• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Brain function analysis using intracranial electrodes in epileptic patients

Research Project

Project/Area Number 09307031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTokyo Women's Medical University (1998-1999)
Tottori University (1997)

Principal Investigator

HORI Tomokatsu  Tokyo Women's Medical University Professor & Chairman, 医学部, 教授 (60010443)

Co-Investigator(Kenkyū-buntansha) TAKENOBU Atsumi  Tokyo Women's Medical University Assistant Professor, 医学部, 助手 (40183454)
TAIRA Takaomi  Tokyo Women's Medical University Assistant, 医学部, 助手 (30167481)
近藤 慎二  鳥取大学, 工学部・附属病院, 助手 (60192069)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥32,600,000 (Direct Cost: ¥32,600,000)
Fiscal Year 1999: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1997: ¥25,800,000 (Direct Cost: ¥25,800,000)
KeywordsHippocampus / Amygdala / Memory test / Temporal lobe epilepsy / Mapping / Emotion / Language / Eloquent / てんかん / 外科治療 / マッピング / 言語野 / 運動野 / 感覚野 / AC-PCライン / アトラス / 脳波 / 脳機能マッピング / 脳深部刺激・焦点切除術
Research Abstract

1) In treating low-grade gliomas(10) or intractable nonlesional epielpsy(8), surgical planning must also take into account to escape from serious neurological sequelae resulting from injury of eloquent cortex.. In these patients, pre- or intraoperative mapping of eloquent cortex is indispensable to do sufficient removal of the lesion without damage of eloqunet cortex.. On the other hand, mapping data of these eloquent cortices in individual patient have been standardized using Talairach's orthogonal axes.
2) To predict memory dysfunction after hippocampectomy, the authors tested verbal learning during hippocampal stimulation in eight patients with intractable temporal epilepsy. All patients but one had passed the amytal memory test, and intracranial EEG recording had detected a unilateral temporal focus in five patients and bilateral temporal. The stimulation-recall test was repeated twice using another wored set. Of the five patients with a unilateral focus, three had an unchanged reca … More ll rate during hippocampal stimulation on the focus side, and underwent hippocampectomy without any neurological defcits. The other two had slightly decreased rates during hippocampal stimulation on the focus side. The three patients with bilateral foci had significantly decreased rates after simulation of each hippocampus.
3) By drilling away the retrolabyrinthine presigmoid bone, at leaset 1cm more space below and 1cm more space medially is obtained than in the subtemporal appraoch, and temporal retraction pressure is diminished when approaching from below. Operative results according to the Engel's classification of seizure control, and pre- and postoperative WAIS, revised WAIS, and WISC scores were measured in 16 patients treated by normal or modified amygdalohippocampectomy. Postoperative follow-up ranged from 8 to 79 onths. There has been no morbidity or mortality among these 16 patients, and postoperative seizure frequency has been diminished to less than l0% of the preoperative level in 15 of the 16. In eight patients, seizures have been eliminated totally. Subtemporal amygdalohippocampectomy achieved significantly increased performance and full scale inteligence quotient within 2 months after surgery, compared to preoperative levels. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Hori T et al: "Retrolabyrinthine presigmoid transpetrosal approach for selective subtemporal amygdalohippocampectomy"Neurol Med Chir (Tokyo). 39. 214-225 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yazawa S, Hori T et al: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschafts portential from medial frontal cortex."Exp Brain Res. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ikeda A, Hori T et al: "Focal ictal direct current shifts in human epilepsy as studied by subdural and scalp recording"Brain. 122. 827-838 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀智勝: "選択的扁桃体・海馬切叙術"医学のあゆみ. 181. 780 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takenobu A, Hori T et al: "Selective amygdalohippocampectomy by the subtemporal transpetrosal approach."Epilepsia. 38. 80 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀智勝 他: "側頭葉てんかんに対する側頭葉下面からの手術"脳神経外科. 25. 977-985 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀智勝・竹信敦充: "神経科学の基礎と臨床VIII大脳辺縁系"薗田高弘. 119-143 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 堀智勝 他: "難治性てんかんの治療 堀智勝(編)"千田顯史. 310 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hori T et al: "Reprolabyrinthine presignoid transpetrosal approach for selective subtemporal amygdalohippo conpectomy"Neurol Med Chir(Tokyo). 39. 214-225 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yazawa S,Hori T et al: "Human pre-supplementary motorway is active before voluntary movement subdural recording of Bereitsch aft potential from medial frontal cortex"Exp. Brain Res. (in press). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda A,Hori T et al: "Focal ictal direct current shifts in human epilepsy as studied by subdurel and Acalp recording"Brain. 122. 827-838 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 智勝: "選択的扁桃体・海馬切除術"医学のあゆみ. 181. 780 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takenobu A,Hori T et al: "Selective amygdalo hippocampectomy by the subtemporal transpetrosal approach"Epilepsia. 38. 80 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 智勝 他: "側頭葉てんかんに対する側頭葉下面からの手術"脳神経外科. 25. 977-985 (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 智勝・竹信敦充: "神経科学の基礎と臨床VIII大脳辺緑系"薗田高弘. PP119〜143 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 堀 智勝 他: "難治性てんかんの治療(編者 堀 智勝)"千田顯史. 310(PP111〜126) (1997)

    • Related Report
      1999 Annual Research Report
  • [Publications] 田中聡,堀智勝他: "グリオーマに対するRT-PCRを用いたindividual adjuvant therapy" Neuro-Oncology. 8(1). 53-58 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 伊関洋,堀智勝他: "手術ナビゲーション技術の進歩" Ope Nursing. 14(1). 44-48 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀智勝,高倉公朋,佐野圭司: "Spinal Nerve Tumers-clinical and operative experiences of 53 cases-" Spinal surgery. 12(3). 263-272 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀智勝,近藤慎二他: "Retro labyrinthine presigmoid transpetrosal approach for selective subtemporal amygdalo hippo compectomy." Neurologia medico-chirurgica. 39(3). 214-225 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田中聡,堀智勝他: "Invitro inhibition of binding of tumor neurosis factor (TNF)-d by monoclonal antibody to TNF receptor on glioma cell and monocyte." Neurolegia medico-chirurgica. 38(12). 812-818 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高野加寿恵,堀智勝,桑山明夫: "アクロメガリーの治療" ホルモンと臨床. 46(8). 95-111 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 竹信敦充,堀智勝 他: "グリオーマの外科(脳機能マッピングを併用した言語運動野グリオーマの手術" (柴田尚武編) メディカ出版, 200-208 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 堀智勝: "脳神経外科の最先端(てんかんの外科治療)" 先端医療技術研究所(堀智勝,平孝臣,伊関洋編), 69-77 (1999)

    • Related Report
      1998 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi