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Development of new allograft valve for canine mitral valve replacement

Research Project

Project/Area Number 09306022
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionTokyo University of Agriculture and Technology, Faculty of Agriculture

Principal Investigator

YMANANE Yoshihisa  Tokyo University of Agriculture and Technology, Faculty of Agriculture, Professor, 農学部, 教授 (50262225)

Co-Investigator(Kenkyū-buntansha) MACHIDA Noboru  Tokyo University of Agriculture and Technology, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (20219364)
SUZUKI Kaoru  Tokyo University of Agriculture and Technology, Assistant Professor, 農学部, 助手 (90226499)
MARUO Kouzi  Tokyo University of Agriculture and Technology, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (40124276)
TOMIZAWA Yasuko  Tokyo Woment's Medical College, Cardiovascular Surgery, Assistant Professor, 日本心臓血圧研究所, 助手 (00159047)
NOISHIKI Yasuharu  Yokohama City University School of Medicine, First Department of Surgery, Lecturer, 医学部, 講師 (60033263)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥23,700,000 (Direct Cost: ¥23,700,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1997: ¥16,700,000 (Direct Cost: ¥16,700,000)
Keywordsextracorporeal circulation / cardiopulmonary bypass system / normothermic CPB / hypothermic CPB / heparin coating / silicon coating / allograft valve / valve replacement / 対外循環 / 心臓弁膜症 / 開心術
Research Abstract

Recently, the incidence of canine mitral regurgiation of acquired heart diseases is the increase with the years.
Therefore, requirement of the radical surgery is advanced by pet owner.
The main object in this study is development of the new allografts valve for canine mitral valve replacement under the open heart surgery.
The aortic valves of pig which were picked from a slaughterhouse were used for the new allograft valves.
Denacol EX-313 solution was used for the treatment of the aortic valve taken from pigs. Continuously the aortic valve was treated with Hepartin and Protamine.
The valve replacement was done under the extracorporeal circulation using a cardiopulmoary bypass sistem. The surgical procedure was established perfectly, Furthermore, the aortic valves of pigs were treated by many kinds of methods and solutions. The allograft valves with stent were made by handmade.
One type of these valves had good hemodynamic properties and in addition have low rates of thromboembolism in dogs without antieoagulation. and was strong, durability. After surgery, these dogs were survived for 6-8months.
However, with the availability of information on long-term implants, it has also been shown that the tissue valve is subject to mineralization in certain indivduals. The mineralization may be a major factor in the long-term failure of these valves.
Next objestives of this study are clucidation of the tissue mineralization and durability.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 山形静夫 他: "小動物用人工心肺装置の開発と臨床応用に関する研究"動物臨床医学. 6. 13-25 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水美希 他: "犬の人工心肺装置無血充填液に関する検討-in vitroにおける回路内無血充填液の犬赤血球に及ぼす影響"動物臨床医学. 8. 9-18 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akira SHIBAZAKI etc.: "A comparative Study between Hypothermic and Normothermic Cardiopulmonary Bypass in Open Heart Surgery in Dogs"J.Vet.Med.Sci.. 61. 331-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 柴崎哲 他: "体外循環下開心術において右室流出路拡大形成術を実施した犬の肺動脈弁狭窄症の1治験例"日獣会誌. 52. 707-710 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yukihito Shiroshita etc.: "Accuracy of a Portable Blood Gas Analyzer Incorporating Optodes for Canine Blood"J.Vet.Inten.Med.. 13. 597-600 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.SHIROSHITA etc.: "Retrospective study of clinical complications occurring after arterial punctures in 111 dogs"Vet.Record. 146. 16-19 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ryou Tanaka etc.: "Platelet aggregation in dogs with mitral valve regurgitation"Am.J.Vet.Res.. 61. 1248-1251 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 柴崎哲 他: "中心冷却体外循環下開心術により流出路拡大形成術を実施した小型犬の肺動脈狭窄症の2治験例"動物臨床医学. 9. 101-109 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuharu Nishiki etc.: "Age Dependency of Neointima Formation on Vasular Prostheses in Dogs"Artificial Organs. 24. 718-728 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yamagata Shizuo, Yamane Yoshihisa. Shibazaki Akira, Matsumoto Hideki, Takashima Kazuaki, Takashima Hisae, Kuno Yoshihiro, Masada Sanae.Masuda Yuko, Oguchi Yoko, Noishiki Yasuharu :: "Studies on the Development and Clinical Use of Cardiopulmonary Bypass System for Small Animal"J.Anim.Clin.Med.. 6(4). 13-25 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miki Shimizu, Uehara Koukichi, Shibazaki Akira, Yamane Yoshihisa :: "Experimental Study of Priming Solutions for the Extracorporel Circulation in Dogs-The Effects on Erythrocyte by Priming Solution in Vitro-"J.Anim.Clin.Med.. 8(1). 9-18 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akira SHIBAZAKI, Hideki MATSUMOTO, Yukihito SHIROSHSITA, Yasuharu NOISHIKI and Yoshihisa YAMANE :: "A Comparative Study between Hypothermic and Normothermic Cardiopulmonary Bypass in Open Heart Surgery in Dogs-Effects on Systemic Hemodynamics-"J.Vet.Med.Sci.. 61(4). 331-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akira SHIBAZAKI, Kazuaki TAKASHIMA, Ryou TANAKA, Katsuitiro HOSHI and Yoshihisa YAMANE :: "A Successful Case of Righi-ventricular Outflow Reconstruction to Correct Valvular Pulmonic Stenosis with Extracorporeal Circulation in Dog"J.Jpn.Vet.Med.Assoc.. 52. 707-710 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yukihito Shiroshita, Ryou Tanaka, Akira Shibazaki, and Yoshihisa Yamane :: "Accuracy of a Portable Blood Gas Analyzer Incorporating Optodes for Canine Blood"J.Vet.Intern.Med.. 13. 597-600 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.SHIROSHITA, R.TANAKA, A.SHIBAZAKI, Y.YAMANE :: "Retrospective study of clinical complications occuring after arterial punctures in III dogs"Vet.Record. 146. 16-19 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ryou Tanaka and Yoshihisa Yamane :: "Platelet aggregation in dogs with mitral valve regurgitation"Am.J.Vet.Res.. 61. 1248-1251 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akira SHIBAZAKI, Kazuaki TAKASHIMA, Ryou TANAKA, Yukiko NAGASHIMA, Katsuitiro HOSHI and Yoshihisa YAMANE :: "Two Successful Case of the Right Ventricle-pulmonary Artery Outflow Tract Repair in Small Dogs with Pulmonic Stenosis using Hypothermic Extracorporeal Circulation"J.Anim.Clin.Med.. 9(2). 105-109 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuharu Noishiki, Yoshihisa Yamane, Yukio Ichikawa, Ichiya Yamazaki, Kenji Yamamoto, Takayuki Kosuge, Takahiro Manabc. and Makot Mo :: "Age Depenency of Neointima Formation on Vascular Prosthses in Dogs"Art.Organs.. 24(9). 718-728 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yukihito Shiroshita: "Accuracy of a Portable Blood Gas Analyzer Incorporating Optodes for Canine Blood"J.Vet. Intern Med.. 13. 597-600 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yukihito Shiroshita: "Retrospective study of clinical complications occurring after arterial puncture in III dogs"Vet. Rec.. 146. 16-19 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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