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Study on Biofunctional Restorative Material with Pulpal Cell

Research Project

Project/Area Number 09045078
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionNiigata University

Principal Investigator

IWAKU Masaaki  Niigata University Faculty of Dentistry, Professor, 歯学部, 教授 (70013927)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Akira  Niigata University Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (10143786)
KOTA Kouichi  Niigata University Faculty of Dentistry, Assistant Professor, 歯学部, 助教授 (90018755)
HOSHINO Etsuro  Niigata University Faculty of Dentistry, Professor, 歯学部, 教授 (90124619)
YOSHIBA Kunihiko  Niigata University Dental Hospital, Assistant, 歯学部・附属病院, 助手 (30220718)
FUKUSHIMA Masayoshi  Niigata University Dental Hospital, Lecturer, 歯学部・附属病院, 講師 (30156773)
GOODIS Harol  カリフォルニア大学, サンフランシスコ校・歯学部, 教授
MARSHALL Sal  カリフォルニア大学, サンフランシスコ校・歯学部, 教授
MARSHALL Gra  School of Dentistry, University of Califo, 教授
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1997: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsbiofunctional materials / adhesive restorative materials / pulpal cells / affinity / physiological activity
Research Abstract

This project undertaken to perform 「Study on Biofunctional Restorative Material with Pulpal cell」, was funded in part by a 3-year grant in aid from the Monbusho (Ministry of Education) International Scientific Research Program -University- to University Cooperative Research, as a joint effort between the Department of Restorative Dentistry, University of California, San Francisco, School of Dentistry and the Department of Operative Dentistry and Endodontics, Niigata University Faculty of Dentistry.
This study consists of the following three parts.
1) Research concerning with the human dentin : the ultra-microstructure of the human sound and carious dentin, dentin demineralization, the dentin substrate, and human dentin and the dentin resin adhesive interface.
2) Research concerning with the dental pulp : the cell-biological and immunohistochemical studies on the pulpal function of normal teeth, and the reaction of dental pulp to the various external irritations.
3) Research concerning with the dental materials : fluoride release from the various adhesive dental materials, fluoride uptake by human enamel and dentin from materials, and its effect to acid resistance.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] G. W. Marshall, Jr.: "Dentin demineralization : Effect of dentin depth, pH and different acids"Den Mater. 13. 338-343 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. W. Marshall, Jr.: "The dentin substrate : structure and properties related to bonding"J. Dent.. 25. 441-458 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. J. Marshall: "Human dentin and the dentin-resin adhesive interface"46. 2529-2539 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. W. Marshall, Jr.: "Effect of citric acid concentration on dentin demineralization, dehydration, and dehydration : Atomic force microscopy study"J. Biomed Mater Res. 42. 500-507 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. I. Rosales: "Acid-etching and hydration influence on dentin roughness and wettability"J Dent Res. 78. 1554-1559 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunihiko Yoshiba: "Expression and localization of Laminin-5 subunits during mouse tooth development"Dev. dyn.. 211. 164-176 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagako Yoshiba: "Expression and localization of Laminin-5 subnits in the mouse incisor"Cell Tissue Res. 292. 143-149 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagako Yoshiba: "Imminohistochemical localizations of class II antigens and nerve fibers in human carious teeth : HLA-DR immunoreactivity in Schwann cells"Arch. Histol. Cytol.. 61. 343-352 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. W. Marshall, Jr., N. Inai, I. W. Magidi, M. Balooch, J. H. Kinney, J. Tagami, and S. J. Marshall: "Dentin demineralization : Effect of dentin depth, pH and different acids."Den Mater. 13. 338-343 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. W. Marshall, Jr., S. J. Marshall, J. H. Kinney and M. Balooch: "The dentin substrate : structure and properties related to bonging."J. Dent.. 25. 441-458 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. J. Marshall, M. Balooch, T. Breunig, J. H. Kinney, A. P. Tomsia, N. Inai, L. G. Watanabe, I. -C. Wu-Magidi and G. W. Marshall Jr.: "Human dentin and the dentin-resin adhesive interface."Acta. Mater.. 46. 2529-2539 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G. W. Marshall. Jr., I. C. Wu-Magidi, L. G. Watanabe, N. Inai, M. Balooch, J. H. Kinney, S. J. Marshall: "Effect of citric acid concentration on dentin deminiralization, dehydration, and rehydration : Atomic force microscopy study."J Biomed Mater Res. 42. 500-507 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] J. I. Rosales, G. W. Marshall, S. J. Marshall, L. G. Watanabe, M. Toledano, M. A. Cabrerizo, and R. Osorio: "Acid-etching and hydration influence on dentin roughness and wettability."J Dent Res. 78. 1554-1559 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kunihiko Yoshiba, Nagako Yoshiba: "Daniel Aberdam, Guerrino Meneguzzi, Fabienne Perrin-Schmitt, Corinne Stoetzel, Jean Victor Ruch, and Herve Lesot : Expression and localization of Laminin-5 subunits during mouse tooth development."Dev. Dyn,. 211. 164-176 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagako Yoshiba, Kunihiko Yoshiba, Daniel Aberdam, Guerrino Meneguzzi: "Fabienne Perrin-Schmitt, Corinne Stoetzel, Jean Victor Ruch, and Herve Lesot : Expression and localization of Laminin-5 subunits during mouse tooth development."Cell Tissue Res. 292. 143-149 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagako Yoshiba, Kunihiko Yoshiba, Masaaki Iwaku and Hidehiro Ozawa: "Imminohistochemical localizations of class II antigens and nerve fibers in human carious teeth : HLA-DR immunoreactivity in Schwann cells."Arch. Histol. Cytol.. 61. 343-352 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G.W. Marshall, Jr.: "Dentin demineralization: Effect of dentin depth, pH and different acids."Den Mater. 13. 338-343 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] G.W. Marshall, Jr.: "The dentin substrate: structure and properties related to bonding."J.Dent.. 25. 441-458 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] S.J. Marshall: "Human dentin and the dentin-resin adhesive interface."Acta.Mater.. 46. 2529-2539 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] G.W. Marshall, Jr.: "Effect of citric acid concentration on dentin deminiralization, dehydration, and rehydration: Atomic force microscopy study."J Biomed Mater Res. 42. 500-507 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] J.I. Rosales: "Acid-etching and hydration influence on dentin roughness and wettability."J Dent Res. 78. 1554-1559 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kunihiko Yoshiba: "Expression and localization of Laminin-5 subunits during mouse tooth development."Dev.Dyn.. 211. 164-176 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagako Yoshiba: "Expression and localization of Laminin-5 subunits in the mouse incisor."Cell Tissue Res. 292. 143-149 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagako Yoshiba: "Immunohistochemical localizations of class II antigens and nerve fibers in human carious teeth: HLA-DR immunoreactivity in Schwann cells."Arch. Histol. Cytol.. 61. 343-352 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagako Yoshiba et al: "Expression and localization of laminin-5 subunits in the mouse incisor" Cell and Tissue Research. 292巻. 143-149 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kunihiko Yoshiba et al: "Expression and localization of laminin-5 subunits during mouse tooth development" Developmental Dynamics. 211巻. 164-176 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagako Yoshiba et al: "Immunohistochemical Localization of Class II Antingens and Nerve Fibers in Human carious Teeth: HLA-DR Immunoreactivity in Schwann Cells" Arch.Histol.Cyto.61巻. 343-352 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 韓 臨麟 et al: "接着性コンポジットレジンにおけるフッ素含有フィラー配合ボンディング材に関する研究-フッ素徐放性,歯質への取り込みおよびその歯質耐酸性に及ぼす影響-" 日歯保存誌. 41巻. 690-697 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡本 明: "抗菌剤を添加した光硬化型裏層用セメントの抗菌剤と材料学的性質" 日本歯科保存学会誌. (発表予定).

    • Related Report
      1997 Annual Research Report
  • [Publications] 岡本 明: "レジンボンディング材と象牙質接着界面の微細構造学的観察" 日本歯科保存学会誌. (発表予定).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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