| Project/Area Number |
09470017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MORIMOTO Taketoshi Kyoto Pref.Univ.Med., Dept.Physiol., Professor, 医学部, 教授 (30079694)
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| Co-Investigator(Kenkyū-buntansha) |
YAEGASHI Kazuhiro Kyoto Pref.Univ.Med., Dept.Physiol., Instructor, 医学部, 助手 (90254367)
TAKAMATA Akira Kyoto Pref.Univ.Med., Dept.Physiol., Instructor, 医学部, 助手 (00264755)
ITOH Toshiyuki Kyoto Pref.Univ.Med., Dept.Physiol., Assoc.Professor, 医学部, 助教授 (90168360)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 1998: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1997: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | the elderly / blood flow / water balance / body temperature regulation / heat stroke |
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| Research Abstract |
Adaptability of older adults to heat stress was assessed in relation to water balance.
1. Changes in water balance with heat acclimation in older adults
Nine oIder and 6 younger adlts were exposed to heat-exercise stress for 8 days, and regulatory responses in body temperature and water balance were compared on the first and 8th day. The results obtained shown lower body fluid volumes, higher losses of water and salts, lower water intake due to the lack of thirst, lower responsiveness of water related hormones, and lesser acclimation to heat in older subject. It is suggested that these factors are relevant to the higher incidences of heat casualty in the elderly (submitted to American Journal of Physiology).
2. Epidemiology of heat stroke
Based on the National Death Statistics between 1968 and 1994, the epidemiology of heat stroke death was analyzed. About 150 deaths have been reported in the years with heat waves in Japan, while 589 cases were reported in 1994 with sever heat waves. Out of the heat stroke death, 64% were found in the elderly people (submitted to International Journal of Biometeorology).
3. The effects of dehydration on body temperature regulation
The experimental results from our laboratory on the effects of dehydration on body temperature regulation were reviewed dividing the effect of hypovolemia (Progress in Brain Research, Vol. 115, Brain Function Hot Environment) and hyperosmolality (Reviews in Clinical & Basic Pharmacology).
The experimental findings obtained in this projects suggests that the high incidences of heat casualty in the elderly are related to the lower level of water balance in older subjects.
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