NAZAKI Tomoyoshi School of Medicine KEIO University, Research fellow, 医学部, 助手 (60198588)
KOBAYASHI Seiki School of Medicine KEIO University, Research fellow, 医学部, 助手 (70112688)
MIURA Sachio School of Medicine KEIO University, Research fellow, 医学部, 助手 (30051858)
KAMIYA Toshiaki School of Medicine Chiristian University, Professor, 医学部, 教授
HAMANO Shinjirou Facluty of Medicine Kyushu University, Research fellow, 医学部, 助手 (70294915)
神谷 俊明 クリスチャン大学, 医学部, 教授
|Budget Amount *help
¥8,900,000 (Direct Cost: ¥8,900,000)
Fiscal Year 1997: ¥8,900,000 (Direct Cost: ¥8,900,000)
Chagas' disease shows the different conditions in each areas, for instance, Santa Cruz in Bolivia in which the seroprevalence of anti-Trypanosoma cruzi (T. cruzi) antibodies among pregnant women shows 2-25%. On the other hand, congenital Chagas' disease has not been reported in Northeast Brazil (Sao Raimundo Nonato, Macaparana, Brejo) though they had been endemic area. We studied about the life situation of the vector, infection rate by T. cruzi and seroepidemiological diagnosis above areas to select pilot area. Part of the study were done in our collaborators'.
1) The antibody against T. cruzi of the inhabitants in Abapo area of Santa Cruz environs in Bolivia were examined by IFA, HAI and ELISA. We also examined by Microhematocrit to check parasitemia, the acute stage. Though parasitemia did not be found, 60-79% of inhabitants had T. cruzi antibody. It is to be regretted that we couldn't meet the case suspected as congenital infection in the municipal hospital of maternity, one of our collaborator, during our visit. We captured many Triatomines in the inhabitants' house and the chicken coop next to their house, now we are isolating T. cruzi from them. We also evaluated about their species, most of them were Triatoma infestans and T. sordida.
2) Congenital Chagas' disease has not been reported in Northeast Brazil, whether it is the effect of the health education, at the same time of vector control in 1988-89, we could hardly find the living environment of Triatomines in the house. But some inhabitants complaint that they come in their house at night, Triatoma braziliensis that the inhabitants brought infected T. cruzi. The seropositive rates of T. cruzi antibody were 2-45%, showed difference between the areas.