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MULTI-CENTER STUDIES FOR CLINICAL APPLICATION OF PEDIATRIC HEART AND LUNG TRANSPLANTATION IN JAPAN

Research Project

Project/Area Number 09307028
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

MATSUDA Hikaru  Osaka Univ, Graduate School of Med, Professor, 医学系研究科, 教授 (00028614)

Co-Investigator(Kenkyū-buntansha) AKADA Shintaro  Osaka Univ.Graduate School of Med, Professor, 医学系研究科, 教授 (30028609)
YASUI Hisataka  Kyushu Univ, School of Medicine, Professor, 医学部, 教授 (20089923)
FUJIMURA Shigehumi  Tohoku Univ, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (40006078)
MOMMA Kazuo  Tokyo Women's Medical College, Professor, 教授 (80075233)
KATO Hirohisa  Kurume Univ, Shool of Medicine, Professor, 医学部, 教授 (30080724)
神谷 哲郎  大阪大学, 国立循環器病センター・臨床栄養部, 部長
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥33,600,000 (Direct Cost: ¥33,600,000)
Fiscal Year 1999: ¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 1998: ¥9,400,000 (Direct Cost: ¥9,400,000)
Fiscal Year 1997: ¥13,000,000 (Direct Cost: ¥13,000,000)
KeywordsHEART TRANSPLANTATION / HEART-LUNG TRANSPLANTATION / LUNG TRANSPLANTATION / CHILDREN / DETERMINATION OF BRAIN DEATH / XENOTRANSPLANTATION / 小児心臓移植 / 小児肺-心臓移植 / 適応基準 / 先天性心疾患 / 心筋症 / 肺高血圧 / 小児脳死判定基準 / Eisenmenger症候群
Research Abstract

During 3 years of the program, 15 investigators have studied each theme shown below.
Regards to operative technique and preservation of pediatric heart and/or lung transplantation, the beneficial effects of steroid on water transport activity in lung preservation (Fujimura), the beneficial effects of superoxide synthesis inhibitor, OPC-6535 on reperfusion injury of pediatric hearts (Yasui), the beneficial effects of nicorandil on reanimation of asphyxiatedly arrest hearts (Sano), application of hybrid artificial vessels for pulmonary artery reconstruction in lung transplantation (Wada), and studies of operative technique and post-operative care of living-donor lobar lung transplantation (Miyoshi) were done.
Regards to indications for pediatric heart and/or lung transplantation, prognosis of dilated cardiomyopathy, congenital heart disease with congestive heart failure, and primary pulmonary hypertension were evaluated using nation-wide questionnaire to pediatric cardiologists or cardiac surgeons who belong to the Society for Japanese Pediatric Cardiology (Okada, Echigo, Kato). Indication of heart/lung transplantation or lung transplantation with combined cardiac repair was evaluated in congenital heart disease (Matsuda), Prognosis of primary pulmonary hypertension was evaluated (Momma). The effects of Intravenous administration of prostacyclin for primary pulmonary hypertension was evaluated (Saji). The outcomes of pediatric patients who underwent heart and/or lung transplantation was evaluated (Kobayashi).
Regards to determination of brain death in children, outcomes of brain dead children in several centers were evaluated (Mitsudome) and diagnosis of brain death in children in Kyoshu was evaluated (Matsuishi).
Finally, the role of preformed antibody against pigs in hyperacute rejection or delayed xenograft rejection was evaluated in infant Japanese monkey to expand donor pool for pediatric organ transplantation (Kawauchi).

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] H Matsuda: "First brain dead donor heart transplantation under new legistlation in Japan"Jpn J Thorac Cardiovasc Surg. 47(10). 499-505 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M Sugita: "Transalveolar fluid absorption ability in rat lungs preserved with Euro-Collins solution and EP4 solution"Transplantation. 67(3). 349-354 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] G Eto: "Assessment of global left ventricular function in normal children and dilated cardiomyopathy."J Am Soc Echocardiography. 12. 1058-1064 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M Kawauchi: "When does hyperacute rejection against xenohearts from newborn pigs develop in infantile monkeys?"Transplant Proc. 30(7). 3824-3825 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中山智孝: "小児原発性肺高血圧症に対するプロスタサイクリン持続静注療法の中期成績"日本小児科学会雑誌. 103(7). 709-714 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 門間和夫: "小児の原発性肺高血圧症"日本小児循環学会雑誌. 14(4). 494-499 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuda-H, Fukushima-N, Sawa-Y, Nishimura-M, Matsumiya-G, Shirakura-R: "First brain dead donor heart transplantation under new legistlation in Japan"Jpn J Thorac Cardiovasc Surg. 47 (10). 499-505 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda-S ; Miyoshi-S ; Inoue-M ; Omori-K ; Okumura-M ; Yoon-HE ; Minami-M ; Matsuda-H.: "Clinical spectrum of congenital cystic disease of the lung in children."Eur-J-Cardiothorac-Surg. Jan. 15 (1). 11-7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki-S ; Noda-M ; Akaizawa-T ; Song-C ; Tsubochi-H ; Suzuki-T ; Fujimura-S.: "Intact alveolar epithelial permeability and transalveolar fluid absorption after thoracic irradiation in rats."Radiat-Res.. 152 (5). 517-22 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki-S ; Noda-M ; Sugita-M ; Ono-S ; Koike-K ; Fujimura-S: "Impairment of transalveolar fluid transport and lung Na (+)-K (+)-ATPase function by hypoxia in rats."J-Appl-Physiol.. 87 (3). 962-8 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nishikawa-T ; Ishiyama-S ; Sakomura-Y ; Nakazawa-M ; Momma-K ; Hiroe-M ; Sekiguchi-M ; Kasajima-T: "Ultrastructural features of the myocardium of children with dilated cardiomyopathy."Heart-Vessels.. 14 (1). 52-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kawauchi-M ; Nakajima-J ; Takeda-M ; Ono-M ; Lee-MC ; Oka-T ; Takamoto-S: "Ontogeny of hyperacute rejection against pig heart : a pig-to-primate heart transplant study."Transplant-Proc.. 30 (1). 79-80 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Lee-MC ; Kawauchi-M ; Nakajima-J ; Takeda-M ; Ono-M ; Oka-T ; Takamoto-S: "When does hyperacute rejection against xenohearts from newborn pigs develop in infantile monkeys?"Transplant-Proc.. 30 (7). 3824-5 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tanoue-Y ; Morita-S ; Ochiai-Y ; Haraguchi-N ; Tominaga-R ; Kawachi-Y ; Yasui-H: "Nitroglycerin as a nitric oxide donor accelerates lipid peroxidation but preserves ventricular function in a canine model of orthotopic heart transplantation."J-Thorac-Cardiovasc-Surg.. 118 (3). 547-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suehiro-K ; Mohri-M ; Takagaki-M ; Hisamochi-K ; Morimoto-T ; Sano-S: "The effect of graft perfusion with warm blood cardioplegia for cadaver heart transplantation."Surg-Today.. 29 (9). 890-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurotobi-S ; Naito-H ; Sano-T ; Arisawa-J ; Matsushita-T ; Takeuchi-M ; Kogaki-S ; Okada-S: "Left ventricular regional systolic motion in patients with right ventricular pressure overload."Int-J-Cardiol.. 67 (1). 55-63 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Utsumi-T ; Mizuta-T ; Fujii-Y ; Shiono-H ; Okumura-M ; Minami-M ; Takeda-S ; Miyoshi-S ; Matsuda-H: "Nitric oxide production by bronchoalveolar cells during allograft rejection in the rat."Transplantation.. 67 (12). 1622-6 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fukuse-T ; Hirata-T ; Nakamura-T ; Kawashima-M ; Hitomi-S ; Wada-H: "Influence of deflated and anaerobic conditions during cold storage on rat lungs."Am-J-Respir-Crit-Care-Med.. 160 (2). 621-7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H Matsuda: "First brain dead donor heart transplantation under new legislation in Japan"Jpn J Thorac Cardiovasc Surg. 47(10). 499-505 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M Sugita: "Transalveolar fluid absorption ability in rat lungs preserved with Euro-Collins solution and EP4 solution"Transplantation. 67(3). 349-354 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] G Eto: "Assessment of global left ventricular function in normal children and dilated cardiomyopathy"J Am Soc Echocardiography. 12. 1058-1064 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M Kawauchi: "When does hyperacute rejection against xenohearts from newborn pigs develop in infantile monkeys?"Transplant Proc. 30(7). 3824-3825 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中山 智孝: "小児原発性肺高血圧症に対するプロスタサイクリン持続静注療法の中期成績"日本小児科学会雑誌. 103(7). 709-714 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 門間 和夫: "小児の原発性肺高血圧症"日本小児循環学会雑誌. 14(4). 494-499 (1998)

    • Related Report
      1999 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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