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Studies on the molecular mechanism of calcium signaling and the role of IP3 receptor in development and differentiation

Research Project

Project/Area Number 09308030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

MIKOSHIBA Katsuhiko  The University of Tokyo, Inst.Medical Science, Professor, 医科学研究所, 教授 (30051840)

Co-Investigator(Kenkyū-buntansha) MICHIKAWA Takayuki  The University of Tokyo, Inst.Medical Science, Research Associate, 医科学研究所, 助手 (90282516)
FURUICHI Teiichi  The University of Tokyo, Inst.Medical Science, Assosiate Prof., 医科学研究所, 助教授 (50219094)
井上 貴文  東京大学, 医科学研究所, 助手 (10262081)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥28,700,000 (Direct Cost: ¥28,700,000)
Fiscal Year 1998: ¥12,400,000 (Direct Cost: ¥12,400,000)
Fiscal Year 1997: ¥16,300,000 (Direct Cost: ¥16,300,000)
KeywordsIP3 receptor / Ca2+ activation / nerve growth / Growth cone / Microinjection / Ca2+ waves / IP3受容体 / Ca2+動態 / 神経伝達物質 / LTP / 胚軸形成 / LTD / IP_3 / IP_3受容体 / カルシウム / 背側化 / 腹側化 / 二次軸形成 / BMP4 / IP_3誘導カルシウム放出
Research Abstract

The inositol 1,4,5-triaphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R(IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion in internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore assisted laser inactivation resulted in growth cones arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.
Changes in [Ca2+]i are an essential factor regulating egg activation. Matured ascidian eggs are arrested at metaphase I , and two series of [Ca2+]i transients have been observed after fertilization : Ca2+ waves just fertilization (Series I) and [Ca2+]i oscillation between the first and second polar body extrusion (Series II). We investigated mechanisms involved in the elevation of [Ca2+]i and the role of the [Ca2+]i transients during egg activation in Ciona savignyi. The monoclonal antibody 18A10 against IP3 receptor type 1, which inhibits IP3-induced Ca2+ release in hamster and mouse eggs, did not show substantial inhibitory effects on series I or egg deformation, whereas Series II and the first cell division were inhibited by the antibody. Ruthenium red, an inhibitor of ryanodine receptor-mediated Ca2+ release, had no apparent effect of [Ca2+]i transients and other events related to the egg activation.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (168 results)

All Other

All Publications (168 results)

  • [Publications] Del Rio,J.A: "A role for Cajal-Retzius cells and reelin in the development of hippocampal connections." Nature.385. 70-74 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Umemori,H.: "Activation of the G Protein Gq/11 through tyrosine phosphorylation of the a subunit." Science.276. 1878-1882 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sheldon,M.: "Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice." Nature.389.730-733 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume,S: "Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos." Science.278.1940-1943 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhao,H.: "Functiona1 expression of a mammalian odorant receptor." Science.279. 237-242 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] D'Arcangelo,G: "Reelin is a secred glycoprotein recognized by the CR-50 monoclonal antibody." J.Neurosci.17. 23-31 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara-ImaizumiM: "Distinct roles of C2A and C2B domains of synaptotagmin in the requlation of exocytosis in adrenal chromaffin cells." Proc.Natl.Acad.Sci.USA.94. 287-291 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume,S: "Developmental Expression of the Inositol 1,4,5-Trisphosphate Receptor and Structural Changes in the Endoplasmic Reticulum during Oogenesis and Meiotic Maturation of Xenopus laevis." Developmental Biology.182. 228-239 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mehrotra,B: "Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins." J.Biol.Chem.272. 4237-4244 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morita,N: "Astrocytic Lineage Analysis by Detection of GFAP Promoter Activity in vitro." Developmental Neuroscience.19. 210-218 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sayers,L.G: "Intracellular targeting and homotetramer formation of a truncated inositol 1,4,5-trisphosphate receptor/green fluorescent protein chimera in Xenopus leavis oocytes." Biochem.J.323. 273-280 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagai,T.: "The expression of the mouse Zic1,Zic2,and Zic3 gene suggests an essential role for Zic genes in body pattern formation." Developmental Biology.182. 299-313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoneshima,H.: "Ca2+ differetly regulates the ligand-affinity ststes of type 1 and type 3 inositol 1,4,5-trisphosphate receptors." Biochem.J.322. 591-596 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tovey.S.C: "Identification and characerization of inositol 1,4,5-trisphosphate receprors in the rat testis." Cell Calcium.21. 311-319 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hisatsume,C.: "Phosphorylation-dependent Regulation of N-Methy1-D-asparate Receptors by calmodulin." J.Biol.Chem.272. 20805-20810 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruyama,T.: "2APB,2-aminoethoxydiphenyl borate, a membrance penetrable modulator of Ins (1,4,5) P3-induced Ca2+ release." J.Biochem.122. 498-505 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruyama,T.: "Attenuation of intracellular Ca2+ and secretory responses by Ins (1,4,5) P3-induced Ca2+ release modulator,2APB,in rat pancreatic acinar cells." Biomedical Research.18. 297-302 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume,S.: "Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 14,5-trisphosphate during early embryogenesis in Xenopus laevis." Mechanisms of Development.66. 157-168 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura,H.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory." Chemico-Biological Interactions.104. 1-9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyata,T.: "Regulation of Purkinje Cell Alignment by Reelin as Revealed with CR-50 Antibody." J.Neurosci.17. 3599-3609 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakayama,T: "Mapping of the Human HPC-1/Syntaxin 1A Gene (STX1A) to Chromosome 7 Band q11.2." Genomics.42. 173-176 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda,M: "Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III." Biochem.J.323. 421-425 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mochida,S.: "Roles of Synaptotagmin C2 Domains in Neurotransmitter secretion and inositol high-polyphosphate binding at mammalian cholinergic synapses." Neurosci.77. 937-943 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajima,K: "Distruption ofhippocampal development in vivo by CR-50 mAb against reelin." Proc.Natl.Acad.Sci.94. 8196-8201 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakata,K.: "Xenopus Zic3,a primary regulator both in neural and neural crest development." Proc.Natl.Acad.Sci.94. 11980-11985 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morikawa,K.: "Transcription Initiation Sites and Promoter Structure of the Mouse Type 2 Inositol 1,4,5-Trisphospharate Receptor Gene." Gene.196. 181-185 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada,E.: "Generation and Characterization of Mice Lacking Gastrin-Releasing Peptide Receptor." Biochem.Biophys.Res.Comm.239. 28-33 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Taketo,M.: "Inositol-1,3,,4,5-tetrakisphosphate Binding Sites in Control and ras-Transformed NIH/3T3 Fibroblasts." Biochem.Biophys.Res.Commun.239. 349-352 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Lang,E.J: "The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic b-cells : action of synaptotagmin at low micromolar calcium." EMBO J.16. 5837-5846 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoneshima,H.: "A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin." Neuroscience Research.29. 217-223 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Konishl,Y: "Demonstration of an E-box and transcriptional regulation of the mouse type 1 Inositol 1,4,5-trisphosphate receptor gene." J.Neurochem.69. 476-484 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kojima,T.: "Characterization of the pleckstrin homology domain of Btk as an Inositol polyphosphate and phosphoinositide binding domain." Biochem.Biophys.Res.Comm.236. 333-339 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura,H.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory organ." Chemico-Biological Interactions.104. 1-9 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aruga,J.et.al.: "Mouse Zic1 is involved in cer ebeller development." J.Neurosci.18. 284-293 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Monkawa,T.et.al.: "Localization of inositol 1,4,5-trisphophate receptors in the rat kidney." Kidney Int.53. 296-301 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhao,H.et.al.: "Functional expression of a mammalian odor ant receptor." Science. 279. 237-242 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato,Y.et.al.: "Adenophostin,a potent agonist of the inositol 1,4,5-trisphosphate receptor, is useful for fertilization of mouse oocytes injected with round spermatids leading to normal offspring" Biology of Reproduction. 58. 867-873 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyamura,T.et.al.: "Metabolic labeling of a subset of glia cells by UDP-galactose : implication for astrocyte lineage diversity." J.Neurosci.Res.52. 173-183 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto-Hino,M.: "Apical vesicles bearing inositol 1,4,5-trisphosphate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland." J.Cell.Biol.141. 135-142 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] lbata,K.et.al.: "Inositol 1,3,4,5-Tetrakisphosphate binding activities of neural and non-neural synaptotagmins." J.Biol.Chem.273. 12 267-12 273 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue,T.et.al.: "Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar purkinje neurons" J.Neurosci.18. 5366-5373 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mathias,R.S.et.al.: "IP3 receptor blockade fails to prevent intracellular Ca2+ release by ET-1 and a-thrombin." Am.J.Physiol.274. C1456-C1465 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirota,J.et.al.: "T-cell receptor signalling in the inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice : is IP3R type 1 essential for T-cell-receptor signalling?" Biochem.J.333. 615-619 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuzono,S.et.al.: "Overproduction and immuno-affinity purification of myelin proteolipid protein. (PLP) ,an inositol hexakisphosphate binding protein,in a baculovirus expression system." Biochem.Biophys.Res.Commun.249. 66-72 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muto,A.et.al.: "Activation of inositol 1,4,5-trisphosphate receptors induces transient changes in cell shape of fertilized Xenopus eggs." Cell Motility and the Cytoskeleton. 39. 201-208 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakata,K.et.al.: "Xenopus Zic family and its role in neural and neural crest development." Mechanisms of Development. 75. 43-51 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakayama,T.et.al.: "Hemizygous deletion of the HPC-1/syntaxin 1A gene (STX1A) in patient with Williams syndrome." Cytogenet Cell Genet.82. 49-51 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshida,M.et.al.: "Role of two series of Ca2+ oscillations in activation of ascidian eggs." Developmenatal Biology. 203. 122-133 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Futatsugi,A.et.al.: "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins (1,4,5) P3 receptor." Biochem.J.334. 559-563 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hata,R.et.al: "Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils." Neuroscience. 83. 201-213 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takei,K.et.al.: "Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptor in growth cones." Science. 282. 1705-1708 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura,H.et.al.: "Molecular cloning and expression of cDNA encoding an olfactory-specific mouse phenol sulphotransferase." Biochem.J.331. 953-958 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshikawa,F.et.al.: "Cooperative formation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains." J.Biol.Chem.274. 328-334 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshikawa,F.et.al.: "Trypsinized cer ebellar inositol 1,4,5-trisphosphate receptor." J.Biol.Chem.274. 316-327 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kabayama,H.et.al.: "Functional involvement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglion neuron." Neuroscience. 88. 999-1003 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhu,C.et.al.: "Inosiotl 1,4,5-trisphosphate receptor down-regulation is activated directly by inositol 1,4,5-trisphosphate binding." J.Biol.Chem.274. 3476-3484 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Del Rio, J.A et al.: "A role for Cajal-Retzius cells and reelin in the development of hippocampal connections." Nature.385. 70-74 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Umemori, H.et al.: "Activation of the G Protein Gq/11 through tyrosine phosphorylation of the a subunit." Science.276. 1878-1882 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sheldon, M.et al.: "Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice." Nature.389. 730-733 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume, S et al.: "Role of Inositol1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos." Science.278. 1940-1943 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhao, H.et al.: "Functional expression of a mammalian odorant receptor." Science.279. 237-242 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ohara-Imaizumi, M et al.: "Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells" Proc.Natl.Acad.Sci.USA. 94. 287-291 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume, S et al.: "Developmental Expression of the Inositol 1,4,5-Trisphosphate Receptor and Structural Changes in the Endoplasmic Reticulum during Oogenesis and Meiotic Maturation of Xenopus laevis." Developmental Biology. 182. 228-239 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mehrotra, B et al.: "Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins." J.Biol.Chem.272. 4237-4244 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kume, S.et al.: "Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-triphosphate during early embryogenesis in Xenopus laevis." Mechanisms of Development.66. 157-168 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakata, K.et al.: "Xenopus Zic3, a primary regulator both in neural and neural crest development." Proc.Natl.Acad.Sci. 94. 11980-11985 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] *rikawa, K.et al.: "Transcription initiation Sites and Promoter Structure of the Mouse Type 2 Inositol 1,4,5-Trisphospharate Receptor Gene." Gene. 196. 181-185 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wada, E.et al.: "Generation and Characterization of Mice Lacking Gastrin-Releasing Peptide Receptor." Biochem.Biophys.Res.Comm.239. 28-33 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takeo, M.et al.: "Inositol-1,3, , 4,5-tetrakisphosphate Bindng Sites in Control and ras-Transformed NIH/3T3 Fibroblasts." Biochem.Biophys.Res.Commun.239. 349-352 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Lang, E.J et al.: "The first C2 domain of synaptotagmin is required or exocytosis of insulin from pancreatic b-cells : action of synaptotagmin at low micromolar calcium." EMBO J. 16. 5837-5846 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoneshima, H.et al.: "A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin." Neuroscience Research. 29. 217-232 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, H.et al.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory organ." Chemico-Biological Interactions. 104. 1-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Morita, N et al.: "Astrocytic Lineage Analysis by Detection of GFAP Promoter Activity in vitro." Developmental Neuroscience. 19. 210-218 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] D'Arcangelo, G et al.: "Reelin is a secred glycoprotein recognized by the CR-50 monoclonal antibody." J.Neurocsi.17. 23-31 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sayers, L.G et al.: "Intracellular targeting and homotetramerformation of a truncated inositol 1,4,5-trisphosphate receptor/green fluorescent protein chimera in Xenopus leavis oocytes." Biochem.J. 323. 273-280 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nagai, T.et al.: "The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation." Developmental Biology.182. 299-313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoneshima, H.et al.: "Ca2+ differently regulates the ligand-affinity st tes of type 1 and thpe3 inositol 1,4,5-trisphosphate receptors." Biochem.J. 322. 591-596 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tovey.S.C et al.: "Identification and characterization of inositol 1,4,5-trisphosphatereceprors in the rat testis." Cell Calcium.21. 311-319 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, H.et al.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory." Chemico-Biological Interactions.104. 1-9 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyata, T.et al.: "Regulation of Purkinje Cell Alignment by Reelin as Revealed with CR-50 Antibody." J.Neurosci.17. 3599-3609 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakayama, T et al.: "Mappping of the Human HPC-1/Syntaxin 1A Gene (STX1A) to Chromosome 7 Band q11.2." Genomics. 42. 173-176 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuda, M et al.: "Regulation by bivalent cations of phospholipid bindng to the C2A domain of synaptotagmin III" Biochem.J.323. 421-425 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mochida, S.et al.: "Roles of Synaptotagmin C2 Domains in Neurotransmitter secretionand inositol high-polyphosphate binding at mammalian cholinergic synapses." Neurosci.77. 937-943 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakajia, K et al.: "Distruption of hippocampal development in vivo by CR-50 mAb against reelin." Proc.Natl.Acad.Sci.94. 8196-8201 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Konishi, Y et al.: "Demonstration of an E-box and transcriptional regulation of the mouse type 1 Inositol 1,4,5-trisphosphate receptor gene." J.Neurochem.69. 476-484 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kojima, T.et al.: "Characterization of the pleckstrin homology domain of Btk as an Inositol polyphosphate and phosphoinositide binding domain." Biochem.Biophys.Res.Comm.236. 333-339 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hisatsume, C.et al.: "Phosphorylation-dependent Regulation of N-Methy1-D-asparate Receptors by calmodulin." J.Biol.Chem.272. 2085-20810 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruyama, T.et al.: "1APB,2-aminoethoxydiphenylborate, a membrance penetrable modulator on Ins (1,4,5) P3-induced Ca2+ release." J.Biochem.122. 498-505 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Maruyama, T.et al.: "Attenuation of intracellular Ca2+ and secretory responses by Ins (1,4,5) P3-induced Ca2+ release modulator, 2APB,in rat pancreatic acinar cells." Biomedical Research. 18. 297-302 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aruga, J.et al.: "Mouse Zic1 is involved in cerebeller development." J.Neurosci.18. 284-293 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Monkawa, T.et al.: "Localization of inositol 1,4,5-trisphophate receptors in the rat kidney." Kidney Int.53. 296-301 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhao, H.et al.: "Functional expression of a mammalian odorant receptor." Science. 279. 237-242 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sato, Y.et al.: "Adenophostin, apotent agonist of the inositol 1,4,5-trisphosphate receptor, is useful for fertilization of mouse oocytes injected with round spermatids leading to normal offspring." Biology of Reproduction. 58. 867-873 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Miyamura, T.et al.: "Metabolic labeling of a subset of glia cells by UDP-galactose : implication for astrocyte lineage diversity." J.Neurosci.Res.52. 173-183 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yamamoto-Hino, M.et al.: "Apical vesicles bearing inositol 1,4,5-trisphosphate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland." J.Cell.Biol.141. 135-142 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Ibata, K.et al.: "Inositol 1,3,4,5-tetrakisphosphate binding activities of neural and non-neural synaptotagmins." J.Biol.Chem.273. 12267-12273 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Inoue, T.et al.: "Type 1 inositol 1,4,5-trisphosphate receptor is requred for induction of long-term depressio in carebellar purkinje neurons." J.Neurosci.18. 5366-5373 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Mathias, R.S.et al.: "IP3 receptor blockade fails to prevent intracellular Ca2+ release *T-1 and a-thrombin." Am.J.Physiol.274. C1456-1465 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hirota, J.et al.: "T-cell receptor signallin in the inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice : is IP3R type 1 essential for T-cell-receptor signalling?" Biochem, J.333. 615-619 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Fukuzono, S.et al.: "Overproduction and immuno-affinity purification of myelin proteolipid protein (PLP), an inositol hexakisphosphate binding protein, in a baculovirus expression system." Biochem.Biophys.Res.Commun. 249. 66-72 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Muto, A., Mikoshiba, K.: "Activtion of inositol 1,4,5-trisphosphate receptors induces transient chages in cell shape of fertilized Xenopus eggs." Cell Motility and the Cytoskeleto. 39. 201-208 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Wakata, K.et al.: "Xenopus Zic family and its role in neural and neural crest development" Mechanisms of Development. 75. 43-51 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nakayama, T.et al.: "Hemizygous deletion of the HPC-1/syntaxin 1A gene (STX1A) in patient with Williams syndrome." Cytogenet Cell Genet.82. 49-51 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshida, M.et al.: "Role of two series of Ca2+ oscillations in activation of ascidian eggs." Developmental Biolog. 203. 122-133 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Futatsugi, A.et al.: "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins (1,4,5) P3 receptor." Biochem.J.334. 559-563 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hata, R.et al.: "Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils." Neuroscience. 83. 201-213 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takei, K.et al.: "Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptor in growth cones." Science. 282. 1705-1708 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Tamura, H.et al.: "Molecular cloning and expression of cDNA encoding an olfactory-specific mouse phenol sulphotransferase." Biochem.J.331. 953-958 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshikawa, F.et al.: "Cooperative formation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains." J.Biol.Chem.274. 328-334 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Yoshikawa, F.et al.: "Trypsinized cerebellar inositol 1,4,5-trisphosphate receptor." J.Biol.Chem.274. 316-327 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kabayama, H.et al.: "Functional involement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglin neuron." Neuroscience. 88. 999-1003 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Zhu, C.et al.: "Inosiotl 1,4,5-trisphosphate receptor down-regulation is activated directly by inositol 1,4,5-trisphosphate binding." J.Biol.Chem.274. 3476-3484 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Aruga, J.et.al.: "Mouse Zic1 is involved in cerebeller development." J.Neurosci.18. 284-293 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Monkawa, T.et.al.: "Localization of inositol 1,4,5-trisphophate receptors in the rat kidney." Kidney lnt.53. 296-301 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zhao, H.et.al.: "Functional expression of a mammalian odor ant receptor." Science. 279. 237-242 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sato, Y.et.al.: "Adenophostin, a potent agonist of the inositol 1,4,5-trisphosphate receptor, is useful for fertilization of mouse oocytes injected with round spermatids leading to normal offspring" Biology of Reproduction. 58. 867-873 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Miyamura, T.et.al.: "Metabolic labeling of a subset of glia cells by UDP-galactose : implication for astrocyte lineage diversity." J.Neurosci. Res.52. 173-183 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yamamoto-Hino, M.: "Apical vesicles bearing inositol 1,4,5-trisphospate receptors in the Ca2+ initiation site of ductal epithelium of submandibular gland." J.Cell.Biol.141. 135-142 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ibata, K.et.al.: "Inositol 1,3,4,5-Tetrakisphosphate binding activities of neural and non-neural synaptotagmins." J.Biol.Chem.273. 12267-12273 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inoue, T.et.al.: "Type 1 inositol 1,4,5-trisphosphate receptor is required for induction of long-term depression in cerebellar purkinje neurons" J.Neurosci.18. 5366-5373 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mathias, R.S.et.al.: "IP3 receptor blockade fails to prevent intracellular Ca2+ release by ET-1 and a-thrombin." Am.J.Physiol.274. C1456-C1465 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hirota, J.et.al.: "T-cell receptor signalling in the inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice : is IP3R type 1 essential for T-cell-receptor signalling?" Biochem. J.333. 615-619 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fukuzono, S.et.al.: "Overproduction and immuno-affinity purification of myelin proteolipid protein (PLP), aninositol hexakisphosphate binding protein, in a bacul ovirus expression system." Biochem.Biophys.Res.Commun.249. 66-72 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Muto, A.et.al.: "Activation of inositol 1,4,5-trisphosphate receptors induces transient changes in cell shape of fertilized Xenopus eggs." Cell Motility and the Cytoskeleton. 39. 201-208 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakata, K.et.al.: "Xenopus Zic family and its role in neural and neural crest development." Mechanisms of Development. 75. 43-51 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakayama, T.et.al.: "Hemizygous deletion of the HPC-1/syntaxin 1A gene (STX1A) in patient with Williams syndrome." Cytogenet Cell Genet.82. 49-51 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshida, M.et.al.: "Role of two series of Ca2+ oscillations in activation of ascidian eggs." Developmenatal Biology. 203. 122-133 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Futatsugi, A.et.al.: "Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 ins (1,4,5) P3 receptor." Biochem.J.334. 559-563 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hata, R.et.al.: "Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils." Neuroscience. 83. 201-213 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Takei, K.et.al.: "Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptor in growth cones." Science. 282. 1705-1708 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tamura, H.et.al.: "Molecular cloning and expression of cDNA encoding an olfactory-specific mouse phenol sulphotransferase." Biochem.J.331. 953-958 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshikawa, F.et.al.: "Cooperative for mation of the ligand-binding site of the inositol 1,4,5-trisphosphate receptor by two separable domains." J.Biol.Chem.274. 328-334 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshikawa, F.et.al.: "Trypsinized cer ebellar inositol 1,4,5-trisphosphate receptor." J.Biol.Chem.274. 316-327 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kabayama, H.et.al.: "Functional involvement of synaptotagmin I/II C2A domain in neurite outgrowth of chick dorsal root ganglion neuron." Neuroscience. 88. 999-1003 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zhu, C.et.al.: "Inosiotl 1,4,5-trisphosphate receptor down-regulation is activated directly by inositol 1,4,5-trisphosphate binding." J.Biol.Chem.274. 3476-3484 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Del Rio,J.A: "A role for Cajal-Retzius cells and reelin in the developement of hippocampal connections." Nature.385. 70-74 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Umemori,H.: "Activation of the G Protein Gq/11 through tyrosine phosphorylation of the a subunit." Science.276. 1878-1882 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sheldon,M.: "Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice." Nature.389.730-733 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kume,S: "Role of Inositol 1,4,5-Trisphosphate Receptor in Ventral Signaling in Xenopus Embryos." Science.278.1940-1943 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Zhao,H.: "Functional expression of a mammalian odorant receptor." Science.279. 237-242 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] D'Arcangelo,G: "Reelin is a secred glycoprotein recognized by the CR-50 monoclonal antibody." J.Neurosci..17.23-31 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ohara-ImaizumiM: "Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells." Proc.Natl.Acad.Sci.USA.94.287-291 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kume,S: "Developmental Expression of the Inositol 1,4,5-Trisphosphate Receptor and Structural Changes in the Endoplasmic Reticulum during Oogenesis and Meiotic Maturation of Xenopus laevis." Developmental Biology.182.228-239 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mehrotra,B: "Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins." J.Biol.Chem.272.4237-4244 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morita,N: "Astrocytic Lineage Analysis by Detection of GFAP Promoter Activity in vitro." Developmental Neuroscience.19.210-218 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Sayers,L.G: "Intracellular targeting and homotetramer formation of a truncated inositol 1,4,5-trisphosphatereceptor/green fluorescent protein chimera in Xenopus leavis oocytes." Biochem.J.323.273-280 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nagai,T.: "The expression of the mouse Zic 1,Zic 2,and Zic 3 gene suggests an essential role for Zic genes in body pattern formation." Developmental Biology.182.299-313 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoneshima,H.: "Ca2+ differetly regulates the ligand-affinity ststes of type 1 and type 3 inositol 1,4,5-trisphosphate receptors." Biochem.J.322.591-596 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tovey.S.C: "Identification and characerization of inositol 1,4,5-trisphosphate receprors in the rat testis." Cell Calcium.21.311-319 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Hisatsume,C.: "Phosphorylation-dependent Regulation of N-Methy1-D-asparate Receptors by calmodulin." J.Biol.Cehm.272.20805-20810 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maruyama,T.: "2APB,2-aminoethoxydiphenyl borate,a membrance penetrable modulator of Ins (1,4,5) P3-induced Ca2+ release." J.Biochem.122.498-505 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Maruyama,T.: "Attenuation of intracellular Ca2+ and secretory responses by Ins (1,4,5) P3-induced Ca2+ release modulator,2APB,in rat pancreatic acinar cells." Biomedical Research.18. 297-302 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kume,S.: "Developmental expression of the inositol 1,4,5-trisphosphate receptor and localization of inositol 1,4,5-trisphosphate during early embryogenesis in Xenopus laevis." Mechanisms of Development.66.157-168 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakata,K.: "Xenopus Zic3,a primary regulator both in neural and neural crest development." Proc.Natl.Acad Sci.94.11980-11985 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Morikawa,K.: "Transcription Initiation Sites and Promoter Structure of the Mouse Type 2 Inositol 1,4,5-Trisphospharate Receptor Gene." Gene.196.181-185 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Wada,E.: "Generation and Characterization of Mice Lacking Gastrin-Releasing Peptide Receptor." Biochem.Biophys.Res.Comm.239.28-33 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Taketo,M.: "Inositol-1,3,4,5-tetrakisphosphate Binding Sites in Control and ras-Transformed NIH/3T3 Fibroblasts." Biochem.Biophys.Res.Commun.239. 349-352 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Lang,E.J: "The first C2 domain of synaptotagmin is required for exocytosis of Insulin from pancreatic b-cells : action of synaptotagmin at low micromolar calcium." EMBO J.16.5837-5846 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yoneshima,H.: "A novel neurological mutant mouse,yotari,which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin." Neuroscience Research.29.217-223 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tamura,H.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory." Chemico-Biological Interactions.104.1-9 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Miyata,T.: "Regulation of Purkinje Cell Alignment by Reelin as Revealed with CR-50 Antibody." J.Neurosci.17.3599-3609 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakayama,T: "Mapping of the Human HPC-1/Syntaxin 1A Gene (STX1A) to Chromosome 7 Band q11.2." Genomics.42.173-176 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Fukuda,M: "Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III." Biochem.J.323. 421-425 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mochida,S.: "Roles of Synaptotagmin C2 Domains in Neurotransmitter secretion and inositol high-polyphosphate binding at mammalian cholinergic synapses." Neurosci.77. 937-943 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakajima,K: "Distruption of hippocampal development in vivo by CR-50 mAb against reelin." Proc.Natl.Acad.Sci.94. 8196-8201 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Konishi,Y: "Demonstration of an E-box and transcriptional regulation of the mouse type 1 Inositol 1,4,5-trisphosphate receptor gene." J.Neurochem.69. 476-484 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kojima,T.: "Characterization of the pleckstrin homology domain of Btk as an Inositol polyphosphate and phosphoinositide binding domain." Biochem.Biophys.Res.Comm.236. 333-339 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tamura,H.: "High sulfotransferase activity for phenolic aromatic odorants present in the mouse olfactory organ." Chemico-Biological Interactions.104.1-9 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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