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Research Project on the Clinical Indication in Japan and the Posttransplant Patient Management in Lung and Heart-Lung Transplantation.

Research Project

Project/Area Number 09357013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Thoracic surgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

FUJIMURA Shigefumi  Institute of Development, Aging and Cancer, Tohoku University. Professor, 加齢医学研究所, 教授 (40006078)

Co-Investigator(Kenkyū-buntansha) MATSUDA Hikaru  First Department of Surgery, Osaka University. Professor, 医学部, 教授 (00028614)
AYABE Hiroyosi  First Department of Surgery, Nagasaki University. Professor, 医学部, 教授 (60128147)
KATO Harufumi  Department of Surgery, Tokyo Medical College. Professor, 教授 (20074768)
SHIRATO Kunio  First Department of Internal Medicine, Tohoku University. Professor, 医学部, 教授 (80004761)
KOYANAGI Hitosi  Department of Cardiovascular Surgery, Tokyo Women's Medical Colledge. Professor, 教授 (90138884)
人見 滋樹  京都大学, 胸部疾患研究所, 教授 (80173186)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥26,600,000 (Direct Cost: ¥26,600,000)
Fiscal Year 1999: ¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1997: ¥12,000,000 (Direct Cost: ¥12,000,000)
KeywordsLung Transplantation / Heart-Lung Transplantation / Pulmonary Preservation / Immunosuppression / Reection Monitoring / Non-Heart-Beatig Donor / 心肺移植 / 適応拡大 / 肺・心肺保存 / 移植後肺水腫 / 心停止ドナー
Research Abstract

(1) Clinical indication
<Chronic pulmonary emphysema> Incidence of the juvenile type emphysema for lung transplantation in our country was found to be 1 to 2% of all, and the benefit of volume reduction surgery as a bridge therapy has been established.
<Primary pulmonary hypertension> Effectiveness of the prostacyclin treatment has been established to date, however, some patients were found to be resistant to this treatment.
<Others> Potential candidates for lung transplantation were most frequently found in patients with idiopathic pulmonary fibrosis among several disease entity (idiopathic pulmonary fibrosis, pulmonary lymphoangiomyomatosis, bronchilitis obliterans, pulmonary emphysema).
(2) Basic research
1) Expansion of the donor pool
Possibility of lung transplantation from non-heart-beating donor was demonstrated, and the research on the size matching in living-related lobar transplantation has been started.
2) Zenotransplantation
Fetal lung as a low antigen-presenting model was challenged for zenograft and its usefulness was suggested. Researches on the mechanisms of immune reaction in zenotransplantation has been progressed.
3) Posttransplant patient management
Platelet was found to be contributory in reimplantation response. Triptolide, a kind of Chinese medicine, was found to be a potent immunosuppressive agent. Molecular biological technique (gene transfection) has been strated to be applied for immunosuppression in both acute and chronic rejection in lung transplantation.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (93 results)

All Other

All Publications (93 results)

  • [Publications] 近藤丘ほか: "細胞外液型肺保存液の開発"低温医学. 23(2). 105-112 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 近藤丘ほか: "肺移植1)移植肺の選択と保存"小児科臨床. 50. 155-160 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 近藤丘ほか: "心停止ドナーからの肺移植の可能性ー動物実験から臨床応用へー"Organ Biology. 4(3). 11-18 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 松村輔二ほか: "臓器移植と臨床検査ー肺移植ー"臨床検査. 41(8). 915-917 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 藤村重文ほか: "臨床医学の展望ー呼吸器外科学"日本醫事新報. 3797. 37-43 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matumura Y.et al.: "Extracellular-type phosphate buffered solution for long-term lung preservation-Experimental studies of canine and primate lung transplants"Cardiovascular Engineering. 2(1). 75-80 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugita M.et al.: "Effects of flushing temperature and preservation solution on alveolar fluid clearance in the preserved rat lungs"Transplant Proc. 29. 1354-1356 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Misao T.et al.: "Effects of donor splenocyte transfusion with a simultaneous single injection of tacrolimus on lung allografts"Transplant Proc. 29. 612-613 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡忠之ほか: "肺保存条件の実験的評価"低温医学. 23(2). 95-99 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sekine Y.et al.: "Donor-specific cytotoxic lymphocyte activity from bronchoalveolar lavage during acute canine lung allograft rejection"Eur J Cardio-thorac Surg. 11. 902-909 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mizuta T.et al.: "Increased nitric oxide levels in exhalted air of rat allografts"J Thorac Cardiovasc Surg. 113. 830-835 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Utsumi T.et al.: "Local production of nitric oxide(NO)on acute rejection of rat lung allografts"Transplant Proc. 29. 1511 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda S.et al.: "Experimental bronchiolitis obliterans induced by in vivo HVJ liposome-mediated endothelin-1 gene transfer"Ann Thorac Surg. 63. 1562-1567 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hachida M.et al.: "Experimental assessment of tumor growth on heart-lung transplantation"Asian J Surgery. 20. 173-176 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakamura T.et al.: "Dibutyryl c AMP attenuates lung injury caused by cold preservation and ischemia-reperfusion"J Thorac Cardiovas Surg. 114. 635-642 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡田克典ほか: "肺保存液と移植肺の機能評価"The LUNG perspectives. 6(2). 69-73 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡田克典ほか: "肺移植"臨床麻酔. 22(12). 1729-1734 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡田克典ほか: "臓器移植のタイミング「肺疾患」"ICUとCCU. 22(8). 553-558 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岡田克典ほか: "生体肺移植および屍体肺移植"ハートナーシング. 11(2). 90-95 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 島田和佳ほか: "臓器移植の今後の展望「肺蔵移植」"日本外科学会雑誌. 99(11). 759-764 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajima J.et al.: "Effect of cryopreservation on the allogenicity of an airway epithelial cell line"Transplant Proc. 30. 3366-3367 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda M.et al.: "Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates"Transplant Proc. 30. 3813-3814 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haraguchi H.et al.: "Pulmonary function and regional distribution of emphysema as determined by high-resolution computed tomography"Respiration. 65. 125-129 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 杉田礼典ほか: "カリウムイオンの影響とカリウムチャンネルブロッカーの効果"日本呼吸器外科学会雑誌. 12. 560-570 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagayasu T.et al.: "Expression of prelefirating cell nulear antigen in bronchial epithelium after lung transplatation in the rat"J Heart Lung Transplat. 566-572 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kishima H.et al.: "Microvascular permeability of the non-heart-beating rabbit lung after warm ischemia and reperfusion : the role of neutrophil elastase"Ann Thorac Surg. 65. 913-918 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 百木義光ほか: "免疫虚血再灌流障害による呼吸不全に対するPartial liquid ventilationの実験的研究"日本胸部外科学会誌. 46(1). 65-70 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 高島成輝ほか: "Effects of Inhaled Nitric Oxide in Canine Lung Transplantation from Non-Heart-Beating Donor"Jpn J Thorac Cardiovasc Surg. 46. 657-663 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hachida M.et al.: "Effectiveness of ischemic preconditioning on long-term myocardial preservation"Transplantation. 65. 1021-1024 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 小阪真二: "30時間冷保存肺の超微形態傷害"日本呼吸器外科学会雑誌. 13(5). 614-626 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S.et al.: "Na+/K+-ATPase Activity in Rat Lungs Preserved with EP4 Solution"Transplant Proc. 31. 193-194 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugita M.et al.: "Transalveolar Fluid Absorption Ability in Rat Lungs Preserved with Euro-Collins Solution and EP4 Solution"Transplantation. 67(3). 349-354 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo T.et al.: "a-adrenergic Blockade in Preventing Posttransplant Edema of Lung Allograft"Tohoku J Exp Med. 189(2). 135-145 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鈴木聡ほか: "保存臓器とviability判定法:肺臓"Low Temp Med. 25(1). 1-8 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Utsumi T.et al.: "Nitric Oxide Production by Bronchoalveolar Cells During Allograft Rejection"Transplantation. 67. 1622-1625 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 関根康雄ほか: "移植肺急性拒絶反応時における局所Chemokine産生とT細胞浸潤に関するドナー肺マクロファージの役割"移植. 34. 147 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyoshi S.et al.: "Chest Size Matching in Single and Double Lung Transplantation"Jpn J Thorac Cardiovasc Surg. 47. 163-170 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai S.et al,: "The Number of Interleukin-1 Receptor on Lung Fibroblasts in Patients with Idio-pathic pulmonary Fibrosis"Respiration. 66. 236-241 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono M.et al.: "Influence of Cryopreservation on Antigen Expression and Immunogenicity of Human Vascular Endothelial Cells"Transplant Proc. 31. 985-987 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagaya N.et al.: "The Effect of Orally Active Prostacyclin Analogue on Survival of Outpatients with Primary Pulmonary Hypertension"J Am Coll Cardiol. 34. 1188-1192 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuwaki K.et al.: "Lazaroid U74389G ameliorates ischemia-reperfusion injury in the rat lung transplantation model"Ann Thorac Cardiovasc Surg. 5. 11-17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsumura Y, et al.: "Extracellular-Type Phosphate Buffered Solution for Long-Term Lung Preservation-Experimental Studies of Canine and Primate Lung Transplants."Cardiovascular Engineering. 2(1). 75-80 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugita M. et al.: "Effect of Flusing Temperature and Preservation Solution on Alveolar Fluid Clearance in the Preserved Rat Lungs."Transplant Proc. 29. 1354-1356 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sekine Y et al.: "Donor-specific cytotoxic lymphocyte activity from bronchoalveolar lavage during acute canine lung allograft rejection"Eur J Cardio-thorac Surg. 11. 902-909 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miuta T et al.: "Increased nitric oxide levels in exhalted air of rat allografts."J Thorac Cardiovasc Sung. 113. 902-909 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda S et al.: "Experimental bronchiolitis obliterans induced by in vivo HVJ liposome-mediated endothelin-1 gene transfer."Ann Thorac Surg. 63. 1562-1567 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hachida M et al: "Effectiveness of ischemic preconditioning on long-term myocardial preservation."Transplantation. 65. 1021-1024 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Haraguchi H et al.: "Pulmonary function and regional distribution of emphysema as determined by high-resolution computed tomography."Respiration. 65. 12-129 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagayasu T et al.: "Expression of prelefirating cell nuclear antigen in bronchial epithelium after lung transplantation in the rat."J Heart Lung Transplat. 566-572 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kishima H et al.: "Microvascular permeability of the non-heart-beating rabbit lung after warm ischemia and reperfusion : the role of neutrophil elastase."Ann Thorac Surg. 65. 913-918 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakajima J et al: "Effect of cryopreservation on the allogenicity of an airway epithelial cell line."Transplant Proc. 30. 3366-3367 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Takeda M et al.: "Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates."Transplant Proc. 30. 3813-3814 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Suzuki S, et al.: "Na+/K+-ATPase Activity in Rat Lungs Preserved with EP4 Solution."Transplant Proc. 31. 193--194 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sugita M, et al.: "Transalveolar Fluid Absorption Ability in Rat Lungs Preserved with Euro-Collins Solution and EP4 Solution"Transplantation. 67. 349-354 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kondo T, et al.: "a-adrenergic Blockade in Preventing Posttransplant Edema of Lung Allograft."Tohoku J Exp Med. 189(2). 135-145 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kuwaki K, et al.: "Lazaroid U74389G ameliorates ischemia-reperfusion injury I the rat lung transplantation model"Ann Thorac Cardiovasc Surg. 5. 11-17 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Utsumi T, et al.: "Nitric Oxide Production by Bronchoalveolar Cells During Allograft Rejection"Transplantation. 67. 1622-1625 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Miyoshi S, et al.: "Chest Size Matching in Single and Double Lung Transplantation"Jpn J Thorac Cardiovasc Surg. 47. 163-170 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagai S, et al.: "The Number of Interleukin-1 Receptor on Lung Fibroblasts in Patients with Idiopathic pulmonary Fibrosis."Respiration. 66. 236-241 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ono M, et al: "Influence of Cryopreservation on Antigen Expression and Immunogenicity of Human Vascular Endothelial Cells."Transplant Proc. 31. 985-987 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nagaya N, et al.: "The Effect of Orally Active Prostacyclin Analogue on Survival of Outpatients with Primary Pulmonary Hypertension."J Am Coll Cardiol. 34. 1188-1192 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 鈴木聡: "保存臓器とviability判定法:肺臓"Low Temp Med. 25(1). 1-8 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kondo T.: "α-adrenergic Blockade in Preventing Posttransplant Edema of Lung Alllograft"Tohoku J Exp Med. 189(2). 135-145 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Suzuki S.: "Na+/K+-ATPase Activity in Rat Lungs Preserved with EP4 Solution"Transplant Proc. 31. 193-194 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugita M.: "Transalveolar Fluid Absorption Ability in Rat Lungs Preserved with Euro-Collins Solution and EP4 Solution"Transplantation. 67(3). 349-354 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kuwaki K.: "Lazaroid U74389G ameliorates ischemia-reperfusion injury in the rat lung transplantation model"Ann Thorac Cardiovasc Surg. 5. 11-17 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 小阪真二: "30時間冷保存肺の超微形態傷害"日本呼吸器外科学会雑誌. 13(5). 614-626 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Utsumi T.: "Nitric Oxide Production by Bronchoalveolar Cells During Allograft Rejection"Transplantation. 67. 1622-1625 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 関根康雄: "移植肺急性拒絶反応時における局所Chemokine産生とT細胞浸潤に関するドナー肺マクロファージの役割"移植. 34. 147 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Miyoshi S.: "Chest Size Matching in Single and Double Lung Transplantation"Jpn J Thorac Cardiovasc Surg. 47. 163-170 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagai S.: "The Number of Interleukin-1 Receptor on Lung Fibroblasts in Patients with Idiopathic pulmonary Fibrosis"Respiration. 66. 236-241 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ono M.: "Influence of Cryopreservation on Antigen Expression and Immunogenicity of Human Vascular Endothelial Cells"Transplant Proc. 31. 985-987 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagaya N.: "The Effect of Orally Active Prostacyclin Analogue on Survival of Outpatients with Primary Pulmonary Hypertension"J Am Coll Cardiol. 34. 1188-1192 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岡田克典 ほか: "生体肺移植および屍体肺移植" ハートナーシング. 11(2). 90-95 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡田克典 ほか: "肺保存液と移植肺の機能評価" The LUNG perspectives. 6(2). 69-73 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 島田和佳 ほか: "臓器移植の今後の展望「肺臓移植」" 日本外科学会雑誌. 99(11). 759-764 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakajima J et al.: "Effect of cryopreservation on the allogenicity of an airway epithelial cell line." Transplant Proc. 30. 3366-3367 (1998)

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  • [Publications] Takeda M et al.: "Immunologic factors contributing to acute rejection in lungs xenotransplanted between primates." Transplant Proc. 30. 3813-3814 (1998)

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  • [Publications] 杉田礼典 ほか: "カリウムイオンの影響とカリウムチャンネルブロッカーの効果" 日本呼吸器外科学会雑誌. 12. 560-570 (1998)

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  • [Publications] 松村輔二 ほか(分担): "テキスト臓器移植" 日本評論社, 271 (1998)

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  • [Publications] Matumura Y et al.: "Extracellular-type phosphate buffered solution for long-term lung preservation-Experimental studies of canine and primate lung transplants" Cardiovascular Engineering. 2(1). 75-80 (1997)

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  • [Publications] Sugita M et al.: "Effects of flushing temperature and preservation solution on alveolar fluid clearance in the preserved rat lungs." Transplant Proc. 29. 1354-1356 (1997)

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  • [Publications] 近藤 丘 ほか: "細胞外液型保存液の開発" 低温医学. 23(2). 105-112 (1997)

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  • [Publications] 近藤 丘 ほか: "心停止ドナーからの肺移植の可能性-動物実験から臨床応用へ-" Organ Biology. 4(3). 11-18 (1997)

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  • [Publications] Misao T et al.: "Effects of donor splenocyte transfusion with a simultaneous single injection of tacrolimus on lung allografts." Transplant Proc. 29. 612-613 (1997)

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  • [Publications] 岡 忠之 ほか: "肺保存条件の実験的評価" 低温医学. 23(2). 95-99 (1997)

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  • [Publications] Sekine Y et al.: "Donor-specific cytotoxic lymphocyte activity from bronchoalveolar lavage during acute canine lung allograft rejection" Eur J Cardio-thorac Surg. 11. 902-909 (1997)

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  • [Publications] Mizuta T et al.: "Increased nitric oxide levels in exhalted air of rat allografts." J Thorac Cardiovasc Surg. 113. 830-835 (1997)

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  • [Publications] Utsumi T et al.: "Local production of nitric oxide (NO) on acute rejection of rat lung allografts" Transplant Proc. 29. 1511 (1997)

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  • [Publications] Takeda S et al.: "Experimental bronchiolitis obliterans induced by in vivo HVJ liposome-mediated endothelinl gene transfer." Ann Thorac Surg. 63. 1562-1567 (1997)

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  • [Publications] Hachida M et al.: "Experimental assessment-of tumor growth on heart-lung transplantation." Asian J Surgery. 20. 173-176 (1997)

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  • [Publications] Nakamura T et al.: "Dibutyryl c AMP attenuates lung injury caused by cold preservation and ischemia-reperfusion" J Thorac Cardiovas Surg. 114. 635-642 (1997)

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  • [Publications] 近藤 丘 ほか(分担): "最新内科学体系" 中山書店, (1997)

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Published: 1997-04-01   Modified: 2016-04-21  

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