| Project/Area Number |
09460132
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
SAITO Masayuki Graduate School of Veterinary Medicine, Hokkaido University, Professor, 大学院・獣医学研究科, 教授 (80036441)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1998: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | interleukin-1 / interleukin-6 / stress / brain / immunomodulation / インターロイキン1 / 交感神経 / リンパ球 |
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| Research Abstract |
Peripheral immune functions are modified by various stressors, but the mechanisms of the stress-induced immunomodulation are poorly understood. There have been reports that brain interleukin (IL)-1 is involved in the stress-induced adrenocortical activation, In this study, I have investigated about possible roles of brain IL-1 in the stress-induced immunomodulation using rats and mice as experimental animals. When mice and/or rats were subjected to immobilization stress, the serum IL-6 level rose in 1 hr, following increased expression of IL-6 mRNA in both the liver and the spleen. Immunohistochemical examinations of liver tissue revealed that the stress induced IL-6 mainly in hepatic parenchymal cells. The serum IL-6 response to the stress was much attenuated when an antibody against IL-1 was injected into the cerebral ventricle, but mimicked by an intracerebroventricular injection of minute amounts of IL-1. It was also found that the brain IL-1 mRNA level rose immediately after the stress. From these results, I conclude that the peripheral IL-6 response to immobilization stress is mediated by brain IL-1.
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