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Japan-UK Joint Study on Molecular Genetics of Streptomyces

Research Project

Project/Area Number 09044205
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field 応用微生物学・応用生物化学
Research InstitutionThe University of Tokyo

Principal Investigator

HORINOUCHI Sueharu  The University of Tokyo, Graduate Shool of Agriculture and Life Sciences Professor, 大学院・農学生命科学研究科, 教授 (80143410)

Co-Investigator(Kenkyū-buntansha) IKEDA Haruo  Kitasato university School of Pharmaceutical Sciences Associate Professor, 薬学部, 助教授 (90159632)
OGAWARA Hiroshi  Meiji College of Pharmacy Department of Biochemistry Professor, 薬学部, 教授 (00097198)
YAMADA Yasuhiro  Osaka University, Graduate School of Engineering Professor, 工学部, 教授 (00011891)
SETO Haruo  The University of Tokyo, Institute of Molecular and Cellular Biosciences Profess, 分子細胞生物学研究所, 教授 (10013335)
BEPPU Teruhiko  Nihon University Department of Applied Biological Sciences Professor, 生物資源科学部, 教授 (80011873)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥5,200,000 (Direct Cost: ¥5,200,000)
KeywordsJapan-UK Joint Study / Streptomyces / Molecular Biology / Antibiotics Production / Genetic Engineering / Molecular Breeding / Secondary Metabolism / Morphological Differentiation / Streptomyces
Research Abstract

The purpose of this study is promoting Japan-UK joint researches on molecular genetics of Streptomyces. A workshop on molecular genetics of Streptomyces was held at John Innes research center (Norwich, UK) on October 1997. Fifteen Japanese researchers took part in the workshop and discussed about joint researches. The proceeding of the workshop was distributed to many researchers who study on Streptomyces.
In the second year, 1998, three professors of John Innes research center (Sir. D.Hopwood, K.F.Chater and M.J.Bibb) visited Japan and discussed about joint researches with Japanese researchers. S.Horinouchi, head investigator of this study, visited John Innes research center on September. Y.Ohnishi, one of inverstigators of this study, stayed for three weeks at John Innes research center. He made experiments with some researchers of the center.
Thanks to this study, many joint researches started and more intimate relationship was established between Japanese and English researchers.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (255 results)

All Other

All Publications (255 results)

  • [Publications] Ando, N.: "Involvement of AfsA in A-factor biosynthesis as a key enzyme" J. Antibiot.50. 847-852 (1997)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ando, N.: "A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and a high concentration of A-factor during carly growth" Microbiology. 143. 2715-2723 (1997)

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      1998 Final Research Report Summary
  • [Publications] Lezhava, A.: "Chromosomal deletions in Streptomyces griscus that remove the afsA locus" Mol. Gen. Genet.253. 478-483 (1997)

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      1998 Final Research Report Summary
  • [Publications] Onaka, H.: "DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences" Mol. Microbiol.24. 991-1000 (1997)

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      1998 Final Research Report Summary
  • [Publications] Onaka, H.: "A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability" J. Bacteriol.179. 2748-2752 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kendrew, S.G.: "Identification of a monooxygenase from Steptomyces coclicolor A3(2) involved in biosynthesis of actinorbodin : purilication and characterization of the recombinant enzyme" J. Bacteriol.179. 4305-4310 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kramer, P.J.: "Rational design and engineered biosynthesis of a novel 1.8-carbon aromatic polyketide" J. Am. Chem. Soc.119. 635-639 (1997)

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      1998 Final Research Report Summary
  • [Publications] Crump, M.P.: "Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Steptomyces coelicolor A3(2)" Biochemistry. 36. 6000-6008 (1997)

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      1998 Final Research Report Summary
  • [Publications] Hopwood, D.A.: "Genetic contributions to understanding polyketide synthases" Chemical Reviews. 97. 2465-2497 (1997)

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      1998 Final Research Report Summary
  • [Publications] Ueda, K.: "Stimulatory effect of copper on anibiotic production and morphological differentiation in Streptomyces tanashiensis" J. Antibiot.50. 693-695 (1997)

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      1998 Final Research Report Summary
  • [Publications] Aubert, M.: "Inactivation or amplification of the spa2 gene, encoding a potential stationary-phase regulator, affects differentiation in Streptomyces ambofaciens." Can. J. Microbiol.43. 1118-1125 (1997)

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      1998 Final Research Report Summary
  • [Publications] Martin, M.C.: "A glgC gene essential only for the first of two spatially distince phases of glycogen synthesis in Streptomyces coelicolor A3(2)" J. Bacteriol.179. 7784-7789 (1997)

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      1998 Final Research Report Summary
  • [Publications] Oh, S.H.: "Denaturation of circular of linear DNA facilitates targeled integralive transformation of Streptomyces coelicolor A3(2) : possible relevance to other organisms" J. Bacteriol.179. 122-127 (1997)

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      1998 Final Research Report Summary
  • [Publications] Nakashita, H: "Studies on yhe biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation : Discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacctaldehyde from phoisphonopyruvate" J. Antibiot.50. 212-219 (1997)

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      1998 Final Research Report Summary
  • [Publications] 瀬戸 治男: "C-P結合形成の分子機構の解明-生物有機化学と分子生物学の接点" 日本農芸化学会誌. 71. 451-453 (1997)

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      1998 Final Research Report Summary
  • [Publications] 越智 幸三: "リボソームの改造による抗生物質の生産性向上" バイオサイエンスとインダストリー. 55. 35-36 (1997)

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      1998 Final Research Report Summary
  • [Publications] Hotta, K.: "Enzymatic 2′-N-acetylation of arbekacin and antibiotic activily of its product" J. Antibiot.49. 458-464 (1996)

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      1998 Final Research Report Summary
  • [Publications] Hotta, K.: "Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273 : involbement of two types of acetyltransferases in resistance to astomicin group antibiotics" J. Antibiot.49. 682-688 (1996)

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      1998 Final Research Report Summary
  • [Publications] 堀田 国元: "アミノグリコシド系薬剤" 日本臨床. 55. 219-225 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kataoka, M.: "Application of the variable region in 16S rDNA to create an index for rapid species identilication in the genus Streptomyces" FEMS Microbiol. Lett.151. 249-255 (1997)

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      1998 Final Research Report Summary
  • [Publications] Wietzorrek, A.: "A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold" Mol. Microbiol.25. 1177-1184 (1997)

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      1998 Final Research Report Summary
  • [Publications] Chakrabutryy, R.: "The ppGpp synthetase gene (rclA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation" J. Bacteriol.179. 5854-5861 (1997)

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      1998 Final Research Report Summary
  • [Publications] Labes, G.: "Isolation and characterization of a strong promoter element from the Streptomyces ghanaensis phage 119 using the gentamicin resistance gene (aacCl) of Tn 1696 as reporter" Microbiology. 143. 1503-1512 (1997)

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      1998 Final Research Report Summary
  • [Publications] Tieleman, L.: "Growth phase-dependent transcription of the Streptomyces ramocissimus tufl gene occurs from two promoters" J. Bacteriol.179. 3619-3624 (1997)

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      1998 Final Research Report Summary
  • [Publications] van Wezel, G.P.,: "The malEFG gene eluster of Streptomyces coelicolor A3(2) : characterization, disruption and transcriptional analysis" Mol. Gen. Genet.254. 604-608 (1997)

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      1998 Final Research Report Summary
  • [Publications] Alves, A.N.C.R.: "Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic parhway of the actinomycete Streptomyces coelicolor A3(2)" Appl. Environ. Microbiol.63. 956-961 (1997)

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      1998 Final Research Report Summary
  • [Publications] van Wezel, G.P.: "Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) controlled by malR, a member of the lacl-galR family of regulatory genes" Mol. Microbiol.23. 537-549 (1997)

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      1998 Final Research Report Summary
  • [Publications] White, J.: "bldA dependence of undeeylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade" J. Bacteriol.179. 627-633 (1997)

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      1998 Final Research Report Summary
  • [Publications] Ikeda, H.: "A vermectin biosynthesis" Chemical Reviews. 97. 2591-2609 (1997)

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      1998 Final Research Report Summary
  • [Publications] Zhang, H.: "Improvement of transformation system is Streptomyces using a modified regencration medium" J. Ferment. Bioeng.83. 217-221 (1997)

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      1998 Final Research Report Summary
  • [Publications] 小河原 宏: "最前線:放線菌遺伝子の発現調節、原核生物型?真核生物型?" ファルマシア. 33. 150-154 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kawachi, R.: "Development of a Transformation System in Streptomyces virginiac" FEMS Microbiol. Lett.157. 46-53 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kawabuchi, M.: "Production of butyrolactone autoregulators by Streptomyces coelicolor A3(2)" FEMS Microbiol. Lett.157. 81-85 (1997)

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      1998 Final Research Report Summary
  • [Publications] Waki, M.: "Cloning and characterization ofthe gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp. strain FRI-5" J. Bacteriol.179. 5131-5137 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kinoshita, H.: "Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiac" J. Bacteriol.179. 6986-6993 (1997)

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      1998 Final Research Report Summary
  • [Publications] Okamoto, S.: "Molecular cloning and characterization of the obg gene of Streptomyces griscus in relation to the onset of morphological differentiation" 179. 170-179 (1997)

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      1998 Final Research Report Summary
  • [Publications] 細谷 仁子: "微生物の潜在能力を引き出す-新規物質の探索、次代謝産物生産菌の生産性向上に新手法-" 化学と生物. 35. 684-686 (1997)

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  • [Publications] Kawamoto, S.: "Expression analysis of the ssgA gene product, associated with sporulation and cell division in Streptomyces griscus" Microbiol.143. 1077-1086 (1997)

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      1998 Final Research Report Summary
  • [Publications] Hesketh, A.: "A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin" J. Antibiot.50. 532-535 (1997)

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      1998 Final Research Report Summary
  • [Publications] Shima, J.: "Novel detoxification of the trichothecene mycotoxin deoxynivalcnol by a soil bacterium isolated by enrichment culture" Appl. Env. Microbiol.63. 3825-3830 (1997)

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      1998 Final Research Report Summary
  • [Publications] Kawamaot, S.: "Molecular analysis of the ribosomal L11 protein gene (rplK=relC) of Streptomyces griseus and identification of a deletion allele" Mol. Gen. Genet. .255. 549-560 (1997)

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  • [Publications] Ochi, K.: "Motecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3(2)" Mol. Gen. Genet. .256. 488-498 (1997)

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      1998 Final Research Report Summary
  • [Publications] Sugiyama, M.: "Site-directed mutagenesis of the A-factor receptor protein : Val-41 important for DNA-binding and Trp-119 important for ligand-binding" Gene. 222. 133-144 (1998)

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      1998 Final Research Report Summary
  • [Publications] Ueda, K: "Characterization of an A-factor-responsive repressor for amfR esscntial for onset of acrial mycelium formation in Streptomyces griseus" J. Bacteriol.180. 5085-5093 (1998)

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      1998 Final Research Report Summary
  • [Publications] Onaka, H.: "Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of seeondary metabolism and morphogenesis" Mol. Microbiol.28. 743-753 (1998)

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      1998 Final Research Report Summary
  • [Publications] Ando, N.: "Gene organization in a 12-kilobase region covering afsA eneoding an A-factor biosynthetic enzyme" Actinomycetol.12. 40-45 (1998)

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      1998 Final Research Report Summary
  • [Publications] Hong, S.-K.: "Effects of protein kinase inhibitors on in vitro protein phosphorylation and on secondary metabolism and morphogenesis in Streptomyces coelicolor A3(2)" J. Microbiol. Biotechnol.8. 325-332 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kang, D.-K.: "Possible involvement of cAMP in aerial mycclium formation and secondary mctabolism in Streptomyces griseus" Microbiology. in press. (1999)

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      1998 Final Research Report Summary
  • [Publications] Tin-Wein Yu: "Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases" J. Am. Chem. Soc.120. 7749-7759 (1998)

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      1998 Final Research Report Summary
  • [Publications] Chong, P.P.: "Physical identification of a chromosomal locus encoding bisynthetie genes for the lipopeptide calcium-dependent antiblotic (CDA) of Streptomyces coelicolor A3(2)" Microbiology. 144. 193-199 (1998)

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  • [Publications] Tropf, S.: "Heterologously expressed acyl carrier protein domain of rat fally acid synthase functions in Escherichia coli fally acid synthase and Streptomyces coelicolor polyketide wvnthase systems" Chemistry & Biology. 5. 135-146 (1998)

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  • [Publications] Ichinose, K.: "The granatiein biosynthetic gene cluster of Streptomyces violaccoruber Tu22 : sequence analysis and expression in a heterologous host" Chemistry & Biology. 5. 647-659 (1998)

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  • [Publications] Ryding, N.J.: "A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3(2)" Mol. Microbiol.29. 343-357 (1998)

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  • [Publications] Tan, H.: "The Streptomyces coelicolor sporulation-specific σWhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation" Gene. 212. 137-146 (1998)

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      1998 Final Research Report Summary
  • [Publications] Ikeda, H.: "Cloning of the gene encoding avermeetin B 5-O-methyltransferase in avermeetin-producing Streptomyces avermililis" Gene. 206. 175-180 (1998)

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  • [Publications] Guthrie, E.P.: "A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket" Microbiology. 144. 727-738 (1998)

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  • [Publications] Kang, S.G.: "Actinorhodin and undeeylprodigiosin production in wild-type and relA mutant strains of Streptomyces coelicolor A3(2) grown in continuous culture" FEMS Microbiol. Lett.168. 221-226 (1998)

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      1998 Final Research Report Summary
  • [Publications] Redenbach, M.: "Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCPl" J. Bacteriol.180. 2796-2799 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kinashi, H.: "Physical mapping of the linear plasmid pSLA2-L and localization of the cryAl and act1 homologs" Biosci. Biotechnol. Biochem.62. 1892-1897 (1998)

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  • [Publications] Hirakata, T.: "Putative protein serine/threonine kinase genes are located in several positions on the chromosome of Streptomyces coelicolor A3(2)." FEMS Microbiol Lett.159. 1-5 (1998)

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  • [Publications] Itohara, T.: "Prelininary protecome analysis of membrane proteins in Streptomyces coelicolor A3(2)" Actinomycetologica. in press. (1999)

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      1998 Final Research Report Summary
  • [Publications] Nakano, H.: "Gene replacement analysis of the Streptomyces vigineae barA gene encoding the bulyolactlanc autoregulaior receptor revealstha BarA acis as a repressor in virginiamycin biosynthesis" J. Bacteriol.180. 3317-3322 (1998)

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      1998 Final Research Report Summary
  • [Publications] Suzuki, N.: "Purification and characterization of virginiamycin Ml reductase from Stepromyces virginiac" Antimicrob. Agents Chemother.42. 2985-2988 (1998)

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      1998 Final Research Report Summary
  • [Publications] Okamoto, S.: "In vitro protein phosphorylation associated with cellular differentiation of Streptomyces griseus" Arch. Microbiol.169. 174-177 (1998)

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      1998 Final Research Report Summary
  • [Publications] Ochi, K.: "Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production in Streptomyces coelicolor A3(2)" J. Antibiot.51. 592-595 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kawamoto, S.: "Comparative ribosomal protein (L11 and L30) sequence analyses of several Streptomyces spp. commonly used in genetic studies" Int. J. Sys. Bacteriol.48. 597-600 (1998)

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      1998 Final Research Report Summary
  • [Publications] Chater, K.F.: "Taking a genetic scalpet to the Streptomyecs colony" Microbiology. 144. 1465-1478 (1998)

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      1998 Final Research Report Summary
  • [Publications] Elliot, M.: "The bldD gene of Streptomyecs coelicolor A3(2) : a regulatory gene involved in morphogenesis and antibiotic production" J. Bacteriol.180. 1549-1555 (1998)

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      1998 Final Research Report Summary
  • [Publications] Kelemen, G.: "Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyecs coelicolor A3(2)" J. Bacteriol.180. 2515-2521 (1998)

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      1998 Final Research Report Summary
  • [Publications] Takahashi, S.: "A l-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-eryth-ritol 4-phosphate in an alternative nonmevalonatc pathway for terpen" Proc. Natl. Acad. Sci. USA. 95. 9879-9884 (1998)

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    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kazuyama, T.: "Direct formation of 2-methyl-D-crythritol 4-phosphate from l-deoxy-D-xylulose 5-phosphate by l-deoxy-D-xylu-lose 5-phosphate reductoisomerase, a new enzyme in the non-mevaionate pathway to isopentenyl diphosphate" Terahedron Lett.39. 4509-4512 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Orihara, N.: "Studies on the biosynthesis of terpenoid compounds produced by actinomyectes. 3. Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus" J. Antibiot.51. 676-678 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Kuzuyama, T.: "Fosmidomyein, a specific inhibitor of l-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmvalonate pathway for terpenoid biosynthesis" Tetrahedron Lett.39. 7913-7916 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Seto, H.: "Studies on the biosynthesis of terpenoids produced by actinomycctes. Part 4. Formation of BE-40644 by the mevalonate and nonmcvalonate pathways" Terahedron Lett.39. 9497-9500 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Takahashi, S.: "Purification, characterization, and cloning of a eubacteral 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids" J. Bacteriol.in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Kuzuyama, T.: "Construction and characterization of Escherichia coli disruptants defective in the yaeM gene" Biosci, Biotechnol. Biochem.in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Hotta, K.: "The novel enzymatic 3″-N-acetylation of arbekacin by an aminoglyeoside 3-N-acctyltransferase of Streptomyces origin and the resulting activity" J. Antibiot.51. 735-742 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Ueda, K.: "Two distinet mechanisms cause heterogencity of 16S rDNA" J. Bacteriol.181. 78-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Hosoya, Y.: "Acquisition of certain streptomyein-resistant (str) mutations enhances antibiotie production in bacteria" Antimicrob. Agents Chemother.42. 2041-2047 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Okamoto, S.: "An essential GTP-binding protein functions as a regulator for differentiation in Streptomyces coelicolor" Mol. Microbiol.30. 107-119 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Kawamoto, S.: "Sequence analysis of the ribosomal L11 protein gene (rplK=relC) in Streptomyces lavendulac using a deletion allele" J. Antibiot.51. 954-957 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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      1998 Final Research Report Summary
  • [Publications] Han, W.-D.: "A novel sporulation-control gene (spoOM) of Bacilus subtilis with a σ_<ll>-regulated promoter" Gene. 217. 31-40 (1998)

    • Description
      「研究成果報告書概要(和文)」より
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  • [Publications] Ichinose, K.: "Biosynthetic gene cluster of benzoisochromanequinone antibioties in Streptomyces spp : identification of genes involved in post-PKS tailoring steps" Actinomycetol.12. 99-109 (1998)

    • Description
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  • [Publications] Ichinose, K.: "Proof that the actVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific phran ring formation in the biosynthesis of actinorhodin" Bioorg. Med. Chem. Lett.9. 395-400 (1999)

    • Description
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  • [Publications] 岡本 晋: "微生物の形態分化に関与するGTP結合タンパク質" 生物工学会誌. 76. 72-75 (1998)

    • Description
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  • [Publications] 瀬戸 治男: "微生物が行うユニークな化学反応-C-P化合物の生合成機構" 日本農芸化学会誌. 72. 1-18 (1998)

    • Description
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  • [Publications] 川本 伸一: "放線菌における二次代謝と緊縮制御" 化学と生物. 36. 144-145 (1998)

    • Description
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  • [Publications] 堀田 国元: "放線菌のアミノグリコシド抗生物質多剤耐性とその応用" 生物工学会誌. 76. 76-81 (1998)

    • Description
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  • [Publications] 堀田 国元: "アミノ配糖体の耐性機序" 医薬ジャーナル. 34. 65-74 (1998)

    • Description
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  • [Publications] 池田 治生: "コンビナトリアル・バイオシンセシス〜ポリケチド化合物を例として" 蛋白質・核酸・酵素. 43. 49-61 (1998)

    • Description
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  • [Publications] 木梨 陽康: "放線菌の線状染色体のダイナミックな構造変化と染色体の起源・進化" 蛋白質・核酸・酵素. 43. 1453-1460 (1998)

    • Description
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  • [Publications] Horinouchi, S.: "Dynamic Aspects of Natural Products Chemistry ; Molecular Biological Approaches" U.Sankawa and K. Ogura (eds. ) Kodansha and Harwood Academic Publishers, Tokyo and Amsterdam, 296 (1997)

    • Description
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  • [Publications] Horinouchi, S.: "Cell-Cell Communication in Bacteia" G. M. Dunny and S. C. Winans (eds.) American Society for Microbiology, Washington, D. C. (in press), (1999)

    • Description
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  • [Publications] Ando, N., et.al.: "Involvement of AfsA in A-factor biosynthesis as a key enzyme" J.Antibiot.50. 847-852 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ando, N., et.al.: "A Streptomyces griseus gene (sgaA) suppresses the growth disturbance caused by high osmolality and high concentration of A-factor during early growth" Microbiology. 143. 2715-2723 (1997)

    • Description
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  • [Publications] Lezhava, A., et.al.: "Chromosomal deletions in Streptomyces griseus that remove the afsA locus" Mol.Gen.Genet.253. 478-483 (1997)

    • Description
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  • [Publications] Onaka, H.et., al.: "DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences" Mol.Microbiol.24. 991-1000 (1997)

    • Description
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  • [Publications] Onaka, H.et., al.: "A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability" J.Bacteril.179. 2748-2752 (1997)

    • Description
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  • [Publications] Hong, S.-K.et., al.: "Effects of protein kinase inhibitors on in vitro protein phosphorylation and on secondary metabolism and morphogenesis in Streptomyces coelicolor A3 (2)" J.Microbiol.Biotechnol.8. 325-332 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Ueda, K., et.al.: "Characterization of an A-factor-responsive repressor for amtR essential for onset of aerial mycelium formation in Streptomyces griseus" J.Bacteriol.180. 5085-5093 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Onaka, H.et.al.: "Involvement of two A-factor recptor homologues in Streptomyces coelicolor A3 (2) in the regulation of secondary metabolism and morphogenesis" Mol.Microbiol.28. 743-755 (1998)

    • Description
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  • [Publications] Ando, N., et.al.: "Gene organization in a 12-kilobase region covering afsA encoding an A-factor biosynthetic enzyme" Actinomycetol.12. 40-45 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Sugiyama, M., et.al.: "Site-directed mutagenesis of the A-factor receptor protein : Val-41 important for DNA-binding and Trp-119 important for ligand-binding" Gene. 222. 133-144 (1998)

    • Description
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  • [Publications] Kang, D.-K., et.al.: "Possible involvement of cAMP in aerial mycelium formation and secondary metabolism in Streptomyces griseus" Microbiology. in press. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Kendrew, S.G., et.al.: "Identification of a monooxygenase from Streptomyces coelicolor A3 (2) involved in biosynthesis of actinorhodin : purification and characterization of the recombinant enzyme" J.Bacteriol.179. 4305-4310 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Kramer, P.J., et.al.: "Rational design and engineerd biosynthesis of a novel 18-carbon aromatic polyketide" J.Am.Chem.Soc.119. 635-639 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Crump, M.P., et.al.: "Solution structure of the actinorhodin polyketide synthase acyl carrier prtein from Streptomyces coelicolor A3 (2)" Biochemistry. 36. 6000-6008 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Hopwood, D.A.: "Genetic contributions to understanding polyketide synthases" Chemical Reviews. 97. 2465-2497 (1997)

    • Description
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  • [Publications] Ueda, K., et.al.: "Stimulatory effect of copper on antibiotic production and morphological differentiation in Streptomyces tanashiensis" J.Antibiot.50. 693-695 (1997)

    • Description
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      1998 Final Research Report Summary
  • [Publications] Aubert, M., et.al.: "Inactivation or amplification of the spa2 gene, encoding an potential stationary-phase regulator, affects differentiation in Streptomyces ambofaciens" Can.J.Microbiol.43. 1118-1125 (1997)

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  • [Publications] Martin, M.C., et.al.: "A glgC gene essential only for the first of two spatially distince phases of glycogen synthesis in Streptomyces coelicolor A3 (2)" J.Bacteriol.179. 7784-7789 (1997)

    • Description
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  • [Publications] Oh, S.H., et.al.: "Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3 (2) : possible relevance to other organisms" J.Bacteriol.179. 122-127 (1997)

    • Description
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  • [Publications] Nakashita, H., et., al.: "Studies on yhe biosynthesis of bialaphos.Biochemical mechanism of C-P bond formation : Discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate" J.Antibiot.50. 212-219 (1997)

    • Description
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      1998 Final Research Report Summary
  • [Publications] Kataoka, M., et., al.: "Application of the variable region in 16S rDNA to create an index for rapid species identification in the genus Streptomyces" FEMS Microbiol.Lett.151. 249-255 (1997)

    • Description
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  • [Publications] Wietzorrek, A., et.al.: "A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold" Mol.Microbiol.25. 1177-1184 (1997)

    • Description
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  • [Publications] Chakraburtty, R., et.al.: "The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3 (2) plays a conditional role in antibiotic production and morphological differentiation" J.Bacteriol.179. 5854-5861 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Labes, G., et.al.: "Isolation and characterization of a strong promoter element from the Streptomyces ghanaensis phage 119 using the gentamicin resistance gene (aacCl) of Tn 1696 as reporter" Microbiology. 143. 1503-1512 (1997)

    • Description
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  • [Publications] Tieleman, L., et.al.: "Growth phase-dependent transcription of the Streptomyces ramocissimus tuf1 gene occurs from two promoters" J.Bacteriol.179. 3619-3624 (1997)

    • Description
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  • [Publications] van Wezel, G.P.et.al.: "The malEFG gene cluster of Streptomyces coelicolor A3 (2) : characterization, disruption and transcriptional analysis" Mol.Gen.Genet.254. 604-608 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Alves, A.M.C.R., et.al.: "Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the actinomycete Streptomyces coelicolor A3 (2)" Appl.Environ.Microbiol.63. 956-961 (1997)

    • Description
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  • [Publications] van Wezel, G.P., et.al.: "Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3 (2) is controlled by malR.a member of the lacl-galR family of regulatory genes" Mol.Microbiol.23. 537-549 (1997)

    • Description
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  • [Publications] White, J., et.al.: "bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3 (2) involves a pathway-specific regulatory cascade" J.Bacteriol.179. 627-633 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ikeda, H., et.al.: "Avermectin biosynthesis" Chemical Reviews. 97. 2591-2609 (1997)

    • Description
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  • [Publications] Zhang, H., et.al.: "Improvement of tranformation system in Streptomyces using a modified regeneration medium" J.Ferment.Bioeng.83. 217-221 (1997)

    • Description
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  • [Publications] Kawachi, R., et.al.: "Development of a Transformation System in Streptomyces virginiae" Actinomycetologica. 11. 46-53 (1997)

    • Description
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  • [Publications] Kawabuchi, M., et.al.: "Production of butyrolactone autoregulators by Streptomyces coelicolor A3 (2)" FEMS Microbiol.Lett.157. 81-85 (1997)

    • Description
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  • [Publications] Waki, M., et.al.: "Cloning and characterization of the gene (farA) encoding the receptor for an extracellular regulatory factor (IM-2) from Streptomyces sp.strain FRI-5" J.Bacteriol.179. 5131-5137 (1997)

    • Description
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  • [Publications] Kinoshita, H., et.al.: "Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae" J.Bacteriol.179. 6986-6993 (1997)

    • Description
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      1998 Final Research Report Summary
  • [Publications] Okamoto, S., et.al.: "Molecular cloning and characterization of the obg gene of Streptomyces griseus in relation to the onset of morphological differentiation" J.Bacteriol.179. 170-179 (1997)

    • Description
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      1998 Final Research Report Summary
  • [Publications] Kawamoto, S., et.al.: "Expression analysis of the ssgA gene product, associated with sporulation and cell division in streptomyces griseus" Microbiology. 143. 1077-1086 (1997)

    • Description
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  • [Publications] Hesketh, A., et.al.: "A novel method for improving Streptomyces coelicolor A3 (2) for production of actinorhodin by by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin" J.Antibiot.50. 532-535 (1997)

    • Description
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      1998 Final Research Report Summary
  • [Publications] Shima, J., et.al.: "Novel detoxification of the trichothecene mycotoxin deoxynivalenol by a soil bacterium isolated by enrichment culture" Appl.Environ.Microbiol.63. 3825-3830 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Kawamoto, S., et.al.: "Molecular analysis of the ribosomal L11 protein gene (rplK=relC) of Streptomyces griseus and identification of a deletion allele" Mol.Gen.Genet.255. 549-560 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ochi, K., et.al.: "Molecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3 (2)" Mol.Gen.Genet.256. 488-498 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Yu, T.-W., et.al.: "Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases" J.Am.Chem.Soc.120. 7749-7759 (1998)

    • Description
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  • [Publications] Chong, P.P., et.al.: "Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicolor A3 (2)" Microbiology. 144. 193-199 (1998)

    • Description
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  • [Publications] Tropf, S., et.al.: "Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems" Chemistry & Biology. 5. 135-146 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Ichinose, K., et.al.: "The granaticin biosynthetic gene cluster of Streptomyces Violaceoruber Tu22 : sequence analysis and expression in a heterologous host" Chemistry & Biology. 5. 647-659 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Ryding, N.J., et.al.: "A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces coelicolor A3 (2)" Mol.Microbiol.29. 343-357 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Tan, H., et.al.: "The Streotimyces coelicolor sporulation-specific sWhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation" Gene. 212. 137-146 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Chater, K.F.: "Taking a genetic scalpel to the Streptomyces colony" Microbiology. 144. 1465-1478 (1998)

    • Description
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  • [Publications] Elliot, M., et.al.: "The bldD gene of Streptomyces coelicolor A3 (2) : a regulatory gene involved in morphogenesis and antibiotic production" J.Bacteriol. 180. 1549-1555 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Kelemen, G., et.al.: "Developmental regulation of transcription of whiE,a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3 (2)" J.Bacteriol.180. 2515-2521 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
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      1998 Final Research Report Summary
  • [Publications] Takahashi, S., et.al.: "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpen" Proc.Natl.Acad.Sci.USA. 95. 9879-9884 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuzuyama, T., et.al.: "Direct formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a new enzyme in the non-mevalonate pathway to isopentenyl diphosphate" Tetrahedron Lett.39. 4509-4512 (1998)

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      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Orihara, N., et.al.: "Studies on the biosynthesis of terpenoid compounds produced by actinomycetes.3.Biosynthesis of the isoprenoid side chain of novobiocin via the non-mevalonate pathway in Streptomyces niveus" J.Antibiot.51. 676-678 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuzuyama, T., et.al.: "Fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis" Tetrahedron Lett.39. 7913-7916 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Seto, H., et.al.: "Studies on the biosynthesis of terpenoids produced by actinomycetes.Part 4.Formation of BE-40644 by the mevalonate and nonmevalonate pathways" Tetraheron Lett.39. 9497-9500 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takahashi, S., et.al.: "Purification, characterization, and cloning of a eubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase, a key enzyme involved in biosynthesis of terpenoids" J.Bacteriol.181 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kuzuyama, T., et.al.: "Construction and characterization of Escherichia coli disruptants defective in the yaeM gene" Biosci.Biotechnol.Biochem.in press. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hotta, K., et.al.: "The novel enzymatic 3"-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity" J.Antibiot.51. 735-742 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ueda, K., et.al.: "Two distinct mechanisms cause heterogeneity of 16S rRNA" J.Bacteriol.181. 78-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ikeda, H., et al.: "Cloning of the gene encoding avermectin B5-O-methyltransferase in avermectin-producing Streptomyces avermitilis" Gene. 206. 175-180 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Guthrie, E.P., et.al.: "A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3 (2) with an amino-termianl domain that lacks a phosphorylation pocket" Microbiology. 144. 727-738 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kang, S.G., et.al.: "Actinorhodin and undecylprodigiosin production in wild--type and relA mutant strains of Streptomyces coelicolor A3 (2) grown in continuous culture" FEMS Microbiol.Lett.168. 221-226 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Redenbach, M., et.al.: "Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1" J.Bacteriol.180. 2796-2799 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kinashi, H., et.al.: "Physical maping of the linear plasmid pSLA2-L and localization of the eryA1 and actI homologs" Biosci.Biotechnol.Biochem.62. 1892-1897 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirakata, T., et.al.: "Putative protein serine/threonine kinase genes are located in several positions on the chromosome of Streptomyces coelicolor A3 (2)" FEMS Microbiol.Lett.159. 1-5 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Itohara, T., et.al.: "Preliminary proteome analysis of membrane proteins in Streptomyces coelicolor A3 (2)" Actinomycetol.(in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakano, H., et.al.: "Gene replacement analysis of the Streptomyces virgineae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis" J.Bacteriol.180. 3317-3322 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Suzuki, N., et.al.: "Purification and characerization of virginiamycin M1 reductase from Streptomyces virginiae" Antimicrob.Agents Chemother. 42. 2985-2988 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okamoto, S., et.al.: "In vitro protein phosphorylation associated with cellular differentiation of Streptomyces griseus" Arch.Microbiol.169. 174-177 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ochi, K., et.al.: "Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production in Streptomyces coelicolor A3 (2)" J.Antibiot.51. 592-595 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawamoto, S., et.al.: "Comparative ribosomal protein (L11 and L30) sequence analyses of several Streptomyces spp.commonly used in genetic studies." Int.J.Sys.Bacteriol.48. 597-600 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hosoya, Y., et.al.: "Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria" Antimicrob.Agents Chemother. 42. 2041-2047 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okamoto, S., et.al.: "An essential GTP-binding protein functions as a regulator for differentiation in Streptomyces coelicolor" Mol.Microbiol.30. 107-119 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawamoto, S., et.al.: "Sequence analysis of the ribosomal L11 protein gene (rplK=relC) in Streptomyces lavendulae using a delection allele" J.Antibiot.51. 954-957 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Han, W.-D., et.al.: "A novel sporulation-control gene (spoOM) of Bacillus subtilis with a sH-regulated promoter" Gene. 217. 31-40 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ichinose, K., et.al.: "Biosynthetic gene cluster of benzoisochromanequinone antibiotics in Streptomyces spp : identification of genes involved in post-PKS tailoring steps" Actinomycetol.12. 99-109 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ichinose, K., et.al.: "Proof that the actVI genetic region of Streptomyces coelicolor A3 (2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin" Bioorg.Med.Chem.Lett.9. 395-400 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sugiyama,M.: "Site-directed mutagenesis of the A-factor receptor protein: Val-41 important for DNA-binding and Trp-119 important for ligand-binding" Gene. 222. 133-144 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ueda,K: "Characterization of an A-factor-responsive repressor for amR essential for onset of acrial myeclium formation in Strep-tomyces grlscus" J.Bacteriol.180. 5085-5093 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Onaka,H.: "Involvement of two A-factor receptor homologucs in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis" Mol.Microbiol.28. 743-753 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ando,N.: "Gene organization in a 12-kilobase region covering afsA cncoding an A-factor biosynthetic enzyme" Actinomycetol.12. 40-45 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hong,S.-K.: "Effects of protein kinase inhibitors on in vitro protein phosphorylation and on secondary mclabolism and morphogenesis in Streptomyces coclicolor A3(2)" J.Microbiol.Biotechnol.8. 325-332 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kang,D.-K.: "Possible involvement of cAMP in acrial mycelium formation and secondary metabolism in Streptomyces griscus" Microbiology. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tin-Wein Yu: "Engincered biosynthesis of novel polyketides from Streptomyces spore pigment polykeide synthases" J.Am.Chem.Soc.120. 7749-7759 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chong,P.P.: "Plysical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent anti-blotie(CDA) of Streptomyces eoelicotor A3(2)" Microbiology. 144. 193-199 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tropf,S.: "Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems" Chemistry & Biology. 5. 135-146 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ichinose,K.: "The granaticin biosynthetic gene cluster of Streptomyces violaeeoruber Tu22:sequence analysis and expression in a heterologous host" Chemistry & Biology. 5. 647-659 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ryding,N.J.: "A developmentally regulated gene encoding a repressor-like protein is essential for sporulation in Streptomyces eoelicolor A3(2)" Mol.Microbiol.29. 343-357 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 〓,H.: "The Streotimyces coelicolor sporulation-specific owen form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation" Gene. 212. 137-146 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chater,K.F.: "Taking a genetic scalpel to the Streptomyces colony" Microbiology. 144. 1465-1478 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Elliot,M.: "The bldD gene of Streptomyces coelicolor A3(2):a regulatory gene involved in morphogenesis and antibiotic production" J.Bacteriol.180. 1549-1555 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kelemen,G.: "Developmental regulation of transcription of whiE,a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3(2)" J.Bacteriol.180. 2515-2521 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takahashi,S.: "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catelyzing the formation of 2-C-methyl-D-eryth-ritol 4-phosphate in an ahemative nonmevalonate pathway for terpen" Proc.Natl.Acad.Sci.USA. 95. 9879-9884 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuzuyama,T.: "Direct formation of 2-C-methyl-D-crythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate by 1-deoxy-D-xylu-lose 5‐phosphate reductoisomerase,a new cnzyme in the non-mevalonate pathway to isopentenyl diphosphate" Tetrahedron Lett.39. 4509-4512 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Orihara,N.: "Studies on the biosynthesis of terpenoid compounds produced by actinomycetes.3.Biosynthesis of the iso-prenoid side chain of novobiocin via the non-mcvalonate pathway in Streptomyces niveus" J.Antibiot.51. 676-678 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuzuyama,T.: "Fosmidomycin,a specific inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in the nonmcvalonate pathway for terpenoid biosynthesis" Tetrahedron Lett.39. 7913-7916 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Seto,H.: "Studies on the biosynthesis of terpenoids produced by actinomycetes.Part-4.Formation of BE-40644 by the mevalonate and nonmevalonate pathways" Tetrahedron Lett.39. 9497-9500 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takahashi,S.: "Purification,characterization,and cloning of a cubacterial 3-hydroxy-3-methylglutaryl coenzyme A reductase,a key enzyme involved in biosynthesis of terpenoids" J.Bacteriol.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kuzuyama,T.: "Construction and characterization of Escherichia coli disruptants defective in the yacM gene" Biosci.Biotechnol.Biochem.(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hotta.K.: "The novel enzymatic 3"-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity" J.Antibiot.51. 735-742 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ueda,K.: "Two distinct mechanisms cause heterogeneity of 16S rRNA" J.Bacteriol.181. 78-82 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikeda,H.: "Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avemitilis" Gene. 206. 175-180 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Guthrie,E.P.: "A response-regulator-like activator of anlibiotic synthesis from Streptomyces eoelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket" Microbiology. 144. 727-738 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kang,S.G.: "Actinorhodin and undecylprodigiosin production in wild-type and relA mutant strains of Streptomyces coelicolor A3(2) grown in continuous culture" FEMS Microbiol.Lett.168. 221-226 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Redenbach,M.: "Cloning and physical mapping of the EcoRI fragments of the giant linear plasmid SCP1" J.Bacteriol.180. 2796-2799 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kinashi,H.: "Physical mapping of the linear plasmid pSLA2-L and localization of the cryAf and actl homologs" Biosci.Biotechnol.Biochem.62. 1892-1897 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirakata,T.: "Putative protein serine/threonine kinase genes are located in several positions on the chromosome of Streptomyces coelicolor A3(2)." FEMS Microbiol Lett.159. 1-5 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Itohara,T.: "Preliminary proteome analysis of membrane proteins in Streptomyces coelicolor A3(2)" Actinomycetologica. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakano,H.: "Gene replacement analysis of the Streptomyces virgineae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis" J.Bacteriol.180. 3317-3322 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suzuki,N.: "Purification and characterization of virginiamyein Ml reductase from Streptomyces virginiac" Antimicrob.Agents Chemother.42. 2985-2988 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okamoto,S.: "In vitro protein phosphorylation associated with cellular differemiation of Streptomyces griseus" Arch.Microbiol.169. 174-177 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ochi,K.: "Genetic mapping and characterization of novel mutations which suppress the effect of a relC mutation on antibiotic production in Streptomyces coelicotor A3(2)" J.Antibiot.51. 592-595 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawamoto,S.: "Comparative ribosomal protein(L11 and L30) sequence analyses of several Strptomyces spp.commonly used in genetic studies" Int.J.Sys.Bacteriol.48. 597-600 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hosoya,Y.: "Acquisition of certain streptomycin-resistant(slr) mutations cnhances antibiotic production in bacteria" Antimicrob.Agents Chemother.42. 2041-2047 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okamoto,S.: "An essential GTP-binding protein functions as a regulator for differentiation in Streptomyces coelicolor" Mol.Microbiol.30. 107-119 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawamoto,S.: "Sequence analysis of the ribosomal L11 protein gene(rplK=relC) in Streptomyces lavendulac using a deletion allele" J.Antibiot.51. 954-957 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Han,W.-D.: "A novel sporulation-control gene(spoOM) of Bacilus subtilis with a On-regulated promoter" Gene. 217. 31-40 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ichinose,K.: "Biosynthetic gene cluster of benzoisochromanequinone antibiotics in Streptomyces spp:identification of genes involved in post-PKS tailoring steps" Actinomycetol.12. 99-109 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ichinose,K.: "Proof that the actV1 genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin" Bioorg.Med.Chem.Lett.9. 395-400 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡本 晋: "微生物の形態分化に関与するGTP結合タンパク質" 生物工学会誌. 76. 72-75 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 瀬戸 治男: "微生物が行うユニークな化学反応--C-P化合物の生合成機構" 日本農芸化学会誌. 72. 1-18 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川本 伸一: "放線菌における二次代謝と緊縮制御" 化学と生物. 36. 144-145 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀田 国元: "放線菌のアミノグリコシド抗生物質多剤耐性とその応用" 生物工学会誌. 76. 76-81 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀田 国元: "アミノ配糖体の耐性機序" 医薬ジャーナル. 34. 65-74 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 〓田 治生: "コンビナトリアル・バイオシンセシス〜ポリケチド化合物を例として" 蛋白質・核酸・酵素. 43. 49-61 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 木梨 陽康: "放線菌の線状染色体のダイナミックな構造変化と染色体の起源・進化" 蛋白質・核酸・酵素. 43. 1453-1460 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Horinouchi,S.: "Cell‐Cell Communication in Bacteria" G.M.Dunny and S.C.Winans(eds.) American Society for Microbiology,Washington.D.C.(in press), (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiroyasu Onaka: "A mutation at proline-115 in the A-fwtor receptur protein of Streptomyces griscus abolishes : DNA-binding ability but not liganid-binding ability" J. Bacteiol.179. 2748-2757 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Alexander Lezhava: "Chromosomal deletiorsin Streptomyces grisens that remove the afsA locus" Mol. Gen. Geret.253. 478-483 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noriko Ando: "A Streptomyces griseus gene (sgaA) suppresses the growth disturbanle caused by high osmolality and ahigh cohcentration of A-faitorduring ewlygrowth" Microbiology. 143. 2715-2723 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroyasu Onaka: "DNA-binding activity of the A-fator receptor protein and its recoginiton DNA sequences" Mol. Microbiol.24. 991-1000 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Noriko Ando: "Involvement of AfsA in A-factor biosynthesis asakey enzyme" J. Antibior.50. 847-852 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroyasu Ohaka: "Involvement of two A-fuctor receptor hanologs in Stteptomycescoclocolor A312 in the regulation of secoindary metxbolism and morphogenesis" Mol. Microbiol.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] H. Nakashita: "Studies on the biosynthesis of bialaphos." J. Antibiot.50. 212-219 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 瀬戸 治男: "C-P結合形成の分子機構の解明-生物有機化学と分子生物学の接点" 日本農芸化学会誌. 71. 451-453 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 瀬戸 治男: "微生物が行なうユニークな化学反応-CP化合物の生合成機構" 日本農芸化学会誌. 72. 1-18 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kenji Ueda: "Stimulatory effect of copper on antibiotic production and morphological differetiution in Strepromyses tonshipnsis" J. Antibiot.50. 693-695 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Harvo Ikeda: "Avermectin bioysnthesis" Chemical Reviews. 97. 2591-2609 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H. Zhang: "Improvement of transformution ststem in Streptomyces using a modified regeneration medrum." J, Ferment. Bioeng.83. 217-221 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Miyoko Waki: "cloning and Characterization of the gene (favA) encoding the receptor for an extracellular regulatory fuctor (2M-2) form strepromyces sp strain PRL-Y" J. Bacteriol.179・16. 5131-5137 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiroshi Kinoshita: "Butyrolactone autoregulator receptor protein (Bar A) as a transriptional requlator in Streptomyces virginiae" J. Bacteriol.179・22. 6986-6993 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀田 国元: "薬剤耐性のメカニズム-アミノグリコンド系抗生物質" 日本臨床. 55. 1231-1237 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀田 国元: "アミノ配糖体の体制機序" 医薬ジャーナル. 34. 583-592 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 堀田 国元: "放線菌のアミノグリコシド抗生物質耐性とその応用" 日本生物工学会誌. 76. 76-81 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 小河原 宏: "最前線・放線菌遺伝子の発現調節、原核生物型?真核生物型?" ファルマシア. 33・2. 150-154 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Toshiyuki Hirakata: "Putative protein serinel threonine kinage genes are located in several positions on the chromosome of streptomyces coeliclor A3 (2)" FEMS Microbiol. Lett.(in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] I. Suzuki: "Three Single strand origins located on both strards of the Streptomyces rolling pSN22" Plasmid. 37. 51-64 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] I. Suzuki: "Nucleotde sequence of a nicking site of the Streptomyces plasmid pSN22 repticating by the rolling cirole mechanism" FEMS Microbiol. Lett.150. 283-288 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S. Okamoto: "Molecular cloning and characterization of the obg genc of Strcptomyces grisens in relation to the onset of morphological differentiation" J. Bacteriol.179. 170-179 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] S. Kawamoto: "Expression analysis of the ssgA genc product, associated with sporulation and cell division in Streptomyces griseus." Microbiol.143. 1077-1086 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] A. Hesketh: "Method for improving, Streptomyces coelicolor A3 (2) for production of actirorhodin by introduction of rpSL (Ending Rilosomal Pretein S12) mmtation conferring resistance to strepTomycen" J. Antibiot.50. 532-535 (1997)

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      1997 Annual Research Report
  • [Publications] J. Shima: "Novel detoxification of the tricho thetene mycotoxin deoxynivalerol by soil bacterium isolatecl by enrichment culture" Appl. Env. Microbiol.63. 3825-3830 (1997)

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      1997 Annual Research Report
  • [Publications] S. Kawamoto: "Molecular analysis of the ribosomel L11 protein gene (rplk=relc) of Stteptumyces grisens and identification of a deletion allele" Mol. Gen. Genet.255. 549-560 (1997)

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      1997 Annual Research Report
  • [Publications] K. Ochi: "Molecular and functional analysis of the ribosomal L11 and s12 protein genes (rplk and rpsL) of strepumyces coelicolor A3 (2)" Mol. Gen. Genet.256. 488-498 (1997)

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      1997 Annual Research Report
  • [Publications] S. Okamoto: "Invitro protein phosphorylation associated with cellular differentiation of streptomyces grisems" Arch. Microbiol.(in press). (1998)

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      1997 Annual Research Report
  • [Publications] S. Kawamoto: "Comparative ribosonal protein (L11 and L30) sequence analyses of sereval Stteptomyces spp. commoly usel in genetic studies" Int. T. Syst. Bacteriol.(in press). (1998)

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      1997 Annual Research Report
  • [Publications] 細谷 仁子: "微生物の潜在能力を引き出す-新規物質の探索・二次代謝産物生産菌の生産性向上に新手法-" 化学と生物. 35・10. 684-686 (1997)

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      1997 Annual Research Report
  • [Publications] 越智 幸三: "リボゲームの改造による抗生物質の生産性向上" バイオサイエンスとインダストリー. 55・12. 35-36 (1997)

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      1997 Annual Research Report
  • [Publications] 川本 伸一: "放線菌における二次代謝と緊縮制御-ppGppが二次代謝の引き金物質として働く-" 化学と生物. (in press). (1998)

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      1997 Annual Research Report
  • [Publications] 岡本 晋: "微生物の形態分化に関与するGTP結合蛋白質" 発酵と工業. (in press). (1998)

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      1997 Annual Research Report
  • [Publications] Sueharu Horinouchi: "Dynamic Aspeits of Natural Produts Chemistry : Molecular Biological Approaches" V. Sankawa and K. Ogura (eds.) kodansha and Havwood Acaclemic Publishors, Tokyo and Ansterdam, 296 (1997)

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      1997 Annual Research Report
  • [Publications] Sueharu Horinouchi: "Cell-Cell Commynication in Bacteria" G. M. Puuny and S. C. Winas (eds.) American Society for Microbiology, Washington, D. C. (in press), (1998)

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      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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