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International Comparative Study on Toxicity Assessment

Research Project

Project/Area Number 09044172
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field 環境影響評価(含放射線生物学)
Research InstitutionOkayama University

Principal Investigator

AOYAMA Isao  Research Institute for Bioresources, Okayama University, Professor, 資源生物科学研究所, 教授 (10026239)

Co-Investigator(Kenkyū-buntansha) HAYATSU Hikoya  Faculty of Pharmaceutical Sciences, Okayama University, Professor, 薬学部, 教授 (10012593)
LUO Rong  Research Institute for Bioresources, Okayama University, Assistant Professor, 資源生物科学研究所, 助手 (10284093)
OKAMARA Hideo  Research Institute for Bioresources, Okayama University, Assistant Professor, 資源生物科学研究所, 助手 (90253020)
NEGISHI Tomoe  Faculty of Pharmaceutical Sciences, Okayama University, Associate Professor, 薬学部, 助教授 (80116491)
ONO Yoshiro  Faculty of Environmental Science and Technology, Okayama University, Associate Professor, 環境理工学部, 助教授 (50152541)
LIU Dickson  カナダ国立水科学研究所, 主任研究員
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥14,500,000 (Direct Cost: ¥14,500,000)
Fiscal Year 1999: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1998: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1997: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsBioassay / Hazardous chemicals / Toxocity evaluation / International comparison / New development of bioassay / 有害化学物質の管理・制御 / バイオアッセイの教材作成 / ミジンコの運動量解析
Research Abstract

Environmental pollution by hazardous chemicals has been recognized as an international and common matter of life and death of ecosystems and mankind in the world. The methods of management and control of environmental pollution by hazardous chemicals are different depending on each country's way of thinking and circumstances. In our country, at first chemical analyze of chemicals is done and then the concentration of chemicals are compared with environmental standards. While in Europe and U.S.A and Canada, the existing of hazardous chemicals in environments is at first confirmed by bioassays. Many kinds of bioassays are developed and used for environmental management of chemicals.
The object of this international co-operative investigation is to contribute to develop the methodology of environmental control and management of chemicals.
In the first year of this research project, Japanese scientists visited Australia and China and reported our trend of the methodology of environmental man … More agement of Japan and collected the information of environmental management from the two countries. We could not find the special management system in the both countries. We invite a co-operative scientist from Canada and a scientist from Japan side visited Canada, and we carried the co-operative research on the bio-gradiation of chemicals and the bioassay using hydra.
In the second year, Japan visited Canada, Czech, Belgium, Switzerland, Austria, China and Taiwan, and scientists from Canada, Switzerland and South Africa were invited to Japan. We discussed about our research project. As for new bioassay method, we developed a high sensitive bioassay method using Daphnia mobility analysis.
In the last year, all of co-operative scientists participated in the International Symposium held at South Africa, Pretoria City and presented the research results. We had a group meeting and exchanged views with each other about our research project and discussed how to arrange the report. Research report was published at March. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] 青山 勳: "ミジンコの運動量解析による有害化学物質のモニタリング"環境技術. 26(4). 255-259 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "化学物質と生態系"化学と工業. 50(4). 549-551 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Liu, Dickson: "Transformation of the antifouling compound irgarol 1051 by Phanerochete crysorium"Water Research. 31 (9). 2363-2369 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 羅 栄: "酵母Saccharomyces cerevisiaeを用いた底質中の有害化学物質の毒性評価"水環境学会誌. 21(4). 244-249 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "産業廃棄物埋立地浸出水の生態毒性評価"環境技術. 27(5). 330-334 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡村 秀雄: "産業廃棄物埋立地浸出水の生態毒性評価および毒性キャラクタリゼーション"環境毒性学会誌. 1(1). 43-50 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "内分泌攪乱作用物質の生態影響評価"日本農薬学会誌. 第24巻. 105-109 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoyama, I.: "Toxicity of Organic and Inorganic Mercury to Saccharomyces cerevisiae"Ecotoxicology and Environmental Safety. 43. 149-155 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Okamura, H.: "Application of short-term bioassay guided chemical analysis for water quality for agricultural land runoff"Sci. Total Environ.. 234. 223-231 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Okamura, H.: "Photodegradation of Irgarol 1051 in water"J. Environ. Aci. Health. B34 (2). 225-238 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hayatsu, H.: "Porphyrins as possible prevents of heterocyclic amine carcinogenesis"Cancer Letters. 143. 185-187 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Negishi, T.: "Somatic cell mutation induced by sunlight in drosophila"Journal of Epidemiology. 9 86). s-66--71 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "環境保全工学"技法堂出版. 227 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "水文・水資源ハンブック"朝倉書店. 980 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山 勳: "検証「環境ホルモン」(化学物質と生態系-エコトキシコロジー)"青木書店. 274 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Aoyama, I.: "Toxicity testing in Japan and the use of Toxkit microbiotests"Kluwer Academic/Plenum Publishers. 552 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Monitoring of Toxic Chemicals by Mobility Analysis of D. Magna"Environmental Conservation Engineering. 26 (4). 255-259 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Chemicals and Industry"Chemistry and Industry. 50 (4). 549-551 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Dickson Liu: "Transformation of the antifouling compound irgarol 1051 by Phanerochete crysorium"Water Research. 31 (9). 244-249 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lou Rong: "Toxicity Evaluation of Toxic Chemicals in Sediments Using S. cerevisiae"J. of Japan Society on Water Environment. 21 (4). 244-249 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Ecotoxicity Assessment of Landfill Leachates using a Battery of Bioassay and Toxicity characterization of the Leachtes"Environmental Conservation Engineering. 27 (5). 330-334 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Okamura, L. Rong and I, Aoyama: "Ecotoxicity Assessment of Landfill Leachates using Battery of Bioassay and Toxicity Characterization of the Leachates"Japan J. Environmental Toxicology. 1 (1). 43-50 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Ecotoxicity Assessment of Endocrine Disrupting Chemicals"J. of Pesticide Science. 24. 105-109 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Toxicity of Organic and Inorganic Mercury to Saccharomyces cerevisiae"Ecotoxicology and Environmental Safety. 43. 149-155 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Okamura: "Application of short-term bioassay guided chemical analysis for water quality of agricultural land runoff"Sci. Total Environ. 234. 223-231 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hideo Okamura: "Photodegradation of Irgarol 1051 in water"J, Environ. Sci. Health. b34 (2). 225-238 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hikoya Hayatsu: "Prophyrins as possible preventers of heterocyclic amine carcinogenesis"Cancer Letters. 143. 185-187 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomoe Negishi: "Somatic cell mutation induced by sunlight in drosophila"J. of Epidemiology. 9 (6). s66-s71 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Environmental Conservation Engineering"Gihodo Publishing Ltd. 227 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Handbook of Hydrology and Water Resources"Asakua Publishing Ltd. 980 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Environmental Hormone (Chemicals and Ecosystem-Ecotoxicology)"Aoki Publishing Ltd. 274 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Isao Aoyama: "Toxicity testing in Japan and the use of Toxkit microbiotests"Kluwer Academic/Plcnum Publishers. 552 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 青山勲: "内分泌攪乱作用物質の生態影響評価"日本農薬学会誌. 第24巻. 105-109 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Aoyama,I.: "Toxicity of Organic and Inorganic Mercury to Saccharomyces cerevisiae"Ecotoxicology and Environmental Safety. 43. 149-155 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okamura,H.: "Application of short-term bioassay guided chemical analysis for water quality of agricultural land runoff"Sci.Total Environ.. 234. 223-231 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okamura,H.: "Photodegradation of Irgarol 1051 in water"J.Environ.Aci.Health. B34(2). 225-238 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hayatstu,H.: "Porphyrins as possible preventers of heterocyclic amine carcinogenesis"Cancer Letters. 143. 185-187 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Negishi,T.: "Somatic cell mutation induced by sunlight in drosophila"Journal of Epidemiology. 9(6). s-66-s-71 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小野芳朗: "雨天時路面排水中塵埃の遺伝毒性・生態毒性評価"水環境学会誌. 22(7). 561-567 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu,Dickson: "Survey for the occurrence of the new antifouling compound Irgarol 1051 in the aquatic environment"Water Research. 33(12). 2833-2843 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu,Dickson: "Mercuric chloride-catalyzed hydrolysis of the new antifouling compound Irgarol 1051"Water Research. 33(1). 155-163 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 青山勲: "検証「環境ホルモン」(化学物質と生態系-エコトキシコロジー)"青木書店. 274 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Aoyama,I.: "Kluwer Academic/Plcnum Publishers"Toxicity testing in Japan and the use of Toxkit microbiotests. (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] LIU,Dickson: "Transformation of the new antifouling compound Irgarol 1051 by Phanerochate Chrysosporium." Water Research. 31・9. 2363-2369 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 羅 栄: "酵母Saccharomyces cerevisiaeを用いた底質中の有害化学物質の毒性評価" 水環境学会誌. 21・4. 244-249 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 青山 勳: "産業廃棄物埋立地浸出水の生態毒性評価" 環境技術. 27・5. 330-334 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] MAKI,Hideaki: "Halogenation and toxicity of the biodegradation products of a nonionic sulfactant, nonyphenol ethoxylate." Env.Toxicol.and Chem.17・4. 650-954 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡村 秀雄: "産業廃棄物埋立地浸出水の生態毒性評価および毒性キャラクタリゼーション" 環境毒性学会誌. 1・1. 43-50 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] LIU,Dickson: "Microbial adsorption of cyanazine and metolachlor" J.Environ.Sci.Health. B33・1. 1-15 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 青山 勳: "水環境のリスク管理" 講談社サイエンティフィック, 362 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] AOYAMA、Isao: "Comparative Evaluation of Environmental Toxicant" KODANSHA SCIENTIFIC LTD., 307 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 青山 勲: "ミジンコの運動量解析による有害化学物質のモニタリング" 環境技術. 26(4). 255-259 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 青山 勲: "化学物質と生態系-エコトキシコロジーの問題" 化学と工業. 50(4). 549-551 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Liu, Dickson: "Transformation of the new antifouling compound irgarol 1051 by phanerochaete chrysorium." Water Research. 31(9). 2363-2369 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hayatsu, Hikoya: "Antigenotoxic activity of natural chlorophylls." Mutation Research. 376. 97-100 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小野 芳朗: "道路路面排水中の多環芳香族化合物ニトロ誘導体由来の遺伝毒性評価" 水環境科学. 20(11). 738-745 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 青山 勲: "環境保全工学,自然保護" 技報堂出版, 227 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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