. 618-620 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hashikura Y,Kawasaki: "Urgent living related liver transplantation using a graft with multiple intrahepatic arteroportal fistulae" Traplantation. 64. 1076-1078 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川崎 誠治: "成人肝疾患に対する生体部分肝移植・肝移植と肝病態" 日本メディカルセンター 東京, 8 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 橋倉泰彦 川崎誠治 他: "成人患者に対する生体部分肝移植" 新外科学体系(肝胆膵の外科 外科と分子生物)中山書店, 7 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawasaki,S,et cl: "Extended lateral segmentectomy using intraoperative ultrasound to obtain a partial graft" American Journal of Surgery. 171. 286-288 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kawasaki,S,et al: "Temporary Shunt between right portal vein and vena cava in living related liver transplantation" J.Am coll Surg. 183. 74-76 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hashikura,Y.et al: "Immunosuppressant switching between cyclosporine and tacrolimus after liver transplantation" Transplantation Proceedings. 28・2. 1034-1035 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦・他: "肝移植術中術後の凝固線溶糸の変動に関する研究" 外科. 58・2. 205-209 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦・他: "肝移植ドナーの術前後の栄養管理" JJPEN. 18・11. 833-836 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ikegami,T.et al: "Should all hepatic arterial branches be reconstructed in living-related liver transplantation?" Surgery. 119. 431-436 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 橋倉泰彦・他: "高木弘(編):シクロスポリンの実際,「生体部分肝移植とシクロスポリン」" 国際医学出版, 19 (1996)

    • Related Report
      1996 Annual Research Report

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Published: 1996-04-01   Modified: 2016-04-21  

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