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Biopsychological study on the role of brain glutamate receptors in learning and memory

Research Project

Project/Area Number 09410021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionUniversity of Tsukuba

Principal Investigator

ICHITANI Yukio  Institute of Psychology, University of Tsukuba, Associate Professor, 心理学系, 助教授 (80176289)

Co-Investigator(Kenkyū-buntansha) YAMADA Kazuo  Institute of Psychology, University of Tsukuba, Research Associate, 心理学系, 助手 (30282312)
IWASAKI Tsuneo  Institute of Psychology, University of Tsukuba, Professor, 心理学系, 教授 (70092509)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1998: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1997: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordslearning / memory / glutamate receptor / NMDA receptor / hippocampus / rat / グルタミン酸 / NMDA受容体 / 線条体
Research Abstract

Although it has recently been suggested that NMDA receptors are associated with memory and learning, there has been only a few behavioral studies on the role of NMDA receptors in specific brain regions. In this study, using radial maze learning task and a microinjection technique of specific agonists and antagonists, we investigated the role of brain NMDA receptors in spatial memory.
We first tested the effects of intrahippocampal microinjection of competitive and non-competitive NMDA receptor antagonists (AP5 and MK-801, respectively) on the rats' performance in radial maze. Both of them markedly impaired the correct performance while the AP5 treatment into the striatum did not have any effect on radial maze performance, suggesting that NMDA receptors in the hippocampus play an important role in spatial memory.
NMDA receptors consist of several subcomponents. We tested the effects of intrahippocampal treatment of DCS, a glycine-site agonist, on spatial memory deficits in radial maze task produced by systemic MK-801. DCS improved the MK-801-induced performance impairment, suggesting that glycine sites are involved in spatial memory through their modulatory action on hippocampal NMDA receptors.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Kawasaki,K.: "Corticosterone levels during extinction of runway response in rats." Life Sciences. 61. 1721-1728 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawabe,K.: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats." Brain Research. 781. 300-306 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Nonaka,H.: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze. learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawabe,K.: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 岡内 隆: "線条体カイニン酸投与ラットにおける線条体細胞外アセチルコリンおよびドーパミンのin vivo測定" 筑波大学心理学研究. 21. 37-44 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 高濱 祥子: "線条体興奮性アミノ酸投与ラットの行動特性に関する研究の概観" 筑波大学心理学研究. 21. 45-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Katsuyoshi Kawasaki et al.: "Corticosterone levels during extinction of runway response in rats." Life Sciences. 61. 1721-1728 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kouichi Kawabe et al.: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats." Brain Research. 781. 300-306 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Hiroi Nonaka et al.: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kouichi Kawabe et al.: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takashi Okauchi et al.: "In vivo measurement of extracellular levels of acetylcholine and dopamine in the striatum of rats treated with intrastriatal kainic acid : a microdialysis study." Tsukuba Psychological Research. 21. 37-44 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Sachiko Takahama et al.: "A review on the behavioral characteristics of rats treated with excitatory amino acids into the striatum." Tsukuba Psychological Research. 21. 45-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Kawabe,K.: "Effects of intrahippocampal AP5 treatment on radial-arm maze performance in rats." Brain Research. 781. 300-306 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawabe,K.: "Intrahippocampal D-cycloserine improves MK-801-induced memory deficits : radial-arm maze performance in rats." Brain Research. 814. 226-230 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nonaka,H.: "Effects of early postnatal AF64A treatment on passive avoidance response and radial maze learning in rats." Japanese Journal of Psychopharmacology. 18. 39-44 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岡内 隆: "線条体カイニン酸投与ラットにおける線条体細胞外アセチルコリンおよびドーパミンのin vivo測定" 筑波大学心理学研究. 21. 37-44 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高濱 祥子: "線条体興奮性アミノ酸投与ラットの行動特性に関する研究の概観" 筑波大学心理学研究. 21. 45-56 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] 山田 一夫: "薬物依存における視床下部-下垂体-副腎皮質ストレス反応系の役割に関する研究の動向" 筑波大学心理学研究. 21. 57-65 (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kawabe,K. 一谷幸男: "Effects of intrahippocampal AP5 treatment on radial-arm mage performance in rats." Brain Research. (印刷中). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 山田 一夫: "慢性ストレスによる海馬の形態的・機能的変化に関する研究の動向" 筑波大学心理学研究. 20. 51-58 (1998)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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