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Mechanisms for temporal control of voluntary movements by the cerebral cortex.

Research Project

Project/Area Number 09308032
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionTohoku University

Principal Investigator

TANJI Jun  Tohoku Univ., Sch.Med.Dept.Physiol., Professor, 大学院・医学系研究科, 教授 (10001885)

Co-Investigator(Kenkyū-buntansha) SHIMA Keisetsu  Tohoku Univ., Sch.Med.Dept.Physiol., Research Associate, 大学院・医学系研究科, 助手 (60124583)
MUSHIAKE Hajime  Tohoku Univ., Sch.Med.Dept.Physiol., Associate Professor, 大学院・医学系研究科, 助教授 (80219849)
Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥27,700,000 (Direct Cost: ¥27,700,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1999: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1998: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1997: ¥14,700,000 (Direct Cost: ¥14,700,000)
KeywordsProcedure for Multiple Movements. / Cerebral Cortex / supplementary motor area / primary motor area / neuronal activity / temporal sequencing of movements / primate / pre-supplementary motor area
Research Abstract

We performed a series of experiments to investigate participation of prefrontal cortex and premotor areas as planned, and then carried out additional sets of experiments to extend our originally planned study. All studies turned out to be successful, yielding findings and results that were published as scientific papers. Starting from our findings that medial frontal motor areas, presupplementary motor and supplementary motor areas, are critically involved in organizing temporal sequence of multiple movements, we analyzed cellular activity in these areas. We found that the supplementary motor area includes cells that are acting to link events in a time series, whereas cells in the presupplementary motor area express the rank order of movements to be performed, and also signify up-dating of forthcoming sequences. We subsequently analyzed cellular activity in the prefrontal cortex to clarify its role on integrating information stored in memory (past information), currently available sensory information (present information), and the nature of forthcoming movement (future information). We found that cellular activity expressing the past and present information are integrated to produce the future information inside the prefrontal cortex. Furthermore, we conducted experiments to reveal the role of premotor cortex in planning the spatial target and the body part to be used for a forthcoming target-reaching movement. We found cellular activity that reflect the process of integrating spatial-target and body-part information necessary to plan future movements.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] Mushiake,H.,Tanatugu,y.,and Tanji,J.: "Neuronal activity in the ventral part of premotor cortex during target-reach movement is modulated by direction of gaze"J.Neurophysiol.. 78. 567-571 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Inase,M.,LiBM,and Tanji,J.: "Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task."Exp Brain Res.. 117. 207-218 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fujii,N.,Mushiake,H.and Tanji,J.: "Intracortical microstimulation of bilateral frontal eye field."J Neurophysiol.. 79. 2240-2244 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kawashima R.Tanji J.Okada K.Sugiura.M.Sato,K..Kinomura.S..Inoue.K..Ogawa A..& Fukuda H.: "Oculomotor sequence learning:a positron emission tomography study."Exp Brain Res.. 133. 1-8 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shima,K.,and Tanji,J.: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortex to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkey"Jpn J Physiol.. 48. 275-90 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shima,K.,and Tanji,J.: "Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements"J Neurophysiol.. 80. 3247-3260 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hoshi,E.,Shima,K.,and Tanji,J.: "Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex."J Neurophysiol.. 80. 3392-3397 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fujii,N,,Mushiake,H.and Tanji,J.: "An oculomotor representation area within the ventral premotor cortex."Proc Natl Acad Sci U S A.. 95. 12034-12037 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shima,K.,and Tanji,J.: "Role for cingulate motor area cells in voluntary movement selection based on reward."Science.. 282. 1335-1338 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sakai,ST.,Inase,M.,Tanji,J.: "Pallidal and cerebellar inputs to thalamocortical neurons projecting to the supplementary motor area in Macaca fuscata:a triple-labeling light microscopic study."Anat Embryol(Berl). 199. 9-19 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mushiake,H.,Fujii,N.,Tanji,J: "Microstimulation of the lateral wall of the intraparietal sulcus compared with the frontal eye field during oculomotor tasks."J Neurophysiol. 81. 1443-1448 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Fujii,N.,Mushiake,H.,Tanji,J.: "Rostrocaudal distinction of the dorsal premotor area based on oculomotor involvement."J.Neurophysiol.. 83. 1764-1769 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hoshi,E.,Shima,K.,Tanji,J.: "Neuronal activity in the primate prefrontal cortex in the process of motor selection based on two behavioral rules."J.Neurophysiol. 83. 2355-2373 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shima,K.,Tanji,J.: "Neuronal activity in the supplementary and presupplementary motor areas for temporal organization of multiple movements."J.Neurophysiol. 84. 2148-2160 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hoshi,E.,Tanji,J.: "Integration of target and body-part information in the premotor cortex when planning action."Nature. 408. 466-470 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Wang,Y.,Shima,K.,Sawamura,H.,Tanji,J.: "Spatial distribution of cingulated cells projecting to the primary,supplementary,and pre-supplementary motor areas:a retrograde multiple labeling study in the macaque monkey."Neuroscience Res.. 39. 39-49 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Jun Tanji: "Sequntiql ortanization of multiple movements:Involvement of cortical motor areas."Annual Reviews Neurosci.. 24. 631-651 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanji,J.& Hoshi,E: "Behavioral planning in the prefrontal cortex."Curent Opinion in Neurobiology. 11(In press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 丹治順: "脳科学大事典"朝倉書店(東京). 9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Tagawa, M.Kano, N.Okamura, M.Higuchi, M.Matsuda, Y.Mizuki, H.Arai, T.Fujii, S.Komemushi, M.Itoh, H.Sasaki, T.Watanabe, and K.Yanai: "Differential cognitive effects of ebastine and d-chlorpheniramine in healthy subjects : Correlation between psychomotor performance and plasma concentration."Br.J.Clin.Pharmacol. (In press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Tagawa, M.Kano, N.Okamura, M.Higuchi, M.Matsuda, Y.Mizuki, H.Arai, R.Iwata, T.Fujii, S.Komemushi, T.Ido, M.Itoh, H.Sasaki, T.Watanabe, and K.Yanai.: "Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET) : A comparative study of ebastine, a second-generation antihistamine, and d-chlorpheniramine, a classical antihistamine."Br.J.Clin.Pharmacol.. (In press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Iwata, C.Pascali, A.Bogni, Y.Miyake, K.Yanai, and T.Ido: "A simple loop method for the automated preparation of [^<11>C] raclopride from [^<11>C] methyl triflate."Applied Radiation Isotopes. 55. 23-28 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Higuchi, K.Yanai, N.Okamura, K.Meguro, H.Arai, M.Itoh, R.Iwata, T.Ido, T.Watanabe, and H.Sasaki: "Histamine H1 receptors in patients with Alzheimer's disease assessed by positron emission tomography (PET)."Neuroscience. 99. 721-729 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Iwata, G.Horvath, C.Pascali, A.Bogni, K.Yanai, Z.Kovacs, and T.Ido: "Synthesis of 3-[1H-imidazol-4-yl] propyl4-[^<18>F] fluorobenzyl ether ([^<18>F]fluroroproxyfan) : A potential radioligand for imaging histamine H3 receptors."J.Labelled Compd.Radiopharm. 43. 873-882 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] M.Tagawa, M.Kano, N.Okamura, M.Itoh, E.Sakurai, T.Watanabe, and K.Yanai: "Relationship between effects of alcohol on psychomotor performances and blood alcohol concentrations."Jap.J.Pharmacol.. 83. 253-260 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] N.Okamura, K.Yanai, M.Higuchi, J.Sakai, R.Iwata, T.Ido, H.Sasaki, T.Watanabe, M.Itoh.: "Functional neuroimaging of cognition impaired by a classical antihistamine, d-chlorpheniramine."Br.J.Pharmacol.. 129. 115-123 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] R.Iwata, C.Pascali, A.Bongi, G.Horvath, Z.Kovacs, K.Yanai and T.Ido.: "A new, convenient method for the preparation of 4-[^<18>F] fluorobenzyl halides."Appl.Radiat.Isot.. 52. 87-92 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Yanai, N.Okamura, M.Tagawa, M.Itoh, and T.Watanabe.: "New findings in pharmacological effects induced by antihistamines : From PET studies to knockout mice."Clin Exp Allergy. 29(Suppl 3). 29-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] T.Nakamura, Y.Hayashi, H.Watabe, M.Matsumoto, T.Horikawa, T.Fujiwara, M.Itoh and K.Yanai.: "Estimation of organ cumulated activities and absorbed doses on intakes of several ^<11>C labeled radiopharmaceuticals from external measurement with thermoluminescent dosimeters."Phys.Med.Biol.. 43. 389-405 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Meguro, M.Itoh, K.Yanai, K.Takase, S.Yamaguchi, T.Ido, and A.Yamadori.: "Psychiatric wandering behavior in dementia patients correlated with increased striatal dopamine D2 receptor as shown by [11C]YM-09151-2 and positron emission tomography."Eur.J.Neurol.. 4. 221-226 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Mushiake,H.,Tanatugu,y.,and Tanji,J.: "Neuronal activity in the ventral part of premotor cortex during target-reach movement is modulated by direction of gaze"J.Neurophysiol.. 78. 567-571 (1997)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inase,M.,Li BM,and Tanji,J.: "Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed Go/Nogo task."Exp Brain Res.. 117. 207-218 (1997)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujii,N.,Mushiake,H.and Tanji,J.: "Intracortical microstimulation of bilateral frontal eye field."J Neurophysiol.. 79. 2240-2244 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawashima R.,Tanji J.,Okada K.,Sugiura,M.,Sato,K.,Kinomura,S.,Inoue.K.,Ocawa A.,& Fukuda H.: "Oculomotor sequence learning : a positron emission tomography study."Exp Brain Res.. 133. 1-8 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shima,K.,and Tanji,J.: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortex to input from the supplementary motor area and somatosensory cortex : studies of task-performing monkeys."Jpn J Physiol.. 48. 275-90. (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shima,K.,and Tanji,J.: "Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements"J Neurophysiol.. 80. 3247-3260 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hoshi,E.,Shima,K.,and Tanji,J.: "Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex."J Neurophysiol.. 80. 3392-3397 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujii,N,,Mushiake,H.and Tanji,J.: "An oculomotor representation area within the ventral premotor cortex."Proc Natl Acad Sci U S A.. 95. 12034-12037 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shima,K.,and Tanji,J.: "Role for cingulate motor area cells in voluntary movement selection based on reward."Science.. 282. 1335-1338 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sakai,ST.,Inase,M.,Tanji,J.: "Pallidal and cerebellar inputs to thalamocortical neurons projecting to the supplementary motor area in Macaca fuscata : a triple-labeling light microscopic study."Anat Embryol(Berl). 199. 9-19 (1998)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mushiake,H.,Fujii,N.,Tanji,J: "Microstimulation of the lateral wall of the intraparietal sulcus compared with the frontal eye field during oculomotor tasks."J Neurophysiol. 81. 1443-1448 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujii,N.,Mushiake,H.,Tanji,J.: "Rostrocaudal distinction of the dorsal premotor area based on oculomotor involvement."J.Neurophysiol.. 83. 1764-1769 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hoshi,E.,Shima,K.,Tanji,J.: "Neuronal activity in the primate prefrontal cortex in the process of motor selection based on two behavioral rules."J.Neurophysiol. 83. 2355-2373 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shima,K.,Tanji,J.: "Neuronal activity in the supplementary and presupplementary motor areas for temporal organization of multiple movements."J.Neurophysiol. 84. 2148-2160 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hoshi,E.,Tanji,J.: "Integration of target and body-part information in the premotor cortex when planning action."Nature. 408. 466-470 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Wang,Y.,Shima,K.,Sawamura,H.,Tanji,J.: "Spatial distribution of cingulated cells projecting to the primary, supplementary, and pre-supplementary motor areas : a retrograde multiple labeling study in the macaque monkey."Neuroscience Res.. 39. 39-49 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Jun Tanji: "Sequntiql ortanization of multiple movements : Involvement of cortical motor areas."Annual Reviews Neurosci.. 24. 631-651 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanji,J.& Hoshi,E: "Behavioral planning in the prefrontal cortex."Curent Opinion in Neurobiology. 11(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 丹治順: "脳科学大事典"朝倉書店(東京). 9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mushiake H.,Fujii N.,Tanji J.: "Microstimulation of the lateral wall of the intraparietal sulcuscompared with the frontal eye field during oculomotor tasks"J. Neurophysiol. 81. 1143-1148 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sakai ST.,Inase M.,Yanji J.: "Pallidal and cerebellar inputs to thalamocortical neurons projecting to the supplementarymotor area in Macaca fuscata: a triple-labeling light microscopic study"Anat.Embryol. 199. 9-19 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shima K,& Tanji,J.: "Role for cingulate motor area cells in voluntary movement selection based on reward." Science.282. 1335-1338 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hoshi E.,Shima K.,& Tanji,J.: "Task-dependent selectivity of movement-related neuronal activity in the primate prefrontal cortex." J Neurophysiol.80. 3392-3397 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shima K.,& Tanji,J.: "Both supplementary and presupplementary motor areas are crucial for the temporal organization of multiple movements." J Neurophysiol.80. 3247-3260 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawashim aR,Tanji J,Inoue K,Fukuda: "Oculomotor sequence learning: a positron emission tomography study." Exp Brain Res.122. 1-8 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Shima K,& Tanji,J.: "Involvement of NMDA and non-NMDA receptors in the neuronal responses of the primary motor cortex to input from the supplementary motor area and somatosensory cortex: studies of task-performing monkeys." Jpn J Physiol.48. 275-290 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujii N.,Mushiake.,H.& Tanji J.: "An oculomotor representation area within the ventral premotor cortex." Proc Natl Acad Sci USA.95. 12034-12037 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Fujii N.,Mushiake,H.& Tanji,J.: "Intracortical microstimulation of bilateral frontal eye field." J Neurophysiol.79. 2240-2244 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 丹治 順: "補足運動野と手の運動の順序制御" 神経進歩. 42. 29-38 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 虫明 元: "前補足運動野と手の運動のプランニング" 神経進歩. 42. 39-48 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Mushiake H, Tanatsugu Y, Tanji J.: "Neuronal activity in the ventral part of premotor cortex during target-reach movement is modulated by direction of gaze." Journal of Neurophysiology. 78. 567-571 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Inase M, Li B-M, Tanji J.: "Dopaminergic modulation of neuronal activity in the monkey putamen through D1 and D2 receptors during a delayed go/nago task" Experimental Brain Research. 117. 207-218 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tanji J, Shima K, Mushiake H.: "Brain and Mind" M.Ito, 223-232 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 丹治 順: "医学書院" 岩本 誠,寺本 明,清水輝夫, 134- (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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