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Relationships between gene diversity and organismal evolution

Research Project

Project/Area Number 09304072
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 遺伝
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MIYATA Takashi  Kyoto Univ., Graduate School of Science, Professor, 大学院・理学研究科, 教授 (20022692)

Co-Investigator(Kenkyū-buntansha) IWABE Naoyuki  Kyoto Univ., Graduate School of Science, Assistant Professor, 大学院・理学研究科, 助手 (80263060)
KUMA Kei-ichi  Kyoto Univ., Graduate School of Science, Assistant Professor, 大学院・理学研究科, 助手 (10221938)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥35,900,000 (Direct Cost: ¥35,900,000)
Fiscal Year 1999: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1998: ¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1997: ¥22,700,000 (Direct Cost: ¥22,700,000)
KeywordsSponge / Cyclostomes / Gene family / Gene duplication / Phylogenetic tree / Organismal diversity / 生物多様性 / シグナル伝達系 / 形態形成遺伝子 / 多様性 / 真核生物 / 多細胞効物 / 進化
Research Abstract

Animals evolved a variety of gene families involved in cell-cell communication and developmental control by gene duplication and domain shuffling. Each family comprises several subtypes or subfamilies with distinct structures and functions which diverged by gene duplications and domain shuffling before the divergence of parazoans and eumetazoans. Since the separation from protostomes, vertebrates expanded the multiplicity of members (isoforms) in the same subfamily by further gene duplications in their early evolution before the fish-tetrapod split. To know the dates of isoform duplications more closely, we have conducted isolation and sequencing of genes belonging to four different subtypes of the protein tyrosine kinase family, five subtypes of protein tyrosine phosphatase family, and other three gene families from Branchiostoma belcheri, an amphioxus, Eptatretus burgeri, a hagfsh and Lampetra reissneri, a lamprey. From a phylogenetic tree of each subfamily inferred from a maximum likelihood (ML) method, together with a bootstrap analysis based on the ML method, we have shown that the isoform duplications frequently occurred in the early evolution of vertebrates around or just before the divergence of cyclostomes and gnathostomes by gene dupli-cations and possibly chromosomal duplications.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] Inoue,T .et al.: "Caenorhabditis elegans has two isozymic forms CE-1 and CE-2 of fructose-1,6-biophosphate aldolase which are encoded by defferent genes"Archives Biochem. Biophys. 339. 226-234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nikoh,N. et al.: "An estimate of devergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks"J. Mol. Evol.. 45. 97-106 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasojima, K. et al.: "Cloning of human snd mouse cDNAs encoking novel zinic finger proteins expressed in cerebellum and hippocampus"Biophys. Biochem. Res. Commun.. 231. 481-487 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga,H. et al.: "Intermittent divergence of the protein tyrosine kinase family during animal evolution"FEBS Lett.. 412. 540-546 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuba,M. et al.: "Molecular evolution of amphioxus fructose-1, 6-bisphosphate aldolase"Archives Biochem. Biophys.. 348. 329-336 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hoshiyama,D. et al.: "Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family"J. Mol. Evol.. 47. 640-648 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koyanagi,M. et al.: "Anicient gene duplication and domain shuffling in animal cyclic nucleotide phosphodiesterase family"FEBS Lett.. 436. 323-328 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura,M. et al.: "A novel centrosomal protein, RanBPM, when overexpressed, causes ectopic microtubule nucleation, similar to g-tubuiln"J. Cell. Biol.. 134. 1041-1052 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koyanagi,M. et al.: "Phospholipase C sDNAs from sponge and hydra : Anitiquity of genes involved in the inositol phospholipid singnaling pathway"FEBS Lett.. 439. 66-70 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuda,F. et al,: "The complete nucleotide sequence of the human immunoglobulin heavy-chain varoab;e region locus"J. Exp. Med.. 188. 2151-2162 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga,H. et al.: "Extensive gene duplication in the early evolution fo animals befor parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra"J. Mol. Evol.. 48. 646-653 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono,K. et al.: "Multiple protein tyrosine phosphatases in sponge and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split"J. Mol. Evol.. 48. 654-662 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga,H. et al.: "Multiple TGF-b receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazan split"FEBS Lett.. 453. 346-350 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga,H. et al.: "Protein tyrosine kinase cDNAs from amphioxus,hagfish and lamprey : Isoform duplications around the divergence of cyclostomes and gnathostomes"J. Mol. Evol.. 49. 601-608 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katoh,K. et al.: "A heuristic approach of maximum likelihood method for inferring phylogenetic tree and an application to the mammalian SOX-3 origin of the testis-determining gene SRY"FEBS Lett.. 463. 129-132 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuraku,S. et al.: "Monophyly of lampreys and hagfishes supported by nuclear DNA-coded genes"J. Mol. Evol.. 49. 729-735 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono-Koyanagi, et al.: "Protein tyrosine phosphatases from amphioxus, hagfish and ray : Divergence of tissue-specific isoform genes in the early evolution of vertebrates"J. Mol. Evol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 宮田隆 他: "ゲノム情報を読む"共立出版. 138 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 宮田隆 他: "分子進化 ―解析の技法とその応用―"共立出版. 196 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 宮田隆: "DNAからみた生物の爆発的進化"岩波書店. 198 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inoue, T. et al: "Caenorhabditis elegans has two isozymic forms CE-1and CE-2 of fructose-1, 6-biophosphate aldolase which are encoded by different genes."Archives Biochem. Biophys. 339. 226-234 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nikoh, N. et al.: "An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks."J. Mol. Evol.. 45. 97-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasojima, K. et al.: "Cloning of human and mouse cDNAs encoding novel zinic finger proteins expressed in cerebellum and hippocampus."Biophys. Biochem. Res. Commun.. 231. 481-487 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga, H. et al.: "Intermittent divergence of the protein tyrosine kinase family during animal evolution."FEBS Lett.. 412. 540-546 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuba, M. et al.: "Molecular evolution of amphioxus fructose-1, 6-bisphosphate aldolase."Archives Biochem. Biophys.. 348. 329-336 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hoshiyama, D. et al.: "Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family."J. Mol. Evol.. 47. 640-648 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koyanagi, M. et al.: "Ancient gene duplication and domain shuffling in animal cyclic uncleotide phosphodiesterase family."FEBS Lett.. 436. 323-328 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura, M. et al.: "A novel centrosomal protein. RanBPM, when overexpressed, causes ectopic microtubule nucleation, similar to g-tubulin."J. Cell. Biol.. 143. 1041-1052 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Koyanagi, M. et al.: "Phospholipase C sDNAs from sponge and hydra : Antiquity of genes involved in the inositol phospholipid signaling pathway."FEBS Lett.. 439. 66-70 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuda, F. et al.: "The complete nucleotide sequence of the human immunoglobulin heavy-chain variable region locus."J. Exp. Med.. 188. 2151-2162 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga, H. et al.: "Extensive gene duplication in the early evolution of animals before parazoaneumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra."J. Mol. Evol.. 48. 646-653 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono, K. et al.: "Multiple protein tyrosine phosphatases in sponge and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split."J. Mol. Evol.. 48. 654-662 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga, H. et al.: "Multiple TGF-b receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazoan split."FEBS lett.. 453. 346-350 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga, H. et al.: "Protein tyrosine kinase cDNAs from amphioxus, hagfish and lamprey : lsoform duplications around the divergence of cyclostomes and gnathostomes."J. Mol. Evol. 49. 601-608 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Katoh, K. et al.: "A heuristic approach of maximum likelihood method for inferring phylogenetic tree and an application to the mammalian SOX-3 origin of the testis-determining gene SRY."FEBS Lett.. 463. 129-132 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuraku, S. et al.: "Monophyly of lampreys and hagfishes supported by nuclear DNA-coded genes."J. Mol. Evol.. 49. 729-735 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono-Koyanagi, K. et al.: "Protein tyrosine phosphatases from amphioxus, hagfish and ray : Divergence of tissue-specific isoform genes in the early evolution of vertebrates."J. Mol. Evol. (in press.).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suga H.et al.: "Extensive gene duplication in the early evolution of animals before parazoaneumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra"J. Mol. Evol.. 48. 646-653 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono K.et al.: "Multiple protein tyrosine phosphatases in sponge and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split"J. Mol. Evol.. 48. 654-662 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suga H.et al.: "Multiple TGF-b receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazoan split"FEBS lett.. 453. 346-350 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suga H.et al.: "Protein tyrosine kinase cDNAs from amphioxus, hagfish and lamprey: lsoform duplications around the divergence of cyclostomes and gnathostomes"J. Mol. Evol.. 49. 601-608 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katoh K.et al.: "A heuristic approach of maximum likelihood methood for inferring phylogenetic tree and an application to the mammalian SOX-3 origin of the testis-determining gene SRY"FEBS Lett.. 463. 129-132 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kuraku S.et al.: "Monophyly of lampreys and hagfishes supported by nuclear DNA-coded genes"J. Mol. Evol.. 49. 729-735 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono-Koyanagi K.et al.: "Protein tyrosine phosphatases from amphioxus, hagfish and ray: Divergence of tissue-specific isoform genes in the early evolution of vertebrates"J. Mol. Evol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Hoshiyama,D.et al.: "Sponge Pax cDNA related to Pax-2/5/8 and ancient gene duplications in the Pax family." J.Mol.Evol. 47. 640-648 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koyanagi,M.et al.: "Ancient gene duplication and domain shuffling in animal cyclic nucleotide phosphodiesterase family." FEBS Lett.436. 323-328 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Koyanagi,M.et al.: "Phospholipase C sDNAs from sponge and hydra: Antiquity of genesinvolved in the inositol phospholipid signaling pathway." FEBS Lett.439. 66-70 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Matsuda,F.et al.: "The complete nucleotide sequence of the human immunoglobulin heavy-chain variable region locus." J.Exp.Med.188. 2151-2162 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Suga,H.et al.: "Explosive gene duplication in the early evolution of animals before parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra." J.Mol.Evol.(in press.). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ono,K.et al.: "Multiple protein tyrosine phosphatases in sponge and explosive gene duplication in the early evolution of animals before the parazoan-eumetazoan split." J.Mol.Evol.(in press.). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 宮田 隆: "DNAからみた生物の爆発的進化" 岩波書店, 198 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inoue,T.: "Caenorhabditis elegans has two isozymic forms CE-1 and CE-2 of fructose-1,6-biophosphate aldolase which are encoded by different genes." Archives Biochem.Biophys. 339. 226-234 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nikoh,N.: "An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks." J.Mol.Evol.45. 97-106 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yasojima,K.: "Cloning of human and mouse cDNAs encoding novel zinic finger proteins expressed in cerebellum and hippocampus." Biophys.Biochem.Res.Commun.231. 481-487 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suga,H.: "Intermittent divergence of the protein tyrosine kinase family during animal evolution." FEBS Lett.412. 540-546 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kuba,M.: "Molecular evolution of amphioxus fructose-1,6-bisphosphate aldolase." Archives Biochem.Biophys.348. 329-336 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 宮田 隆: "ゲノム情報を読む" 共立出版, 138 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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