• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

STUDY ON MOLECULAR DIAGNOSIS OF ORAL PREMALIGNANT LESION EXPECTED TO BE TRANSFORMED INTO SQUAMOUS CELL CARCINOMA

Research Project

Project/Area Number 09307047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

ENOMOTO Shoji  TOKYO MEDICAL AND DENTAL UNIVERSITY,FACULTY OF DENTISTRY,PROFESSOR, 歯学部, 教授 (40013940)

Co-Investigator(Kenkyū-buntansha) HIRANO Yasumasa  TOKYO MEDICAL AND DENTAL UNIVERSITY,FACULTY OF DENTISTRY,INSTRACTOR, 歯学部, 助手 (00302878)
SAKAI Eiki  TOKYO MEDICAL AND DENTAL UNIVERSITY,FACULTY OF DENTISTRY,INSTRACTOR, 歯学部, 助手 (60292976)
上田 晶義  東京医科歯科大学, 歯学部, 助手 (00272609)
草間 幹夫  東京医科歯科大学, 歯学部, 講師 (60124690)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 1998: ¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1997: ¥15,000,000 (Direct Cost: ¥15,000,000)
KeywordsSquamous cell carcinoma (SCC) / Premalignant lesions / leukoplakia or erythroplakia / p53 tumor suppressor gene / diagnostic marker / lmmunohistochemical analysis / clinical prognosis / pathological malignancy score / survival rate / PCR法 / 塩基配列決定法
Research Abstract

Squamous cell carcinoma (SCC) constitutes vast majority of the oral malignancy. The surgical treatment of oral SCC causes severe postoperative disfunction or, disfigurement. To minimize these problems, it is important to trea the patients immediately, based on the accurate diagnoses. It is well understood that some oral SCCs are developed from its premalignant lesions such as leukoplakia or erythroplakia, which give us hints to understand the mechanism of oral SCC carcinogenesis.
In this study, we examined the status of p53 tumor suppressor gene in these oral premalignant lesions, which we showed to be mutated in 2/3 of oral SCCs, and if the p53 alteration could be used as a diagnostic marker of the premalignant lesions expected to be transformed into SCC later. Immunohistochemical analysis showed that p53 protein was highly expressed in many cases of the oral leukoplakia which were found to be subsequently transformed into SCC, suggesting that p53 gene alteration may possibly occur prior to malignant transformation. This result indicate that p53 alteration may possibly serve as a diagnostic marker of oral. SCC premalignant lesions.
In addition, p53 gene mutation and clinical prognosis of the patient was compared to know the role of the gene in the progression of oral SCC.We could not find obvious correlation between the status of p53 and pathological malignancy score, the rate of recurrence and survival rate, suggesthig that p53 may possibly play a role rather in the initiation than prpgression of oral SCC.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] A.Kikegawa, E.Sakai, S.Enomoto: "Study on p53 Alteration in Oral Premalignant lesions (in Japanese)" (submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Hirano, E.Sakai, A.Kikegawa, T.Kishi, M.Kusama & S.Enomoto: "The p53 mutation or abnormal protein accumulation as a prognostic marker of oral squamous cell carcinoma." (submitted). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Y.Nakajima: "interaction of E2F/Rb Family Members with Factor Binding to Co-repressor Element on B-myb and E2F1 Promotors" The Journal of The Stomatological Society, Japan. 65,2. 18-34 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] S.Mogi: "Studies on Generation of Cytotoxic T Lymphocytes against Oral Squamous Cell Carcinoma by Gene-Transduction of a Co-stimulatory molecule" CD80 The Journal of The Stomatological Society, Japan. 66,1. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tobiume: "Charactorization of Mouse Apotosis Signal-reguratingkinase 1" The Journal of The Stomatological Society, Japan. 65,1. 42-52 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] K.Tobiume, T.lnage, K.Takeda, S.Enomoto, K.Miyazono & H.lchijo: "Molecular Cloning and Characterization of the Mouse Apoptosis Signal-Regulating Kinase 1" Biochem.Biophysic.Res.Com.905-910 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] M.Hujii ;: "Growth Suppression of Squamous Cell Carcinoma Cell Lines by PKCs-Possible Application to Gene Therapy-" The Journal of The Stomatological Society, Japan. 64,1. 18-34 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi