• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comparative Study of Salt Sensitivity and Heredity in Nepal

Research Project

Project/Area Number 09041186
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research Field Circulatory organs internal medicine
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

KAWASAKI Terukazu  INSTITUTE OF HEALTH SCIENCE,PROFESSOR, 健康科学センター, 教授 (00038704)

Co-Investigator(Kenkyū-buntansha) ACHARYA Gopa  トリブバン大学, 医学部, 教授
SAITO Atsushi  INSTITUTE OF HEALTH SCIENCE,ASSOCIATE PROFESSOR, 健康科学センター, 助教授 (90195975)
OGAKI Tetsurou  INSTITUTE OF HEALTH SCIENCE,ASSOCIATE PROFESSOR, 健康科学センター, 助教授 (20101470)
KOBAYASHI Shigeru  DEPARTMENT OF HUMAN GEOGRAPHY GRADUATE SCHOOL OF LETTERS,OSAKA UNIVERSITY PROFES, 大学院文学研究科, 教授 (30087150)
ITOU Kazue  DIVISION OF FOOD AND NUTRITION,NAKAMURAGAKUEN COLLEGE,PROFESSOR, 家政学部, 教授 (80104983)
GOPAL P.Acharya  INSTITUTE OF MEDICINE,TRIBHUVANUNIVERSITY,PROFESSOR
GOPAL P.Acha  トリプバン大学, 医学部, 教授
SHARMA Sashi  トリブバン大学, 医学部, 助教授
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1998: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1997: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsNepal / isolated hill village / hypertension / salt sensitivity / seasonal variation / ACE gene polymorphism / 目給自足的農村 / 食塩感受精 / 率節変動 / アンジオテンシン変換酵素遺伝子多 / 丘陵地農村 / 正常血圧集団 / 生活形態 / ミネラル摂取
Research Abstract

We found that there were very few hypertensive subjects in the inhabitants of one Nepalese hill (Kotyang) village, even though their salt consumption was as high as the citizens in many westernized countries including Japan. To evaluate the genetic factors involved in this phenomenon, we studied whether or not they had a special genotype distribution of angiotensin converting enzyme (ACE) gene L/D polymorphism, which was recently reported to be involved salt sensitivity. One hundred and thirty-eight subjects (aged in range 20 to 84 years) were evaluated at Kotyang village in Nepal. Only 9 subjects (6.5%) in this population were hypertensives (140/90 mmHg and over) while consuming 11-12g per day of salt, which also confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-to ten-times -more hypertensives while consuming almost as much salt as Nepalese, but signiticantly different from those in Caucasians. The present study reports, for the first time, the genotype distribution of ACE gene I/D polymorphism in Nepalese subjects. Furthermore, the results suggest ACE gene polymorphism may not be involved in the 'salt-resistance' in this population.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Umemura S, Kawasaki T, Ishigami T, et al: "Angiotensin-converting enzyme gene polymorphism in Nepal" Journal of Human Hypertension. 12. 527-531 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Umemura S,Kawasaki T,Ishigami T,et al: "Angiotensin-converting enzyme gene polymorphism in Nepal" Journal of Human Hypertension. 12. 527-531 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] マラリア抵抗因子: "寄生中"

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi