| Project/Area Number |
09045083
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGATAKE Tuyoshi Institute of Tropical Medicine, Nagasaki University, Professor, 熱帯医学研究所, 教授 (30164445)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Kiwao Institute of Tropical Medicine, Nagasaki University, Research Associate, 熱帯医学研究所, 助手 (20220874)
WATANABE Hiroshi Institute of Tropical Medicine, Nagasaki University, Research Associate, 熱帯医学研究所, 助手 (90295080)
OISHI Kazunori Institute of Tropical Medicine, Nagasaki University, Associate Professor, 熱帯医学研究所, 助教授 (80160414)
KOBAYASHI Shinobu University Hospital Attached to the School of Medicine, Nagasaki University, Research Associate, 医学部・附属病院, 助手 (10274656)
タラビチクル フラシット チェンマイ大学, 附属病院中央検査部, 助教授
シリサンタナ チラ チェンマイ大学, 医学部, 学部長
プラシット タラビチクル チェンマイ大学, 附属病院中央検査部, 助教授
チラ シリサンタナ チェンマイ大学, 医学部, 学部長
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Thailand / AIDS / HIV / respiratory infection / 肺炎 / MIC |
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| Research Abstract |
Background: Prevalence of HIV infection is increasing in Thailand. However, clinical and microbiological characteristics of respiratory infections among such patients is not clear at present.
Methods: We prospectively analyzed the types and characteristics of respiratory infections in 126 HIV-infected patients (127 episodes, 81 males and 45 females, mean age 33.5 years) who were admitted to Nakornping Hospital in northern Thailand.
Results: The mean peripheral blood CD4 lymphocyte count (CD4/CD8) in 72 patients was 46.9/mmィイD13ィエD1(0.08). The most common diagnoses included pneumonia in 70, pneumocystis carinii pneumonia-like interstitial pneumonia in 24, pulmonary mycobacteriosis in 20, and pulmonary nocardiosis in 7. The most common organisms detected in the sputum induced Haemophilus influenzae (23), Pseudomonas aeruginosa (9), Rhodococcus equi (6), Streptococcus pneumoniae (6), and Staphylococcus aureus (6). Fourteen cases (11%) had mixed infections. Severe fungal infection caused by Penicillium marneffei in 9, life-threatening meningitis in 4 (cryptococcal in 3 and tuberculous in 1) and septicemia in 3 (S. aureus in 1, Pseudomonas spp. In 1, and Salmonella spp. In 1) were noted, resulting in 16 fatalities (12.6%).
Conclusions: Several types of organisms and respiratory infections exist in HIV-positive patients in northern Thailand. In such cases, early diagnosis and treatment are important for a satisfactory clinical outcome.
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