| Project/Area Number |
09044295
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Osaka University |
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Principal Investigator |
KANOSUE Kazuyuki Osaka University Faculty of Medicine, Professor, 医学部, 教授 (50127213)
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| Co-Investigator(Kenkyū-buntansha) |
CRAWSHAN Lar Portland州立大学, 教授
SCHMIDT Ingr MaxーPlanck臨床生理研究所, 研究員
SHIDO Osamu Kanazawa University Medical School, Associate Professor, 医学部, 助教授 (40175386)
HOSONO Takayoshi Osaka University Faculty of Medicine, Assistant Professor, 医学部, 助手 (60294104)
YAMATODANI Atsushi Osaka University Faculty of Medicine, Professor, 医学部, 教授 (30116123)
INGRID Schmidt Max-Planck Institute, Researcher
LARRY I Crawshaw Portland Stat University, Professor
CRAWSHAW Lar Partland州立大学, 教授
田中 英登 横浜国立大学, 教育学部, 助教授 (60163557)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 1998: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1997: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | thermaregulation / behavior / opovant learning / fasling |
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| Research Abstract |
The body temperature of homeothermic animal is controlled by multiple autonomic and behavioral responses and thermoreceplors are distributed throghout the body. This multiple input-output system is regulated by the central nervous system, on the top of which the hypothalamus including the preoptic area is located. Even though neural mechanism of autonomic regulation is well understand, that of behavioral regulation is still unknown. In the present project, this question is analysed from the viewpoint of comparative physiology, In the first year, we developped an operant system used for the study for behavioral thermoregulation, an animal that is put into a cold or hot environment gets warm or cool reinforcements when it enters a specific area. A rat moves freely in the box and its location is monitored photoelectrically while its deep body temperature is monitored by a telemetry system. In heat-escape experiments a hot wind blows through the box and when the rat enters a reward zone th
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e wind is switched to cool one for a given period (typically 30 sec). Conversely, in cold-escape experiments a cold wind blows through the box and when the rat enters the reward zone the wind is switched to warm one. Experiments show that rats quickly learn to stay near the reward zone and move in and out of it periodically. This system is based on behavior more natural than lever-pressing and is suitable for use in neurophysiological studies of behavioral thermoregulation. In the second year, we analysed the effect of fastingn on behavioral body temperature regulation using the system developped in the previous-year. Fasting induced decrease in body temperature in the inactive phase in circadian Cycle, and cold escape behavior was enhanced during that period, while heat escape behavior was unchanged. Similar experiment was done in fish and birds. Fasting showed similar effect in birds but had no effect in fish. Fasting would modulate thermoregulalory behavior so that energy expenditure is reduced in homeothermic animals but not in poikilothermic animals. Less
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