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Immunodiagnosis and epidemiology of Echinococcosis/Cysticercosis in Asia

Research Project

Project/Area Number 09044279
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research .
Research Field 寄生虫学(含医用動物学)
Research InstitutionASAHIKAWA MEDICAL COLLEGE (1998)
Gifu University (1997)

Principal Investigator

ITO Akira  ASAHIKAWA MEDICAL COLLEGE,DEPARTMENT OF PARASITOLOGY,PROFESSOR, 医学部, 教授 (70054020)

Co-Investigator(Kenkyū-buntansha) NAKAO Minoru  ASAHIKAWA MEDICAL COLLEGE,DEPARTMENT OF PARASITOLOGY,ASSISTANT PROFESSOR, 医学部, 助手 (70155670)
OKAMOTO Munehiro  OSAKA UNIVERSITY MEDICAL SCHOOL,ASSISTANT PROFESSOR, 医学部, 助手 (70177096)
ITOH Makoto  AICHI MEDICAL COLLEGE,DEPARTMENT OF PARASITOLOGY,ASSOCIATE PROFESSOR, 医学部, 助教授 (90137117)
HORII Toshihiro  OSAKA UNIVERSITY,INSTITUTE OF MICROBIAL DISEASES,ASSOCIATE PROFESSOR, 助教授 (80142305)
KANAZAWA Tamotsu  UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH,DEPARTMENT OF PARASITOLOGY A, 医学部, 教授 (10194888)
SCHANTZ Pete  アメリカ国立防圧センター, 副部長
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1998: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1997: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsAlveolar echinococcosis / Cystic echinococcosis / Neurocysticercosis / Differential serodiagnosis / DNA diagnosis / Epidemiology / Parasitic Zoonoses / Emerging, Re-emerging diseases / エキノコックス症 / 有鉤嚢虫症 / 血清診断
Research Abstract

The main purpose of this international collaboraiton project was to establish better resolution for (1) differential serodiagnosis of alveolar echinococcosis (AE), cystic echinococcosis (CE) and neurocysticercosis (NCC), (2) differential molecular diagnosis for these three very severe larval cestode infections in humans, and (3) application for epidemiological study in endemic areas. From this project, we have published 32 original papers in peer reviewed international journals, 9 papers for books or proceedings etc. and presented 23 papers at international meetings.
Using huge number of confirmed serum samples from AE, CE, NCC or other parasitic diseases or hepatoma etc. from USA, Mexico, Korea, China, Nepal, Indonesia, Australia, Turkey, Jordan, UK, Switzerland and Poland, we succeeded in establishing a better serodiagnostic methods for these three diseases each. Using the new serodiagnostic methods for AE, CE and NCC, we have started to apply these for the field survey in Tibetan peo … More ple in China (mainly for differentiation of AE from CE) and Indonesia for detection of NCC from local people in Irian Jaya. At moment, we have been asked to join or help some other groups working on NCC in Peru, Ecuador, South Africa, Thanzania, India, Thailand and Papua New Guinea (Australia). As this project has been accepted for further promosion from 1999, we are pleased to develop further international collaboration for control and prevention of these zoonotic larval cestode infections.
Dr.Nakao has already analyzed the full lenght of mitochondrial DNA of Echinococcus multilocularis. It is a break through in molecular parasitology. Based on this quite new information on DNA, we have been developing molecular phylogeny, molecular diagnosis for isolates of E.multilocularis, E.granulosus, E.vogeli, Taenia solium, T.saginata and some other taeniid cestodes.
Our group might be the only which can do serodiagnosis for AB, CE and NCC and DNA analysis based on the full length of mitochondrial DNA in the world. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (133 results)

All Other

All Publications (133 results)

  • [Publications] Wandra T.: "Epileptic seizures and burns associated with cysticercosis in Assologaima, Jayawijaya, Irian Java, Indonesia" Transactions of the Royal Society of Tropical Medicine and Hygiene. 93 accepted. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "ELISA and immunoblot for serodiagnosis of cysticercosis in pigs naturally infected with Taenia solium" Journal of Helminthology. 73 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Case report : Neurocysticercosis case with a single cyst in the brain showing dramatic drop in specific antibody titers within one year after curative surgical resection" Parasitology International. 48 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsaki Y.: "A case of neurocysticercosis wthout detectable specific antibody" Internal Medicine. 38 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura M.: "Cystic echinococcosis in a Jordanian patient : albendazole in a short-term immigrant" Journal of Travel Medicine. 6 in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Differential serodiagnosis for cystic and alveolar echinococcosis using fractions of Echinococcus granulosus cyst fluid (antigen B) and E. multilocularis protoscolex" American Journal of Tropical Medicine and Hygiene. 60(2) in press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Human Taenia in severe combined immunodeficiency mice" Parasitology Today. 15. 64-67 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaya K.: "Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole" Journal of Helminthology. 72. 349-354 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Niwa A.: "Eosinophi1 chemotactic factors from cysticercoids of Hymenolepis nana" Journal of Helminthology. 72. 273-275 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Novel antigens for neurocysticercosis : simple method for preparation and evaluation for serodiagnosis" American Journal cf Tropical Medicine and Hygiene. 59. 291-294 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yang H.J.: "Immunoblot analysis of a 10 kDa antigen in cyst fluid of Taenia solium metacestodes" Parasite Immunology. 20. 483-488 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kong Y.: "Immunoblobulin G (IgG) subclass and IgE responses in human paragonimiases caused by three different species" Clinical and Diagnostic Laboratory Immunology. 5. 474-478 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Evaluation of Eml8-, Eml6, antigen B-Western blots, Em2plus-ELISA and four other tests for differentiatial serodiagnosis of alveolar and cystic echinococcosis pateints in Poland" Parasitology International. 47. 95-99 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus specific DNA sequences" American Journal of Tropical Medicine and Hygiene. 58. 790-792 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato Y.: "Experimental infection of larval Echinococcus multilocularis in the rodent brain as a model for cerebral alveolar echinococcosis" Journal of Helminthology. 72. 59-64 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Ultrasonographic and serologic studies of experimental cysticercosis in rats infected with Taenia taeniaeformis" Parasite Immunology. 20. 105-110 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Serodiagnosis of alveolar echinococcosis : Detection of antibodies against Em18 in patients and rodents" Southeast Asian Journal of Tropical Medicine and Public Health. 28. 117-124 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaya K.: "Echinococcus multilocularis : mouse strain difference in hydatid development" Journal of Helminthology. 71. 53-56 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fan P.C.: "Vaccination trials against Taiwan Taenia eggs in pigs injected with frozen oncospheres of Taeiwan Taenia, Korea Taenia, T.saginata or T.solium" Parasitology. 114. 541-544 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okamoto M.: "Phylogenetic relationships of three hymenolepidid species inferred from nuclear ribosomal and mitochondrial DNA sequences" Parasitology. 115. 661-666 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Blair D.: "Geographic genetic structure within the human lung fluke, Paragonimus westermanii, detected by DNA sequences" Parsitology. 115. 411-417 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Human Taenia eggs develop into cysticerci in scid mice" Parasitology. 114. 85-88 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Immunodiagnosis of alveolar echinococcosis by enzyme-linked immunosorbent assay using a partially purified Eml8/16 enriched fraction" Clinical and Diagnostic Laboratory Immunology. 4. 57-59 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Antibody responses against Eml8 and Eml6 serodiagnosis markers in alveolar and cystic echinococcosis patients from northwest China" Japanese Journal of Medical Sciences and Biology. 50. 19-26 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ma L.: "Alveolar echinococcosis : Em2plus-ELISA and Em18-Western blots for follow-up after treatment with albendazole" Transactions of the Royal Society of Tropical Medicine and Hygiene. 91・5. 476-478 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Simanjuntak G.M.: "Taeniasis/Cysticercosis in Indonesia as an emerging disease" Parasitology Today. 13・9. 321-323 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "In vitro hatched oncospheres of Asian Taenia from Korea and Taiwan develop into cysticerci in the peritoneal cavity of female scid mice" International Journal for Parasitology. 27・6. 631-633 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Cystic metacestodes of a rat-adapted Taenia taeniaeformis established in the peritoneal cavity of scid and mude mice" International Journal for Parasitology. 27・8. 903-905 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kong Y.: "Variation of antigenic proteins of eggs and developmental stages of Paragonimus westermani" Korean Journal of Parasitology. 35・3. 197-202 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Basic and applied immunology in cestode infections : from Hymenolepis to Taenia and Echinococcus" International Journal for Parasitology. 27・10. 1203-1211 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 辻 守康: "日本における寄生虫学の研究・第7巻" 目黒寄生虫館(日本寄生虫学会),(in press), (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 伊藤 亮: "日本における寄生虫学の研究・第6巻" 目黒寄生虫館 (日本寄生虫学会),(in press), (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Proceedings of the International Workshop on Cysticercosis" ARC-Onderstepoort Veterinary Institute, 130 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Forum Cheju-3" Korea Society of Parasitologists, 72 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wadra T.: "Epileptic seizures and burns aasociated with cysticercosis in Assologaima, Irian Jaya, Indonesia" Transactions of the Royal Society of Tropical Medicine and Hygiene. accepted. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "ELISA and immunoblot for serodiagnosis of cysticercosis in pigs naturally infected with Taenia solium" Journal of Helminthology. accepted. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Case report : Neurocysticercosis case with a single cyst in the brain showing dramatic drop in specific antibody titers within one year after curative surgical resection" Parasitology International. 48, (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohsaki Y.: "A case of neurocysticercosis without detectable specific antibody" International Medicine. 38, (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura M.: "Cystic echinococcosis in a Jordanian patient : albendazole in a short-term immigrant" Journal of Travel Medicine. 6, (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Differential serodiagnosis for cystic and alveolar echinococco-sis using fractions of Echinococcus granulosus cyst fluid (antigen B) and E.multilocularis protoscolex (Em 18)" American Journal of Tropical Medicine. 60, (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Human Taenia in severe combined immunodeficiency mice" Parasitology Today. 15. 64-67 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaya K.: "Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole" Journal of Helminthology. 72. 349-353 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Niwa A.: "Eosinophil chemotactic factors from cysticercoids of Hymenolepis nana" Journal of Helminthology. 72. 273-275 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Novel antigens for neurocysticercosis : simple mehtod for preparation and evaluation for serodiagnosis" American Journal of Tropical Medicine. 59. 291-294 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yang H.J.: "Immunoblot analysis of a 10 kDa antigen in cyst fluid of Taenia solium metacestodes" Parasite Immunology. 20. 483-488 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kong Y.: "Immunoglobulin (IgG) subclass and IgE responses in human paragonimiases caused by three different species" Clinical and Diagnostic Laboratory Immunology. 5. 474-478 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Evaluation of Em18-, Em16, antigen B-Western blots, Em2puls-ELISA and four other tests for differential serodiagnosis of alveolar and cystic echinococcosis patients in Poland" Parasitology International. 47. 95-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Short report : An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus specific DNA sequences" American Journal of Tropical Medicine and Hygiene. 58. 790-792 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato Y.: "Experimental infection of larval Echinococcus multilocularis in the rodent brain as a model for cerebral alveolar echinococcosis" Journal of Helminthology. 72. 59-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Ultrasonographic and serologic studies of experimentral cysticercosis in rats infected with Taenia taeniaeformis" Parasite Immunology. 20. 105-110 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Serodiagnosis of alveolar echinococcosis : Detection of antibody against Em 18 in patients and rodents" Southeast Asian Journal of Tropical Medicine and Public Health. 28 (Supple). 117-124 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakaya K.: "Echinococcus multilocularis : mouse strain difference in hydatid developmjent" Journal of Helminthology. 71. 53-56 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fan P.C.: "Vaccination trials against Taiwan Taenia eggs in pigs injected with frozen oncospheres of Taiwan Taenia, Korea Taenia, T.saaginata or T.solium" Parasitology. 114. 541-544 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ma L.: "Alveolar echinococcosis : Em2plus-ELISA and Em 18-Western blots for follow-up after treatrment with albendazole" Transaction of the Royal Society of Tropical Medicine and Hygiene. 91. 476-478 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Okamoto M.: "Phylogenetic relationships of three hymenolepidid species" Parasitology. 115. 661-666 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Blair D.: "Geographical genetic structure within the human lung fluke, Paragonimus westermanii, detected by DNA sequences" Parasitology. 115. 411-417 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kong Y.: "Variation of antigenic proteins of eggs and developmental stages of Paragonimus westermanii" Korean Journal of Parasitology. 35. 197-202 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Human Taenia eggs develop into cysticerci in scid mice" Parasitology. 114. 85-88 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Immunodiagnosis of alveolar echinococcosis by enzyme-linked immunosorbent assay using a partially purified Em 18/16 enriched fraction" Clinical and Diagnostic Laboratory Immunology. 4. 57-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Basic and applied immunology in cestode infections : from Hymenolepis to Taenia and Echinococcus" International Journal for Parasitology. 27. 1203-1211 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Cystic metacestodes of a rat-adapted Taenia taeniasformis established in the peritoneal cavity of scid and nude mice" International Journal for Parasitology. 27. 903-905 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "In vitro hatched oncospheres of Asian Taenia from Korea and Taiwan develop into cysticerci in the peritoneal cavity of female scid (severe combined immunodeficiency) mice" International Journal for Parasitology. 27. 631-633 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Simanjuntak G.: "Taeniasis/cysticercosis in Indonesia as an emerging disease" Parasitology Today. 13. 321-323 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ma L.: "Evaluation of the diagnostic value of Em 18 and Em 16 antigens in Echinococcus multilocularis by Western blotting" Chinese Journal of Parasitology and Parasitic Diseases. 15. 65-68 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ito A.: "Antibody responses against Em18 and Em16 serodiagnostic markers in alveolar and cystic echinococcosis patients from northwest China" Japanese Journal of Medical Sciences and Biology. 50. 19-26 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wandra T.: "Epileptic seizures and burns associated with cysticercosis in Assologaima,Jayawijaya,Irian Java,Indonesia" Transactions of the Royal Society of Tropical Medicine and Hygiene. 93(accepted). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "ELISA and immunoblot for serodiagnosis of cysticercosis in pigs naturally infected with Taenia solium" Journal of Helminthology. 73(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Case report:Neurocysticercosis case with a single cyst in the brain showing dramatic drop in specific antibody titers within one year-after curative surgical resection" Parasitology International. 48(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsaki Y.: "A case of neurocysticercosis without detectable specific antibody" Internal Medicine. 38(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura M.: "Cystic echinococcosis in a Jordanian patient:albendazole in a short-term immigrant" Journal of Travel Medicine. 6(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Differential serodiagnosis for cystic and alveolar echinococcosis using fractions of Echinococcus granulosus cyst fluid(antigen B)and E.multilocularis protoscolex" American Journal of Tropical Medicine and Hygiene. 60(2)(in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Human Taenia in severe combined immunodeficiency mice." Parasitology Today. 15. 64-67 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakaya K.: "Morphological changes of larval Echinococcus multilocularis in mice treated with albendazole or mebendazole" Journal of Helminthology. 72. 349-354 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Niwa A.: "Eosinophil chemotactic factors from cysticercoids of Hymenolepis nana" Journal of Helminthology. 72. 273-275 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Novel antigens for neurocysticercosis:simple method for preparation and evaluation for serodiagnosis" American Journal of Tropical Medicine and Hygiene. 59. 291-294 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yang H.J.: "Immunoblot analysis of a 10 kDa antigen in cyst fluid of Taenia solium metacestodes" Parasite Immunology. 20. 483-488 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kong Y.: "Immunoblobulin G(IgG)subclass and IgE responses in human paragonimiases caused by three different species" Clinical and Diagnostic Laboratory Immunology. 5. 474-478 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Evaluation of Em18-,Em16,antigen B-Western blots,Em2plus-ELISA and four other tests for differentiatial serodiagnosis of alveolar and cystic echinococcosis" Parasitology International. 47. 95-99 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "An imported case of cystic echinococcosis in Japan diagnosed by imaging and serology with confirmation of Echinococcus granulosus specific DNA sequences" American Journal of Tropical Medicine and Hygiene. 58. 790-792 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato Y.: "Experimental infection of larval Echinococcus multilocularis in the rodent brain as a model for cerebral alveolar echinococcosis" Journal of Helminthology. 72. 59-64 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Ultrasonographic and serologic studies of experimental cysticercosis in rats infeeted with Taenia taeniaeformis" Parasite Immunology. 20. 105-110 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Serodiagnosis of alveolar echinococcosis:Detection of antibodies against Em18 in patients and rodents" Southeast Asian Journal of Tropical Medicine and Public Health. 28. 117-124 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakaya K.: "Echinococcus multilocularis:mouse strain difference in hydatid development" Journal of Helminthology. 71. 53-56 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fan P.C.: "Vaccination trials against Taiwan Taenia eggs in pigs injected with frozen oncospheres of Taeiwan Taenia,Korea Taenia,T.saginata or T.solium" Parasitology. 114. 541-544 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Okamoto M.: "Phylogenetic relationships of three hymenolepidid species inferred from nuclear ribosomal and mitochondrial DNA sequences" Parasitology. 115. 661-666 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Blair D.: "Geographic genetic structure within the human lung fluke,Paragonimus westermanii,detected by DNA sequences" Parsitology. 115. 411-417 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Human Taenia eggs develop into cysticerci in scid mice" Parasitology. 114. 85-88 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Immunodiagnosis of alveolar echinococcosis by enzyme-linked immunosorbent assay using a partially purified Em18/16 enriched fraction" Clinical and Diagnostic laboratory Immunology. 4. 57-59 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Antibody responses against Em18 and Em16 serodiagnosis markers in alveolar and cystic echinococcosis patients from northwest China" Japanese Journal of Medical Sciences and Biology. 50. 19-26 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ma L.: "Alveolar echinococcosis:Em2plus-ELISA and Em18-Western blots for follow-up after treatment with albendazole" Transactions of the Royal Society of Tropical Medicine and Hygiene. 91・5. 476-478 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Simanjuntak G.M.: "Taeniasis/Cysticercosis in Indonesia as an emerging disease" Parasitology Today. 13・9. 321-323 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "In vitro hatched oncospheres of Asian Taenia from Korea and Taiwan develop into cysticerci in the peritoneal cavity of female scid mice" International Journal for Parasitology. 27・6. 631-633 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Cystic metacestodes of a rat-adapted Taenia taeniaeformis established in the peritoneal cavity of scid and nude mice" International Journal for Parasitology. 27・8. 903-905 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kong Y.: "Variation of antigenic proteins of eggs and developmental stages of Paragonimus westermani" Korean Journal of Parasitology. 35・3. 197-202 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Basic and applied immunology in cestode infections:from Hymenolepis to Taenia and Echinococcus" International Journal for Parasitology. 27・10. 1203-1211 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] 辻 守康: "日本における寄生虫学の研究・第7巻" 目黒寄生虫館(日本寄生虫学会)(in press), (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 伊藤 亮: "日本における寄生虫学の研究・第6巻" 目黒寄生虫館(日本寄生虫学会)(in press), (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Proceedings of the International Workshop on Cysticerocsis" ARC-Onderstepoort Veterinary Institute, 130 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Forum Cheju-3" Korea Society of Parasitologists, 72 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ito A.: "Immounodignosis of alveolar echinococcosis by enzyme-linked immunosorbent assay using a partially purified Em18/16 enriched fraction" Clinical and Diagnostic Laboratory Immunology. 4・1. 57-59 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Human Taenia eggs develop into cysticerci in scid mice" Parasitology. 114・1. 85-88 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ma L.: "Evaluation of the diagnostic value of Em18 and Em16 antigens in echinococcus multilocularis by Western blotting" Chinese Journal of Parasitology and Parasitic Diseases. 15・2. 65-68 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Antibody responses against Em18 and Em16 serodiagnostic markers in alveolar and cystic echinococcosis patients from northweste China" Japanese Journal of Medical Science and Biology. 50・1. 19-26 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakaya K: "Echinococcus multiolcularis : mouse strain difference in hydatid development" Journal of Helminthology. 71・1. 53-56 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fan P.C.: "Vaccination trials against Taiwan Taenia eggs in pigs injected with frozen oncospheres of Taiwean Taenia,Korea Taeania,T.saginata or T.solium" Parasitology. 114・4. 541-544 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ma L.: "Alveolar echinococcosis : Em2plus-ELISA and Em18-Western blots for follow-up after treatment with albendazole" Transactions of the Royal Society of Tropical Medicine and Hygiene. 91・5. 476-478 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Simanjuntak G.M.: "Taeniasis/Cysticercosis in Indonesia as an emerging disease" Parasitology Today. 13・9. 321-323 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "In vitro hatched oncospheres of Asian Taenia from Korea and Taiwan develop into cysticerci in the peritoneal cavity of female scid mice" International Journal for Parasitology. 27・6. 631-633 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Cystic metacestoldes of a rat-adapted Taenia taeniaeformis established in the peritoneal cavity of scid and mude mice" International Journal for Parasitology. 27・8. 903-905 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kong Y.: "Variation of antigenie proteins of eggs and developmental stages of Paragonimus westermani" Korean Journal of Parasitology. 35・3. 197-202 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Basic and applied immunology in cestode infections : from Hymenolepis to Taenia and Echinococus" International Journal for Parasitology. 27・10. 1203-1211 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Blair D.: "Geographic genetic structure within the human lung fluke,Paragonimus westermani,detected from DNA sequences" Parasitology. 115・10. 411-417 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Okamoto M.: "Phylogenetic relationships of three hymenolepidid species inferred from nuclear ribonsomal and mitochondrial DNA sequences" Parasitology. 115・12. 661-666 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Ultrasonographic and serologic studies of experimental cysticercosis in rats infected with Taenia taeniaeformis" Parasite Immunology. 20・3. 105-110 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "An imported cystic echinococcosis case in Japan diagnosed by image and serology with confirmation of Echinococcus granulosus specific DNA sequences" American Journal of Tropical Medicine and Hygiene. 58・6(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sato Y.: "Experimental infection of larval Echinococous multilocularis in the rodent brain as a model for cerebral echinococcosis" Journal of Helminthology. 72・1(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Novel antigens for neurocysticerosis : simple method for preparation and evaluation for serodiagnosis" American Journal of Tropical Medicine and Hygiene. 58(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yang H.J.: "Immunoblot analysis of a 10kDa antigen in cyst fluid of Taenia solium metacestodes" Parasite Immunology. 20(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Evaluation of Em18-western blot,Em16-western blot,antigen B-western blt,Em2plus-ELISA and five other tests for differential serodiagnosis of AE and CE from Poland" Parasitology Intermational. 2(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Niwa A,: "Eosinophil chemotactic factors from cysticercoids of Hymenolepis nana" Journal of Helminthology. 72(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kong Y.: "IgG subclass and IgE responses in human paragonimiasis caused by three different species" Clinical and Diagnostic Laboratory Immunology. 5(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Serodiagnosis of cysticercosis in humans" Proceedings of the International Cysticercosis Workshop. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Differential serodiagnosis of cysticercosis" Forum Cheju-3. 3(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Serodiagnosis of alveolar echinococcosis : detection of antibody aganinst Em18 in patients and rodents" Southeast Asian Journal of Tropical Medicine and Public Health. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Neurocysticercosis with single cyst in the brain,resected surgically and followed up serologically" American Journal of Tropical Medicine and Hygiene. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤 亮: "単包虫症例:術前の血清診断、術後の遺伝子診断ならびに画像成績" Clinical Parasitology. 8(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤 亮: "テニア条虫症と有鉤嚢中症の問題点ならびに有鉤嚢中症に関する血清診断法について" Clinical Parasitology. 8(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤 亮: "単包虫症に関する血清診断法の現状と問題点" Clinical Parasitology. 8(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤 亮: "嚢中症の新しい血清診断法" 検査と技術. 26・4(印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "Human Taenia in SCID mice" Parasitology Today. 14(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ito A.: "A multicenter study of differential serodiagnosis for cystic and alveolar echinococcosisusing fractions of Echinococcus granulosus cyst fluid and E.multilocularis protoscolex (Em18)" American Journal of Tropical Medicine and Hygiene. 58(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 伊藤 亮: "日本における寄生虫学の研究第7巻" 目黒寄生虫館(印刷中), (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 辻 守康: "日本における寄生虫学の研究第6巻" 目黒寄生虫館(印刷中), (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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