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Epstein-Barr Virus and Human Cancer

Research Project

Project/Area Number 09253103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionTottori University Faculty of Medicine

Principal Investigator

SAIRENJI Takeshi  Tottori University Faculty of Medicine, Department of Biosignaling, Professor, 医学部, 教授 (10117351)

Co-Investigator(Kenkyū-buntansha) AOZASA Katsuyuki  Osaka University Medical School, Department of Pathology, Professor, 医学部, 教授 (30115985)
EIZURU Yoshito  Kagoshima University School of Medicine, Division of Persisten and Oncogenic Viruses, Professor, 医学部, 教授 (00041351)
HIRAI Kanji  Medical Research Institute, Tokyo Medical and Dental University, Department of Tumor Virology, Professor, 難治疾患研究所, 教授 (00100991)
YANAI Hideo  Yamaguchi University School of Medicine, Department of Internal Medicine, Instructor, 医学部, 講師 (60220175)
FUKAYAMA Masashi  Graduate School of Medicine, Tokyo University, Department of Pathology, Professor, 医学部, 教授 (70281293)
徳永 正義  鹿児島大学, 医学部, 講師 (80041317)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥105,000,000 (Direct Cost: ¥105,000,000)
Fiscal Year 1999: ¥35,000,000 (Direct Cost: ¥35,000,000)
Fiscal Year 1998: ¥35,000,000 (Direct Cost: ¥35,000,000)
Fiscal Year 1997: ¥35,000,000 (Direct Cost: ¥35,000,000)
KeywordsEpstein-Barr virus (EBV) / EBV associated gastric cancer / EBV associated malignant lymphoma / NK lymphoma / LMP1 / tumorigenesis / EBV positive cell lines / apoptosis / EBV関連悪性りンパ腫 / SCIDマウス / LMPl / 腫瘍形成 / EBV感染 / 胃癌 / 悪性リンパ腫 / SCIPマウス / LMP1 / 腫瘍発生 / EBV細胞株
Research Abstract

(l) We demonstrated that EBV associated gastric carcinomas (EBV aGC) represent a clonal proliferation even in gastric mucosa at very early stages of the development. The carcinomas accompany with multiple carcinomas infected with EBV.
(2) We defined that EBV aGC develops in front of chronic atrophic gastritis and associates closely with the gastric mucosa border which is the place for remodel of tubular structures.
(3) We found a new type of EBV aGC which EBV infection is restricted in a small portion of the carcinoma. Two EBV infected cell lines were established from the cancerous and non-cancerous portions, respectively.
(4) We re-evaluated that nasal T/NK cell lymphomas were originated from NK cells and defined the EBV latency type 2 infection in the cells.
(5) We demonstrated that lethal midline granuloma (rhintis gangrenosa progressiva) is originated from NK or T cells and established the cell lines which have the characters of the lymphoma. The all cell lines were EBV positive NK cells and had the abnormality of chromosom 6 accompanied with a deletion of the long arm.
(6) We defined the difference of escaping to cytotoxic T-cell mediated immune surveillance mechanisms between pyothorax-associated lymphoma and nasal natural killer-cell lymphoma.
(7) We characterized EBNA-LP and defined the expression in cytoplasm and the co-localization with a cellular regulating factor HAX-1 and homo-dimelization of EBNA-LP.
(8) We analyzed that the C-terminal regions of LMP-l is critical for the regulation of apoptosis and BHRFinhibits the apoptosis with TRAIL by suppression of caspase 8 activity.

Report

(4 results)
  • 2000 Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (144 results)

All Other

All Publications (144 results)

  • [Publications] Gao,X. et al.: "Nitric oxide down-regulates Epstein-Barr virus reactivation in epithelial cell lines"Virology. 258. 375-381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sairenji,T.: "Epstein-Barr virus (EBV) infection and gastric carcinoma : The approach through EBV infected epithelial cell lines"Jpn.J.Infect.Dis.. 52. 110-112 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izawa,M. et al.: "Identification of an alternative form of caspasa-9 in human gastric cancer cell lines : a role of a caspase-9 variant in apoptosis resistance"Apoptosis. 4. 321-325 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanamori et al.: "Differential effects of TPA on cell growth and Epstein-Barr virus reactivation in epithelial cell lines depived from gastric tissues and B cell line Raji"Virus Genes. 20. 113-121 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikuta et al.: "Detection of Epstein-Barr virus in salivas and throat washings in healthy adults and children"Microbes and Infection. 2. 1-6 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuda et al.: "Inhibition of cell growth and Epstein-Barr virus (EBV) reactivation by CD 40 stimutation in EBV-transformed B cells"Viral Immunol.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takanashi,M., et al.: "Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-1-mediated growth Innibition"Arch.Virol.. 144. 241-257 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawaguchi K., et al.: "The cellular elongation factor 1 is modified in cells infected with representative alpha-, beta-, or gamma-herpesviruses"J.Virol.. 73. 4456-4460 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka,M., et al.: "Sequence variations of Epstein-Barr virus LMP2A gene in gastric carcinoma in Japan"Virus Genes. 19. 103-111 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shirakata,M. et al.: "Requirement of cellular l : censing process for the dyad symmotry region-dependent replication of the EBV oriP minichromosome"Virology. 263. 42-54 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto,T., et al.: "Epstein-Barr virus (EBV)-infected cells were frequently but dispersely detected in T-cell lymphomas of various types by in situ hybridization with a RNA probe specific to EBV-spesific nuclear antgen 1"Virus Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda,T., et al.: "Detection of lymphocytes productively infected with Epstein-Barr virus in non-neoplastic tonsils"J.gon.Virol.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mori,S., et al.: "Deletions and Single-basemutations with in the carboxy-termial region of the Datent membrane protein 1 oncogene in Epstein-Barr virus-related gastric cancers of southern Japan"J.Med.Virol.. 57. 152-158 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Herrera・Goepfert,R. et al.: "Epstein-Barr virus-associated gastric carcinoma in Mexico. Analysis of 135 consecutive gastrectomies in two hospitals"Modern Pathol.. 12. 873-878 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shinkura,R. et al.: "Epstein-Barr virus specific antibodies in EBV-positive and -negative gastric carcinoma cases in Japan"J.Med.Virol.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohsawa,M. et al.: "Immunophenotypic and genotypic characterization of nasal lymphome with polymorphic reticulosismorphology"Int.J.Cancer. 81. 865-870 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanno,H. et al.: "HLA-A alleles of patients with pyothorax-associated lymphoma : Delinoation of anti-Spstein-Barr virus (EBV) host immune response during the development of EBV latent antigen-pegitive lympromss"Int.J.Cancer. 82. 630-634 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takakuwa,T. et al.: "No evidence of replication error phenotype in nasal NK/T cell lymphoma"Int.J.Cancer. 84. 623 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miwa,H., et al.: "Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated apoptosis"Free Rad.Res. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanno,H. et al.: "Low frequency of HLA-Ao201 allele in patients with Epstein-Barr virus positive nasal lymphomas with polymorphic reticulosis morphology"Int.J.Cancer. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Li,T., et al.: "Mutations of p53 gene in nasal NK/T cell lymphoma"Lab Invest. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaizaki,Y., et al.: "Atrophic gastritis, Spstein-Barr virus infection, and Epstein-Barr virus-associated gastric carcinoms"Gastric Cancer. 2. 101-108 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yanai,H., et al.: "Epstein-Barr virus infection of the colon with inflammatory bowel desease"Am.J.Gastrienterol.. 94. 1582-1586 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yanai,H. et al.: "Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis"J.Clinic.Gastroenterol.. 29. 39-43 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawanishi,M.: "The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells : the role of LMP1 C terminal activation regions land2"Virology. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Gao, X., Tajima, M.and Sairenji, T.: "Nitric oxide down-regulates Epstein-Barr virus reactivation in epithelial cell lines."Virology. 258. 375-381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sairenji, T.: "Epstein-Barr virus (EBV) infection and gastric carcinoma. : The approach through EBV infected epithelial cell lines."Jpn.J.Infect.Dis. 52. 110-112 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izawa, M., Mori, T., Satoh, T., Teramachi, A.and Sairenji, T.: "Identification of an alternative form of caspase-9 in human gastric cancer cell lines : a role of a caspase-9 variant in apoptosis resistance."Apoptosis. 4. 321-325 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanamori, M., Tajima, M., Satoh, Y., Hoshikawa, Y., Miyazawa, Y., Okinaga, K., Kurata, T.and Sairenji, T.: "Differential effects of TPA on cell growth and Epstein-Barr virus reactivation in epithelial cell lines derived from gastric tissues and B cell line Raji."Virus Genes. 20. 113-121 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikuta, K., Satoh, Y., Hoshikawa, Y.and Sairenji, T.: "Detection of Epstein-Barr virus in salivas and throat washings in healthy adults and children."Microbes and Infection. 2. 1-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fukuda, M., Satoh, T., Takanashi, M., Hirai, K., Ohnishi, E., and Sairenji, T.: "Inhibition of cell growth and Epstein-Barr virus(EBV) reactivation by CD 40 stimulation in EBV-transformed B cells."Viral Immunol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takanashi.M, Jifen Li.J.-F., Shirakata.M, Mori.S.and Hirai.K.: "Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-1-mediated growth inhibition."Arch. Virol.. 144. 241-257 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawaguchi, Y., Matsumura, T., Roizman, B., and Hirai, K.: "The cellular elongation factor 1 is modified in cells infected with representative alpha-, beta-, or gamma- herpesviruses."J.Virol.. 73. 4456-4460 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka, M., Kawaguchi, Y., Yokofujita, J., Takage, M., Eishi, Y., and Hirai, K.: "Sequence Variations of Epstein-Barr virus LMP2A gene in gastric carcinoma in Japan."Virus Genes. 19. 103-111 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shirakata, M., Imadome, K., and Hirai, K.: "Requirement of cellular licensing process for the dyad symmetry region-dependent replication of the EBV oriP minichromosome."Virology. 263. 42-54 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yamamoto, T., Nakamura, Y., Kishimoto, K., Takeuchi, H., Shirakata, M., Mitsuya, T., and Hirai, K.: "Epstein-Barr virus(EBV)-infected cells were frequently but dispersely detected in T -cell lymphomas of various types by in situ hybridization with a RNA probe specific to EBV-specific nuclear antigen 1."Virus Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ikeda, T., Kobayashi, R., Horiuchi, M., Nagata, Y., Hasegawa, M., Mizuno, F., and Hirai, K.: "Detection of lymphocytes productively infected with Epstein-Barr virus in non-neoplastic tonsils."J.Gen.Virol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mori S, Itoh T, Tokunaga M, Eizuru Y.: "Deletions and single-basemutations within the carboxy-terminal region of the latent membrane protein 1 oncogene in Epstein-Barr virus-related gastric cancers of southern Japan."J.Med.Virol.. 57. 152-158 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Herrera-Goepfert, R., Reyes, E., Hermandez-Avila, M., Mohar, A., Shinkura, R., Fujiyama, C., Akiba, S., Eizuru, Y., Harada, Y., Tokunaga, M.: "Epstein-Barr virus-associated gastric carcinoma in Mexico. Analysis of 135 consecutive gastrectomies in two hospitals."Modern Pathol. 12. 873-878 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shinkura, R., Yamamoto, N., Fujiyama, C., Shinmura, Y., Eizuru, Y., Tokunaga, M.: "Epstein-Barr virus specific antibodies in EBV-positive and -negative gastric carcinoma cases in Japan."J.Med.Virol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ohsawa, M., Nakatsuka, S., Kanno, H., Miwa, H., Kojya, S., Harabuchi, Y., Yang, WI., Aozasa, K.: "Immunophenotypic and genotypic characterization of nasal lymphoma with polymorphic reticulosismorphology."Int.J.Cancer. 81. 865-870 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanno, H., Ohsawa, M., Hashimoto, M., Iuchi, K., Nakajima, Y., Aozasa, K.: "HLA-A alleles of patients with pyothorax-associated lymphoma : Delineation of anti-Epstein-Barr virus (EBV) host immune response during the development of EBV latent antigen-positive lymphomas."Int.J.Cancer. 82. 630-634 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takakuwa, T., Aozasa, K.: "No evidence of replication error phenotype in nasal NK/T cell lymphoma."Int.J.Carcer. 84. 623 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Miwa, H., Aozasa, K.: "Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated apoptosis."Free Rad. Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kanno, H., Aozasa K.: "Low frequency of HLA-A 0201 allele in patients with Epstein-Barr virus positive nasal lymphomas with polymorphic reticulosis morphology."Int.J.Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Li, T., Aozasa, K.: "Mutations of p53 gene in nasal NK/T cell lymphoma."Lab Invest. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kaizaki, Y., Sakurai, S., Chong, JM., Fudayama, M.: "Atrophic gastritis, Epstein-Barr virus infection, and Epstein-Barr virus-associated gastric carcinoma."Gastric Cancer. 2. 101-108 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yanai, H., Shimizu, N., Nagasaki, S., Mitani, N.and Okita, K.: "Epstein-Barr virus infection of the colon with inflammatory bowel desease."Am. J.Gastrienterol. 94. 1582-1586 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yanai, H., Muakimi, T., Yoshiyama, H., Takeuchi H., Nishikawa, J., Nakamura, H., Okita, K., Miura, O., Shimizu, N.and Takada, K.: "Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis."J.Clinic. Gastroenterol.. 29. 39-43 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawanisi, M.: "The Epstein-Barr virus latent membrance protein 1 (LMPl) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells : the role of LMPl C-terminal activation regions 1 and 2."Virology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Gao,X. et al.: "Nitric oxide down-regulates Epstein-Barr virus reactivation in epithelial cell lines"Virology. 258. 375-381 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sairenji,T.: "Epstein-Barr virus(EBV) infection and gastric carcinoma:The approach through EBV infected epithelial cell lines"Jpn.J.Infect.Dis.. 52. 110-112 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Izawa,N. et al: "Identification of an alternative form of caspase-9 in human gastric cancer cell lines : a role of p caspase 9 variant in apoptosis resistance"Apoptosis. 4. 321-325 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanamori et al.: "Differential effects of TPA ** cell growth and Epstein-Barr virus reactivation in epithelial cell lined derived from gastric tissues and B cell line Raji"Virus Genes. 20. 113-121 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikuta et al.: "Defection of Epstein-Barr virus in salivas and throat washings in healthy adults and children"Microbes and Infection. 2. 1-6 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fukada et al.: "Inhibition of cell growth and Epstein-Barr virus(EBV) reactivation by CD 40 stimulation in EBV-transformed B cell"Viral Immunol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takanashi,M.,et al.: "Tumorigenicity of mouse BALB/c3T3 fibroblast cells witch express Epstein-Barr viruse ncoded LMPI and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-I:mediated growth inhibition"Arch.Virol.. 144. 241-257 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kawaguchi,K.,et al.: "The cellular elongation factoe I is modified in cells infected with representative alpha-,beta-,or gamma-herpesviruses"J.Virol.. 73. 4456-4460 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanaka,M.,et al.: "Sequence variations of Epstein-Barr virus LMP2A gene in gastric carcinoma in Japan"Virus Genes. 19. 103-111 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shirakata,M.et al.: "Requirement of cellular licensing process for the dyad symmetry region:dependent replication of the EBV or iP minichromosome"Virology. 263. 42-54 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamamoto,T.,et al.: "Epstein-Barr virus(EBV) infected cells were frequently but dispersely detected in T-cell lymphomas of various types by insitu hybridization with a RNA probe specific to EBV specific nuclear antigen 1"Virus Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda,T.,et al.: "Defection of lymphocytes productively infected with Epstein-Barr virus in non-neoplastic tonsils"J.gon.Virol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mori,S,et al: "Deletions and Single-basemutations within the oarboxy-terminal region of the latent membrane protein1 encogene in Epstein-Barr virus related gastric cancer of southern Japan"J.Med.Virol.. 57. 152-158 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Herrera.Goepfert,R. et al.: "Epsttein-Barr virus associated gastric carcinoma in Mexico.Analysis of 135 consecutive gastrectomies in two hospitals"Modern Pathol.. 12. 873-878 (199)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shinkura,R.et al.: "Epstein-Barr virus specific antibodies in EBV-positive and negative gastric carcinoma cases in Japan"J.Med.Virol.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ohsawa,M.et al.: "Immunophenotypic and genotypic characterization of nasal lymphoma with polymorphic reticulosismorphology"Int.J.cancer. 81. 865-870 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanno,H.et al.: "HLA-A alleles of patients with pyothorax associated lymphoma:Delineation of anti-Epstein-Barr virus(EBV) host immune response during the development of EBV patent antigen poritive lymphomas"Int.J.cancer. 82. 630-634 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takakuwa,T.et al.: "No evidence of replication error phenotype in nasal NK/T cell lymphoma"Int.J.cancer. 84. 623 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Miwa,H,et al.: "Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated apoptosis"Fres Rad.Res.. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanno,H.et al.: "Low frequency of HLA-AO201 allele in patients with Epstein-Barr virus positive nasal lymphomas with polymorphic reticulosis morphology"Int.J.cancer. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Li,T.,et al.: "Mutations of p53 geno in nasal NK/T cell lymphoma"Lad Invest. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kaizaki,Y.,et al.: "Atrophic gastritis Epstein-Barr virus infection, and Wpstein-Barr virus-associated gastric carcinoma"gastric Cancer. 2. 101-108 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yanai,H.,et al.: "Epstein-Barr virus infection of the colon with inflammatory bowel desease"Am.J.Gastrienterol. 94. 1582-1586 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yanai,H.,et al.: "Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis"J.clinic.Gastroenterrol. 29. 39-43 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kawanishi,M.: "The Epstein-Barr virus latent membrane proteinI(LMPI) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells : the role of LMPI terminal activation regions land2"Virology. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yamauchi,Y.,et al.: "Evaluation of antibodies to the Epstein-Barr virus immediate early gene product,ZBBRA by a new enzyme-linked immunosorbent assay." Intervirology. 41. 000-000 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sairenji,T.,et al.: "Induction of interleukin-10 on activation of Epstein-Barr virus(EBV)in EBV infected B cell lines." Viral Immunol.11. 221-231 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Satoh,T.,et al.: "The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata B cells." Virus Genes. 18. 57-64 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Satoh,Y.,et al.: "Effective PCA amplification of Epstein-Barr virus DNA to extracted DNA from paraffin-embedded gastric carcinoma tissues by pretreatment with restriction enzyme or bovine serum albumin." J.Clin.Microbiol.36. 3423-3425 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takasaka,N.,et al.: "Productive infection of Epstein-Barr virus(EBV)in EBV-genoma-positive epithelial cell lines (GT38 and GT39) derived from gastric tissues." Virology. 247. 152-159 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirai,K.,et al.: "Epstein-Barr virus genome in infected cel1s and cancer." Gann Monograph on Cancer Res.45. 29-39 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shirakata,M.,et al.: "Identification of minimal oriP of Epstein-Barr virus required for DNA replication." J.Biochem.123. 175-181 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kobayashi,R.,et al.: "Detection of Epstein-Barr virus infection in the epithelial cells and lymphocytes of non-neoplastic tonsils by in situ hybridization and in situ PCR." Arch.Virol.143. 803-813 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takanashi,M.,et al.: "Tumorigenicity of mouse BALB/c 3T3 fibroblast cells which express Epstein-Barr virus-encoded LMP1 and show normal growth phenotypes in vitro is correlated with loss of transforming growth factor-β 1-mediated growth inhibition." Arch.Virol.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Mori,S.,et al.: "Delations and single-base mutation within the carboxy-terminal region of the LMP-1 oncogene in EBV-related gastric cancers of southern Japan." J.Med.Virol.57. 152-158 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Machida,H.,et al.: "Anti-herpesvirus activity profile of 4′-rthioarabinofuranosyl purine and uracil nucleosdes and activity of 1-β-D-2′-fluoro-4′-thioarabinofuranosyl guanine and 2,6-diamonopurine against clinical isoiates of human cytomegalovirus." Antiviral.Res.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Murakami,K.,et al.: "A case of large vessel arteritis associated with chronic active Esptein-Barr virus infection." Arth.Rheum.41. 369-373 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizuki,M.,et al.: "Natura killer cell-derived large granular lymphocyte of lung developed in a patient with hypersensitivity to mosquito bites and reactivated Esptein Barr virus infection." Am.J.Hematol.59. 309-315 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hogyo,T.,et al.: "Frequent p53 mutations at dipyrimidine sites in patients with pyothorax-associated lymphoma (PAL)." Cancer Res.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsawa,M.,et al.: "Rick of non-Hodgkin′s lymphoma in patients with hepatitis C virus infection." Int.J.Cancer.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Iwasaki,Y.,et al.: "Establishment and characterization of a human Esptein-Barr virus-associated gastric carcinoma in SCID mice." J.Virol.72. 8321-8326 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukayama,M.,et al.: "Epstein-Barr virus and gastric carcinoma." Gastic Cancer (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Nishiwaki,J.,et al.: "Hypoechoic submucosal nodules ; A sign of Epstein-Barr virus-associated early gastric cancer." J.Gastroenterol Hepatol.13. 585-590 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohsawa,M.,et al.: "Characteristics of non-Hodgkin's lymphoma complicnted with renal cell malignancies." Oncogene. 55. 482-486 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanno,H.,et al.: "Mechanisms for the development of pyothorax-associated lymphoma." Pathol.Int.48. 653-664 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hongyo,T.,et al.: "Frequent p53 mutation at dipyrimidine sites in patients with pyothorax-associated lymphoma (PAL)." Cancer Res.58. 1105-1107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kanno,H.,et al.: "Appearance of different clone of Epstein-Barr virus genome in recurrent tumor of pyothorax-associated lymphoma (PAL) and a mini-review of PAL." Leukemia. 12. 1288-1294 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kojya,S.,et al.: "Site spectic localization of Epstein-Barr virus in the pharyngeal carcinomas." Jpn.J.Cancer Res.89. 510-515 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomita,Y.,et al.: "Plasmacytoma of the gastrointestinal tract in Korea : higher incidence rate than in Japan and EBV-association." Oncology. 55. 27-32 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanai,H.,et al.: "Epstein-Barr virus infection of the colon with inflammatory bowel disease." Am.J.Gastroenterol.(in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanai,H.,et al.: "The backgraound atrophic gastristis for Epstein-Barr virus-associated gastrc carcinoma." J.Clin.Gastroenterol. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Tada-Oikawa,S.,et al.: "Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential DNA alkylation-induced apoptosis." FEBS Letters. 442. 65-69 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yang,W-I.,et al.: "Epstein-Barr virus and gastrointestinal lymphomas in Korea." Yonsei.Med.J.39. 268-276 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sairenji,T.,et al.: "Immune responses to Epstin-Barr virus infection." In Herpes-Virus and Immunity (Medveczky et a1.,eds) Plenum Press.,NY,USA., (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tokunaga,M.,et al.: "Epstein-Barr virus involvement in gaatric cancer : Biomarker for lymphnode metastnasis" Cancer Epidemiology,Biomarker & Prevention. (in press),

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanai,H.,et al.: "The gastric mucosa surrounding Epstein-Barr virus-associated gastric cancers." In″Gann Monograph on Cancer Research NO.45″ed.Osato T.Japan Scientific Societies Press,Tokyo pp., (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ohonishi,E.,et al.: "Interleukin-4 production in Epstein-Barr virus-transformedB cell lines from peripheral mononuclear cells of patients with atopic dermatitis." J.Interfer.Cyt.Res.17. 597-602 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takasaka,N.,et al.: "Productive infection of Epstein-Barr virus (EBV) in EBV-genome positive epitherial cell lines (GT38 and GT39) derived from gastric tissues." Virolgy. (in press) (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogata,T.,et al.: "No significant role of Epstein-Barr virus in the tumorigenesis of Warthin tumor." J.Med.Dent.Sci.44. 45-52 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takeuchi,H,et al.: "Detection of latent Epstein-Barr virus (EBV) DNA in paraffin sections of nasopharyn-geal carcinomas expressing no EBV-encoded small RNAs using in situ PCR" :Arch.Virol.142. 1743-1756 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ishihara,S.,et al.: "Clonal lymphoproliferation following chronic active EB virus infection and hypersensitivity to mosquito bites." Am.J.Hematol. 54. 276-281 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Goto,T.,et al.: "Detection of Epstein-Barr virus DNA in virus-infected cells by electron microscopic in situ hybridization" J.Electron Microsc.46. 431-437 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kobayashi,R,et al.: "Detection of Epstein-Barr virus infection in the epithelial cells and lymphocytes of non-neoplastictonsile by in situ hybridization and in situ PCR." Arch.Virol.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hirai,K.,et al.: "Epstein-Barr virus genome in infected cells and cancer" Gann Monogaraph on Cancer Res.45(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Arikawa,J.,et al.: "Morphological characteristics of Epstein-Barr virus-related early gastric carcinoma : A case-control study." Pathol.Int.47. 360-367 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sidagis,J.,et al.: "Molecular epidemiology of Epstein-Barr virus (EBV) in EBV-related malignancies." Int.J.Cancer. 72. 72-76 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Arikawa,J.,et al.: "Epstein-Barr virus-positive muliple early gastric cancer and dysplastic lesions : A case report." Pathol.Int.47. 730-734 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Galetskyl,SA.,et al.: "Epstein-Barr virus associated gastric cancer in Russia." Int.J.Cancer. 73. 786-789 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tokunaga,M.,and Land,CE.: "Epstein-Barr virus involvement in gastric cancer : Biomarker for lymph node metastasis." Cancer Epidemiology,Biomarker & Prevention. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanno,H.,et al.: "Induction of the immuno-suppressive cytokine,interleukin-10,by Epstein-Barr virus expressing pyothorax-associated lymphoma : Possible role of in the development of overt lymphoma in immuno-suppressive hosts." Am.J.pathol.105. 349-357 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita,Y.,et al.: "Epstein-Barr virus in lymphoproliferative diseases in the sinonasal regions : Close association with CD56 immunophenotype and polymorphic reticulosis morphology." Int.J.Cancer. 70. 9-13 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Qiu,K.,et al: "Epstein-Barr virus in gastric carcinoma in Suzhou, China and Osaka,Japan : Association with clinico-pathologic factors and HLA-subtype." Int.J.Cancer. 71. 155-158 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshida,Y.,et al.: "Cancer risk after renal transplantation in Japan" Int.J.Cancer. 71. 517-520 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tomita.Y.,et al.: "Plasmacytoma of the gastrointestinal tract in Korea : higher incidence rate than in Japan and EBV-association." Oncology. 55. 27-32 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hoshida,Y.,et al.: "Epstein-Barr virus in malignancies developing in renel transplants in Japan" J.Cancer Res.Clin.Oncol.123. 509-516 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hongyo,T.,et al.: "Frequent p53 mutations at dipyrimidine sites in patients with pyothoraxassociated lymphoma (PAL)." Cancer Res.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Chong,J-M.,et al.: "CD44 variants in gastric carcinoma in association with or without Epstein-Barr virus." Int.J.Cancer. 74. 450-454 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yanai,H.,et al.: "The gastric mucosa surrounding Epstein-Barr virus-associated gastric cancers." Gann Monograph on Cancer Res.45(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yanai,H.,et al.: "Endo-scopic ultrasonography and endoscopy for staging depth of invasion in early gastric cancer : a pilot study." Gastrointest Endosc.45. 236-242 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yanai,H.,et al.: "Epstein-Barr virus infection in non-carcinomatous gastric epithelium" J.Pathol.183. 293-298 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimizu,N.,and Takada,K.: "Epstein-Barr virus infection of human gastric carcinoma cells : Implication of the existance of a new virus receptor different from CD21." J.Virol.71. 5688-5691 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wen,J.,et al.: "Association of EBV with Sjogren's syndrome Differential EBV expression between epithelial cells and lymphocytes in salivary glands." Am.J.Pathol.149. 1511-1517 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawanishi,M.: "Expression of Epstein-Barr virus latent membrane protein 1 protects Jurkat T cells from apoptosis induced by serum deprivation." Virology. 228. 244-250 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawanishi,M.: "Epstein-Barr virus BHRF1 protein protects intestine 407 epithelial cells from apoptosis induced by tumor necrosis factor alpha and anti-Fas antibody." J.Virol.71. 3319-3322 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 西連寺 剛: "B細胞内EBウイルス活性化機構" 日本臨床. 55・2. 316-320 (1997)

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      1997 Annual Research Report
  • [Publications] 山本貴子、 平井莞二: "EBウイルス感染細胞と関連腫瘍の分子病理学的解析" 日本臨床. 55・2. 452-460 (1997)

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      1997 Annual Research Report
  • [Publications] 西川潤、 柳井秀雄、 松元裕輔、他: "多彩な分化像を呈した Epstein-Barr virus 関連早期胃癌の1例" Gastroenterol Endosc. 39・. 62-67 (1997)

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      1997 Annual Research Report
  • [Publications] 柳井秀雄、 水柿雄三、 西川潤、他: "EBウイルス関連胃癌の診断と非胃癌粘膜におけるEBウイルス感染" 日本臨床. 55・2. 374-380 (1997)

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      1997 Annual Research Report
  • [Publications] 柳井秀雄、 西川潤、 多田正弘、他: "Epstein-Barr ウイルスと消化器がん" 最新医学. 52・11. 1335-1342 (1997)

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      1997 Annual Research Report
  • [Publications] 柳井秀雄、 西川潤、 多田正弘、他: "EBウイルスと胃癌" G.I.Research. 5・. 437-443 (1997)

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      1997 Annual Research Report
  • [Publications] 川西美知子: "EBウイルス蛋白質LMP1によるアポトーシスの抑制" 日本臨床. 55・2. 305-310 (1997)

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      1997 Annual Research Report
  • [Publications] 川西美知子: "EBウイルス潜伏期蛋白LMP1および早期蛋白BHRF1によるアポトーシスの制御" ウイルス. 47・1. 89-97 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sairenji,T.and Kurata,T: "Immune responses against Epstin-Barr virus infection. In Molecular Immunology of Herpes-virus (Friedman et al.,eds)." Plenum Publishing Co.,NY,USA (in press), (1998)

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      1997 Annual Research Report
  • [Publications] 西連寺 剛: "臨床免疫学 EBウイルス感染と免疫応答" 朝倉書店, 2 (1997)

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      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2019-02-15  

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