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遺伝的素因と環境因子の相互作用による神経細胞死

Research Project

Project/Area Number 09280103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionJuntendo University

Principal Investigator

水野 美邦  順天堂大学, 医学部, 教授 (30049043)

Co-Investigator(Kenkyū-buntansha) 直井 信  応用生化学研究所, 脳科学研究部門, 部長 (50022786)
太田 茂  広島大学, 医学部, 教授 (60160503)
清水 信義  慶應大学, 医学部, 教授 (50162706)
小澤 敬也  自治医科大学, 医学部, 教授 (30137707)
小川 紀雄  岡山大学, 医学部, 教授 (90033208)
柳原 武彦  大阪大学, 医学部, 教授 (70243201)
永津 郁子  藤田保健衛生大学, 医学部, 教授 (80084573)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥266,000,000 (Direct Cost: ¥266,000,000)
Fiscal Year 2000: ¥68,000,000 (Direct Cost: ¥68,000,000)
Fiscal Year 1999: ¥66,000,000 (Direct Cost: ¥66,000,000)
Fiscal Year 1998: ¥64,000,000 (Direct Cost: ¥64,000,000)
Fiscal Year 1997: ¥68,000,000 (Direct Cost: ¥68,000,000)
Keywords神経細胞死 / パーキンソン病 / 家族性パーキンソン病 / 遺伝的素因 / 黒質神経毒 / 環境因子 / 遺伝子治療 / 神経栄耀因子
Research Abstract

常染色体性劣性遺伝の家族性パーキンソン病の原因蛋白であるParkinについて機能解析を推進し,これがユビキチンリガーゼの一種であることを明らかにした.Parkinの欠損により,これによりポリユビキチン化される蛋白が黒質に蓄積して黒質変性が進行すると推定できる.またParkinは,Golgi装置を経て軸索輸送小胞に結合し,シナプス小胞に運ばれ,その膜に存在することを明らかにした.今後alpha-synucleinとの関連や孤発型パーキンソン病におけるParkinの解析で,パーキンソン病の原因に関する研究の進展が期待できる.Parkin遺伝子については,その欠失変異の切断点が18タイプに分類されることを明らかにした.エキソン4欠失の切断点は日本人5家系,韓国人1家系に共通していた.更にFISHプローブを調製し,複合ヘテロ接合体の欠失変異のDNA診断を可能にした.
孤発型パーキンソン病に関しては,PD患者リンパ球で内在性神経毒N-methyl(R)-salsolinol生成律速酵素である中性N-methyltransferase活性が著しく高い例が存在することを明らかにした.本神経毒はアポトーシスを誘導して黒質神経細胞死を起こす.更にpropargylamine誘導体はこの細胞死機構に介入しアポトーシスを抑制して神経細胞保護活性を示すことを見い出した.またドパミン系作用薬が核内移行し,転写因子に直接作用している可能性を明らかにした.パーキンソン病の遺伝子治療に関しては,チロシン水酸化酵素,芳香族アミノ酸脱炭酸酵素,テトラヒドロビオプテリン合成の律速酵素GTPシクロヒドロラーゼIの各遺伝子を全て搭載したアデノ随伴ウイルスベクターをMPTP投与により作製したラットモデルで1年以上改善が継続することを明らかにし,サルを用いた前臨床研究でも効果を確認した.

Report

(4 results)
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (202 results)

All Other

All Publications (202 results)

  • [Publications] Shimura H, et al.: "Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase"Nature Genet. 25. 302-305 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kobayashi T, et al.: "Exonic deletion mutations of the Parkin gene among sporadic patients with Parkinson's disease"Parkinsonism Rel Disord. 6. 129-131 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Zhang J, et al.: "Polymeropoulos, M.H., Mizuno, Y. : Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 gene and sparadic Parkinson's disease"Parkinsonism Rel Disord. 6. 195-197 (2000)

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      2000 Annual Research Report
  • [Publications] Zhang J, et al.: "Failure to find mutations in ubiquitin caroboxy-terminal hydrolase L1 gene in familial Parkinson's disease"Parkinsonism Rel Disord. 6. 199-200 (2000)

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      2000 Annual Research Report
  • [Publications] Hattori N, et al.: "Autosomal recessive juvenile parkinsonism : a Key to understanding nigral degeneration in sporadic Parkinson's disease"Neuropathology. 20. S85-S90 (2000)

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      2000 Annual Research Report
  • [Publications] Kitada T, et al.: "Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene"Mammalian Genome. 11. 417-421 (2000)

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      2000 Annual Research Report
  • [Publications] Minoshima S, et al.: "Keio Mutation Database (KMDB) for Human Disease Gene Mutations"Nucl Acids Res. 28. 364-368 (2000)

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      2000 Annual Research Report
  • [Publications] Kuriyama H, et al.: "Characterization and Chromosomal Mapping of a Novel Human Gene, ANKHZN,"Gene. 253. 151-160 (2000)

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      2000 Annual Research Report
  • [Publications] Ohtsubo M, et al.: "Interruption of NFkB-STAT1 Signaling Mediate EGF-induced Cell Cycle Arrest"J Cell Physiol. 184. 131-137 (2000)

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      2000 Annual Research Report
  • [Publications] Sango, et al.: "Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain"Neurosci Lett. 283. 224-226 (2000)

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      2000 Annual Research Report
  • [Publications] Maruyama W, et al.: "Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl (R) salsolinol, in dopaminergic SH-SY5Y cells."J.Neural Transm. (in press). (2000)

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      2000 Annual Research Report
  • [Publications] Maruyama W, et al.: "Mechanism underlying anti-apoptotic activity of (-) deprenyl-related propargylamines"Mech Aging Devel. (in press). (2000)

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      2000 Annual Research Report
  • [Publications] Sogawa CA, et al.: "Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g)"Brain Res. 853. 310-316 (2000)

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      2000 Annual Research Report
  • [Publications] Higashi Y, et al.: "Inhibition of tyrosinase reduces cell viability in catecholaminergic neuronal cel"J Neurochem. 75. 1771-1774 (2000)

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      2000 Annual Research Report
  • [Publications] Miyazaki I, et al.: "Expression of metallothionein-III mRNA and its regulation by Levodopa in the basal ganglia of hemi-parkinsonian rats"Neurosci Lett. 293. 65-68 (2000)

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      2000 Annual Research Report
  • [Publications] Hayashi H, et al.: "Morphological aspects of the postnatal development of submandibular glands in malerats : Involvement of apoptosis"Neurosci Lett. 283. 224-226 (2000)

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      2000 Annual Research Report
  • [Publications] Ikemoto K, et al.: "Human midbrain dopamine neurons express serotonin 2A receptor : an immunohistochemical demonstration"Brain Res. 853. 377-380 (2000)

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      2000 Annual Research Report
  • [Publications] Kitahama K, et al.: "Distribution of dopamine-immunoreactive fibers in the rat brainstem"Neuroanatomy. 18. 1-9 (2000)

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      2000 Annual Research Report
  • [Publications] Shen Y, et al.: "Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic I-amino acid decarboxylase, and GTP cyclohydrolase I"Gene Ther. 11. 1509-1519 (2000)

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      2000 Annual Research Report
  • [Publications] Shimazaki K, et al.: "Adeno-associated virus vector-mediated bcl-2 gene transfer into post-ischemic gerbil brain in vivo : prospects for gene therapy of ischemia-induced neuronal death"Gene Ther. 7. 1244-1249 (2000)

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      2000 Annual Research Report
  • [Publications] Urabe M, et al.: "Self amplification system for recombinant adeno-associated virus production"Biochem Biophys Res Commun. 276. 559-563 (2000)

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      2000 Annual Research Report
  • [Publications] Tanaka M, et al.: "Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain"Mech Ageing Dev. 116. 65-76 (2000)

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      2000 Annual Research Report
  • [Publications] Shimokata H, et al.: "Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)."Epidemiol. 10. S46-S55 (2000)

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      2000 Annual Research Report
  • [Publications] Matsunaga H, et al.: "Anti-atherogenic mitochondrial genotype in patients with type 2 diabetes"Diabetes Care. (in press). (2000)

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      2000 Annual Research Report
  • [Publications] Mabuchi T, et al.: "Contribution of microglia/macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats"Stroke. 31. 1735-1743 (2000)

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      2000 Annual Research Report
  • [Publications] Yang G, et al.: "Regional difference of neuronal vulnerability in the murine hippocampus after transient forebrain ischemia"Brain Res. 870. 195-198 (2000)

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      2000 Annual Research Report
  • [Publications] Kitagawa K, et al.: "Extended neuronal protection induced after sublethal ischemia adjacent to the area with delayed neuronal death"Neuroscience. 96. 141-146 (2000)

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      2000 Annual Research Report
  • [Publications] Asai A,T, et al.: "Hlgh level calcineurin activity predisposes neuronal cells to apoptosis"J Biol Chem. 274. 34450-34458 (2000)

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      2000 Annual Research Report
  • [Publications] Kawai H, et al.: "Inhibition of dopamine receptors by endogenous amines : binding to striatal receptors and pharmacological effects on locomotor activity"Bioorg Medic Chem Lett. (in press). (2000)

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      2000 Annual Research Report
  • [Publications] Mizuno Y: "Genetics of Parkinson's disease"Biomed Pharmacother. 53. 109-116 (1999)

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      1999 Annual Research Report
  • [Publications] Shimura H: "Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autocomal Juvenile Parkinsonism pationts"Ann Neurol. 45. 668-672 (1999)

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      1999 Annual Research Report
  • [Publications] Wang M.: "Polymorphism in the Parkin gene in sporadic Parkinson's disease"Ann Neurol. 45. 655-658 (1999)

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      1999 Annual Research Report
  • [Publications] Shimura-Miura H,: "Increased 8-oxo=dGTPase in the mitochondria of substantia nigra neurons in Parkinson's disease Ann Neurol 46: 920-924. 1999"Ann Neurol. 46. 920-924 (1999)

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      1999 Annual Research Report
  • [Publications] Kitada T: "Positional cloning of the autosomal recessive juvenile parkinsonism (AR-JP) gene and its diversity in deletion mutations"Parkinsonism Rel Disord. 5. 163-168 (1999)

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      1999 Annual Research Report
  • [Publications] Oya T: "Mehtylglyoxal modification of protein"J Biol Chem. 274. 18492-18502 (1999)

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      1999 Annual Research Report
  • [Publications] Sumitomo M: "Induction of apoptosis on cytokine-producing bladder cancer cells by adenovirus-mediated over expression"Hum Gene Ther. 10. 37-47 (1999)

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      1999 Annual Research Report
  • [Publications] Heino M: "Mutation analyses of north American APS-1 patients"Hum Mutat. 13. 69-74 (1999)

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      1999 Annual Research Report
  • [Publications] Minoshima S: "Keio Mutation Database for Eye Disease Genes (KMeyeDB)"Nuc Acids Res. 27. 358-361 (1999)

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      1999 Annual Research Report
  • [Publications] Shimura-Miura H,: "Increased 8-oxo=dGTPase in the mitochondria of substantia nigra neurons in Parkinson's disease. Ann Neurol 46: 920-924, 1999"Ann Neurol. 46. 920-924 (1999)

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      1999 Annual Research Report
  • [Publications] Mashima Y: "A novel mutation at codon 124(R124L) in the BIGH3 gene is associated with a superficial variant of granular corneal dystrophy"Arch Ophthalmol. 117. 91-93 (1999)

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      1999 Annual Research Report
  • [Publications] *hang X: "Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene"Biochem Biophys Res Commun. 255. 59-63 (1999)

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      1999 Annual Research Report
  • [Publications] Yamakawa T: "Biosynthesis of a parkinsonism-preventing substrance, 1-methyl-1, 2, 3, 4-tetrahydroiso-quinoline, is inhibited by parkinsonism-inducing compounds in rat brain mitochondria"Neurosci Let. 259. 157-160 (1999)

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      1999 Annual Research Report
  • [Publications] Kawai H: "Dopaminergic activity of endogenous 1BnTIQ derivatives"Neurochem Res. 24. 127-127 (1999)

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      1999 Annual Research Report
  • [Publications] T. Yamakawa: "Biosynthesis of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance in the brain"Neurochem Res. 24. 129-129 (1999)

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      1999 Annual Research Report
  • [Publications] Maruyama W: "An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, in the cerebrospinal fluid decreases with progression of Parkinson's diease"Neurosci Lett. 262. 13-16 (1999)

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      1999 Annual Research Report
  • [Publications] Akao Y: "Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3"Neurosci Left. 267. 153-156 (1999)

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      1999 Annual Research Report
  • [Publications] Naoi M: "Cell death of dopamine neurons in aging and Parkinson's disease"Mechan Ageing Develop. (in press). (1999)

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      1999 Annual Research Report
  • [Publications] Borgeld H-JW: "Appropriately spaced nuclear localizing signals are necessary for efficient nuclear impor of non-nuclear proteins"Biochem Biophys Res Commun. 256. 278-283 (1999)

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      1999 Annual Research Report
  • [Publications] Iwata-Ichikawa E: "Glial cells protect neuronal cells against oxidative stress via transcriptional up-regulatior of the glutathione system"J Neurochem. 72. 2334-2344 (1999)

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      1999 Annual Research Report
  • [Publications] Kondo Y: "Immunohistochemical localization of connective tissue growth factor in the rat central nervous system"Brain Res. 834. 146-151 (1999)

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      1999 Annual Research Report
  • [Publications] Iida M: "Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist"Brain Res. (in press).

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      1999 Annual Research Report
  • [Publications] Kawahara N: "The gene for heparin-binding epidermal growth factor-like growth factor is stress-inducible: its role in cerebral ischemia"J Cereb Blood Flow Metab. 19. 307-320 (1999)

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      1999 Annual Research Report
  • [Publications] *e T: "Ubiquitin stress response in postischemic hippocampal neurons under nontolerant and tolerant conditions"J Cereb Blood Flow Metab. 19. 750-756 (1999)

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      1999 Annual Research Report
  • [Publications] Ogasawara Y: "Efficient production of adeno-associated virus vectors using split type helper plasmids"Jpn J Cancer Res. 90. 476-483 (1999)

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      1999 Annual Research Report
  • [Publications] Ikemoto K: "Cholonergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of mouse"Neurosci Lett. 271. 53-56 (1999)

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      1999 Annual Research Report
  • [Publications] Ikemoto K: "Tyrsine hydroxylase and aromatic L-amino acid decarboxylase do not coexist in neurons in the human anterior cingulate cortex"Neurosci Lett. 269. 37-40 (1999)

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      1999 Annual Research Report
  • [Publications] Onozuka M: "Reduced mastication stimulates impairment of spatial memory and degeneration of hippocampal neurons in aged SAMP8 mice"Brain Res. 826. 148-153 (1999)

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      1999 Annual Research Report
  • [Publications] Nagatsu I: "Specific localization of the guanosine triphosphate (GTP) cyclehydrolase l-immunoreactivity in the human brain"J Neural Transm. (in press).

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      1999 Annual Research Report
  • [Publications] Karasawa N: "Age-associated changes in the dopamine synthesis as determined by GTP cycle hydrolase l inhibitor in the brain of senescence-accelerated mouse-prone inbred strains"J Neurosci Res. (in press).

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      1999 Annual Research Report
  • [Publications] Yagita Y: "Molecular cloning of a novel member of the HSP110 family of genes, ischemia-responsive protein 94kDa (irp94), expressed in rat brain after transient forebrain ischemia"J Neurochem. 72. 1544-1551 (1999)

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      1999 Annual Research Report
  • [Publications] Ueda H: "A combined analysis of regional energy metabolism and immunohistochemical ischemic damage in the gerbil brain"J. Neurochem. 72. 1232-1242 (1999)

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      1999 Annual Research Report
  • [Publications] Yagita Y: "DNA cleavage and proteolysis of microtubule-associated protain 2 after cerebral ishemia of different severity"Neuroscience. 92. 1417-1424 (1999)

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      1999 Annual Research Report
  • [Publications] Kitagawa K: "Species differences in fodrin proteolysis in the ischemic brain"J Neurosci Res.. 55. 643-649 (1999)

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      1999 Annual Research Report
  • [Publications] Ozawa K: "Strategies for gene therapy of Parkinson's disease using adeno-associate d virus (AAV) vectors"Biogenic Amines. 15. 21-37 (1999)

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      1999 Annual Research Report
  • [Publications] *rabe M.: "Charged-to-alanine scanning mutagenesis of the N-terminal half of adeno-associated virus type 2 Rep78 protein"J Virol. 73. 2682-2693 (1999)

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      1999 Annual Research Report
  • [Publications] Mizuno Y: "Genetic spects in Parkinson's disease. In: Mental Dysfunction in Parkinson's Disease II"Academic Pharmaceutical Productions. 53 (1999)

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      1999 Annual Research Report
  • [Publications] Shimizu N: "Current Status, Keio Strategy and Prospects In: Mental Dysfunction in Parkinson's Disease II"Springer-Verlag Tokyo. 5 (1999)

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      1999 Annual Research Report
  • [Publications] Kitada T: "Deletion mutation in a novel protein “Parkin" gene causes autosomal recessive juvenile parkinsonism(AR-JP)" Nature. 39. 605-608 (1998)

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      1998 Annual Research Report
  • [Publications] Hattori N: "Allele in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex l and susceptibility to Parkinson's disease" Genomics. 49. 52-58 (1998)

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      1998 Annual Research Report
  • [Publications] Hattori N: "Point mutation (Thr240Arg and Gln311Stop) in the Parkin gene" Biochem Biophy Res Commun. 249. 754-758 (1998)

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      1998 Annual Research Report
  • [Publications] Matsumine H: "Paralysis agitans of early onset with marked diurnal fluctuation of symptoms (PEDF) maps to the locus for autosomal recessive iuvenile parkinsonism (ARJP)" Neurology. 50. 1340-1345 (1998)

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      1998 Annual Research Report
  • [Publications] Matsumine H: "A microdeletion spanning D6S305 co-segregates with autosomal recessive juvenile parkinsonism(ARJP)" Genomics. 49. 143-146 (1998)

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      1998 Annual Research Report
  • [Publications] Moro H: "Pthologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q" Neurology. 54. 890-892 (1998)

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      1998 Annual Research Report
  • [Publications] Yamamura Y: "Clinical,pthologic and genetic studies on autosomal recessive early-onset parkinsonism with diurnal fluctuation" Parkinsonism & Relted Disord. 4. 65-72 (1998)

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      1998 Annual Research Report
  • [Publications] Kobayashi T: "Polymorphism of the gene encoding dihydrolipoamide succinyltransferase is associated with the susceptibility to Parkinson disease: a population based study" Ann Neurol. 43. 120-123 (1998)

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      1998 Annual Research Report
  • [Publications] Morikawa N: "Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes" J Neural Transm. 105. 677-688 (1998)

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      1998 Annual Research Report
  • [Publications] Urabe T: "Colocalization of Bcl-2 and 4-hydroxynonenal modified proteins in microglial cells and neurons of rat grain following transient focal ischemia" Neurosci Lett. 247. 159-162 (1998)

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      1998 Annual Research Report
  • [Publications] Mizuno: "Neurochemical and neurogenetic correlates of Parkinson's disease" J Neurochem. 71. 893-902 (1998)

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      1998 Annual Research Report
  • [Publications] Mizuno: "A comprehensive study on the mechanism underlying the pathogenesis of Parkinson's disease and its treatment" Asian Med J. 41. 62-71 (1998)

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      1998 Annual Research Report
  • [Publications] Mizuno: "Apoptosis in neurodegenerative disorders" Intern Med. 37. 192-193 (1998)

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      1998 Annual Research Report
  • [Publications] Hattori N: "Molecular analysis of a novel ubiquitin-like protein (PARKIN) gene in Japanese families with AR-JP:evidence of homozygous deletions in the PARKIN gene in affected individuals" Ann Neurol. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Wang M: "Polymorphism in the parkin gene among sporadic Parkinson's desease" Ann Neurol. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shimura H: "Immunohistochemical and subcellular localization of Parkin: absence of protein in AR-JP." Ann Neurol. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawai H: "Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism" J Neurochem. 70. 745-751 (1998)

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      1998 Annual Research Report
  • [Publications] Okada T: "Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells" Neurosci Res. 30. 87-90 (1998)

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      1998 Annual Research Report
  • [Publications] Kotake Y: "Deprenyl decreases an endogenous parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice in vivo and in vitro studies" Brain Res. 787. 341-343 (1998)

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      1998 Annual Research Report
  • [Publications] Matsubara K: "Sturactural significance of azaheterocyclic amines related to Parkinson's disease for dopamine transporter" Eur J Pharmacol. 348. 77-84 (1998)

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      1998 Annual Research Report
  • [Publications] Yoshihara S: "Imvolvement of hepatic aldehyde oxidase in conversion of 1-methyl-4-phenyl-2,3-dehydro-pvridinium(MPDP+) to 1-methyl-4-phenyl-5,6-dihydro-2-pyridone" Arch Biochem Biophys. 360. 93-98 (1998)

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      1998 Annual Research Report
  • [Publications] Naoi M: "(R)Salsolinol N-methyltransferase activity increases in Parkinsonian lymphocytes" Ann Neurol. 43. 2212-2216 (1998)

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      1998 Annual Research Report
  • [Publications] Maruyama W,: "(-)-Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide" J Neurochem. 70. 2510-2515 (1998)

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      1998 Annual Research Report
  • [Publications] Minami C: "Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopami-nergic neurotoxin,(R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells" J Neural Transm. 105. 397-405 (1998)

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      1998 Annual Research Report
  • [Publications] Umeda M: "Oxidation of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine,a 1-amino analog of MPTP by type A and B monoamine oxidase" J Neural Transm. 105. 1253-1264 (1998)

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      1998 Annual Research Report
  • [Publications] Ohkuwa T: "A novle assay for glutathione reductase activity by use of high performance liquied chromatography with electrochemical detection" J Chromatogr. 705. 23-28 (1998)

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      1998 Annual Research Report
  • [Publications] Tanaka M,: "Mitochondrial genotype associated with longevity" Lancet. 351. 185-186 (1998)

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      1998 Annual Research Report
  • [Publications] Gong JS: "Mitochondrial genotype frequent in centenarians predisposes resistance to adult onset diseases" J Clin Biochem Nutr. 24. 105-111 (1998)

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      1998 Annual Research Report
  • [Publications] Zhang J: "Peroxide production and apoptosis in cultured cells carrying mtDNA mutation causing encephalomyopathy" Biochem Mol Biol Int. 46. 71-79 (1998)

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      1998 Annual Research Report
  • [Publications] Borgeld H-JW: "Appropriately spaced nuclear localizing signals are necessary for efficient nuclear import of non-nuclear proteins" Biochem Biophys Res Commun.in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikemoto K: "Does tyrosinase exist in the neuromelanin-pigmented neurons in the human substantia nigra?" Neurosci Lett. 253. 198-200 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikemoto K: "A dopamine-synthesizing cell group demonstrated in the human basal forebrain by dual labeling immu nohistochemical technique of tyrosine hydroxylase and aromatic L-AAD" Neurosci Lett. 243. 129-132 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ikemoto K: "Do all of human midbrain tyrosine hydroxylase neurons synthesize dopamine?" Brain Res. 805. 255-258 (1998)

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      1998 Annual Research Report
  • [Publications] Kitahama K: "Dopamine synthesizing enzymes in paraventricular hypothalamic neurons of the human and monkey(Macaca fuscata)" Neurosci Lett. 243. 1-4 (1998)

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      1998 Annual Research Report
  • [Publications] Nagatsu I: "Phenylethanolamine-N-methyl-transferase- immuno reactive nerve terminals afferent to the mouse substantia nigra" Neurosci Lett. 245. 41-44 (1998)

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      1998 Annual Research Report
  • [Publications] Nishii K: "Motor and learning dysfunctions during postnatal development in mice defective in dopamine neuronal transmission" J Neurosci Res. 54. 450-464 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Onozuka M.: "Glial reaction linked with P-70-inuced seizure activity in the cerebral cortex of rats" Neurosci Res Commun. 23. 111-117 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sawada H: "Autoomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system" J Neurosci Res. 51. 162-173 (1998)

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      1998 Annual Research Report
  • [Publications] Fujii T: "Transient expression of only phenylethanolamine- N-methyltransferase- immunoreactive neurons in the medulla oblongata of the mouse during postnatal development" Biogenic Amines. 14(in press). (1998)

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      1998 Annual Research Report
  • [Publications] Okuda S: "Forebrain expression of GluT3 mRNA in 6-hydroxydopamine-lesioned rats" Biogenic Amines. 14(in press). (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kitahama K: "Aromatic L-amino acid decarboxylase and tyrosine hydroxylase immunohistochemistry in the adult human hypothalamus" J Chemical Neuroanatomy. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nagatsu I: "Specific localization of the guanosine triphosphate (GTP)cyclohydrolase I-immunoreactivity in the human brain" J Neural Transm. in press. (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iida K: "Effects of repeated cyclosporin A administration on immunodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain" Neurosci Res. 30. 185-193 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Gomez-Vargas,M.,: "Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regionsof the rat brain" Brain Res. 790. 202-208 (1998)

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      1998 Annual Research Report
  • [Publications] Kondo F: "Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gergiles" Brain Res. 791. 352-356 (1998)

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      1998 Annual Research Report
  • [Publications] Aoki C: "Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expresson of metallothionein-III(GIF)mRNA in immoralized mouse brain glial cells(VR-2g)" Brain Res. 792. 335-339 (1998)

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      1998 Annual Research Report
  • [Publications] Iwata E: "Protective effects of nicergoline against hydrogenn peroxide toxicity in neuronal cell line." Neurosci Lett. 251. 49-52 (1998)

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      1998 Annual Research Report
  • [Publications] Yokoi I: "Effects of kynurenine metabolites on the electrocorticographic activity in the rat" J Neural Tranms. 105. 147-160 (1998)

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      1998 Annual Research Report
  • [Publications] Tanaka K: "Chronic cerebral hypoperfusion disrups discriminative behavior in acquired-learning rats" J Neurosci Methods. 84. 63-68 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsushita K: "Alterations of BCL-2 family proteins precede cytoskeletal proteolysis in the penumbra,but no in infarct centres following focal cerebral ischemia in mice" Neuroscience. 83. 439-448 (1998)

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      1998 Annual Research Report
  • [Publications] Nakano M: "Measurement of regional N-acetyl aspartate after transient globalischemia in gerbils with and without ischemic tolerance: an index of neuronal survival" Ann Neurol. 44. 334-340 (1998)

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      1998 Annual Research Report
  • [Publications] Hata R: "Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils" Neuroscience. 83. 201-213 (1998)

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      1998 Annual Research Report
  • [Publications] Kitagawa K: "Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: evaluation of the patency of the posterior communicating artery" J Cereb Blood Flow Metab. 18. 570-579 (1998)

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      1998 Annual Research Report
  • [Publications] Kitagawa K: "Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia" Cereb Blood Flow Metab. 18. 1336-1345 (1998)

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      1998 Annual Research Report
  • [Publications] Imuta N: "Induction of 72-KDa inducible heat shock protein 72(HSP72)in cultured rat astrocytes after energy depletion" J Neurochem. 70. 550-557 (1998)

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      1998 Annual Research Report
  • [Publications] Ogasawara Y: "The use of heterologous promoters for adeno-associated virus (AAV) protein expression in AAV vector production" Microbiol Immunol. 42. 177-185 (1998)

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      1998 Annual Research Report
  • [Publications] Fan D: "Behavioral recovery in 6-OHDA-lesioned rats by contransduction of striatum with tyrosine hydroxylase and aromatic L-amino acid decarboxylase genes using two separate AAV vectors" Hum Gene Ther. 9. 2527-2535 (1998)

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      1998 Annual Research Report
  • [Publications] Fan D: "Prevention of dopaminergic neuron death by adeno-associated virus vector-mediated GDNF gene transfer in rat mesencephalic cells in vitro" Neurosci Lett. 248. 61-64 (1998)

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      1998 Annual Research Report
  • [Publications] Maeda Y: "Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors" J Mol Cell Cardiol. 30. 1341-1348 (1998)

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      1998 Annual Research Report
  • [Publications] Kokubun K: "Apoptosis mediated regulation of recombinant human granulocyte colony-stimulating factor production by genetically engineered fibroblast" Gene Ther. 5. 923-929 (1998)

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      1998 Annual Research Report
  • [Publications] Shinoura N: "Construction,propagation,and titer estimation of recombinant adenoviruses carrying proapoptotic genes" Hum Gene Ther. 9. 2683-2689 (1998)

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      1998 Annual Research Report
  • [Publications] Morikawa E: "Attenuation of focal ischemic brain injury in mice deficient in the epsilon 1 (NR2A)subunit of NMDA receptor" J Neurosci. 18. 9727-9732 (1998)

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      1998 Annual Research Report
  • [Publications] Shinoura N: "Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas ligand to geioma cells. implications for gene therapy" Hum Gene Ther. 9. 1983-1993 (1998)

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      1998 Annual Research Report
  • [Publications] Kawahara N: "Propentofylline potentiates induced tolerance in gerbil hippocampal neurons via adenosine receptor" J Cereb Blood Flow Metab. 18. 472-475 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Todo T: "Neuroant iocalization of fibroblast growth factor-9 immunoreactivity in human and rat brain." Brain Res. 783. 179-187 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawai K: "Preconditioning in vivo ischemia inhibits anoxic long-term potentiation and functronally protects CA1 neurons in the gerbil" J Cereb Blood Flow Metab. 18. 288-296 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizuno Y: "Mitochondrial dysfunction in Parkinson's disease" Olanow CW,Jenner P,eds,Wells Medical Limited Beyond The Decade Of The Brain,Neuroprotection in Parkinson's Disease volume 3, 189-202 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mizuno Y: "Genetic aspects of Parkinson's disease" Fisher A,Hanin I,Yoshida M,eds,Plenum Press Progress in Alzheimer's and Parkinson's Diseases, 393-399 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsumine H, Shimizu Y, Kobayashi T, Mizuno Y,et al.: "Paralysis agitans of early onset with marked diurnal fluctuation of symptoms (PEDF) maps to the locus for autosomal recessive juvenile parkinsonism (ARJP)" Neurology. (in ptess). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hattori N, Yoshino H, Tanaka M, Suzuki H, Mizuno Y: "Allele in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex 1 and susceptibility to Parkinson′s disease" Genomics. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kobayashi T, Matsumine H, Matuda S, Mizuno Y,et al.: "Polymorphism of the gene encoding dihydrolipoamide succinyltransferase is associated with the susceptibility to Parkinson disease : a population based study" Ann Neurol. 43. 120-123 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koshimura I, lmai H, Hidano T, Endo K, Mizuno Y,et al.: "Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to nigrostriatal system" Brain Res. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morikawa N, Naoi M, Maruyama W, Ohta S, Kotake Y, Mizuno Y,et al.: "Effects of various tetrahydroisoquinoline derivatives on mitochonrial respiration and the electron transfer complexes" J Neural Transm. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumine H, Saito M, Shimoda-Matsubayashi S, Mizuno Y,et al.: "Localization of a gene for an autosomal recessive form of juvenile parkinsonism to chromosome 6q25.2-27" Am J Hum Genet. 60. 588-596 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mishima K, Asai A, Kodamatsu K, Ino Y, Kirino T,et al.: "lncreased expression of midkine during the progression of human astrocytomas" Neurosci Lett. 233. 29-32 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ogasawara Y, Urabe M, Ozawa K: "The use of heterologous promotoers for adeno-associated virus (AAV) protein expression in AAV vector production" Mlcrobiol lmmunol. (in press). (1998)

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      1997 Annual Research Report
  • [Publications] Surosky RT, Urabe M, Ozawa K,et al.: "Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome" J Virol. 71. 7951-7959 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Surosky RT, Urabe M, Ozawa K,et al.: "Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome" J Virol. 71. 7951-7959 (1997)Urabe M, Hasumi Y, Ozawa K,et al.:

    • Related Report
      1997 Annual Research Report
  • [Publications] "A novel dicistronic AAV (adeno-associated virus) vector using a short lRES (internal ribosome entry site) segment derived from hepatitis C virus genome" Gene. 200. 157-162 (1997)

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      1997 Annual Research Report
  • [Publications] Maeda Y, Ikada U, Ozawa K,et al.: "Gene transfer into vascular cells using adeno-associated virus (AAV) vectors" Cardiovascular Res. 35. 514-521 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawai H, Makino Y, Hirobe M, Ohta S,et al.: "Novel endogenous1,2,3,4-tetrahydroisoquinoline derivatives : uptake by dopamine transporter and activity to induce parkinsonism" J Neurochem. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kotake Y, Tasaki Y, Hirobe M, Ohta S,et al.: "Deprenyl decreases an endogenous parkinsonism-inducing compound,1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice : in vivo and vitro studies" Brain Res. (in press). (1998)

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      1997 Annual Research Report
  • [Publications] Okada T, Sato K, Shimada S, Ohta S,et al.: "Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine trnsporter expressed in HEK293 cells" Brain Res. (in press ). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Takahashi T, Maruyama W, Deng Y, Ohta S,et al.: "Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells" J Neural Transm. 104. 59-66 (1997)

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      1997 Annual Research Report
  • [Publications] Yamakawa T, Ohta S: "lsolation of 1-methyl-1,2,3,4-tetrahydroisoquinoline-synthesizing enzyme from rat brain : a possible Parkinson's disease-preventing enzyme" Biochem Biophys Res Commun. 236. 676-681 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naoi M, Maruyama W, Nakao N,et al.: "(R) Salsolionl N-methyltransferase activity increses in parkinsonian lymphocytes" Ann Neurol. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naoi M, Maruyama W, Matsubara K,et al.: "A neutral N-methyltransferase activity in the striatum determines the level of an endogenous MPP^+-like neurotoxin,1,2-dimethyl-6,7-dihydroxyisoquinoln ium ion,in the subustantia nigra" Neurosci Lett. 235. 81-81 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maruyama W, Strolin Benedetti M, Takahashi T,et al.: "A neurotoxin N-methy (R) salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells" Neurocsi Lett. 232. 147-150 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maruyama W, Naoi M, Kasamatsu K,et al.: "An endogenous dopaminergic neurotoxin,N-methyl-(R)-salsolinol,induces DNA damage in human dopaminergic neuroblastoma SH-SY5Y cells" J Neurochem. 69. 322-329 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Naruyama W, Sobue G, Matsubara K,et al.: "A dopaminergic neurotoxin,1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisquinoline,N-methyl (R) salsolinol, and its oxidation product accmulate in the nigio-striatal system" Neurosci Lett. 223. 61-64 (19997)

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      1997 Annual Research Report
  • [Publications] Tanaka M, Gong J-S, Zhang J,et al.: "Mitochondrial genotype associated with longevity" Lancet. 351(in press). (1998)

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      1997 Annual Research Report
  • [Publications] Islam MM, Suzuki H, Yoneda M, Tanaka M,et al.: "Primary structure of the smallest (6.4-kDa) subunit of human and bovine ubiquinol-cytochrome c reductase deduced from cDNA sequences" Biochem Mol Biol lnt. 41. 1109-1119 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shimoda-Matsubayashi S, Hattori T, Matsumine H, Mizuno Y,et al.: "Mn SOD activity and protein in a patient with chromosome 6-linked automal recessive parkinsonism in comparison with Prakinson's disease and control" Neurology. 49. 1257-1262 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoritaka A, Hattori N, Mori H, Kato K, Mizuno Y.: "An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease" J Neurol Sci. 148. 1811-186 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoritaka A, Hattori N, Mori H, Kato K, Mizuno Y.: "An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease" J Neurol Sci. 148. 181-186 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Goto K, Mochizuki H, Hattori T, Nakamura N, Mizuno Y: "Neurotoxic effects of papaverine,tetrahydropapaverine and dimethoxphenylamine on dopamiergic neurons in ventral mesencephalic-striatal co-cuture" Brain Res. 754. 260-268 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoshino H, Hattori N, Urabe T, Uchida K, Tanaka M, Mizuno Y: "Postichemic accumulation of lipid peroxidation products in the rat brain : immunohistochemical detection of 4-hydroxy-2-nonenal modified proteins" Brain Res. 767. 81-86 (1997)

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      1997 Annual Research Report
  • [Publications] Mochizuki H, Mori H, Mizuno Y: "Apoptosis in neurodegenerative disorders" J Neural Transm. [Suppl]50. 125-140 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumine H, Shimizu Y, Kobayashi T, Mizuno Y,et al.: "Paralysis agitans of early onset with marked diurnal fluctuation of symptoms (PEDFR) maps to the locus for autosomal recessive juvenile parkinsonism (ARJP)" Neurology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hattori N, Yoshino H, Tanaka M, Suzuki H, Mizuno Y: "Allele in the 24-kDa subunit gene(NDUFV2) of mitochondrial complex l and suscepyibility to Parknson's disease" Genomics. (in perss). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kobayashi T, Matsumine H, Matuda S, Mizuno Y,et al.: "Polymorphism of the gene encoding dihydrolipoamide succintlyransferase is associated with the susceptibility to Parkinson disease : a population based study" Ann Neurol. 43. 120-123 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Koshimura I, Imai H, Hidano T, Enndo K, Mizuno Y,et al.: "Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system" Brain Res. (in perss). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morikawa N, Naoi M, Maruyama W, Ohta S, Kotake Y, Mizuno Y,et al.: "Effects of various tetrahydroisoquinoline derivatives on mitochondrial respiration and the electron transfer complexes" J Neural Transm. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsumine H, Saito M, Shimoda-Matsubayashi S, Mizuno Y,et al.: "Localization of a gene for an autosomal recessive from of juvenile parkinsonism to chromosome 6q25.2-27" Am J Hum Genet. 60. 588-596 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitagawa K, Matsumoto M, Yanagihara T,et al.: "Ischemic tolerance in hippocampal CA1 neurons studied using contralateral controls" Neuroscience. 81. 989-998 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yang G, Yanagihara T, Matsumoto M,et al.: "C57BL/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains" Brain Res. 752. 209-218 (1997)

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      1997 Annual Research Report
  • [Publications] LiLY, Ueda H, Yanagihara T,et al.: "A near-infrared spectroscopic study of cerebral ischemia and ischemic tolerance in gerbils" stroke. 28. 1451-1457 (1997)

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      1997 Annual Research Report
  • [Publications] Mandai K, Matsumoto M, Yanagihara T,et al.: "Ischemic damage and ssubsequent proliferation of oligodendrocytes in focal cerebral ischemia" Neuroscience. 77. 849-861 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kawahara N, Ide T, Saito N, Kawai K, Kirino T: "Propentofyline potentiates induced tolerance in gerbil hippocampal neurons via adenosine receptor" J Cereb Blood Flow Metab. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakagomi T, Kanemitsu H, Takagi K, Morikawa E, Kirino T, Tamura A: "Effect of L-arginine and NG-nitro-L-arginine on detayed neuronal death in the gerbil hippocampus" Neurol Res. 19. 426-430 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iida K, Iwata E, Asanuma M, Ogawa N,et al.: "Effects of repeated cyclosporin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain" Neurosci Res. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iwata E, Asanuma M, Nishibayashi S, Ogawa N,et al.: "Differential effects of oxidative stress on activation of transcription factors in neuronal and glial cells" Mol Brain Res. 50. 213-220 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsuura K, Makino H, Ogawa N: "Cyclosporin a attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons in rats with intrastriatal injection of 6-hydroxydopamine" Exp Neurol. 146. 526-535 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo Y, Asanuma M, Nishibayashi S, Ogawa N,et al.: "Late-onset lipid peroxdation and neuronal cell death following transient forebrain ischemia in rat brain" Brain Res. 772. 37-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asanuma M, Asanuma SN,Gomez-Vargas M, Ogawa N,et al.: "Ketoprofen,a non-steroidal anti-inflammatory drug prevents the late-onset reduction of muscarinic acetylcholine receptors in the gerbil hippocampus after transient ischemia" Neurosci Lett. 225. 109-112 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitagawa K, Matsumoto M, Yanagihara T,et al: "Cerebral ischemia following bilateral carotid occlusion and intraluminal suture occlusion in mice : evaluation of the patency of the posterior communicating artery" J Cereb Blood Flow Metab. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morikawa S, Kurauchi O, Tanaka M,et al.: "Increased mitochondrial damage by lipid peroxidation in trophoblast cells of preeclamtic placentas" Biochem Mol Biol Int. 41. 767-775 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagatsu I, Sakai M, Nagatsu T.et al.: "Immunocytochemical evidence of novel catecholamine or blopterin-related neurons of mammalian brains" Adv Pharmacol. 42. 859-862 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ikemoto K, Kitahama k, Nagatsu I,et al.: "Demonstration of L-dopa decarboxylating neurons specific to human striatum" Neurosci Lett. 232. 111-114 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagatsu I, Yamada K, Nagatsu T,et al.: "Tyrosine hydroxylase (TH)-only-immunoreactive non-catecholamiergic neurons in the brain of wild mice or the human TH transgenic do not contain GTP cyclohydrolase I" Neurosci Lett. 228. 55-57 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagatsu I, Arai R, Nagatsu T,et al.: "Immunohistochemical colocalization of GTP cyclohydrolase I in the nigrostriatal system with tyrosine hydroxylase" Neurosci Lett. 224. 185-188 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Karasawa N, Isomura G, Nagatsu I,et al.: "Coexistense of tyrosine hydroxylase and serotonin in the raphe nucleus of the laboratory shrew (Suncus murinus) during postnatal life" Dev Brain Res. 99. 121-125 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iida K, Iwata E, Asanuma M, Ogawa N,et al.: "Effects of repeated cyclosprin A administration on iminodipropionitrile-induced dyskinesia and TRE-/CRE-binding activities in rat brain" Neurosci Res. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iwata E, Asanuma M, Nishibayashi S, Ogawa N,et al.: "Differential effects of oxdative stress on activation of transcription factors in neuronal and glial cells" Mol Brain Res. 50. 213-220 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Matsuura K, Makino H, Ogawa N: "Cyclosporin A attenuates the decrease in tyrosine hydroxylase immunoreactivity in nigrostriatal dopaminergic neurons in rats with intrastriatal injection of 6-hydroxydopamine" Exp Neurol. 146. 526-535 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kondo Y, Asanuma M, Nishibayashi S, Ogawa N,et al.: "Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain" Brain Res. 772. 37-44 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Asanuma M, Asanuma SN, Gomez-Vargas M, Ogawa N,et al.: "Ketoprofen,a non-steroidal anti-inflammatory drug prevents the late-onset reduction of muscarinic acetylcholine receptors in the gerbil hippocampus after transient ischemia" Neurosci Lett. 225. 109-112 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kitagawa K, Matsumoto M, Yanagihara T,et al: "Cerebral ischemia following bilateral carotid occlusion and intraluminal suture occlusion in mice : evaluation of the patency of the posterior communicating artery" J Cereb Blood Flow Metab. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mizuno Y, Ikebe S, Hattori N, Mochizuki Y, Hattori Y, Kondo T: "Movement Disorders.Neurologic principles and practice (Etiology of Parkinson's disease)" Watts RL,Koller WC,eds,The McGraw-Hill,New York, 161-182(21) (1997)

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      1997 Annual Research Report
  • [Publications] 水野美邦, 池邊紳一郎: "ミトコンドリア病(Parkinson病と老化)" 埜中征哉, 後藤雄一編,医学書院,東京, 167-182(15) (1997)

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      1997 Annual Research Report
  • [Publications] 小笠原洋治, 小澤敬也: "医学とサイエンスシリーズ(アデノ随伴ウイルス(AAV)ベクター)" 小澤敬也編,羊土社,東京, 66-71(6) (1997)

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      1997 Annual Research Report
  • [Publications] Naoi M, Maruyama W, Dostert P: "Handbook of Endogenous Neurotoxins (An animal model of Parkinson's disease prepared by endogenous N-methyl (R) saloolinol)" Moser A,ed,Birkhauser,Boston, 41-61(21) (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mizuno Y, Ikebe S, Hattori N, Mochizuki H, Hattori Y, Kondo T: "Movemet Disorders. Neurologic principles and practice (Etioloy of Parkinson's disease)" Watts RL,Koller WC,eds,The McGraw-Hill,New York, 161-182(21) (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 水野美邦, 池邊紳一郎: "ミトコンドリア病(Parkinson病と老化)" 埜中征哉, 後藤雄一編,医学書院,東京, 167-182(15) (1997)

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      1997 Annual Research Report
  • [Publications] Kirino T: "Primer on Cerebrovascular Diseases (Ischemic tolerance in Welch KMA)" Caplan LR,Reis DJ,Siesjo BK,Welr B (Eds),Academic Press,San Diego, 240-243(4) (1997)

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      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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