| Project/Area Number |
09307036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KAGAWA MEDICAL UNIVERSITY |
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Principal Investigator |
OGLI Kenji KAGAWA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (40079934)
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| Co-Investigator(Kenkyū-buntansha) |
SUEZAKI Yukio KAGAWA MEDICAL UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (80069484)
KANESHINA Shoji THE UNIVERSITY OF TOKUSHIMA, FACULTY OF ENGINEERING, PROFESSOR, 工学部, 教授 (80035617)
SHIRAHAMA Keishiro SAGA UNIVERSITY, FACULTY OF SCIENCE AND ENGINEERING, PROFESSOR, 理工学部, 教授 (50039252)
MASHIMO Takashi OSAKA UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学部, 教授 (60157188)
TERADA Hiroshi THE UNIVERSITY OF TOKUSHIMA, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (00035544)
谷口 吉弘 立命館大学, 理工学部, 教授 (70066702)
柴田 あきら 徳島大学, 薬学部, 助教授 (40035556)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1999: ¥7,300,000 (Direct Cost: ¥7,300,000)
Fiscal Year 1998: ¥6,700,000 (Direct Cost: ¥6,700,000)
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| Keywords | ANESTHETICS / ANESTHETIC MECHANISMS / NON-SPECIFIC BINDING / MOLECULAR ENVIRONMENT / 分子環境 / ファンデルワールスカ / 構造水 / 両親媒性領域 / 麻酔薬作用機序 / site specific / non-site specific / 膜の極性 / 膜濃縮過程 / 両親媒性ドメイン / 膜蛋白質 |
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| Research Abstract |
More than a hundred years have passed since the study of mechanisms of anesthesia began. Overton's lipid theory has been the most fundamental theory for physicochemists in this field. However, this theory only dealt with how the anesthetic molecules exist in the action site, and did not explain the mechanisms of their action. Why are the concentrations of anesthetics that affect the physicochemical parameters of lipid membranes much higher than the clinical concentrations? On the other hand some effects of anesthetics on proteins can be observed at clinical concentrations. Therefore the use of proteins such as neurotransmitters and/or receptors for the study of anesthetic mechanisms is becoming popular. There have been many papers published regarding the "specific" action of anesthetics on proteins.
In order to obtain a valuable theory, it is necessary to analyze a wide range of research. Therefore, it is important to continue physicochemical studies as well as biochemical studies. This project includes both physicochemical and biochemical investigators. During the project, we met together several times and discussed about how the environment around anesthetic at the action site is. To extend the discussion, we held an international workshop. Inviting many researchers from various fields concerning anesthetic mechanism, we have had a very meaningful talk.
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