| Project/Area Number |
09307012
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
NAKADA Tsutomu Niigata University Brain Research Institute Professor, 脳研究所, 教授 (50281720)
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| Co-Investigator(Kenkyū-buntansha) |
SOMA Yoshiaki Niigata University Brain Research Institute Associate Professor, 脳研究所, 助教授 (30163132)
TSUJI Shoji Niigata University Brain Research Institute Professor, 脳研究所, 教授 (70150612)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Keywords | Alzheimer's disease / MRI / diffusion-weighted image / axonography |
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| Research Abstract |
Among the various contrast mechanics for magnetic resonance (MR) imaging, apparent diffusion possesses the unique property of directional dependency (anisotropic diffusion), In the central nervous system, anisotropism has empirically been shown to primarily originate from axons. It is therefore possible to obtain axonal information in vivo by diffusion tensor analysis, non-invasively, in humans (axonography). The project represents clinical applications of this axonographic method in attempt to obtain further insight into the pathophysiology of degenerative neurological disorders such as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. The project has successfully introduced various techniques in axonography and clearly demonstrates that quantitative analysis of fast axonal flow is now feasible in humans.
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