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Development of Amperometric Biochemical Imaging Sensors Using Photoconductive Materials

Research Project

Project/Area Number 09359005
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 広領域
Research InstitutionOsaka University

Principal Investigator

IWASAKI Hiroshi  Osaka University, the Institute of Scientific and Industrial Research(ISIR), Professor, 産業科学研究所, 教授 (00029901)

Co-Investigator(Kenkyū-buntansha) KITAGAWA Masatosi  Matsushita El.Inds.Co.Ltd., Senior Researcher, 主任研究員
YOSHINOBU Tatsuo  Osaka University, ISIR, Assistant Professor, 産業科学研究所, 講師 (30243265)
SAKATA Yoshiteru  Osaka University, ISIR, Professor, 産業科学研究所, 教授 (60029874)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥25,900,000 (Direct Cost: ¥25,900,000)
Fiscal Year 1999: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1998: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1997: ¥21,300,000 (Direct Cost: ¥21,300,000)
Keywordslight-addressable potentiometric sensor(LAPS) / chemical imaging sensor / electrolysis / ion diffusion coefficient / metal dot array / porphyrin / SAM / ion imaging sensor / 化学センサ / バイオセンサ / イメージセンサ / 半導体センサ / イオン拡散 / 神経培養 / アルミナ薄膜 / センサ
Research Abstract

In this study, the chemical imaging sensor system was further developed to achieve higher performance and multifunctions that will meet the requirements of future applications. As an example, a dynamically changing electrochemical system was visualized and quantitatively analyzed. Visualization of chemical quantities other than pH was realized. A high-speed measurement system was proposed.
Firstly, the diffusion process of ions was observed by measuring the distribution of ion concentrations in the proximity of the electrode after electrolysis. The Gaussian distribution of the ion concentration was observed as derived from the Fick's law. The ionic diffusion constants were experimentally determined for various ions. Secoedly, a sensor with a Au dot array pattern was developed for visualization of the redox potential distribution. As an application, the photo response of the porphirin was measured. Finally, a high-speed measurement system was proposed for the chemical imaging sensor.
The technologies developed in this study can be combined and applied to chemical imaging of various specimens.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] T.Yoshinobu,H.Iwasaki,M.Nakao,S.Nomura,T.Nakanishi,S.Takamatsu and K.Tomita: ""Visualization of pH change of E.coil with a novel pH imaging microscope""Bioimages. 5. 143-147 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎裕,吉信達夫: "「pHイメージセンサーを用いた細菌コロニーのイメージング」"応用物理. 66. 488-489 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu,H.Iwasaki,M.Nakao,S.Nomura,T.Nakanishi,S.Takamatsu and K.Tomita: ""Application of chemical imaging sensor to electrogenerated pH distribution""Jpn.J.Appl.Phys.. 37. L353-L355 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中尾基,野村聡,中西剛,高松修司,冨田勝彦,吉信達夫,岩崎裕: "「微小領域二次元pH分布可視化のための光走査型化学顕微鏡」"分析化学. 47. 369-373 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中尾基,野村聡,高松修司,冨田勝彦,吉信達夫,岩崎裕: "「高分解能半導体化学イメージングセンサ」"電気学会論文誌E. 118. 584-589 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎裕,原田哲郎,Abu Bakar Md.Ismail,吉信達夫: "「新しい化学センサとその応用」"マテリアルインテグレーション. 12. 47-52 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Tanaka,T.Yoshinobu and H.Iwasaki: ""Application of chemical imaging sensor to electrophysiological measurement of a neural cell""Sensors & Actuators B. 59. 21-25 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail,T.Harada,T.Yoshinobu,H.Iwasaki,M.J.Schoning and H.Luth: ""Investigation of pulsed laser-deposited Al_2O_3 as a high pH-sensitive layer for LAPS-based biosensing applications""Sensors & Actuators B. 71. 169-172 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu,T.Harada and H.Iwasaki: ""Application of the pH-imaging sensor to determining the diffusion coefficients of ions in electrolytic solutions""Jpn.J.Appl.Phys.. 39. .L318-L320 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I.Hirata,H.Iwata,A.B.Md.Ismail,H.Iwasaki,T.Yukimasa and H.Sugihara: ""Surface modification of Si_3N_4-coated silicon plate for investigation of living cells""Jpn.J.Appl.Phys.. 39. 6441-6442 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail,T.Yoshinobu and H.Iwasaki: ""An organic film/SiO_2/Si heterostructures as a novel biological interface of a light-addressable potentiometric sensor""電気学会論文誌E. 121. 94-99 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu,H.Ecken,A.Poghossian,H.Luth,H.Iwasaki and M.J.Schoning: ""Alternative sensor materials for light-addressable potentiometric sensors""Sensors and Actuators. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail,T.Yoshinobu and H.Iwasaki: ""A novel low noise and low background measurement principle for light-addressable potentiometric sensors""Sensors and Actuators. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.J.Schoning,A.poghossian,T.Yoshinobu and H.Luth: ""Semiconductor-based field-effect structures for chemical sensing""SPIE. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu,H.Ecken,A.Poghossian,A.Simonis,H.Iwasaki,H.Luth and M.J.Schoning: ""Constant-current-mode LAPS for detection of penicillin""Electroanalysis. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.Poghossian,T.Yoshinobu,B.A.Simonis,H.Ecken,C.H.Luth and D.M.J.Schoning: ""Penicillin detection by means of field-effect based sensors:EnFET,capacitive EIS sensor or LAPS?""

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Mourzina,T.Yoshinobu,J.Schubert,H.Luth,H.Iwasaki and M.J.Schoning: ""Ion-selective light-addressable potentiometric sensor(LAPS) with chalcogenide thin film prepared by pulsed laser deposition""

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu, H.Iwasaki, M.Nakao, S.Nomura, T.Nakanishi, S.Takamatsu and K.Tomita: "Visualization of pH change of E.coli with a novel pH imaging microscope"Bioimages. 5. 143-147 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Iwasaki and T.Yoshinobu: "Imaging of Microbial Colonies by pH Imaging Snsor"Oyo Butsuri. 66. 488-489 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu, H.Iwasaki, M.Nakao, S.Nomura, T.Nakanishi, S.Takamatsu and K.Tomita: "Application of chemical imaging sensor to electrogenerated pH distribution"Jpn.J.Appl.Phys. 37. L353-L355 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Nakao, S.Nomura, T.Nakanishi, S.Takamatsu, K.Tomita, T.Yoshinobu and H.Iwasaki: "Scanning Chemical Microscope for the Visualization of a Microscopic pH Distribution"BUNSEKI KAGAKU. 47. 369-373 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Nakao, S.Nomura, S.Takamatsu, K.Tomita, T.Yoshinobu and H.Iwasaki: ""High Resolution Chemical Imaging Sensor Using Semiconductor Si"(in Japanese)"Trans.IEE of Japan. 118E. 584-589 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Iwasaki, T.Harada, Abu Bakar Md.Ismail and T.Yoshinobu: "A Novel Chemical Senosr and Its Applications(in Japanese, review paper)"Materials Integration. 12. 47-52 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H.Tanaka, T.Yoshinobu and H.Iwasaki: "Application of chemical imaging sensor to electtophysiological measurement of a neural cell"Sensors & Actuators B. 59. 21-25 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail, T.Harada, T.Yoshinobu, H.Iwasaki, M.J.Schoning and H.Luth: "Investigation of pulsed laser-deposited Al_2O_3 as a high pH-sensitive layer for LAPS-based biosensing applications"Sensors & Actuators B. 71. 169-172 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu, T.Harada and H.Iwasaki: "Application of the pH-imaging sensor to determining the diffusion coefficients of ions in electrol solutions"Jpn.J.Appl.Phys.. 39. L318-L320 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] I.Hirata, H.Iwata, A.B.Md.Ismail, H.Iwasaki, T.Yukimasa and H.Sugihara: "Surface modification of Si_3N_4-coated silicon plate for investigation of living cells"Jpn.J.Appl.Phys.. 39. 6441-6442 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail, T.Yoshinobu and H.Iwasaki: "An organic film/SiO_2/Si heterostructure as a novel biological interface of a light-addressable potentiometric sensor"Trans.IEE of Japan E. 121. 94-99 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu, H.Ecken, A.Poghossian, H.Luth, H.Iwasaki and M.J.Schoning: "Alternative sensor materials for light-addressable potentiometric sensors"Sensors and Actuators. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] A.B.Md.Ismail, T.Yoshinobu and H.Iwasaki: "A novel low noise and low background measurement principle for light-addressable potentiometric sensors"Sensors and Actuators. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.J.Schoning, A.Poghossian, T.Yoshinobu and H.Luth: "Semiconductor-based field-effect structures for chemical sensing"SPIE. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Yoshinobu, H.Ecken, A.Poghossian, A.Simonis, H.Iwasaki, H.Luth and M.J.Schoning: "Constant-current-mode LAPS for detection of penicilin"Electroanalysis. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] H. Iwasaki, T. Harada, Abu Bakar Md. Ismail and T. Yoshinobu: "A Novel Chemical Senosr and Its Applications (in Japanese)"Materials Integration. 12. 47-52 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Tanaka, T. Yoshinobu and H. Iwasaki: "Application of Chemical Imaging Sensor to Electrophysiological Measurement of a Neural Cell"Sensors & Actuators B. 59. 21-25 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Abu Bakar Md. Ismail, T. Harada, T. Yoshinobu and H. Iwasaki: "Investigation of Pulsed Laser-Deposited Al_2O_2 as a high pH-sensitive layer for LAPS-based biosensing applications"Sensors & Actuators B. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] T. Yoshinobu, T. Harada and H. Iwasaki: "Applicaticn of the pH-imaging sensor to determining the dlffusion coefficients of ions in electrolytic solution"Jpn. J. Appl. Phys.. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yoshinobu,H.Iwasaki et al.: "Application of Chemical Imaging Sensor to Electrogenerated pH Distribution" Jpn.J.Appl.Phys.37. L353-L355 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中尾他: "微小領域二次元pH分布可視化のための光走査型化学顕微鏡" 分析化学. 47. (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] H.Tanaka,T.Yoshinobu and H.Iwasaki: "Application of Chemical Imaging Sensor to Electrophysiological Measurement of a Neural Cell" Sensors & Actuators B. (in press).

    • Related Report
      1998 Annual Research Report
  • [Publications] 岩崎裕、吉信達夫: "pHイメージセンサを用いた細菌コロニーのイメージング" 応用物理. 66・5. 488-489 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Yoshimobu et al.: "Visualization of Chemical Waves in Belousov-Zhabotinsky Reaction by Chemical Imaging Sensors" Journal of Electrochemical Society. 144・11. 3919-3921 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] T.Yoshimobu et al.: "Application of Chemical Imaging Sensor to Electrogenerated pH Distribution" Japanese Journal of Applied Physics. (in press).

    • Related Report
      1997 Annual Research Report
  • [Publications] 中尾 基 他: "微小領域二次元pH分布可視化のための光走査型化学顕微鏡" 分析化学. (in press).

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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