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ヨーロッパなどががん研究先進国との研究交流

Research Project

Project/Area Number 09042009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research Field Experimental pathology
Research InstitutionShowa University

Principal Investigator

黒木 登志夫  昭和大学, 腫瘍分子生物学研究所, 所長 (90006073)

Co-Investigator(Kenkyū-buntansha) 石川 冬木  東京工業大学, 生命理工学部, 教授 (30184493)
樋野 興夫  癌研究所, 病理部, 部長 (90127910)
菊池 章  広島大学, 医学部, 教授 (10204827)
開 祐司  京都大学, 再生医科学研究所, 教授 (40144498)
宮園 浩平  癌研究所, 生化学部, 部長 (90209908)
佐谷 秀行  熊本大学, 医学部, 教授 (80264282)
貝淵 弘三  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (00169377)
山本 雅  東京大学, 医科学研究所, 教授 (40134621)
時野 隆至  札幌医科大学, 医学部, 教授 (40202197)
秋山 徹  大阪大学, 微生物学研究所, 教授 (70150745)
高橋 雅英  名古屋大学, 医学部, 教授 (40183446)
田中 信之  東京大学, 医学部, 助教授 (80222115)
武藤 誠  東京大学, 薬学部, 教授 (70281714)
堀井 明  東北大学, 医学部, 教授 (40249983)
Project Period (FY) 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥28,700,000 (Direct Cost: ¥28,700,000)
Fiscal Year 1999: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 1998: ¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 1997: ¥10,100,000 (Direct Cost: ¥10,100,000)
Keywordsがん遺伝子 / がん抑制遺伝子 / シグナル伝達 / がん細胞 / DNA修復 / がん転移 / ヒトゲノム / 2国間協同研究 / 2国間共同研究
Research Abstract

1.研究背景: がん遺伝子の発見をきっかけに、がん研究は遺伝子の時代に入り、欧米のがん研究先進国を中心に激しい研究競争を繰り広げている。地理的に隔離されているわが国の研究者は、研究者との直接の討論、情報、資料交換に自ら制限があり、ともすると孤立しかねない。この問題点を克服するため、わが国の第一線の研究者を積極的にがん研究先進国に送る必要がある。本研究は、ヨーロッパのがん研究先進諸国との研究交流を目的に組織された。特に、日独、日仏がんワークショップはそれぞれ一年毎にヨーロッパ本国と日本と場所をかえて行われているが、本年度は日独をヨーロッパで、日仏を日本で開催した。本年度は10名をヨーロッパ諸国に派遣した。
2.日独がん研究連絡会議: 1999年7月29〜31日独国・エッセン、エッセン大学において「分子細胞生物学的がん研究」に関する日独がんワークショップを開催した。わが国から黒木登志夫(昭和大・腫瘍分子研)、秋山 徹(東大・分生研)、菊池 章(広島大・医)、樋野興夫(癌研)、石川冬木(東工大・生命理工学)が本研究費で出席した。
3.日仏がん研究連絡会議: 1999年9月8〜10日、東北大学・医学部において、「21世紀のがん研究に向けての新しい戦略」をテーマに日仏ワークショップが開催された。フランス側から12名、わが国からは黒木登志夫(昭和大・腫瘍分子研)、石川冬木(東工大・生命理工学)、宮園浩平(癌研)、広橋説御、塚田俊彦、落合孝広(国立がんセ・研)、渋谷正史、中村祐輔(東大・医科研)、中山敬一(九大・生医研)、月田承一郎、武田俊一(京大・医)、伊藤嘉明(京大・ウイルス研)、菅野晴夫(癌研)、豊島久真男(住友病院)が本研究費で出席した。
4.その他の派遣者: 宮園浩平(癌研)、藤井穂高(東大・医)、丸義朗(東大・医科研)、開祐司(京大・再生医研)、千葉英樹(札幌医大・医)をヨーロッパの先進研究室に派遣した。

Report

(3 results)
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Kuroki, T.: "Adenovirus-mediated gene transfer to keratinocytes - A Review -"J. Invest. Dermatol. Symp. Proc.. 4. 153-157 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hamada, F.: "Negative regulation of Wingless singnaling by D-Axin, a Drosophila homologue of Axin"Science. 283. 1739-1742 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fujii, M.: "Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblastic and chondroblastic defferentiation"Mol. Biol. Cell. 10(11). 3801-3813 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakashima, S.: "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors"EMBO J.. 18. 3629-3642 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayami, Tadashi: "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo"FEBS Lett.. 458. 436-440 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takeda, N.: "The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosm group B protein"Proc. Natl. Acad. Sci. USA. 96. 203-207 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tsujino S: "Critical role of the the membrane-proximal, proline-rich motif of the interleukin-2 receptor gc chain in the Jak3-independent signal transduction"Genetic Cells. 4. 363-373 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Igarashi, Y.: "Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier"Biochem. Biophys. Res. Com.. 261. 108-112 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hino, O.: "TSC2 gene mutant (Eker) rat model of a mendelian dominantly ingerited cancer. Prog. Exp. Tumor Res"Prog. Exp. Tumor Res. (eds. Hiai, H. and Hino, O. ) , Karger, Basel. 35. 95-108 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ohba,M.: "Induction of differentiation in normal human keratinocytes by adnovirus-mediated introduction of the η and δ isoforms of protein kinase C." Mol.Cell.Biology. 18. 5199-5207 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Han,H.-J.: "CSR,a scavenger receptor-like protein with a protective role against cellular damage caused by UV irradiation and oxidative stress." Human Molecular Genetics. 7. 1039-1046 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suwa,T.: "Increased invasiveness of MUCI and cDNA-transfected human gastric cancer MKN74 cells." Int.J.Cancer. 76. 377-382 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikuta,T.: "Nuclear localization and export signals of the human aryl hydrocarbon receptor." J.Biol.Chem.273. 2895-2904 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida,Y.: "ANA,a novel member of Tob/BTG1 family,is expressed in the ventricular zone of the developing central nervous system." Oncogene. 16. 2687-2693 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chida,K.: "Assignment of protein kinase Cη(Pkcη)to mouse chromosome band 12C3-D2 by in situ hybridization." Cytogenet.Cell Genet.82. 30-31 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Naito,T.: "Circular chromosome formation in a fission yeast mutatn defective in two ATM-homologues." Nature Genetics. 20. 203-206 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kondo,Y.: "Analysis of conserved ambisense within CB virus C." J.Infectious Diseases. 178. 1185-1188 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanagisawa,K.: "Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells." Oncogenes. 17. 1743-1747 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumoto,H.: "Suppression of heat-induced HSF activation by CDDP in human glioblastoma cells." Int.J.Radiat.Oncol.Biol.Phys.41. 915-920 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuroda,S.: "Role of IQGAP1,a target of the small GTPase Cdc42 and Racl,in the regulation of E-cadherin-mediated cell-cell adhesion." Science. 281. 832-835 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakamura,H.: "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region." Oncogene. 16. 1009-1019 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,H.: "Evidence for a putative telomerase repressor gene on the 3p14.2-p21.1 region." Genes,Chrom.and Cancer. 23. 123-133 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kashiwagi, M: "Specific inhibition of hair follicle formation by epidermal growth factor in an organ culture of developing mouse skin." Develop.Biol.189. 22-32 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shibanuma, M.: "Induction of senescemce-like phenotypes by forced expression of hic-5,which encodes a novel LIM motif protein,in immortalized human fibroblasts." Molecular Cellular Biology. 17. 1224-1235 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Oshima, H.: "Morphological and molecular process of polyp formation in ApcD716 knockout mice." Cancer Res.57. 1644-1649 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo, T.: "Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity." Oncogene. 15. 1275-1281 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito, S.: "Biological properties of ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A,familial medullary thyroid carcinoma,and hirschsprung's disease phenotype." Cancer Res.57. 2870-2872 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Satoh, K.: "DAP-1,a novel protein that interacts with the guanylate kinase-like domains of DLG and PSD-95." Genes to Cells. 2. 145-424 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yang, T.T.: "p53 induced by ionizing radiation mediates DNA end-joining activity,but not apoptosis of thyroid cells.Oncogene" Oncogene. 14. 1511-1519 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Makino, K.K.: "Cloning and characterization of NE-dlg:a novel human homolog of the Drosophila discs large(dlg)tumor suppressor protein interacts with the APC protein."

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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