| Project/Area Number |
09045074
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kitasato University |
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Principal Investigator |
YOSHIKAWA Takashi KITASATO UNIVERSITY, DEPARTMENT OF VETERINARY MEDICINE AND ANIMAL SCIENCES, PROFESSOR, 獣医畜産学部, 教授 (80050467)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takashi KITASATO UNIVERSITY, DEPARTMENT OF VETERINARY MEDICINE AND ANIMAL SCIENCES, PROFESSOR, 獣医畜産学部, 教授 (80050665)
KAWAMURA Seiichi KITASATO UNIVERSITY, DEPARTMENT OF VETERINARY MEDICINE AND ANIMAL SCIENCES, PROFESSOR, 獣医畜産学部, 教授 (60050530)
TSUBAKI Shiro KITASATO UNIVERSITY, DEPARTMENT OF VETERINARY MEDICINE AND ANIMAL SCIENCES, PROFESSOR, 獣医畜産学部, 教授 (70050507)
YOSHIKAWA Hiroyasu KITASATO UNIVERSITY, DEPARTMENT OF VETERINARY MEDICINE AND ANIMAL SCIENCES, 獣医畜産学部, 助教授 (70101516)
WANG Shuiqin CHANGCHUN UNIVERSITY OF CHINA, DEPARTMENT OF VETERINARY MEDICINE, PROFESSOR
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1997: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Enzootic cardiomyopathy / Pathology / Selenium-VitaminE deficiencey / Ceroid-lipofuscinosis / Glutathione peroxidase / Sika deer / China / セレニュウム欠乏 / グルタチオンペルオキシダーゼ / セロイド・リポフスチン沈着症 / セレニュウム / ビタミンE |
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| Research Abstract |
1. Myocardial lesions from enzootic cardiomyopathy in Sika deer: On a stock farm in the northeastern district of China, histopathological and electronmicroscopic examinations were made of 40 Sika deer (Cervus nippon Temminck) aged from 1 day to 2 years and suffering cardiac arrest. Ultrastructural examination revealed mitochondrial deformation and calcium deposition. These phenomena resemble those observed in cases of cardiomyopathy caused in other animals by selenium-vitamin E deficiency.
2. Hepatic ceroid-lipofuscinosis in enzootic cardiomyopathy of Sika deer: Hepatic lesions in 25 Sika deer (Cervus nippon Temminck) aged 1-15 days, affected by selenium deficient cardiomyopathy, were examined histopathologically. Characteristic pathological findings, induced by stagnation of the plasma proteins of the cytoplasm, consisted of vacuolar degeneration of hepatocytes, formation of hyalin droplets, and ceroid-lipofuscinosis. Electron microscopically, these changes were closely associated with
… More
degeneration of the endoplasmic reticulum and mitochondria. Peroxisomes, which were observed around the vacuoles, were regarded as a reactive result of membrane disturbance caused by a decrease in glutathione peroxidase (GSH-Px).
3. Pulmonary mycosis associated with selenium-deficient cardiomyopathy in Sika deer: Pulmonary mycosis four domestic Sika deer aged 1 to 2 weeks suffering from selenium deficiency (enzootic cardiomyopathy) were examined histopathologically, histochemically and by electron microscopy. From the morphological features of mycosis there were diagnosed aspergillosis in three cases and mucormycosis in one case. The pathologic reaction within lesions of aspergillus was dominated by granulomatous type with neutrophils, macrophages and giant cells, and mucor lesions were remarkable vasculitis with fungal thrombi. It is suggested that the atrophy of lymph follicles and decrease number of T lymphocytes in lympatic organs is closely correlated with selenium deficiency and immunological disorders. Less
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