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Comparative analysis of genetic factor in Buerger disease

Research Project

Project/Area Number 09041176
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KOBAYASHI Yasushi  Tokyo Medical and Dental Univ., Assist Professor, 医学部, 助手 (70225548)

Co-Investigator(Kenkyū-buntansha) NOSE Masato  Ehime University, Professor, 医学部, 教授 (70030913)
KIMURA Akinori  Tokyo Medical and Dental University., Professor, 難治疾患研究所, 教授 (60161551)
YASUKOCHI Yukio  Tokyo Medical dental University, Professor, 難治疾患研究所, 教授 (60037398)
NISHIMURA Yasuharu  Kumamoto University, Professor, 医学部, 教授 (10156119)
NUMANO Fujio  Tokyo Medical and Dental Univ., Professor, 医学部, 教授 (40013958)
岩井 武尚  東京医科歯科大学, 医学部, 教授 (90111591)
中林 公正  杏林大学, 医学部, 教授 (90086603)
渡辺 照男  筑波大学, 医学部, 教授 (40037396)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1998: ¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1997: ¥7,300,000 (Direct Cost: ¥7,300,000)
KeywordsBuerger's disease / Throboangitis Obliterans / HLA / 血管炎 / バ-ジャー病 / 閉塞性血栓性血管炎
Research Abstract

Buerger's Disease, Thromboangitis obliterans, is known to be a intractable vasculitis maimly involving middle size arteries of lower extremities and also vein. It also involves the aretry of upper arm and visceral arteries. The pathogenesis of Buerger's disease is atill unknown even smoking is known exacerbate this morbid condition.
Inthis project, we focused in the genetic factor of Buerger's disease to know its pathogenesis especially on HLA and MIC-A in the patients of Japanese, other Asian countries, Middle East, South Americans.
At the biginning, we showed HLA-DR4, 15a and 16 was significantly associated with Buerger's disease in Japanese. The we started registration of Buerger's disease from Japan, India, Thailand, Mexico, Colombia, Turkey, Israel and U.S.A.according the standard criteria of diagnisis of Buerger's disease.
And we held two International Conference on Buerger's Disease. 1st conference was held in Karuizawa, Japan from Novemver 4 to 6, 1997 and second congress was in Atlanta, U.S.A.from October 5 to 8,1998.
We invited specialists on Buger's disease and discussed on 1) clinical views, 2) pathogenesis, 3) molecular mechanism of thrombogenesis in Buerger's disease, 4) the risk of smoking in Buerger's disease, 5) genetic factor in the pathogenesis of Buerger's disease, 6) adhesion molecules, 7) diagnosis and so on. We also discussed on Talayasu Arteritis , Temporal arteritis, and IAAA as well.
Finally we reported our activity of this project in the special issue of lnternational Journal of Cardiology in 1998.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Kimura A, Kobayashi Y, et al: "MICA gene polymorhism in Takayasu's arteritis and Buerger's disease" International Journal of Cardiology. 66, sup 1. 107-113 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numano F: "Takayasu arteritis, Buerger Disease and lnflammatory abdominal aortic aneurysm : is there a commmon pathway in their pathogenesis?" International Journal of Cardiology. 66, sup 1. 3-10 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Lie JT: "Visceral intestinal Buerger's disease." International Journal of Cardiology. 66, sup 1. 107-113 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Iwai T: "Buerger's disease with intesitinal involvement." International Journal of Cardiology. 66, sup 1. 257-263 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shionoya S: "Diagnostic criteria of Buerger's disease." International Journal of Cardiology. 66, sup 1. 249-256 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka K: "Pathology and pathgenesis of Buerger's disease." International Journal of Cardiology. 66, sup 1. 237-242 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Numano F: "Takayasu arteritis, Bueger Disease and Inflammatory abdominal aortic aneurysm : Is there a commmon pathway in their pathogenesis?" International Journal of Cardiology. 66 supple1. 3-10 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura A,Kobayashi Y,Takahshi M,Ohbuchi N,Kitamura H,Nakamura T,Satoh M,Sasaoka T,Hiroi S,Arimura T,Akai J,Aerbajinai W,Yasukochi Y,Numano F: "MICA gene polymorhism in Takayasu's arteritis and Bueger's disease." International Journal of Cardiology. 66 supple 1. 107-113 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tanaka K: "Pathology and pathgenesis of Bueger'd disease." International Journal of Cardiology. 66 supple 1. 237-242 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Shionoya S: "Diagnostic criteria of Bueger's disease." International Journal of Cardiology. 66 supple 1. 249-256 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] J T Lie: "Visceral intestinal Bueger's disease." International Journal of Cardiology. 66 supple 1. 107-113 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Iwai T: "Bueger'd disease with intesitinal involvement." International Journal of Cardiology. 66 supple 1. 257-263 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Jimenez-Parades CA,Canas-Davila CA,Sanchez A,Restrepo JF,Pena M,Igresias-Gamarra A.: "Bueger's disease at the San Juan De Dios Hospital, Santa Fe De Bogota, Colombia" International Journal of Cardiology. 66 supple 1. 267-272 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kishi Y,Sakita S,Ohta S,Watanabe R,Wanatabe T,Kobayashi Y,Maruyama Y,Ashikaga T,Numano F: "Platelet-Endothelium Interaction-A key Connection ot Atherombotic Evevts." Jounal of Atherosclerosis and Thrombosis. 4. 144-148 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima N: "The change in concept and surgical treatment on Bueger's disease-personal experience and review" International Journal of Cardiology. 66 supple 1. 273-280 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] J T Lie: "Pathology of isolated nonclassical and catastrophic manifestations of Takayasu arteritis" International Journal of Cardiology. 66 supple 1. 11-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Noguchi S,Numano F,MB gravanis JN Wilcox: "Increased level of soluble forms of adhesion molecules in Takayasu arteritis." International Journal of Cardiology. 66 supple 1. 23-33 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nose M,Terada M,Nishimura M,Kamogawa J,Miyazaki T,Mori S,Nishimura M,Wang Y,Kamoto T,Hiai H: "Vasculitis-susceptible genes in mice with a deficit in FAS-mediated apoptosis." International journal of Cardiology. 66 supple 1. 37-41 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Watanabe T,Fan J: "Atherosclerosis and Inflammation.Mononuclear Cell Recruitment and Adhesion Moleculear with Reference to the Implication of ICAM-1/LFA-1 Pathway in Atherogenesis." International journal of Cardiology. 66 supple 1. 45-53 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ma X,Huang W,She M: "Effects and Mechanism of Tissue-Type Plasminogen Activator and Plasminogen activator Inhibitor on Vascular Smooth Cell Proliferation." International Journal of Cardiology. 66 supple 1. 57-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nishimura Y,Kanai T,Oiso M,Tabata H,Ito H,Kira J,Chen YZ,Matsusita S: "Molecular analyses of HLA Class II-associated susceptibility to subtypes of autoimmune diseases unique to Asians." International journal of Cardiology. 66 supple 1. 93-104 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Flamm SD,White RD,Hoffman GS: "The Clinical Application of "EdemaWighted" MR Imaging in the Assessment of Takayasu's Arteritis." International journal of Cardiology. 66 supple 1. 151-159 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Moncade G,Kobayashi Y,Kaneko E,Nishiwaki Y,Kishi Y,Numano F.: "Subclavian steal syndrome secondary to Takayasu arteritis." International journal of Cardiology. 66 supple 1. 231-236 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura A,Kobayashi Y,et al: "MICA gene polymorhism in Takayasu's srieritis and Bueger's disease." International Journal of Cardiology. 66,sup 1. 107-113 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numano F: "Takayasu arteritis,Bueger Disease and Inflammatory abdominal aortic aneurysm Is there a commmon pathway in their pathogenesis?" Internaltiona Journal of Cardiology. 66,sup 1. 3-10 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lie JT: "Visceral interstinal Buerger's disease." International Journal of Cardiology. 66,sup 1. 107-113 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iwai T: "Buerger's disease with intesitinal involvement." International Journal of Cardiology. 66,sup 1. 257-263 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shionoya S: "Diagnostic criteria of Buerger's disease." International Journal of Cardiology. 66,sup 1. 249-256 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka K: "Pathology and pathgenesis of Buerger's disease." International Journal of Cardiology. 66,sup 1. 237-242 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Numano F et al: "HLA alleleits strongly associated with the Parhogeucas" Aduances in Reserch on DNA Polyuosphissun. 10. 373-379 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] MoncadaG et al: "A-longtermm patency of aovco-aovtic groft by pass is a patisit." Internal Medcciue. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林 靖: "高安動脈炎(大動脈炎症候群)" 臨床科学. 33(11). 1405-1411 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小林 靖: "高安動脈炎" 病理と臨床. 16(3). 282-285 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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