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Immune regulation and signal tranduction

Research Project

Project/Area Number 09044334
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research Field Immunology
Research InstitutionJuntendo University School of Medicine

Principal Investigator

OKUMURA Ko  Juntendo Univ., Sch.of Med., Prof., 医学部, 教授 (50009700)

Co-Investigator(Kenkyū-buntansha) WATANABE Takeshi  Kyusyu Univ., Med.Inst.of Bioreg., Prof., 生体防御医学研究所, 教授 (40028684)
MIYAZONO Kouhei  Japanese Foundation for Cancer Research the Cancer Institute, Tokyo., Chief., 癌研究所, 部長 (90209908)
KIKUTANI Hitoshi  Osaka Univ., Research Institute for microbial Diseases, Prof., 微生物学研究所, 教授 (80161412)
SASAZUKI Takehiko  Kyusyu Univ.Med.Inst.of Bioreg., Prof., 生体防御医学研究所, 教授 (50014121)
KISHIMOTO Tadamitsu  Osaka Univ., Sch.of Med., Prof., 医学部, 教授 (10093402)
Project Period (FY) 1997
Project Status Completed (Fiscal Year 1997)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1997: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsSTAT / SSl-1 / TCR-peptides / CD40-CD40L / TGF-beta / Lyn / Src / FasL / Lyn / アポトーシス
Research Abstract

By getting support from the grant for international research collaboration, we could get following scientific recults.
1) Kishimoto's group revealed the regulatory mechanisms of intracellular signaling system after the cytokine stimulation, especially through the success of cloning new STAT regulatory modecules SSl-1.
2) Sasazuki's group reported the significance of specific TCR-peptide interaction for positive selection of thymic T cell by utilizing several types of transgenic mouse which they established.
3) Kikutani's group further studied the immunological significance of CD40-CD40L interaction by establishing knock-out mouse of these molecules which naturally developes autoimmune diseases.
4) Miyazono's group studied the signaling suppression mechanisms through TGF-beta and they revealed the importance of one of signaling molecules Smad.
5) Watanabe's group established Lyn-kinase knock-out mouse and they analyzed this knock-out mouse associating new type of autoimmune phenomenon.
6) Okumura's group found new type of inflammatory associating rejection phenomenon by establishing tumor rejection systems using FasL transfectants.

Report

(2 results)
  • 1997 Annual Research Report   Final Research Report Summary
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Seino,K.,et al.: "Antitumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Naka,T.,et al.: "Structure and function of a new STAT-induced STATinhibitor-1." Nature. 387. 924-929 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fuyuki,Y.,et al.: "Positive and negative CD4^+ thymocyte selection by a single MHC classII/peptied ligand affected by its expression level in the thymus." Immunity.6. 401-410 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Gonzalez,A.,et al.: "Genetic control of diabetes progression." Immunity. 7. 873-883 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imamura,T.,et al.: "Smad6 inhibits signalling by the TGF-β superfamily." Nature. 389. 622-626 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki,Y.,et al.: "HAX-1,a novel intracellular protein, localized on mitochondria,directly associates with HS1,a substrate of Src-family tyrosine kinases." J.Immunol.158. 2736-2744 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki,N. et al.: "Polymorphism of murine Fas ligand that affects the biological activity." Proc.Natl.Acad.Sci.USA.94. 3914-3919 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujio,Y.,et al.: "Signals through gp130 up-regulates bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes." J.Clin.Invest.99. 2898-2905 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Gapin L.,et al.: "A highly diverse but skewed T-cell repertoire is selected in mice transgenic for a single peptide/MHC comlex." J.Exp.Med.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Higashi,Y. et al.: "Impairment of T cell development in δEF1 mutant mice." J.Exp.Med.185. 1467-1479 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao,A.,et al.: "TGF-β receptor-mediated signalling through Smad2,Smad3 and Smad4." EMBOJ.16. 5353-5362 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masuda,K.,et al.: "Reduced susceptibility to Fas-mediated apoptosis in B-1 cells." Eur.J.Immunol.27. 449-455 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Antitumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Naka, T., et al.: "Structure and function of a new STAT-induced STAT inhibitor-1." Nature. 387. 924-929 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fuyuki, Y., et al.: "Positive and negative CD4^+ thymocyte selection by a single MHC class II/peptied ligand affected by its expression level in the thymus." Immunity. 6. 410-410 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Gonzalez, A., et al.: "Genetic control of diabetes progression." Immunity. 7. 873-883 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Imamura, T., et al.: "Smad6 inhibits signalling by the TGF-beta superfamily." Nature. 389. 622-626 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Suzuki, Y., et al.: "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src-family tyrosine kinases." J.Immunol.158. 2736-2744 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Kayagaki, N., et al.: "Polymorphism of murine Fas ligand that affects the biological activity." Proc.Natl.Acad.Sci.USA.94. 3914-3919 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Fujio Y., et al.: "Signals through gp130 up-regulates bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes." J.Clin.Invest.99. 2898-2905 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Gapin L., et al.: "A highly diverse but skewed T-cell repertoire is selected in mice transgenic for a single peptide/MHC comlex." J.Exp.Med.(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Higashi, Y., et al.: "Impairment of T cell development in deltaDFl mutant mice." J.Exp.Med.185. 1467-1479 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Nakao, A., et al.: "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4." EMBO J.16. 5353-5362 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Masuda, K., et al.: "Reduced susceptibility to Fas-mediated apoptosis in B-1 cells." Eur.J.Immunol.27. 449-455 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1997 Final Research Report Summary
  • [Publications] Seino, K., et al.: "Antitumor effect of locally produced CD95 ligand." Nature Med.3. 165-170 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naka, T., et al.: "Structure and function of a new STAT-induced STAT inhibitor-1." Nature. 387. 924-929 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fuyuki, Y., et al.: "Positive and negative CD4^+ thymocyte selection by a single MHC class II/peptied ligand affected by its expression level in the thymus." Immunity. 6. 401-410 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Gonzalez, A., et al.: "Genetic control of diabetes progression." Immunity. 7. 873-883 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Imamura, T., et al.: "Smad6 inhibits signalling by the TGF-β superfamily." Nature. 389. 622-626 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suzuki, Y., et al.: "HAX-1,a novel intracellular protein localized on mitochondria,directly associates with HSl,a substrate of Src-family tyrosine kinases." J.Immunology. 158. 2736-2744 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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