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Prediction and prevention of postpartum onset of autoimmune disease

Research Project

Project/Area Number 09307055
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionOsaka University

Principal Investigator

AMINO Nobuyuki  Faculty of Medicine, Osaka University Professor, 医学系研究科, 教授 (60028694)

Co-Investigator(Kenkyū-buntansha) TATSUMI Keita  Faculty of Medicine, Osaka University Lecturer, 医学系研究科, 講師 (00222109)
TADA Hisato  Faculty of Medicine, Osaka University Lecturer, 医学系研究科, 講師 (80263242)
HIDAKA Yoh  Faculty of Medicine, Osaka University Research Associate, 医学系研究科, 助教授 (30243231)
IZUMI Yukiko  Faculty of Medicine, Osaka University Research Associate, 医学系研究科, 助手 (00252685)
TAKANO Toru  Faculty of Medicine, Osaka University Lecturer, 医学系研究科, 講師 (00263236)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥26,900,000 (Direct Cost: ¥26,900,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1997: ¥13,500,000 (Direct Cost: ¥13,500,000)
KeywordsAutoimmune disease / Pregnancy / Postpartum thyroiditis / Graves' disease / Autoimmune myocarditis / Autoimmune hepatitis / Rheumatoid arthritis / Autoimmune hypophysitis
Research Abstract

We established that thyroid dysfunction developed after delivery from subclinical autoimmune thyroid disease. On the basis of this observation, we searched for other postpartum autoimmune diseases. Rheumatoid arthritis developed 6 times more frequently at postpartum period company to other time in female patients and postpartum onset could be predicted by measuring rheumatoid factor in early pregnancy. Moreover, we found new clinical entity, named postpartum autoimmune hypophysitis, postpartum autoimmune myocarditis, and postpartum autoimmune hepatitis. Relating these diseases we established new methods for defection of heart or liver specific autoantibodies. These postpartum abnormalities were summarized as postpartum autoimmune syndrome. Finally we proposed total health care system for postgravid women.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (47 results)

All Other

All Publications (47 results)

  • [Publications] Amino N et al.: "Enzyme-linked immunosorbent assay for anti-tropomyosin antibodies and its clinical application to various heart diseases."Clin Chim Acta. 299. 179-192 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application."Clin Chem. 46. 112-117 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Changes in cytokine production during and after normal pregnancy."Am J Reprod Immunol. 44. 143-147 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Postpartum autoimmune thyroid syndrome."Endocr J. 47. 645-655 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Influence of breast-feeding on the production of cytokines."Am J Reprod Immunol. 45. 100-102 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Characteristics of experimental autoimmune hypophysitis in rats : Major antigens are growth hormone, thyrotropin, and luteinizing hormone in this model."Autoimmunity.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Endocrinology, 4th edition, DeGroot LJ ed., Chronic (Hashimoto's) Thvroiditis (Chapter 103)"W.B.Saunders Company, Philadelphia. 10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Changes in T, B, and NK lymphocyte subsets during and after normal opregnancy."Am J Reprod Immunol. 37. 368-377 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Prediction of postpartum onset of rheumatoid arthritis."Ann Rheum Dis. 57. 460-463 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Incidence of postpartum onset of disease among patients with rheumatoid arthritis."J Rheumatol. 26. 755-756 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Postpartum autoimmune thyroid syndrome : A model of aggravation of autoimmune disease."Thyroid. 9. 705-713 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Postpartum onset of acute heart failure possibly due to postpartum autoimmune myocarditis : a report of three cases."J Intern Med. 245. 199-203 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Postpartum autoimmune thyroid syndrome."Endocr J. 47. 645-655 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application."Clin Chem. 46. 112-117 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Changes in cytokine production during and after normal pregnancy."Am J Reprod Immunol. 44. 143-147 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Enzyme-linked immunosorbent assay for anti-tropomyosin antibodies and its clinical application to various heart diseases."Clin Chim Acta. 299. 179-192 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al: "Influence of breast-feeding on the production of cytokines."Am J Reprod Immunol. 45. 100-102 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amino N et al.: "Enzyme-linked immunosorbent assay for anti-tropomyosin antibodies and its clinical application to various heart diseases."Clin Chim Acta. 299. 179-192 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Enzyme immunoassay for autoantibodies to human liver-type arginase and its clinical application."Clin Chem. 46. 112-117 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Changes in cytokine production during and after normal pregnancy."Am J Reprod Immunol. 44. 143-147 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Postpartum autoimmune thyroid syndrome."Endocr J. 47. 645-655 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Influence of breast-feeding on the production of cytokines."Am J Reprod Immunol. 45. 100-102 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Characteristics of experimental autoimmune hypophysitis in rats : Major antigens are growth hormone, thyrotropin, and luteinizing hormone in this model."Autoimmunity.

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Endocrinology, 4th edition, DeGroot LJ ed., Chronic (Hashimoto's) Thyroiditis (Chapter 103)"W.B.Saunders Company, Philadelphia. 10 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Amino N et al.: "Therapeutic controversy : Screening for postpartum thyroiditis"J Clin Endocrinol Metab. 84. 1813-1821 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Amino N et al.: "Postpartum autoimmune thyroid syndrome : A model of aggravation of autoimmune disease"Thyroid. 9. 705-713 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] lijima T et al.: "Incidence of postpartum onset of disease among patients with rheumatoid arthritis"J Rheumatol. 26. 755-756 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yagoro A et al.: "Postpartum onset of acute heart failure possibly due to postpartum autoirnmune myocarditis : a report of three cases"J Intern Med. 245. 199-203 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Okumura M et al.: "CD30 expression and IL-4 and lEN- γ production of intrathyroidal lymphocytes in Graves' disease"Thyroid. 9. 333-339 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hidaka Y et al.: "Increased serum concentration of interleukin-12 in patients with silent thyroiditis and Graves' disease"Thyroid. 9. 149-153 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Amino N et al.: "Postpartum Autoimmune Endocrine Syndromes (Chapter 11), In : Volpe R ed., Autoimmune Endocrinopathies,"Humana Press Inc. 20 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimaoka Y et al.: "Serum concentration of soluble fas in patients with autoimmune thyroid diseases." Thyroid. 8. 43-47 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hidaka Y et al.: "Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis." Thyroid. 8. 235-239 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nojima j et al.: "High prevalence of thrombocytopenia in SLE patients with a high level of anticardiolipin antibodies combined with lupus anticoagulant." Am J Hematology. 58. 55-60 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Watanabe Y et al.: "Effect of solubilization of porcine thyrotropin(TSH)receptor on TSH binding and on radio-receptor assay for anti-TSH receptor antibodies." Biochem Biophys Res Commun. 248. 110-114 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Iijima T et al.: "Prediction of postpartum onset of rheumatoid arthritis." Ann Rheum Dis. 57. 460-463 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Amino N et al.: "Therapeutic controversy on screening for postpartum thyroiditis:Screeening for postpartum thyroid dysfunction in the general population is beneficial." J Clin Endocrinol Metab. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] Amino N et al.: "Postpartum thyroid disease.C.W.Bardin ed,Current Therapy in Endocrinology and Metabolism,6th edition" Mosby-Year Book,Inc., 4 (1997)

    • Related Report
      1998 Annual Research Report
  • [Publications] Amino N et al: "Chronic(Hashimito's)Thyroiditis(Chapter 107)DeGroot LJ ed.,Endocrinology,4th edition (in press)" W.B.Saunders Company,

    • Related Report
      1998 Annual Research Report
  • [Publications] Amino N et al.: "Subtypes of anti-TSH receptor antibodies classified by various assays using CHO cells expressing wild type or chimeric human TSH receptor." Thyroid. 7・1. 13-19 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Changes in T,B,and NK lymphocyte subsets during and after normal pregnancy." American Journal of Reproductive Immunology. 37・5. 368-377 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Effect of thyrotropin stimulation blocking antibodies on TSH-and epidermal growth factor-induced DNA synthesis in FRTL-5 cells." Thyroidology. 9・1. 5-9 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Detection of thyroid-stimulating antibodies by using frozen stocks of Chinese hamster ovary cells transfected with cloned human thyrotropin receptor." Endocrine Journal. 44・3. 431-435 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Increased serum concentration of soluble CD30 in patients with Graves' disease and Hashimoto's thyroiditis." Journal of Clinical Endocrinological Metabolism. 82・6. 1757-1760 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Effects of autoantibodies on the course of pregnancy and fetal growth." Obstetrics&Gynecology. 90・3. 364-369 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Endocrinology,3rd edition" W.B.Saunders Company,Philadelphia, 16 (1995)

    • Related Report
      1997 Annual Research Report
  • [Publications] Amino N et al.: "Current Therapy in Endocrinology and Metabolism,6th edition" Mosby-Year Book,Inc.,Philadelphia, 4 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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