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Identification of genes responsible for developmental mutant mice

Research Project

Project/Area Number 09044325
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Laboratory animal science
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

YAMAMURA Ken-ichi  KUMAMOTO UNIVERSITY SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (90115197)

Co-Investigator(Kenkyū-buntansha) BALLING Rudo  ドイツ哺乳類遺伝学研究所, 所長
IMAI Kenji  Institute of Mammalian Genetics, GSF,Researcher, 研究員
ARTZT Karen  テキサス大学オースチン校, 動物学部, 教授
HRABE de Ang  ドイツ哺乳類遺伝学研究所, 研究員
ABE Kuniya  KUMAMOTO UNIVERSITY,Associate Professor, 医学部, 助教授 (40240915)
KAREN Artzt  University of Texas at Austin, Professor
MARTIN Hrabe de Angelis  Institute of Mammalian Genetics, GSF,Researcher
RUDOLF Balling  Institute of Mammalian Genetics, GSF,Director
RUDOLF Balli  ドイツ哺乳類遺伝学研究所, 所長
KAREN Artzt  テキサス大学オースチン校, 動物学部, 教授
MARTIN Hrabe  ドイツ哺乳類遺伝学研究所, 研究員
要 匡  熊本大学, 医学部, 助手 (40264288)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1997: ¥3,400,000 (Direct Cost: ¥3,400,000)
KeywordsBAC / mutant mouse / development / transgenic mouse / positional cloning / ボンショナルクローニング / YAC / 胚発生 / ゲノム解析
Research Abstract

Transgenic techonology has been very useful and successful for delineating functions of any genes of interest in vivo. However, there are several technical limitations in conventional transgenic techniques. Since introns and essential regulatory sequences required for correct in vivo expression are omitted in the constructs, transgene expression is sometimes different from the expression of corresponding endogenous gene. So-called 'postion-effect' that affect foreign gene expression depending on its chromosomal integration site also conpromise the transgene expression. In addition, the maximum size of transgene is only 40-50 kb, due to constraints on the insert length that can be cloned in phage or cosmid vectors. These limitations can be overcome by using cloning systems which accomodate submegabase DNA such as YAC (yeast artificial chromosome) or BAC (bacterial artificial chromosome) in the generation of transgenic mice.
On the other hand, more than a thousand mouse mutants have been … More identified and maintained over the past century and the number will drastically increase in near future by several 'large scale' mutagenesis projects operating in international mouse communities. However, the task of isolating the responsible gene for any of these mutantions is still labor intensive and so limits the usufullness of thisexperimental resources. Again, the ability to introduce large size DNA into the mouse germ lines should help rectify this situation. It should be possible to define the location of the responsible gene on a large DNA fragment by introducing YACs or BACs into mutant mice and examining the functional rescue of the mutant phenotype.
Toward this end, we have established a series of techniques to introduce large size DNA into mouse germ lines. During these processes, we found that YAC clones contain cloning artifacts including chimerism and deletions, we have switched to use BAC which contain less DNA rearrangements.
We have produced more than fifty founder transgenic mice carrying BAC clones derived from the t-complex region of Chr. 17, tail kinks (tk) locus and PaxI locus. We have identified and characterized qkL gene, a candidate for the classical neurological mutation, quaking. We introduced a transgenic line harboring a 160-kb BAC that contains the whole qkI locus and crossed the strain with the mutant animals. quaking is a recessive mutantion with tremors due to hypomyelination in CNS.Introduction of the qkl containing BAC successfully corrected the mutant phenotype ; homozygous mutant with the BAC do not show tremor phenotype and myelination occurred normaly. We have also rescued brachynry mutation which affect notochord development and tail morphology. These results thus demonstrated the usufullness of the BAC transgenesis particulary in identification and functional analysis of mutated genes in mice. Less

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] Rennebeck G,Kleymenova EV, Anderson R,Yeung RS, Artzt K,Walker CL: "Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development." Proc Natl Acad Sci USA. 95. 15629-15634 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Rennebeck G,Lader E,Fujimoto A,Lei EP, Artzt K: "Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct" Genetics. 150. 1125-1131 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wilm, B.,Dahl, E.,Peters, H.,Balling, R.,Imai. K.: "Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency" Proc. Natl. Acad. Sci. USA. 95. 8692-8697 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wakana, S.,Imai, K.: "Mouse Chromosome 9." Mammalian Genome. 8. 180-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Igakura, T.,Kadomatsu, K.,Kaname, T.,Muramatsu, H.,Fan, Q.-W.,Miyauschi, T.,Toyama, Y.,Kuno, N.,Yuasa, S.,Takahashi, M.,Senda, T.,Taguchi, O.,Yamamura, K.,Arimura, K.and Muramatsu, T.: "A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis." Dev. Biol.194. 152-165 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ihara, Y.,Yoshimura, M.,Miyoshi, E.,Nishikawa, A.,Sultan, A.S.,Toyosawa, S.,Ohnishi, A.,Suzuki, M.,Yamamura, K.,Ijuhin, N.and Taniguchi, N.: "Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage." Proc. Natl. Acad. Sci. USA. 95. 2526-2530 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hofmann C, Drossopoulou G,McMahon A,Balling R,Tickle C: "Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development." Dev Dyn. 213. 199-206 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Peters H,Neubuser A,Kratochwil K,Balling R: "Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities" Genes Dev. 12. 2735-2747 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Pusch C,Hustert E,Pfeifer D,Sudbeck P,Kist R,Roe B,Wang Z,Balling R,Blin N,Scherer G: "The SOX10/sox10 gene from human and mouse : sequence, expression, and transactivation by the encoded HMG domain transcription factor" Hum Genet. 103. 115-123 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuda, J.,Suzuki, M.,Nozaki, C.,Shinya, N.,Tasiro, K.,Mizuno, K.,Uchino, Y.and Yamamura, K.: "Transgenic mouse expressing a full-length hepatitis C virus cDNA" Jpn. J.Cancer Res. 89. 150-158 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sekimoto, T.,Yoshinobu, K.,Yoshida, M.,Kuratani, S.,Fujimoto, S.,Araki, M.,Tajima, N.,Araki, K.and Yamamura, K.: "Region-specific expression of murine Hox genes implies the Hox coed-mediated patterning of the digestive tract." Genes to Cells. 3. 51-64 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujimoto, S.,Araki, K.,Chisaka, O.,Araki, M.,Takagi, K.and Yamamura, K.: "Analysis of the murine Hoxa-9 cDNA : an alternatively spliced transcript encodes a truncated protein lacking the homeodomain." Gene. 209. 77-85 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oike, Y.,Hata, A.,Mamiya, T.,Kaname, T.,Noda, Y.,Suzuki, M.,Yasue, H.,Nabeshima, T.,Araki, K.and Yamamura, K.: "Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice : lmplication of a dominant negative mechanism." Human Mol. Genet. 8. 387-396 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaname, T.,Uehara, K.,Abe, K.,Muramatsu, T.and Yamamura, K.: "Testis b-1,4-galactosyltransferase gene maps to mouse chromosome 5." Genomics. 53. 117-118 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuki, Y.,Kaname, T.,Suematsu, S.,Yamaguchi, Y.,Abe K,and Yamamura, K.: "Mouse K-glypican gene, Gpc4, maps to chromosome X." Genomics. 54. 358-359 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura, S.,Fujishita, S.,Ikezawa, M,Ogawa, M.,Abe, K.and Miike, T.: "Muscle type promoter and its first intronabnormalities in dystrophin gene in patients with Duchenne muscular dystrophy." J.Child Neurol.13. 290-292 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe. K.,Ko, M.S.H.and MacGregor, G.R: "A Systematic Molecular Genetic Approach to Study Mammalian Germ Line Development." Int. National J.Dev. Biol.42. 1051-1065 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Kawakami, Mitsunaga, K.,Kikuti, Y.Y.,Ando, A.,Inoko, H.,Yamamura, K.and Abe, K.: "Tctex-3, related to Drosophila Polycomblike, isspecifically expressed in male germ cells andmapped to t-complex of mouse." Mammalian Genome. 9. 874-880 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] A.,Kikuti, Y.Y.,Abe, K.,Shigenari, A.,Kawata. H.,Ikemura, T.,Kimura M.,and Inoko, H.: "cDNA cloning, Northern hybridization and mapping Shigenari, A.,Kawata, H.,Ikemura, T.analysis of a putative GDS (guanine nucleotide dissociation, Kimura M.,and Inoko,H.stimulator of G proteins)-related protein gene at the centromeric ends of the human and mouse MHC regions." Immunogenetics. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, T.,Furuta, T.,Mitsunaga, K.,Ebersole, T.,Shichiri, M.,Artzt, K.,Yamamura, K.and K.Abe.: "Genomic organization and expression analysis of the mouse qkllocus." Mammalian Genome. 印刷中.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 前田浩、澤智裕: "21世紀に向けての癌治療のパラダイムシフト-ミサイル療法、DDS、QOLcareの次にくるもの-" Drug Delivery System. 64(印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Jun Wu,他: "Modulation of enhanced vascular permeabillity in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger" Cancer Research. 58. 159-165 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoichiro Noguchi,他: "Early phase tumor accumulation of macromolecules : A great difference between the tumor vs normal tissue in their clearance rate" Japanese Journal of Cancer Research. 89. 307-314 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Len W.Seymour,他: "A novel dosage approach for evaluation of SMANCS in the treatment of primary hepatocellular carcinoma" Int'l J.Oncology. 12. 1217-1223 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Masami Kimua,他: "Intracavitary administration : Pharmacokinetic advantages of macromolecular anticancer agents against peritoneal and pleural carcinomatoses" Anticancer Research. 18. 2547-2550 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 前田浩: "肝癌に対する高分子抗癌剤動注療法における癌組織集積性-とくにスマンクス/リピオドール療法を中心に-" 医学のあゆみ. 184. 385-391 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 前田浩: "SMANCS研究の最近のあゆみ" 癌と化学療法. 25. 1-9 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Rennebeck G,Kleymenove EV,Anderson R,Yeung RS,Artzt K,Walker CL: "Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development." Proc Natl Acad Sci USA. 95. 15329-15634 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Rennebeck G,Lader E,Fujimoto A,Lei EP,Artzt K: "Mouse Brachyury the Second(T2)is a gene next to classical T and a candidate gene for tct" Genetics. 150. 1125-1131 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wilm, B., Dahl, E., Peters, H., Balling, R., Imai.K.: "Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency" Proc.Natl.Acad.Sci.USA. 95. 8692-8697 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wakana, S., Imai, K.: "Mouse Chromosome 9." Mammalian Genome. 8. 180-199 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.-W., Miyauschi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, T., Taguchi, O., Yamamura, K., Arimura, K.and Muramatsu, T.: "A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis." Dev.Biol.194. 152-165 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ihara, Y., Yoshimura, M., Miyoshi, E., Nishikawa, A., Sultan, A.S., Toyosawa, S., Ohnishi, A., Suzuki, M., Yamamura, K., Ijuhin, N.and Taniguchi, N.: "Ectopic expression of N-acetylglucosaminyltransferase III in transgenic hepatocytes disrupts apolipoprotein B secretion and induces aberrant cellular morphology with lipid storage." Proc.Natl.Acad.Sci.USA. 95. 2526-2530 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hofmann C,Drossopoulou G,McMahon A,Balling R,Tickle C: "Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development." Dev Dyn. 213. 199-206 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Peters H,Neubuser A,Kratochwil K,Balling R: "Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities." Genes Dev. 12. 2735-2747 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Pusch C,Hustert E,Pfeifer D,Sudbeck P,Kist R,Roe B,Wang Z,Balling R,Blin N,Scherer G: "The SOX10/Sox10 gene from human and mouse : sequence, expression, and transactivation by the encoded HMG domain transcription factor." Hum Genet. 103. 115-123 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuda, J., Suzuki, M., Nozaki, C/, Shinya, N., Tasiro, K., Mizuno, T., Uchino, Y.and Yamamura, K.: "Transgenic mouse expressing a full-length hepatitis C virus cDNA" Jpn.J.Cancer Res.89. 150-158 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sekimoto, T., Yoshinobu, K., Yoshida, M., Kuratani, S., Fujimoto, S., Araki, M., Tajima, N., Araki, K.and Yamamura, K.: "Region-specific expression of murine Hox genes implies the Hox coed-mediated patterning of the digestive tract." Genes to Cells. 3. 51-64 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fujimoto, S., Araki, K., Chisaka, O., Araki, M., Takagi, K.and Yamamura, K.: "Analysis of the murine Hoxa-9 cDNA : an alternatively spliced transcript encodes a truncated protein lacking the homeodomain." Gene. 209. 77-85 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Uchimura, K., Kadomatsu, K.Fan, Q-W., Muramatsu, H., Kurosawa, N., Kaname, T., Yamamura, K., Fukuta, M., Habuchi, O.and Muramatsu, T.: "Mouse chondroitin 6-sulfotransferase : molecular cloning, characterization and chromosomal mapping." Glycobiology. 8. 489-496 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Oike, Y., Hata, A., Mamiya, T., Kaname, T., Noda, Y., Suzuki, M., Yasue, H., Nabeshima, T., Araki, K.and Yamamura, K.: "Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice : Implication of a dominant negative mechanism" Human Mol.Genet.8. 387-396 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Kawakami, Mitsunaga, K., Kikuti, Y.Y., Ando, A., Inoko, H., Yamamura, K.and Abe, K.: "Tctex-3, related to Drosophila Polycomblike, is specifically expressed in male germ cells and mapped to t-complex of mouse." Mammalian Genome. 9. 874-880 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaname, T., Uehara, K., Abe, K., Muramatsu, T.and Yamamura, K.: "Testis b-1,4-galactosyltransferase gene maps to mouse chromosome 5." Genomics. 53. 117-118 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Matsuki, Y., Kaname, T., Suematsu, S., Yamaguchi, Y., Abe, K.and Yamamura, K.: "Mouse K-glypican gene, Gpc4, maps to chromosome X." Genomics. 54. 358-359 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kimura, S., Fujishita, S., Ikezawa, M Ogawa, M., Abe, K.and Miike, T.: "Muscle type promoter and its first intron abnormalities in dystrophin gene in patients with Duchenne muscular dystrophy." J.Child Neurol.13. 290-292 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Abe, K., Ko, M.S.H.and MacGregor, G.R: "A Systematic Molecular Genetic Approach to Study Mammalian Germ Line Development." Int.National J.Dev.Biol.42. 1051-1065 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Vernet, C.Abe, K.and Artzt, K.: "Genetic mapping of 10 microsatellites in the t complex region of mouse chromosome 17" Mammalian Genome. 9. 472 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ando, A., Kikuti, Y.Y., Abe, K., Shigenari, A., Kawata, H., Ikemura, T., Kimura M., and Inoko, H.: "cDNA cloning, Northern hybridization and mapping analysis of a putative GDS(guanine nucleotide dissociation stimulator of G proteins)-related protein gene at the centromeric ends of the human and mouse MHC regions." Immunogenetics. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kondo, T., Furuta, T., Mitsunaga, K., Eversole, T., Shichiri, M., Artzt, K., Yamamura, K.and K.Abe: "Genomic organization and expression analysis of the mouse qk/locus." Mammalian Genome. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kaname,T.et al.: "Testis b-1,4-glactosyltransferase gene maps to mouse chromosome 5." Genomics. 53. 117-118 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsuki,Y.et al.: "Mouse K-glypican gene,Gpc4,maps to chromosome X." Genomics. 54. 358-359 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kimura,S.et al.: "Muscle type promoter and its first intronabnomalities in dystrophin gene in patients with Duchenne muscular dystrophy." J.Child Neurol.13. 290-292 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe,K.et al.: "A Systematic Molecular Genetic Approach to Study Mammalian Germ Line Development." Int.National J.Dev.Biol.42. 1051-1065 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] S,Kawakami.et al.: "Tctex-3,related to Drosophila Polycomblike,isspecifically expressed in male germ cells and mapped to t-complex of mouse." Mammalian Genome. 9. 874-880 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A,Kikuti.et al.: "cDNA Cloning,Northern hybridization and mapping Shigenari,A.,Kawata,H.,Ikemura,T.analysis of a putative GDS(guanine nucleotide dissociation,Kimura M.,and Inoko,H.stimulator of G proteins)-related protein gene at the centromeric ends of the human and mouse MHC regions." Immunogenetics. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kondo,T.et al.: "Genomic organization and expression analysis of the mouse qki locus." Mammalian Genome. (印刷中). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abe.K.and Noce, T.: "A DEAD-box family protein gene,Ddx4,encoding a murine homolog of Drosophila vasa,maps to the distal end of mouse Chromosome 13." Mammalian Genome. 8,. 622-623. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kimura, S, .Abe.K., Suzuki, M., Yoshioka, K., Ogawa, M., Kaname, T., Miike, T.and Yamamura, K.: "A 900 bp genomic region from the mouse dystrophin promoter directs lacz reporter expression only to the right heart of transgenic mice." Dev.Growth Diff.39. 257-265 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka, H., Abe.K and Kim, C.-H.: "Quaking gene expression in the zebrafish embryo." Mech.Dev.(印刷中). (1998)

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      1997 Annual Research Report
  • [Publications] Abe.K., Ko, M.S.H.and MacGregor, G.R.: "A Systematic Molecular Genetic Approach to Study Mammalian Germ Line Development." Int.National J.Dev.Biol.(印刷中). (1998)

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      1997 Annual Research Report
  • [Publications] Kimura, S., Fujishita, S., Ikezawa, M Ogawa, M., Abe.K.and Miike, T.: "Muscle type promoter and its first intron abnormalities in dystrophin gene in patients with Duchenne muscular dystrophy." J.Child Neurol.(印刷中). (1998)

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      1997 Annual Research Report
  • [Publications] C.Vernet, K.Abe and K.Artzt: "Genetic mapping of 10 microsatellites in the t complex region of mouse chromosome 17" Mammalian Genome. (印刷中). (1998)

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      1997 Annual Research Report
  • [Publications] 阿部 訓也: "ネオ生物学シリーズ 8.マウス[DNA生物学のゆりかご]「しっぽの短いねずみくん話」" 勝木元也編 共立出版, 29 (1997)

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      1997 Annual Research Report
  • [Publications] 阿部 訓也: "蛋白質核酸酵素 増刊号「生殖細胞の発生と性分化」「マウス始原生殖細胞における遺伝子発現」" 岡田益吉・長濱嘉孝・中辻憲夫 編 共立出版(印刷中),

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      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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