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Chemical Studies on Bioluminescent Material and Natural Product in Tropical Area

Research Project

Project/Area Number 09041153
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionNagoya University

Principal Investigator

ISOBE Minoru  Nagoya University, Agricultural Sciences, Professor, 農学部, 教授 (00023466)

Co-Investigator(Kenkyū-buntansha) SOYTONG Kasem  Faculty of Agricultural Technology, King Mongkut's Institute of technology Ladkr, 農学部, 助教授
KANOKMEDHAKUL Somdej  Faculty of Science, Khon Kaen University, Associate Professor, 理学部, 助教授
BUSSARAWIT S  プーケット海洋生物学センター, 海洋生物学研究員
SUWAN Sarhor  チュラロンコン大学, 科学技術研究所, 主任研究員
ICHIKAWA Yoshiyasu  Nagoya University, Agricultural Sciences, Associate Professor, 農学部, 助教授 (60193439)
SOMCHAI Bussarawit  Phuket Marine Biological Center, Marine Biologist
SWAN Sathorn  Scientific and Technological Research Equipment Center, Chuylalongkorn Universit
SUWAN Sarhom  チュラロンコン大学, 科学技術研究所, 主任研究員
SUWAN Sathor  名古屋大学, 農学部, リサーチアソシエイト
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1997: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsBIOLUMINESCENCE / LUMINOUS SOUID / LUMINOUS WORM / MALAYSIA / THAILAND / LUMINOUS SEA PEN / PEPTAIBOL / LUMINOUS ORGANISMS
Research Abstract

In the field of chemistry of naturally occurring bioactive materials there have been remarkable progress of new structures and important compounds from marine organisms. This project aims at searching for a new bioluminescent system in new luminous organisms in tropical area. It also includes strongly active natural products in these tropical area. For comparison, those luminous systems as well as other biologically active materials have been compared with those in Okinawan area.
Fiscal year H10, 5 researchers have visited and stayed for one or two months to continue their research work, particularly analytical studies with NMR and Mass Spectroscopy. As a results many sequence heterogeneity of peptaibol, trichotoxin, have been established as well as some cyclic peptides. In respect to the luminescence, various many kinds of luminous organisms have been found, particularly during joining the sampling cruise with the activity of Phuket Marine Biology Center. They are sea pen, nudibranch, squid, worm, ostracod in Andaman Sea, South Thailand. Bringing a CCD spectrometer, a portable HPLC, etc afforded quite productive results for identification of the possible luminous system.
New research channel among natural product chemists in Nagoya University and Chulalongkom, Khon Keen, King Mong Institute of Technology, Mahidol, Prince of Songkla Universities have been established through the current cooperative research program. It was quite successful in scientifically.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Tsuboi, K. ; Ichikawa, Y. ; Jiang, Y. ; Naganawa, A. ; Isobe, M.: "Total Synthesis of (+)-Tautomycin.a" Tetrahedron. 53. 5123-5142 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuboi, K. ; Ichikawa, Y. ; Isobe, M.: "Synthesis of Okadaic Acid-Tautomycin Hybrid." Synlett. 713-715 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yenjai, C. ; Isobe M.: "One-Step Recyclization of Sugar Acetylenes to form Medium Ether Rings via Dicobalthexacarbonyl Complexes." Tetrahedron. 54. 2509-2520 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kanokmedhakul, S. ; Kanokmedhakul, K. ; Ohtani, I.I. ; Isobe, M.: "A Diynoic Acid from Polyalthia evecta." Phytochemistry. 47. 131-133 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Isobe, M. ; Kuse, M. ; Yasuda, Y. ; Takahashi, H.: "Synthesis of 13C-Dehydrocoelenterazine and Model Studies on Symplectoteuthis Squid Bioluminescence." BioMed.Chem.Lett.8(#20). 2919-2924 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiba, K. ; Hoshi, M. ; Isobe, M. ; Hirose, E.: "Bioluminescence in the Tunic of the Colonial Ascidian, Clavelina miniata : Identification of Luminous Cells in Vitro." The Journal of Experimental Zoology. 281. 546-553 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Isobe, M., Tsuboi, K. ; Hosokawa, S. ; Bamba, M. ; Kira, K. ; Shibuya, S. ; Ohtani, I.I. ; Nishikawa, T. ; Ichikawa, Y.: "Enzyme inhibitors, synthesis and approach to mechanism." Pure & Appl.Chem., 6 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 坪井 克憲、磯部 稔: "「3 阻害物質と阻害薬 阻害剤の全合成とコンフォメーション解析」 IIプロテインセリン・スレオニンフォスファターゼ" 蛋白質・核酸・酵素, 8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuboi, K. ; Ichikawa, Y.iJiang, Y ; Naganawa, A ; Isobe, M.: "Total Synthesis of (+) -Tautomycin.a" Tetrahedron. 53. 5123-5142 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuboi, K. ; Ichikawa, Y. ; Isobe, M.: "Synthesis of Okadaic Acid-Tautomycin Hybrid." Synlett. 713-715 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yenjai, C. ; Isobe M.: "One-Step Recyclization of Sugar Acetylenes to form Medium Ether Rings via Dicobalthexacarbonyl Complexes." Tetrahedron. 54. 2509-2520 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kanokmedhakul, S. ; Kanokmedhakul, K. ; Ohtani, I.I. ; Isobe, M.: "A Diynoic Acid from Polyalthia evecta." Phytochemistry. 47. 131-133 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Isobe, M. ; Kuse, M. ; Yasuda, Y. ; Takahashi, H.: "Synthesis of 13C-Dehydrocoelenterazine and Model Studies on Symplectoteuthis Squid Bioluminescence." BioMed.Chem.Lett.8 (#20). 2919-1924 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiba, K. ; Hoshi, M. ; Isobe, M. ; Hirose, E.: "Bioluminescence in the Tunic of the Colonial Ascidian, Clavelina miniata : Identification of Luminous Cells in Vitro." The Journal of Experimental Zoology. 281. 546-553 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Isobe, M., Tsuboi, K, ; Hosokawa, S. ; Bamba, M. ; Kira, K. ; Shibuya, S. ; Ohtani, I.I. ; Nishikawa, T. ; Ichikawa, Y.: "Pure & Appl.Chem." Enzyme inhibitors, synthesis and approach to mechanism.997. 6 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Isobe, M. ; Nishikawa, T. ; Nishizawa: "Synthesis of Sugar Acetylenes" L.J.Chem.Soc., Chem.Commun. (Feature Article). 2665-2676 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tsuboi,K.;Ichikawa,Y.;Jiang,Y.;Naganawa,A:Isobe,M: "Total Synthesis of (+)-Tautomycin.a" Tetrahedron. 53. 5123-5142 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tsuboi,K.;Ichikawa,Y.;Isobe,M: "Synthesis of Okadaic Acid-Tautomycin Hybrid." Synlett. 713-715 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yenjai,C.;Isobe,M: "One-Step Recyclization of Sugar Acetylenes to form Medium Ether Rings via Dicobalthexacarbonyl Complexes." Tetrahedron. 54. 2509-2520 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanokmedhakul,S.;Kanokmedhakul,K;Ohtani,I.I.;Isobe,M: "A Diynoic Acid from Polyalthia evecta." Phytochemistry. 47. 131-133 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Isobe,M.;Kuse,M.;Yasuda,Y.;Takahashi,H.: "Synthesis of 13C-Dehydrocoelenterazine and Model Studies on Symplectoteuthis Squid Bioluminescence." BioMed.Chem.Lett.8(♯20). 2919-2924 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiba,K.;Hoshi,M.;Isobe,M.;Hirose,E.: "Bioluminescence in the Tunic of the Colonial Ascidian,Clavelina miniata:Identification of Luminous Cells in Vitro." The Journal of Experimental Zoology. 281. 546-553 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Isobe,M.,Tsuboi,K:Hosokawa,S.:Bamba,M.:Kira,K.:Shibuya,S.:Ohtani,I.I.:Nishikawa,T.:Ichikawa,Y.: "Enzyme inhibitors,synthesis and approach to mechanism." Pure & Appl.Chem., 6 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 坪井克憲、磯部 稔: "「3 阻害物質と阻害薬 阻害剤の全合成とコンフォメーション解析」II プロテインセリン・スレオニンフォスファターゼ" 蛋白質・核酸・酵素, 8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takahashi, K.;Isobe, M.;Muto S.: "An increase in cytosolic calcium ion concentration precedes hypoosmotic shock-induced activation of protein kinases in tobacco suspension culture cells." FEBS Lett.,. 401. 202-206 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanokmedhakul, S.;Kanokmedhakul, K, ;Ohtani, I.I.;Isobe, M.: "A Diynoic Acid from Polyalthia evecta." Phytochemistry. 47. 131-133 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 磯辺 稔: "化学発光と生物発光およびその利用" ファルマシア, 4 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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