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Malaria transmission blocking with reference to gametocyte

Research Project

Project/Area Number 09309010
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 広領域
Research InstitutionJichi medical School

Principal Investigator

ISII Akira  Jichi Medical School, Department of Medical Zoology, Prof., 医学部, 教授 (40012752)

Co-Investigator(Kenkyū-buntansha) CHINZEI Yasuo  Mie University, School of Medicine, Department of Medical Zoology, Prof., 医学部, 教授 (60024709)
KAWAMOTO Fumihiko  Nagoya University, School of Medicine, Department of International Health, Ass.Prof., 医学部, 助教授 (40115556)
MATSUOKA Hiroyuki  Jichi Medical School, Department of Medical Zoology, Ass.Prof., 医学部, 助教授 (10173816)
SUGURI Setsuo  Kagawa Medical University, Department of Medical Zoology, Ass.Prof., 医学部, 助教授 (00032897)
KAWABATA Masato  Kobe University, School of Medicine, International Medical Center.Prof., 医学部, 教授 (30175294)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 1999: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1998: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1997: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordsmalaria / gametocyte / malaria control / epidemiology / primaquine / G6PD / TRAP / GIS / マラリア対策 / 伝播 / 蚊 / 対策 / ワクチン / ベクター
Research Abstract

Sporozoites were found to enter in the intestinal system. Sporozoites were demonstrated in prediuresis fluid. Changes in salivary gland components after the feeding process were chased and a salivary gland specific band was cloned. It has 30% homology with a allergen from salivary gland of Aedes aegypti, Detection of sporozoites in mosquito was made possible by the use of PCR. Gametocyte formation was found to be enhanced with increase of hamatocrit in culture. Superoxide was found to affect oocyst formation in P47 knockout mice. Chitinase was found to play roles in oocyst formation. A adhesion molecule on ookinate surface was found crucial on invasion into the midgut. IgG subclass found to differ in host immune reactions to malaria antigen. Some more vaccine candidate molecules such as neutrophil chemotactic factor were investigated with a hope of transmission blocking. Chemotherapeutic malaria control was attempted with simple diagnostic kit and G6PD deficiency detection kit (SSS -system). Chemotherapy was done for blood positives with chloroquine and primaquine to kill gametocytes. This was proved to be effective in the field and promising in computer simulation with a mathematical epidemiology model. GIS was applied to analyze transmission capability of the field.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (75 results)

All Other

All Publications (75 results)

  • [Publications] Tantular.S., et al: "Field trials of a rapid test for G6PD deficieny in combination with a rapid diagnosis of malaria."Trop.Med.Internat. Hlth.. 4(4). 245-250 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii,A., et al: "Chemotherapeutic malaria control as a slelective primary bealth care activity with cost analysis in the Solomon Islands."Parassitologia. 41(1/3). 383-384 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S.Yoshida, et al: "A single-chain antibody fragment specific for the Plasmodium berghei ookinate protein Pbs21 confers transmission blockade in the mosquito midgut."Mol.Biochem.Parasitol.,. 104(2). 195-204 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明、他: "選択的プライマリーヘルスケアにおけるマラリア対策方法の検討:ソロモン諸島における治療対策の試みと費用分析。"国際保健医療. (印刷中). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fu,J., et al: "A simple screening method detecting bindings between oligopeptides and HLA-DR molecules on filter papers."Microbiol.Immunol.. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Luo,E, et al: "Changes of salivary proteins during feeding and detection of salivary proteins in the midg after feeding in a malaria vector mosquito,Anopheles stephensi (Diptera:Culicidae)."Med.Ent.Zool.,. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tantular,I.S., et al: "Field survey of malaria the Flores island,East Nusa Tenggara Province,Indonesia, and detection of Plasmodium malariae and P.ovale using two PCR-based diagnoses."Folia Medica Indonesia,. 35. 38-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Da Silveria,L.A., et al: "Allelic diversity and antibody recognition of Plasmodium falciparum merozoite surface protein l during hypoendemic malaria transmission in the Brazilian Amazon region."Infection & Immunity,. 67. 5906-5916 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 川本文彦、他: "マラリア原虫を見落とすな-アクリジンオレンジ染色。"臨床検査. 43. 1625-1629 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kawamoto,F., et al: "How prevalent are Plasmodium ovale and P.malariae in east Asia?"Parasitol.Today. 15. 422-426 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fu J, et al: "Epitope-specific impairment of production of antibody against merozoite sueface glycoprotein 1 of Plasmodium falciparum in symptomatic patients with malaria."Parasitology Research,. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fu J, et al: "A simple screening method detecting bindings between oligopeptides and HLA-DR molecules on filter papers:Possible application for mapping of putative helper T cell epitopes on MSP1 of Plasmodium falciparum."Microbiology and Immunology,. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Yuda, et al: "Structure and expression of an adhesive protein-like molecule of mosquito invasive-stage malaria parasite."J.Exp.Med.. 189. 1947-1952 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Yuda, et al: "Targetted disruption of the Plasmodium berghei CTRP gene reveals its essential role in malaria infection of the vector mosquito."J.Exp.Med.. 190. 1711-1715 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明、他: "マラリア学100年会議(Malariology Centenary Conference)"医学のあゆみ. 188(8). 806-811 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明: "世界保健機構(WHO)の新しい国際寄生虫病対策戦略 特集:地球規模での寄生虫病対策の時代"医学のあゆみ. 191(1). 3-6 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明: "マラリア対策と日本の協力,国際医療協力を考える"第25回医学会総会 会誌III. III. 382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明: "4類感染症の診断と治療の進め方,マラリア"Medical Practice. 16(11). 1813-1816 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.Ishii,N.Nihei & M.Sasa(ed): "Malaria Reseasch in the Solomon Jslands."Inter Group.. 192 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 石井明、鎮西康雄、太田伸生: "標準医動物学"医学書院. 309 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fu, M. Kunimitsu, J. L. Leafasia, N. Kere, K. Tanabe, K. Hirayama, Ishii, A. Saitoh-Ito, M. Sasaki and N. Ohta: "MSPI-reactive T cells in individuals in malaria Solomon area and in non-immune Japanese"Parasitology International. 46(1). 7-16 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] C. M. Rzepczyk, K. Hale, N. Woodroffe, A. Bobogare, P. Csurhes, A. Ishii and A. Ferrante: "Humoral immune responses of Solomon Isalnders to the merozoite surface antigen 2(MSA2, MSP2) of Plasmodium falciparum show pronounced skewing towards anitibodies of the Ig G3 subclass"Infect.Immun.. 65(3). 1098-1100 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsuok, H., H. Matsubara, P. Waidhet, T. Hashiimoto, A. Ishii, Y. Saito, K. Ando and Y. Chinzei: "Depletion of salivary gland proteins in Anopheles stephensi (Diptera:culicidae) on blood feeding, and induction of antibodies to the proteins in mice being fed"Med.Entomol.Zool.. 48(3). 211-218 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakazawa, M., H. Ohmae, A. Ishii, J. Leafasia: "Malaria infection and human behavioral factors : A stochastic model analysis for direct observation data in the Solomon Islands"Am.J.Human Biol.. 10. 781-789 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A. Yoshida, A. Ishii, J. L. Leafasia, D. Zhou, E. Chen, L. Tang, C. Lie, D. Qiu, H. Ohmae and N. Ohta: "Polymorphism of Tumor Necrosis Factor α gene in the Melanesian and East-Asian populations"Immunogenetics. 47(6). 497-498 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tantular. S., K. Iwai, Klin, S. Basuki, T. Horie, H. H. Htay, H. Matsuoka, H. Marwoto, C. Wongsrichanalai, Y. O. Dachlan, S. Kojima, A. Ishii & F. Kawamoto: "Field trials of a rapid test for G6PD deficieny in combination with a rapid diagnosis of malaria"Trop.Med.Internat.Hlth.. 4(4). 245-250 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii, A., N. Nagai, M. Arai, M. Kawabata, T. Matsuo, A. Bobogare & J. Leafasia: "Chemotherapeutic malaria control as a slelective primary health care activity with cost analusis in the Solomon Islands"Parassitologia. 41(1/3). 383-384 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] S. Yoshida, H. Matsuoka, E. Luo, K. Iwai, M. Arai, R. E. Sinden and A. Ishii: "A single-chain antibody fragment specific for the Plasmodium berghei ookinate protein Pbs21 confers transmission blockade in the mosquito midgut"Mol.Biochem.Parasitol.. 104(2). 195-204 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishikawa, H., A. Ishii and A. Kaneko: "The prevalence of Plasmodium vivax in Vanuatu Islands : Computer simulation of malaria control trials"J.Faculty Environmental Science and Technology, Okayama University. 5(1). 1-6 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fu, J., Hato, M., Igarashi, K., Suzuki, T., Matsuoka, H., H., Ishii, A., Leafasia, J., Chinzei, Y., Ohta, N.: "A simple screening method detecting bindings between oligopeptides and HLA-DR molecules on filter papers"Microbiol.Immunol.. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Luo, E., H. Matsuoka, D. Yoshida, K. Iwai, M. Arai and A. Ishii: "Changes of salivary proteins during feeding and detection of salivary proteins in the midgut after feeding in a malaria vector mosquito, Anopheles stephensi (Diptera:Culicidae )"Med.Ent.Zool.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akira Ishii: "Medical Information on the Solomon Islands p17-18. Ishii, Nihei & Sasa(ed.) "Malaria Research In The Solomon Islands""Inter Group Co., Tokyo. 192 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tantular. S., et al: "Field trials of a rapid test for G6PD deficieny in combination with a rapid diagnosis of malaria"Trop. Med. Internat. Hlth.. 4(4). 245-250 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishii, A., et al: "Chemotherapeutic malaria control as a slelective primary health care activity with cost analysis in the Solomon Islands"in the Solomon Islands.. 41(1/3). 383-384 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] S. Yoshida, et al: "A single-chain antibody fragment specific for the Plasmodium berghei ookinate protein Pbs21 confers transmission blockade in the mosquito midgut"Mol. Biochem. Parasitol.,. 104(2). 195-204 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石井 明、 他: "選択的プライマリーヘルスケアにおけるマラリア対策方法の検討:ソロモン諸島における治療対策の試みと費用分析"国際保健医療. (印刷中). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fu, J., et al: "A simple screening method detecting bindings between oligopeptides and HLA-DR molecules on filter papers"Microbiol. Immunol.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Luo, E., et al: "Changes of salivary proteins during feeding and detection of salivary proteins in the midgut after feeding in a malaria vector mosquito, Anopheles stephensi (Diptera : Culicidae)"Med. Ent. Zool.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Tantular, I. S., et al: "Field survey of malaria at the Flores island, East Nusa Tenggara Province, Indonesia, and detection of Plasmodium malariae and P. ovale using two PCR-based diagnoses"Folia Medica Indonesia. 35. 38-42 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Da Silveria, L. A., et al: "Allelic diversity and antibody recognition of Plasmodium falciparum merozoite surface protein I during hypoendemic malaria transmission in the Brazilian Amazon region"Infection & Immunity,. 67. 5906-5916 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 川本文彦、 他: "マラリア原虫を見落とすな-アクリジンオレンジ染色"臨床検査. 43. 1625-1629 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kawamoto, F., et al: "How prevalent are Plasmodium ovale and P. malariae in east Asia ?"Parasitol. Today. 15. 422-426 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fu J, et al: "Epitope-specific impairment of production of antibody against merozoite surface glycoprotein 1 of Plasmodium falciparum in symptomatic patients with malaria"Parasitology Research. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Fu J. et al: "A simple screening method detecting bindings between oligopeptides and HLA-DR molecules on filter papers : Possible application for mapping of putative helper T cell epitopes on MSP1 of Plasmodium falciparum"Microbiology and Immunology. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Yuda, et al: "Structure and expression of an adhesive protein-like molecule of mosquito invasive-stage malaria parasite"J. Exp. Med.. 189. 1947-1952 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M. Yuda, et al: "Targetted disruption of the Plasmodium berghei CTRP gene reveals its essential role in malaria infection of the vector mosquito"J. Exp. Med.. 190. 1711-1715 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石井 明、 他: "マラリア学100年会議 (Malariology Centenary Conference)"医学のあゆみ. 188(8). 806-811 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石井 明: "世界保健機構(WHO)の新しい国際寄生虫病対策戦略 特集:地球規模での寄生虫病対策の時代"医学のあゆみ. 191(1). 3-6 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石井 明: "マラリア対策と日本の協力,国際医療協力を考える"第25回医学会総会 会誌III. III. 382 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 石井 明: "4類感染症の診断と治療の進め方,マラリア"Medical Practice. 16(11). 1813-1816 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Liu,Q.,et al.: "Sequence variation in small subunit ribosomal RNA gene of Plasmodium malariae and its local prevalence in Sichuan,China." J.Clin.Microbiol.36. 3378-3381 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ferreira,M.U., et al.,: "Allelic diversity at the merozoite surface protein-1(MSP-1)locus in natural Plasmodium falciparum populations: A brief overview." Mem.Inst.Oswald Cruz.93. 631-638 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ferreira,M.U.,et al.: "Allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southwestern Brazilian Amazon." Am.J.Trop.Med.Hyg.59. 474-480 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zhou,M.,et al.: "High prevalence of Plasmodium malariae and P.ovale in malaria patients along the Thai-Myanmar Border,as revealed by acridine orange staining and PCR-based diagnoses." Trop.Med.& Int.Health. 3. 304-312 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ferreira,M.U., et al.: "Stable patterns of allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from Southern Vietnam." J.Eukaryotic Microbiol.45. 131-136 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 川本文彦ら: "アクリジンオレンジ染色によるマラリアの迅速診断法" 臨床検査. 42. 243-247 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tantular I.S.,et.al.: "Field trials of a repid test for G6PD deficiency in combination with a rapid diagnosis of malaria." Trop.Med.& Int.Health. (in press.).

    • Related Report
      1998 Annual Research Report
  • [Publications] Ferreira,M.U., et al.: "Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple clone Plasmodium falciparum infections in northem Tanzania." J.Parasitol.(in press.).

    • Related Report
      1998 Annual Research Report
  • [Publications] 石井明(分担): "疫学ハンドブック" 柳川洋ら 南江堂, 374 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akira Ishii: "“Malaria Research In The Solomon Islands"" Ishii,Nihei & Sasa Inter Group Co., 192 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 石井明(分担): "標準医動物学 第2版" 石井、鎮西、太田 医学書院, 309 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] A.Ishii, N.Ohta et al.: "MSP1-reactive T cells in individuals in Malaria endemic Solomon area and in non-immune Japanese." Parasitology International. 46・1. 7-16 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Ishii et al.: "Humoral immune responses of Solomon lslanders to the merozoite surface antigen 2(MSA2,MSP2) of Plasmodium falciparum show pronounced skewing towards antibodies of the 1g G3 subclass." Infect.Immun.65・3. 1098-1100. (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Matsuoka, A.Ishii et al.: "Depletion of salivary gland proteins in Anopheles stephensi(Diptera : culicidae)on blooc feeding,and induction of antibodies to the proteins in mice being fed." Med.Entomol.Zool.48・3. 211-218 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Matsuoka, Y.Chinzei et al.: "Development of Plasmodium berghei ookinetes to matured oocysts in the Anopheles stephensi mosquitoes : An electron microscopic study." Japanese Journal of Medical Science and Biology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] H.Matsuoka, F.Kawamoto et al.: "High prevalence of Plasmodium malariae and P.ovale in malaria patients along the Thai-Myanmar Border,as revealed by acridine orange staining and PCR-based diagnoses." Trop.Med.& Int.Health. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Ishii, N.Ohta et al.: "Polymorphism of Tumor Necrosis Factor α gene in the Melanesian and East-Asian pupulations." Immunogenetics. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from southwestern Brazillian Amazon." Am.J. Trop.Med.Hyg.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Stable patterns of allelic diversity at the merozoite surface protein-1 locus of Plasmodium falciparum in clinical isolates from Southern Vietnam." J.Eukaryotic Microbiology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 川本文彦 他: "アクリジンオレンジ染色によるマラリアの迅速診断法" 臨床検査. 42・2. 243-247 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Plasmodium falciparum. Allelic variation in the merozoite surface protein 1 gene in wild isolates from Southern Vietnam." Exp.Parasitol.86・1. 45-57 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Kawamoto et al.: "Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene." Parasitol.Int. 46. 91-95 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] F.Kawamoto et al.: "In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials." Acta Tropica. 63・2-3. 151-158 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M.Ohashi et al.: "Granulocyte-macrophage colony-stimulating factor production by T lymphocytes in Plasmodium berghei-infected mice." South East Asian Journal of Tropical Medicine and Public Health. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] A.Ishii et al.: "Malaria Research In The Solomon Islands." Inter Group, 192 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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