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Studies on Polygenic Diseases : Search for Host Modifier Genes

Research Project

Project/Area Number 09307004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HIAI Hirosahi  Dept. Pathol., Kyoto Univ., Professor, 医学研究科, 教授 (10073131)

Co-Investigator(Kenkyū-buntansha) KAMOTO Toshiyuki  Dept. Vrdogy., Kyoto University Assist. Prof., 医学研究科, 助手 (00281098)
TOYOKUNI Shinya  Dept. Pathol., Kyoto Univ., Assoc. Prof., 医学研究科, 助教授 (90252460)
FUKUMOTO Manabu  Dept. Pathol., Tohoko Univ., Professor, 加齢医学研究所, 教授 (60156809)
ISHIMOTO Akinori  Virus Inst. Kyoto Univ., Professor, ウイルス研究所, 教授 (50073127)
鶴山 竜昭  京都大学, 大学院・医学研究科, 助手 (00303842)
阿不江 ぱ塔爾  京都大学, 医学研究科, 助手 (60293875)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥33,200,000 (Direct Cost: ¥33,200,000)
Fiscal Year 1999: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1997: ¥22,200,000 (Direct Cost: ¥22,200,000)
KeywordsPolygenic Disease / Modifier Gene / Virus Integration Site / Lymphoma / Lef1 / Recombinant Inbred Strains / Autoimmunity / Cancer Susceptibility / 肝癌 / モディファイアー遺伝子 / 遺伝子解析 / GTL / 肺癌 / RI系統 / Pre B リンパ腫 / 肺癌感受性遺伝子 / 膀胱癌 / lprマウス / ナカノカタラクト / 腎形成不全
Research Abstract

We studied effects of genetic background of host on various diseases. Defect in lpr gene causes a spectrum of autoimmunities in MRL mice, but not in C3H mice. Analyzing(MRL-lpr x C3H-lpr)FィイD22ィエD2 mice, we could show several host genes or their combinations to determine the spectrum of autoimmunities. Similar polygenic trait was found in SL/Kh pre-B lymphoma system. Lymphomas were induced by somatic integration of endogenous ecotropic MuLV to Slv1-8 hot spots, their host-junctional fragments were cloned with a modified inverse PCR technique. SL/Kh mice showed a unique pre-B cell expansion in pre-lymphoma BM. Such expansion was induced by Bomb1 host locus on Chr. 3 mapped us. A candidate gene for Bomb1 is Lef1, a transcription factor in Wnt/Frzl pathway, expressed in both T and pre-B cells. SL/Kh thymocytes showed very low responsiveness to Con A. Immunological abnormalities in B-lineage may induce expansion of the target cells for virus integration. We could identify several other host genes affecting type of lymphomas, length of latent period, and resistance to lymphoma development. These studies clearly indicate that lymphomagenesis is tightly bound to host modifying genes that regulate steps of carcinogenesis. In addition to lymphomas, we could map modifier genes for tongue cancer, bladder cancer, lung cancer and liver cancers using quantitative trait mapping. In these studies, we showed that the recombinant inbred strains is a highly useful tool to analyze complicated trait such as cancer susceptibility.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (126 results)

All Other

All Publications (126 results)

  • [Publications] Hiai,H. Higashi,K.: "Genetic resisitance to chemical carcinogen-induced preneoplastc hepatic iesions in DRH strain rats"Cancer Res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shisa,H., Hiai,H., Kitano M.: "Five quantitative trait loci predisposing rats to 4-nitroquinoline 1-oxide-induced toung cancer"Molec. Carcinog.. (submitted).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Iwasa,Y., Hiai,H., Toyokuni.: "Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress"Amer. J. Pathol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni,S., Tanaka,T., Hiai,H.: "Overexpression of hOGG1 gene and high 8-hydroxy-2-deoxyguanosine I;uase activity in human colorectal carcinoma : requlation mechanism of 8-hydroxy-2-deoxyguanosine level"Clin. Cancer Res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ogawa,O., Hiai,H.: "Allelic imbalance on chromosome 20 in human bladder cancers"Jpn J Cancer res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Momoi H, Hiai H.: "Analysis of genetic changes in intrahepatic cholangiocarcinoma induced by thorotrast"Radiat Res. 152. -124 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takahashi K, Hiai H,: "Induction of follicular gastritis following postthymectomy autoimmune gastritis in helicobacter pylori-infected BALB/c mice"Infect Immun. 68. 100-106 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H ; Minato-H ; Honjo-T: "Development of lupus-like autoimmune diseases by disruption of the PD-1 qene encoding an ITIM motif-carrying immunoreceptor"Immunity.. 11. 141-151 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lu, LM., Hiai, H.: "Mixed phenotype Lymphomas in thymectomized (AKR X SL/Kh)F1 mice"Jpn. J. Cancer Res.. 90. 1218-1223 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo S, Toyokuni S, Hiai H: "Persisent oxidative strss in human colorectal carcinoma, but not in adenoma"Free Radic Biol Med. 27. 401-410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H ; Toyokuni-S: "High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats"Oncogene. 18. 3793-3797 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] **isa,H., Hiai,H.: "Polygenic susceptibility and resistance to 4-nitroquinoline-1-oxide-lnduced tongue carcinomas in the rat"Lab. Anim. Sci.. 40. 65-74 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai, H., Tsuruyama, T.: "Genetic and epigenetic susceptibility to endogenous retrovirus-induced Iymphomas in SL mice"Prog-Exp-Tumor-Res.. 35. 64-77 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni, S., Hiai, H.: "Intranuclear distribution of 8-hydroxy-2'-deoxyguanosine. An immunocyto-chemical study"J-Histochem-Cytochem.. 47. 833-836 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zeng, Z., Hiai, H.: "Bone marrow pre-B-1 (Bomb1) : aquantitative trait locus inducing bone marrow expansion in lymphoma-prone SL/Kh mice"Cancer-Res.. 59. 2593-2595 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai, H.: "Propylnitrosourea-induced T-lym-phomas in LEXF RI strains of rats : genetic analysis"Br-J-Cancer.. 80. 855-861 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni, S., Uchida, K., Hiai, H.: "Formation of 4-hydroxy-2 nonenal-modified proteins and 3-nitro-L-tyrosine in rat island skin flaps during and after ischemia"Ann-Plast-Surg.. 42. 293-298 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai, H., Seino, Y.: "Hyperglycemis causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes"Diabetes.. 48(4). 927-932 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamoto, T., Hiai, H: "Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis"Int-J-Cardiol. 66 Suppl 1. -41 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H.: "Mapping of Nakano cataract gene nct on mouse chromosome 16"Genomics.. 50(1). 119-120 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H.: "Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers"Oncogene.. 17(23). 3209-3033 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamoto-T ; Hiai-H.: "Host genes affecting survival period of chemically induced bladder cancer in mice"J-Cancer-Res- Clin-Oncol.. 124(12). 670-676 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H ; Fukumoto-M: "Expression of class I human leukocyte antigen (HLA) and beta2-microglobulin is associated with decidualization of human endometrial stromal cells"Hum-Reprod.. 13(8). 2246-2251 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S ; Hiai-H: "Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes"Jpn-J-Cancer-Res.. 89(8). 814-820 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Nikaido-O: "A comparison of UVB-carcinogenesis between nude mica and nude beige mice"J-Radiat-Res-Tokyo.. 89(8). 814-820 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Nikaido-O: "An UVB-carcinogenesis model with KSN nude mice"J-Radiat-Res-Tokyo.. 39(1). 73-81 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Toyokuni-S: "Over-expression of glutathione S-transferase Yp isozyme and concomitant downregulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitriloace"Carcinogenesis. 19(5). 897-903 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Kamoto-T ;: "Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat"Cancer-Res.. 58(8). 1660-1664 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Toyokuni-S: "Involvement of nitric oxide in survival of random pattern skin flap"Plast-Reconstr-Surg.. 101(3). 785-792 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Fukumoto-M: "Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas"Br-J-Cancer.. 77(1). 147-152 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Fukumoto-M: "Cyclin-D1-gene amplification is a more potent prognostic factor tha its protein over-expression in human head-and-neck squamous-cell carcinoma"Int. J. Cancer. 74(6). 576-781 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H: "Host modifier genes affect mouse autoimmunity induced by the lpr gene"Am-J-Pathol.. 151(6). 1791-1798 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamoto-T ; Hiai-H.: "Quantitative trait loci associated with promoting effects of sodium L-ascorbate on two-stage bladder carcinogenesis in rats"Jpn-J-Cancer-Res.. 88(7). 633-638 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Toyokuni-S: "Inducton and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney : independence of tubular necrosis and sulfhydryl depletion"Lab-Invest.. (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S ; Hiai-H: "Induction of a wide range of C(2-12)aldehydes and C(7-12)acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate"Free-Radic-Biol-Med.. 22(6). 1019-1027 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai,H ; Kamoto-T ;: "To be or not to be a T-lymphoma, that is determined by a dominant gene Tlsm-1 in mouse models"Leukemia.. 11. 193-194 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamoto-T ; Hiai-H.: "Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains"Cancer-Res.. 57(14). 2904-2908 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S ; Hiai-H: "Biomarker evidence of DNA oxidation in lung cancer patients : association of urinary 8-hydroxy-2'-deoxyguanosine excretion with radioth"FEBS-Lett.. 409. 287-291 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H: "The LEXF : a new set of rat recombinant inbred strains between LE/Stm and F344"Mamm-Genome.. 8. 324-327 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H: "Expression of LECAM-1and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/KH mica"Leuk-Res.. 21(4). 337-342 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S ; Hiai-H: "Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyquanosine by a monoclonal antibody N45.1 : its application to ferric nitrilotriacetate-induced"Lab-Invest.. 76(3). 365-374 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukumoto-M ; Hiai-H ; Toyokuni-S: "Overexpression of integrin-associated protein(CD47) in rat kidney treated with a renal carcinogen,ferric nitrilotriacetate"Jpn-J-Cancer-Res.. 88(2). 120-128 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H: "Rupture of lens cataract : a novel hereditary recessive cataract model in the mouse"Exp-Eye-Res.. 64(1). 107-113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H ; Ishimoto-A: "Susceptibility of nude mica carrying the Fv-4 gene to Friend murine leukemia virus infection"J-Virol.. 71(1). 750-754 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H: "New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus"EFEBS-Lett.. 417(1). 150-152 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zheng, Z-Z., Higashi, S., Kitayama, W., Denda, A., Yan, Y., Matsuo, K., Konishi, Y., Zeng, Z-B., Hiai, H. Higashi, K.: "Genetic resistance to chemical carcinogen-induced preneoplastic hepatic lesions in DRH strain rats."Cancer Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanuma, J., Fujii, K., Hirano, M., Matsuuchi, H., Shisa, H., Hiai, H., Kitano, M.: "Five quantitative trait loci predisposing rats to 4-nitroquinoline 1-oxide-induced toung cancer."Molec. Carcinog.. (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka, T., Kondo, S., Iwasa, Y., Hiai, H., Toyokuni.: "Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress."Amer. J. Pathol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo, S., Toyokuni, S., Tanaka, T., Hiai, H., Onodera, H., Kasai, H., Imamura, M.: "Overexpression of hOGG1 gene and high 8-hydroxy-2-deoxyguanosine l; uase activity in human colorectal carcinoma : regulation mechanism of 8-hydroxy-2-deoxyguanosine level."Clin. Cancer Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Higashi, S., Habuchi, T., Takahashi, T., Kamoto, T., Kasehi, Y., Ogawa, O., Hiai, H.: "Allelic imbalance on chromosome 20 in human bladder cancers."Jpn J Cancer Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamikawa T, Amenomori M, Itoh T, Momoi H, Hiai H, Machinami R, Ishikawa Y, Mori T, Shimahara Y, Yamaoka Y, Fukumoto M: "Analysis of genetic changes in intrahepatic cholangiocarcinoma induced by thorotrast."Radiat Res. 152 (6 Suppl). S118-124 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Oshima-C; Okazaki-K; Matsushima Y, Sawada M, Chiba T, Takahashi K, Hiai H, Katakai T, Kasakura S, Masuda T: "Induction of follicular gastritis following postthymectomy autoimmune gastritis in helicobacter pylori-infected BALB/c mice"Infect Immun. 68. 100-106 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishimura-H; Nose-M; Hiai-H; Minato-N; Honjo-T: "Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor."Immunity.. 11. 141-151 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lu, LM., Hiai, H.: "Mixed phenotype Lymphomas in thymectomized (AKR X SL/Kh) F1 mice."Jpn. J. Cancer Res. 90. 1218-1223 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo S, Toyokuni S, Iwasa Y, Tanaka T, Onodera H, Hiai H, Imamura M: "Persistent oxidative stress in human colorectal carcinoma, but not in adenoma."Free Radic Biol Med. 27. 401-410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka-T; Iwasa-Y; Kondo-S; Hiai-H; Toyokuni-S: "High incidence of allelic loss on chromosome 5 and inactivation of p 15 INK 4B and p 16 INK 4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats."Oncogen. 18. 3793-3797 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanuma, J., Kitano, M., Shisa, H., Hiai, H.: "Polygenic susceptibility and resistance to 4-nitroquinoline-1-oxide-Induced tongue carcinomas in the rat."Lab. Anim. Sci.. 40. 65-74 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai, H., Yamada, Y., Abujiang, P., Lu, L., Kamoto, T., Tsuruyama, T.: "Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice."Prog-Exp-Tumor-Res.. 35. 64-77 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni, S., Iwasa, Y., Kondo, S., Tanaka, T., Ochi, H., Hiai, H.: "Intranuclear distribution of 8-hydroxy-2'-deoxyguanosine. An immunocyto-chemical study."J-Histochem-Cytochem.. 47. 833-836 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lu, LM, Shimada, R., Higashi, S., Zeng, Z., Hiai, H.: "Bone marrow pre-B-1 (Bomb1) : a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice."Cancer-Res.. 59. 2593-2595 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lu, LM., Shisa, H., Tanuma, J., Hiai, H.: "Propylnitrosourea-induced T-lym-phomas in LEXF RI strains of rats : genetic analysis."Br-J-Cancer.. 80. 855-861 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Um, SC., Suzuki, S., Toyokuni, S., Uchida, K., Hiai, H., Nishimura, Y.: "Formation of 4-hydroxy-2-nonenal-modified proteins and 3-nitro-L-tyrosine in rat island skin flaps during and after ischemia."Ann-Plast-Surg.. 42. 293-298 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ihara, Y., Toyokuni, S., Uchida, K., Odaka, H., Tanaka, T., Ikeda, H., Hiai, H., Seino, Y., Yamada, Y.: "Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes."Diabetes.. 48 (4). 927-32 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nose, M.,Terada, M., Nishihara, M., Kamogawa, J., Miyazaki, T., Mori, S., Nishimura, M., Wang, Y., Kamoto, T., Hiai, H.: "Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis."Int-J-Cardiol. 66 Suppl 1. S37-41 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai, H., Kato, S., Horiuchi, Y., Shimada, R., Tsuruyama, T., Watanabe, T., Matsuzawa, A.: "Mapping of Nakano cataract gene nct on mouse chromosome 16."Genomics.. 50 (1). 119-20 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Abujiang, P., Mori, TJ., Takahashi, T., Tanaka, F., Kasyu, I., Hitomi, S., Hiai, H.: "Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers."Oncogene.. 17 (23). 3029-3033 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Higashi-S; Murai-T; Mori-S; Kamoto-T; Yoshitomi-M; Arakawa-Y; Makino-S; Fukushima-S; Yoshida-O; Hiai-H: "Host genes affecting survival period of chemically induced bladder cancer in mice"J-Cancer-Res-Clin-Oncol.. 124 (12). 670-676 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Komatsu-T; Konishi-I; Mandai-M; Mori-T; Hiai-H; Fukumoto-M: "Expression of class I human leukocyte antigen (HLA) and beta2-microglobulin is associated with decidualization of human endometrial stromal cells."Hum-Reprod.. 13 (8). 2246-2251 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S; Okada-K; Kondo-S; Nishioka-H; Tanaka-T; Nishiyama-Y; Hino-O; Hiai-H: "Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes."Jpn-J-Cancer-Res.. 89 (8). 814-820 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishigaki-Y; Yasuda-K; Hashimoto-N; Hayakawa-J; Hiai-H; Nikaido-O: "A comparison of UVB-carcinogenesis between nude mice and nude beige mice."J-Radiat-Res-Tokyo.. 39 (2). 119-127 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishigaki-Y; Suzuki-F; Hayakawa-J; Hiai-H; Nikaido-O: "An UVB-carcinogenesis model with KSN nude mice."J-Radiat-Res-Tokyo.. 39 (1). 73-81 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka-T; Nishiyama-Y; Okada-K; Satoh-K; Fukuda-A; Uchida-K; Osawa-T; Hiai-H; Toyokuni-S: "Over-expression of glutathione S-transferase Yp isozyme and concomitant down-regulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitriloace"Carcinogenesis. 19 (5). 897-903 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanuma-J; Shisa-H; Hiai-H; Higashi-S; Yamada-Y; Kamoto-T; Hirayama-Y; Matsuuchi-H; Kitano-M: "Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat."Cancer-Res.. 58 (8). 1660-1664 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Um-SC; Suzuki-S; Toyokuni-S; Kim-BM; Tanaka-T; Hiai-H; Nishimura-Y: "Involvement of nitric oxide in survival of random pattern skin flap."Plast-Reconstr-Surg.. 101 (3). 785-92 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suwa-H; Ohshio-G; Imamura-T; Watanabe-G; Arii-S; Imamura-M; Narumiya-S; Hiai-H; Fukumoto-M: "Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas."Br-J-Cancer.. 77 (1). 147-152 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyomoto-R; Kumazawa-H; Toda-Y; Sakaida-N; Okamura-A; Iwanaga-M; Shintaku-M; Yamashita-T; Hiai-H; Fukumoto-M: "Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma."Int. J. Cancer.. 74 (6). 576-781 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang-Y; Nose-M; Kamoto-T; Nishimura-M; Hiai-H: "Host modifier genes affect mouse autoimmunity induced by the lpr gene."Am-J-Pathol.. 151 (6). 1791-8 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Leinonen-J; Lehtimaki-T; Toyokuni-S; Okada-K; Tanaka-T; Hiai-H; Ochi-H; Laippala-P; Rantalaiho-V; Wirta-O; Pasternack-A; Alho-H: "New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus."FEBS-Lett.. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kamoto-T; Mori-S; Murai-T; Yamada-Y; Makino-S; Yoshida-O; Hiai-H: "Quantitative trait loci associated with promoting effects of sodium L-ascorbate on two-stage bladder carcinogenesis in rats."Jpn-J-Cancer-Res.. 88(7). 633-8 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanaka-T; Nishiyama-Y; Okada-K; Hirota-K; Matsui-M; Yodoi-J; Hiai-H; Toyokuni-S: "Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney : independence of tubular necrosis and sulfhydryl depletion."Lab-Invest.. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S; Luo-XP; Tanaka-T; Uchida-K; Hiai-H; Lehotay-DC: "Induction of a wide range of C (2-12) aldehydes and C (7-12) acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate."Free-Radic-Biol-Med.. 22 (6). 1019-27 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai-H; Yamada-Y; Shisa-H; Kamoto-T; Abujiang-P; Lu-LM: "To be or not to be a T-lymphoma, that is deter mined by a dominant gene Tlsm-1 in mouse models."Leukemia.. 11 Suppl 3. 193-194 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Abujiang-A; Nishimura-M; Kamoto-T; Ichioka-K; Sato-M; Hiai-H: "Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains."Cancer-Res.. 57 (14). 2904-8 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Erhola-M; Toyokuni-S; Okada-K; Tanaka-T; Hiai-H; Ochi-H; Uchida-K; Osawa-T; Nieminen-MM; Alho-H; Kellokumpu-lehtinen-P: "Biomarker evidence of DNA oxidation in lung cancer patients : association of urinary 8-hydroxy-2'-deoxyguanosine excretion with radioth"FEBS-Lett.. 409 (2). 287-291 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shisa-H; Lu-L; Katoh-H; Kawarai-A; Tanuma-J; Matsushima-Y; Hiai-H: "The LEXF : a new set of rat recombinant inbred strains between LE/Stm and F344."Mamm-Genome.. 8 (5). 324-327 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lu-LM; Ogawa-M; Kamoto-T; Yamada-Y; Pataer-A; Hiai-H: "Expression of LECAM-1 on pre-B Iymphoma cells but not on preneoplastic pre-B cells in SL/KH mice."Leuk-Res.. 21 (4). 337-342 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toyokuni-S; Tanaka-T; Hattori-Y; Nishiyama-Y; Yoshida-A; Uchida-K; Hiai-H; Ochi-H; Osawa-T: "Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1 : its application to ferric nitrilotriacetate-induced"Lab-Invest.. 76 (3). 365-374 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishiyama-Y; Tanaka-T; Naitoh-H; Mori-C; Fukumoto-M; Hiai-H; Toyokuni-S: "Overexpression of integrin-associated protein (CD47)in rat kidney treated with a renal carcinogen, ferric nitrilotriacetate."Jpn-J-Cancer-Res.. 88 (2). 120-128 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lida-F; Matsushima-Y; Hiai-H; Uga-S; Honda-Y: "Rupture of lens cataract : a novel hereditary recessive cataract model in the mouse."Exp-Eye-Res.. 64 (1). 107-113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Higo-K; Kubo-Y; Lwatani-Y; Ono-T; Maeda-M; Hiai-H; Masuda-T; Kuribayashi-K; Zhang-F; lamin-TY; Adachi-A; Lshimoto-A: "Susceptibility of nude mice carrying the Fv-4 gene to Friend murine leukemia virus infection."J-Virol.. 71 (1). 750-754 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiai H.,Toyokuni S.: "High incidence of allelic loss on chromosome 5 and inactivation of p151NK4B and p161NK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats"Oncogene. 18. 3793-3797 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shisa,H.,Hiai,H.,Tanuma,J.,Kitano,M.: "Polygenic susceptibility and resistance to 4-nitroquinoline-1-oxide-Induced tongue carcinomas in the rat"Lab. Anim. Sci.. 40. 65-74 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Higashi S.,Zeng Z.,Hiai H.: "Bone marrow pre-B-1(Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice"Cancer-Res.. 59. 2593-2595 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Lu LM.,Shisa H.,Tanuma J.,Hiai H.: "Propylnitrosourea-induced T-lym-phomas in LEXFRI strains of rats: genetic analysis"BR. J. Cancer.. 80. 855-861 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Lu LM.,Hiai H.: "Mixed phenotype Lymphomas in thymectomized (AKR X SL/Kh) F1 mice"Jpn. J. Cancer Res.. 90. 1218-1223 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiai H.,Kato S.,Horiuchi Y.: "Mapping of Nakano cataract gene nct on mouse chromosome 16"Genomics.. 50. 119-120 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hiai, H., Hino, O.: "Animal Models of Cancer Predisponsition Syndromes"KARGER. 175 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanuma,J.: "Quantitative trait loci affecting 4NQO…induced tongue carcinoge in the rat" Cancer Res.58. 1660-1664 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lu,LM.: "Further characterization of LEXF RI strains of rats" Rat genome. 4. 13-25 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiai,H.: "Mapping of Nakano cataract gene nct on mouce chromosome 16." Genomics. 50. 119-120 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka,T.: "Overexpression of glutathione S-transferase Yp isozyme and concomitant downregulation of Ya isozyme in renal cell carcinoma of rats induced by ferric nitrilotriacetate" Carcinogenesis. 19. 897-903 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Toyokuni,S.: "Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the TSC2 and VHL tumor suppressor genes." Jpn.J.Cancer Res.89. 814-820 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Higashi,S.: "Host genes affecting survival period of chemical-induced bladder cancer in mice" J.Cancer Res.Clin.Oncol.124. 670-676 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Abujiang P.: "Loss of heterozygosity(LOH)at 17q and 14q in human lung Cancer" Oncogene. 17. 3029-3034 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nose,M.: "Vasculitis-susceptible genes in mice with a deficitin Fas-mediated apoptosis." Int.J.Cardiol.66. S37-41 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Lu,LM.: "Propylnitrosourea-Induced T-lymphomas in LEXF RI Stains of rats:Genetic analysis" Brit.J.Cancer. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Tanaka T.: "High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16Ink4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rat." Oncogene. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiai,H.: "Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice" In Progress in Experimental Tumor Research Vol.37 Animal Models of Cancer Predisposition Syndrome's, in press

    • Related Report
      1998 Annual Research Report
  • [Publications] Hiai H.: "Geneti jnedispo sitin to lmrphouas in uie" Pathol,Tntun. 46. 707-718 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Suwa,H.: "Oveuxmessin of the rhoc gene colati with mogursin of ductal adinocaicinuwa of the panaeas" Biit J.Caucn. 77. 147-152 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanuma T.: "Owantitatuie ttait loci affe ctihg 4NCao-inauced tingue caacirogeuesis in the rat." Canw Res. in press. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hiai H.: "Mapping of Nakano cataract gune nct on nwure chumes some 16." Genonics. in press. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lu-LM.: "Furthu chara itui3 atuin of LEXF R1 setauis of rats" in press. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lu,L-M.: "Lays gauular lepuplw ati lepuphomas d+aeliping in Hume ctonujed (SLAci XAKR)F_1 mice" Amu,J,rathol.in press. (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shisa H., et al.: "A new set of rat recombinaut iubud straius between LE/Stm and F344." Mammal.Gerwme. 8. 324-327 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Toyokuni,S., et al.: "Quantitative irunuro histo chemical deteruiratin of 8-bydcoxy 2′-deoxyguanosiu by a monocbonal auti body N45.1." Lab Fuvest.76. 365-374 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kamoto,T.et al.: "Quautitative trait loci associated aith prouoting effets of sodium L-ascorbate on two stage bladder carciuogeueis in rats." Jpn.J.Cancer Res.88. 633-638 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Abujiang,P., et al.: "Geneti resis bewe to urethaue induced puluronay aderumas in SMXA R1 stains." Caucr Res.57. 2904-2908 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wang.bf., et al.: "Host modifier geres affecting movse autuirumuring indecee by Lpr gene." Ainer.J,Pathol. 151. 1791-1798 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanaka,T: "9nowctius ofnd nuclear trauslocatin of thiosedoxin by oxidatine damage in the uioare kidney : indupenonce of tubular necrosi and sulfhydryl defletin" Lab.Fuvest.77. 145-155 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Iida F, et al.: "Rupture of leus cataraot = A novel hereditary recessive cataract moael in the neouse." Exp. Eye Res.64. 107-113 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hattori,Y., et al.: "8-hydroxy-2′-deoxyguanosine is increased in epiaermal ueles of hairless mice after chunic ultrariolit B exposure." Mvest.Derwatol.107. 733-737 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Higo,K.et al.: "Suocepeibility of nude ruio carrying the FN-4gene to Frience murine laubenia virus in duction" T.Virol. 71. 750-754 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lu,L-M.et al.: "Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic preB cells in SL/Kh mice." Leuk,Res.21. 337-342 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Toyokuni,S., et al.: "Induction of a wide rauge of C2-12 aldihydi and C17-12 aujloius in the kianey of Wistar rats after tieatment cutik a renal" Frce Rad.Biol.Med.22. 1019-1027 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nishiyama,Y.et al.: "Overexpression of iutegrin-associatcd proteri(CD47)in rat kidney treatid uictl a revel carcinogeu,fevric vitrilo a cetate" Jpn.J.Caucer Res.88. 120-128 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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