| Project/Area Number |
09044307
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| Research Category |
Grant-in-Aid for international Scientific Research
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Field |
内分泌・代謝学
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| Research Institution | Kobe University |
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Principal Investigator |
INUI Akio University Hospital, Associate Professor, 医学部・附属病院, 講師 (80168418)
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| Co-Investigator(Kenkyū-buntansha) |
SCHWARTZ Thue W. Copenhagen University School of Medicine, Professor, 医学部, 教授
SAMUELSON Li ミシガン大学, 医学部, 助教授
SAMUELSON Linda C. Michigan University School of Medicine, Associate Professor
SCHWARTZ Thu コペンハーゲン大学, 医学部, 教授
SOMUELSON Li ミシガン大学, 医学部, 助教授
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1997: ¥3,700,000 (Direct Cost: ¥3,700,000)
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| Keywords | feeding behavior / transgenic mouse / knockout mouse / neuropeptide / neuropeptide Y / 神経ペクチド / Neuropeptide Y |
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| Research Abstract |
Recently novel molecular mediators and regulatory pathways for feeding and body weight regulation have been identified in the brain and the periphery. Mice overexpressing or lacking these mediators have been produced by gene targeting, and observations on mutant mice have shed new light on the role of each element in the homeostatic loop of body weight regulation. We have developed neuropeptide Y overexpressing mouse which exhibited anxiety-like behavior (heteromouse) and obese tendency (homomouse). We have also developed pancreatic polypeptide overex-pressing mouse which exhibited thin phenotype associated with decreased food intake and gastric emptying rates. These are examples that were produced in support of this research grant.
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