| Project/Area Number |
09440230
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
MATSUDA Hideki Nagoya Institute of Technology, Dept. Applied Chemistry, Professor, 工学部, 教授 (50209441)
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| Co-Investigator(Kenkyū-buntansha) |
OZAWA Tomohiro Institute for Molecular Science, Coordination Chemistry Lab., Research Assistant, 分子科学研究所, 助手 (70270999)
JITSUKAWA Koichiro Nagoya Institute of Technology, Dept. Applied Chemistry, Associate Professor, 工学部, 助教授 (50235793)
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| Project Period (FY) |
1997 – 1999
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| Project Status |
Completed (Fiscal Year 1999)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 1999: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1998: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1997: ¥9,200,000 (Direct Cost: ¥9,200,000)
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| Keywords | small molecule activation / Oxygen species / Amino acids / Self-organization / Unique reaction system / Non-covalent interaction / Non-heme enzyme model / 活性酸素 / 酸素錯体 / 金属錯体 / 部位特異的分子認識 / ATPase / ビタミンB6 / 金属酵素 / 酵素機能 / 生体系特殊反応場 / 非ヘム酵素 / モデル錯体 / 銅錯体 / 鉄錯体 |
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| Research Abstract |
Some novel structural and/or functional model complexes for metalloenzymes were constructed, which have synthetically coordinated non-covalent interaction groups such as hydrogen bonding, hydrophobic, electrostatic, and π-π stacking interactions. 1. Fundamental analysis of such weak interactions were studied and the principle of self-organization was examined. 2. The metal complexes that enable to recognize amino acids and peptides were constructed as a peptidase model. 3. Transamination was examined by the use of Co(III)-pyridoxal-amino acids under non-enzymatic conditions. 4. Carbonic anhydrase model was constructed by the use of Zn(II)-polypyridylamine ligands. 5. The organic compounds recognizing and capturing the biologically essential metal elements were prepared. 6. The oxidase models that enable to recognize and activate oxygen species were constructed and some reaction intermediates with oxygen species were prepared and examined physico-chemically. 7. Hydrogenase models were synthesized by the use of Ni(II)-NィイD22ィエD2SィイD22ィエD2 complexes that regulate the redox potential.
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