• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Bioartificial organs which promote self organ regeneration.

Research Project

Project/Area Number 09357012
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIMIZU Yasuhiko  Kyoto University, Institute for Frontier Medical Sciences, Professor, 再生医科学研究所, 教授 (00027111)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Tatsuo  Kyoto University, Institute for Frontier Medical Sciences, Ass. Professor, 再生医科学研究所, 助教授 (70227908)
筏 義人  京都大学, 再生医科学研究所, 教授 (00025909)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥22,600,000 (Direct Cost: ¥22,600,000)
Fiscal Year 1999: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1998: ¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1997: ¥10,600,000 (Direct Cost: ¥10,600,000)
Keywordsregeneration of auto-tissue / extracellular matrix / enzyme extraction collagen / growth factor / stem cell / three-dimensional structure / 人工臓器 / 再生医学 / 人工血管 / 人工食道 / 人工気管 / コラーゲン / 人工神経
Research Abstract

The collagen which is a natural derived biopolymer material plays large role for differentiation, proliferation, repair, maintenance of the organism as a extracellular matrix. In our project, what kind of renewal process the cell of the organism took using this collagen, was clarified. The completely new bio-artificial organ that reproduces and induces self-organization and self organ by giving the scaffold of this collagen, is developed. Continuously artificial esophagus, artificial trachea, artificial blood vessel, artificial nerve experimentally were produced in last year, the experiment was mainly carried out in dogs. Artificial esophagus of 15cm length was tried in pleural cavity, the IVH management was carried out throughout for 2 months, and the regeneration of the gullet organization was observed. The self-organization entered the collagen implanted after 2 months, and it was proven that the tube made of fibrous tissue was formed. However, it rapidly contracted after the stent … More removal, and this tube is stenosed, the dog dies in this reason. It seemed to be the key technique that improves by preventing the stenosis after this stent evulsion. As for the improvement of the result by the artificial trachea, the trachea wall was improved, which was composed of collagen sponge which promoted the regeneration and differentiation of the self-organization, so as to prevent fistula. With this improvement, operative result was rapidly improved on Y-type bifurcation-type artificial treacheae since autumn, 1998. At present, the dog which succeeded in the bifurcational reconstruction has exceeded 10. The artificial blood vessel also was continuously subject of the experiment in which transplants XENO artificial blood vessel was designed from carotid artery of pigs and applied to an abdominal aorta of the dog. Blood vessel component cell of the pig was removed with detergent In removing, heparinized technique which gives antithrombogenesity has been established. The artificial nerve was studied namely the method for coupling the peripheral nerve in the collagen tube, and we tried the experiment which rapidly induce the regeneration of 8cm gap with a tube filled by the collagen fiber coated by laminin, and it succeeded in the regeneration. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (96 results)

All Other

All Publications (96 results)

  • [Publications] 津田透: "肺手術時の胸膜欠損部におけるヒトコラーゲン膜による空気漏れ防止効果"人工臓器. 25(2). 417-420 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清谷哲也: "PGA-コラーゲン複合チューブによる末梢神経の再生の誘導"人工臓器. 25(2). 476-480 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayoshi Teramachi: "Intrathoracic Tracheal Reconstruction with a Collagen Conjugated Prosthests - An evaluation of the efficacy of omital wrapping"Journal of Thoracic and Cardiovascular Surgery. 113. 701-711 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuya Kiyotani: "Nerve regeneration across a 25-mm gap bridged by a polyglycolic acid-collagen tube : a histological and electrophysiological evaluation of regenerated nerves"Brain Research. 740. 66-74 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本恭通: "医用材料としての羊膜由来精製ヒト・コラーゲン膜の作成法"人工臓器. 26(1). 219-224 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshihisa Suzuki: "Evaluation of a novel alginate gel dressing : Cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo"J Biomed Mater Res. 39. 317-322 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yong Ho Lee: "Mesothelial Cell Regeneration in Purified Human Amnion Membrane Grafis Implanted in Dog Pericardium"Tissue Engineering. 4(2). 131-141 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yukinobu Takimoto: "The Experimental Replacement of Artificial Esophagus with Collagen Matrix and Silicone Stent"J Thorac Cardioy Surg. 116. 98-106 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本恭通: "熱架橋繊維化コラーゲンの綿状防止血材への応用"人工臓器. 27(1). 262-268 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 上田寛樹: "動脈選択的分解処理と血管壁細胞外マトリックスに関する基礎的実験"人工臓器. 27(2). 528-533 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鈴木京子: "PGA-コラーゲン末梢神経再生チャンネルの開発-機能的評価"人工臓器. 27(2). 490-494 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Americo K Kitahara: "Evaluation of collagen nerve guide in facial nerve regeneration"Journal of Artificia Organs. 1. 22-27 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Americo K Kitahara: "Facial nerve repair using collagen nerve conduit in cat"Scandinavian Jounal of Plastic and Reconstructive Surgery and Hand Surgery. 33. 187-193 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akitoshi Tatsumi: "Bioabsorbable Poly-L-Lactide Costal Coaptation Pins and Their Clinical Application In Thoracotomy"Ann Thorac Surg. 67. 765-768 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Sekine: "Replacement of the tracheobroncheal bifurcation buy a newly developed Yshaped artificial trachea"ASAIO Journal. 45. 131-134 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuya Matsumoto: "A novel surgical material and form collagen with high mechanical strengthcollagen sandwich membrane"ASAIO Journal. 45. 288-292 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Yamamoto: "Experimental replacement of the thoracic esophagus with a bioabsorbable artificial collagen silicone composite tube"ASAIO Journal. 45. 311-316 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toru Tsuda: "Prevention of Air Leakage From Lungs After Srutgery Using a Purified Collagen Membrabne PGA Sheet"Annalus of Thoracic Surgery. 68. 339-342 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Suzuki: "Regeneration of the peripheral nervous system by artificial nerve conduit"Tissue engineering for therapeutic use. 3. 71-76 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中村達雄: "コラーゲン加工メッシュ人工気管の開発"外科. 61(2). 158-161 (199)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Yamamoto: "Intrathoracic esophageal replacement in the dog with the use of an artificial esophagus composed of a collagen sponge with a double-layered silicone tube"Journal of Thoracic Cardiovascular Surgery. 118(2). 276-286 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松本和也: "抽出コラーゲンのみから縫合可能な手術用材料を作成する成型加工法について"人工臓器. 28(1). 211-216 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山本恭通: "酸化セルロース線維を混和したスポンジ状コラーゲンの止血材への応用"人工臓器. 28(1). 217-224 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水慶彦: "縦隔臓器の再建・再生"現代医学. 31(12). 125-129 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水慶彦: "末梢神経の再生"ティッシュ・エンジニアリング-組織工学の基礎と応用. 186-197 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水慶彦: "再生医学はどこまでいくのか"Pharma Medica. 18(1). 93-95 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中村達雄: "軟組織(膜・気管・食道)の再生"Pharma Medica. 18(1). 75-80 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 清水慶彦: "神経を再生する医療"Materials Integration. 13(2). 51-57 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中村達雄: "21世紀への人工臓器"先端技術研究所. 130-137 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toru Tsuda: "Effectiveness of a human amnion collagen membrane in treating an air lerkage following pleural resection."The Japanese Journal of Artificial Organs.. 25 (2). 417-420 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuya Kiyotani: "Peripheral nerve regeneration in a PGA-collagen composite tube."The Japanese Journal of Artificial Organs.. 25 (2). 476-480

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Masayoshi Teramachi: "Intrathoracic Tracheal Reconstruction with a Collagen Conjugated Prosthesis-An evaluation of the efficacy of omital wrapping."Journal of Thoracic and Cardiovascular Surgery. 113. 701-711 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tetsuya Kiyotani: "Nerve regeneration across a 25-mm gap bridged by a polyglycolic acid-collagen tube : a histological and electrophysiological evaluation of regenerated nerves"Brain Research. 740. 66-74 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasumichi Yamamoto: "Development of purified human aminion collagen membrane as a biomaterial."The Japanese Journal of Artificial Organs. 26 (1). 219-224 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yoshihisa Suzuki: "Evaluation of a novel alginate gel dressing : Cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo."J Biomed Mater Res. 39. 317-322 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yong Ho Lee: "Mesothelial Cell Regeneration in Purified Human Amnion Membrane Grafts Implanted in Dog Pericardium"Tissue Engineering. 4 (2). 131-141 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yukinobu Takimoto: "The Experimental Replacement of Artificial Esophagus with Collagen Matrix and Silicone Stent."J Thorac Cardiov Surg. 116. 98-106 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasumichi Yamamoto: "Development of collagen like hemostat made from DHT treated fibrous collagen."The Japanese Journal of Artificial Organs. 27 (1). 262-268 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hiroki Ueda: "Study on extracellural matrix of cell removed arteries with various methods."The Japanese Journal of Artificial Organs. 27 (2). 528-533 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kyoko Suzuki: "Development of peripheral nerve guide channel made from PGA-Collagen composite-functional evaluation of regenerated nerbe-."The Japanese Journal of Artificial Organs. 27 (2). 490-494 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Americo K Kitahara: "Evaluation of collagen nerve guide in facial nerve regeneration."Journal of Artificial Organs. 1. 22-27 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Americo K Kitahara: "Facial nerve repair using collagen nerve conduit in cat."Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 33. 187-193 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akitoshi Tatsumi: "Bioabsorbable Poly-L-Lactide Costal Coaptation Pins and Their Clinical Application in Thoracotomy."Ann Thorac Surg. 67. 765-768 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takashi Sekine: "Replacement of the tracheobroncheal bifurcation buy a newly developed Y-shaped artificial trachea."ASAIO Journal. 45. 131-134 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuya Matsumoto: "A novel surgical material and form collagen with high mechanical strength-collagen sandwich membrane."ASAIO Journal. 45. 288-292 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasumichi Yamamoto: "Experimental replacement of the thoracic esophagus with a bioabsorbable artificial collagen silicone composite tube."ASAIO Journa. 45. 311-316 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Toru Tsuda: "Prevention of Air Leakage From Lungs After Srutgery Using a Purified Collagen Membrabne PGA Sheet."Annalus of Thoracic Surgery. 68. 339-342 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K. Suzuki: "Regeneration of the peripheral nervous system by artificial nerve conduit."Tissue engineering for therapeutic use. 3. 71-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tatsuo Nakamura: "Development of artificial trachea with collagen conjugated mesh."Surgery. 61 (2). 158-161 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasumichi Yamamoto: "Intrathoracic esophageal replacement in the dog with the use of an artificial esophagus composed of a collagen sponge with a double-layered silicone tube."Journal of Thoracic Cardiovascular Surgery. 118 (2). 276-286 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kazuya Matsumoto: "A novel method for the manufacture of surgical materials from extracted collagen alone with strong mechanical properties for suturing."The Japanese Journal of Artificial Organs. 28 (1). 211-216 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasumichi Yamamoto: "Hemostats with collagen coated oxy cellurose."The Japanese Journal of Artificial Organs. 28 (1). 217-224 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuhiko Shimizu: "Regeneration of mediastinal organs."New horizon for medicine.. 31 (12). 125-129 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuhiko Shimizu: "Regeneration of peripheral nerve."Tissue Engineering.. 186-197 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuhiko Shimizu: "Future of the tissue engineering for therapeutic use."Pharma Medica. 18 (1). 93-95 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tatsuo Nakamura: "Regeneration of soft tissue (membranes, trachea, esophagus)."Pharma Medica. 18 (1). 75-80 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasuhiko Shimizu: "Tissue engineering for peripheral nerve regeneration."Materials Integration. 13 (2). 51-57 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Book Tatsuo Nakamura: "The artificial organ to the twenty-first century"The advanced technology laboratory. 130-137 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Americo K Kitahara: "Facial nerve repair using collagen nerve conduit in cat"Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 33. 187-193 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Akitoshi Tatsumi: "Bioabsorbable Poly-L-Lactide Costal Coaptation Pins and Their Clinical Application in Thoracotomy"Ann Thorac Surg. 67. 765-768 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Takashi Sekine: "Replacement of the tracheobroncheal bifurcation buy a newly developed Y-shaped artificial trachea"ASAIO Journal. 45. 131-134 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazuya Matsumoto: "A novel surgical material and form collagen with high mechanical strength-collagen sandwich membrane"ASAIO Journal. 45. 288-292 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Yamamoto: "Experimental replacement of the thoracic esophagus with a bioabsorbable artificial collagen silicone composite tube"ASAIO Journal. 45. 311-316 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toru Tsuda: "Prevention of Air Leakage From Lungs After Surgery Using a Purified Collager Membrabne PGA Sheet"Annalus of Thoracic Surgery. 68. 339-342 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Suzuki: "Regeneration of the peripheral nervous system by artificial nerve conduit"Tissue engineering for therapeutic use. 3. 71-76 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中村 達雄: "コラーゲン加工メッシュ人工気管の開発"外科. 61(2). 158-161 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Yamamoto: "Intrathoracic esophageal replacement in the dog with the use of an artificial esophagus composed of a collagen sponge with a double-layered silicone tube"Journal of Thoracic Cardiovascular Surgery. 118(2). 276-286 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 松本 和也: "抽出コラーゲンのみから縫合可能な手術用材料を作成する成型加工法について"人工臓器. 28(1). 211-216 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山本 恭通: "酸化セルロース線維を混和したスポンジ状コラーゲンの止血材への応用"人工臓器. 28(1). 217-224 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水 慶彦: "縦隔臓器の再建・再生"現代医療. 31(12). 125-129 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水 慶彦: "末梢神経の再生"ティッシュ・エンジニアリング-組織工学の基礎と応用. 186-197 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水 慶彦: "再生医学はどこまでいくのか"Pharma Medica. 18(1). 93-95 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中村 達雄: "軟組織(膜・気管・食道)の再生"Pharma Medica. 18(1). 75-80 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 清水 慶彦: "神経を再生する医療"Materials Integration. 13(2). 51-57 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshihisa Suzuki: "Evaluation of a novel alginate geldressing:Cytotoxicity to fibroblasts in vitro and foreign body reaction inpig skin in vivo." Journal of Biomedical Materials Research. 39. 317-322 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yong Ho Lee: "Mesothelial cell regeneration in purified human amnion membrane grafts implanted in dog pericardium." Tissue Engineering. 4(2). 131-141 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yukinobu Takimoto: "The Experimental Replacement of a Cervical Esophageal Segment with an Artificial Prosthesis with the Use of Collagen Matrix and a Silicone Stent." The Journal of Thoracic and Cardiovascular Surgery. 116. 98-106 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 上田寛樹: "動脈の選択的分解処理と血管壁細胞外マトリクスに関する基礎的研究" 人工臓器. 27(2). 528-533 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ameriko K Kitahara: "Evaluation of collagen nerve guide in facial nerve regenaration." Journal of Artificial Organs. 1. 22-27 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ameriko K Kitahara: "Facial nerve repair using collagen nerve conduit." Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] 鈴木 京子: "PGA-コラーゲン末梢神経再生チャンネルの開発-機能的評価-" 人工臓器. 27(2). 490-494 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Sekine Takashi: "New type of artificial trachea: Replacement of tracheobroncheal bifurcation by Y-shaped artificial trachea" ASAIO Journal. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] Kazuya Matsumoto: "A novel surgical material made from collagen with tough mechanical strength-collagen sandwich membrane-." ASAIO Journal. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村 達雄: "人工気管" 21世紀への人工臓器. 130-137 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村 達雄: "コラーゲン加工メッシュ人工気管の開発" 外科. 61(2). 158-161 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Toru Tsuda: "Prevention of air leakage from lungs after srutgery using a purified collagen membrane PGA sheet." Annals of Thoracic Surgery. (印刷中).

    • Related Report
      1998 Annual Research Report
  • [Publications] 清谷 哲也: "PGA-コラーゲン複合チューブによる末梢神経の再生の誘導" 人工臓器. 25(2). 476-480 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] 津田 透: "肺手術時の胸膜欠損におけるヒトコラーゲン膜による空気漏れ防止効果" 人工臓器. 25(2). 417-420 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Tetsuya Kiyotani: "Nerver regeneration across 25-mm gap bridged by a polyglycolic acid collagen tube : a histological and electrophysiological evaluation of regenerated nerves." Brain Reaearch. 740(1,2). 66-74 (1996)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masayoshi Teramachi: "Intrathoracic Tracheal Reconstruction with a Collagen-Conjugated Prosthesis : Evaluation of the Efficacy of Omental Wrapping." The Jornal of Thoracic and Cardiovascular Surgery. 113(4). 337-345 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Masayoshi Teramachi: "Porous-Type Tracheal Prosthesis Sealed With Collagen Sponge." Ann Thorac Surg. 64. 965-969 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山本 恭通: "医用材料としての羊膜由来精製ヒト・コラーゲン膜の作成法" 人工臓器. 26(1). 219-224 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Yong Ho Lee: "Mesothelial cell regeneration in purified human amnion membrane grafts implanted in dog pericardium." Tissue Engineering. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] Yukinobu Takimoto: "The Experimental Replacement of Artificial Esophagus with Collagen Matrix and Silicone Stent." The Journal of Thoracic and Cardiovascular Surgery. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 鈴木 京子: "PGA-コラーゲン末梢神経再生チャンネルの開発-機能的評価-" 人工臓器. (印刷中).

    • Related Report
      1997 Annual Research Report
  • [Publications] 上田 寛樹: "動脈の選択的分解処理と血管壁細胞外マトリックスに関する基礎的研究" 人工臓器. (印刷中).

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi