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ELUDICATION OF ASSOCIATION AND SIGNAL TRANSDUCTION PATHWAY BETWEEN BETA-KATENIN AND GROWTH FACTOR RECEPTOR AT THE CANCER INVASION

Research Project

Project/Area Number 09470056
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionNational Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

Principal Investigator

OCHIAI Atsushi  National Cancer Center Research Institute East, Pathology Division, Chief, 支所・臨床腫瘍病理部, 部長 (60183034)

Co-Investigator(Kenkyū-buntansha) KANAI Yae  National Cancer Center Research Institute East, Pathology Division, Head., 支所・臨床腫瘍病理部, 室長 (00260315)
NAKANISHI Hiroyuki  National Cancer Center Research Institute East, Pathology Division, Researcher, 支所・臨床腫瘍病理部, 主任研究官 (10260316)
SAKAMOTO Michiie  National Cancer Center Research Institute East, Pathology Division, Chief, 支所・臨床病理部, 部長 (40221270)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1999: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1997: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsβ-catenin / Growth factor receptor / Signal transduction / Cell adhesion system / Invasion / Tyrosine phosphorylation / 細胞接着因子
Research Abstract

1) Down regulation of the cadherin-mediated cell adhesion and tyrosine phosphoryaltion of β-catenin was stimulated by growth factors as epidermal growth factor (EGF) and transforming growth factor α (TGF α) using human cancer cell lines. Tyrosine phosphrylation of β-catenin was confirmed to be present in human colon cancer tissue at the invasive front where cancer cells dissociate from cancer nests in a single cells.
2) Physical association between β-catenin and c-erB-2 was confirmed using deletion mutants of β-catenin. The 12th armadillo repeat which locates at the center of β-catenin was found to bind the growth factor receptors as EGF receptor and c-erB-2. Tyrosine phosphoryaltion of the 12th armadillo repeat was occurred by EGF and TGF α stimulation. These results indicate the presence of signal transduction pathway between growth factor receptor and β-catenin.
3) A monoclonal antibody which recognizes tyrosine phosphorylated 12th armadillo repeat of β-catenin was generated using tyrosine phosphoryalted peptides. This antibody allows us to analyze the molecular mechanism of dysfunction of cadherin-mediated cell adhesion system through the growth factor receptor that activation of growth factor receptor phosphoryaltes β-catenin and stimulates dissociation between α and β-catenin.
4) Immunohistochemical staining of β-catenin in human colon cancer tissues showed that tyrosine phosphorylation of b-catenin at the 12th armadillo repeat specifically occurs at the invasive front where cancer cells dissociate from cancer nests. These results confirm the presence of signal transduction pathway between growth factor receptor and β-catenin in human cancer tissues and importance of this signal transduction in the cancer invasion and metastasis.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report

Research Products

(74 results)

All Other

All Publications (74 results)

  • [Publications] Emura, M., Ochiai A., et al.: "In vitro reconsitution of human respiratory epithelium"In Vitro Cell Dev. Biol.. 33. 602-605 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Minamoto, T., Ochiai A. et al.: "Combined analysis of microsatellite instability and K-ras muatation incease detection incidence of normal samples from colorectal cancer patients"Clincal Cancer Res.. 3. 1413-1417 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanai Y. Ochiai, a., et al.: "The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas"Int. J. Cancer. 71. 355-359 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Naknishi, Y., Ochiai, A et al.: "Expression of E-cadherin, α-catenin, β-catenin and plakoglobin in esophageal carcinomas and its prognostic significance"Oncology. 54. 158-165 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasui, N., Ochiai, A., et al.: "Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors"Invesion and Metasatsis. 17. 259-269 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Naknishi, Y., Ochiai, A et al.: "Clinicolathological significance of small Lugol's Iodine Unstained areas in the mucosa surrounding resected esophageal cancer"Cancer. 82. 1454-1459 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimoto, S., Ochiai, A., et al.: "Expression of Cadherin- catenin cell adhesion molecules, phoaphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers"Jpn. J. Cancer Res.. 89. 829-836 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inomata, M., Ochiai, a., et al.: "Macroscopic features at the deepest site of tumor penetration predicting liner metastases of colorectal cancer"Jpn. J. Clin. Oncol.. 28. 123-128 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanai Y., Ochiai A., et al.: "DNA hypermenthylation at the D17S5 locus is associated with gastric carcinogenesis"Cancer Letters. 122. 135-141 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurisu Y., Ochiai A., et al.: "Histlogic and immunohistrochemical analysis of early submucosal invasive carcinoma of the colon and rectum"Pathol. Int.. 49. 608-616 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Harabayashi, T., Ochiai A., et al.: "Reduction of integrin b4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinoma"J Urology.. 161. 1364-1371 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito A., Ochiai A., et al.: "Disruption of E-cadherin-mediated cell adhesion system in young patients with cancers"Jpn. J. Cancer Res.. 90. 993-999 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimura K., Ochiai A., et al.: "Familial gastric cancer : clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations"Carcinogenesis. 20. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Naknishi, Y., Ochiai, A et al.: "Clinical implication of lymph node mecrometastases in pstients with colorectal cancers. A case control study"Oncology. 57. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Becker K-F., Ochiai A., et al.: "Analysis of E-cadherin in diffuse type gastric cancer using an mutation-specific monconal antibody"Am. J. Pathol.. 156. (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Konishi, K., Ochiai A., et al.: "Clinicolathological differences between colonic and recatl carcinomas : are they based on the same mechaism of carcinogenesis?"Gut. 45. 818-821 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Emura M., Ochiai A., et al.: "Development of myofibroblasts from human bone marrow mesenchymal atem cells co-cultured with human colon carcinomas and TGF beta 1"In Vitro Cell Dev. Biol.. 36. 77-80 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii Y, Ochiai A., et al.: "Integin b4 as a suppressor and a predictive marker for peritoneal dissemination in humann gastric cancer"Gastroenterology. 118. 197-506 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasebe T., Ochiai A., et al.: "Proliferative activity of intratumoral fibroblasts closely correlated with lymph node and distant organ mentastases of invasive ductal carcinoma of the breast"Am J Pathol.. (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasebe T., Ochiai A., et al.: "Histopathological findings predicting lymph node metastasis and prognosis in patients with superficial esopahgeal cancer. Analysis of 240 surgically resected tumors"Cancer. 88. 1285-1293 (200)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai A., et al.: "Gastric cancer"Oxford University Press, Oxford New York. 309 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai A., et al.: "Molecular pathology of gastrointestinal cancer : application to clinical practice"springer Verag, Tokyo. 259 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai A., Kanai, Y. et al.: "Epithelial morphogenesis and diseases."W and C Birchmeyer. 489 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Emura M., Ochiai A., et al.: "In vitro reconstitution of human respiratory epithelium."In vitro Cell Dev. Biol.. 33. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Minamoto T., Ochiai A. et al.: "Combined analysis of microsatellite instability and K-ras muatation incease detection incidence of normal samples from colorectal cancer patients."Clincal Cancer Res.. 3. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanai Y. Ochiai, A., et al.: "The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas."Int. J. Cancer. 71. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] nakanishi, Y., Ochiai, A. et al.: "Expression of E-cadherin, a-catenin, __-catenin and plakoglobin in esophageal carcinomas and its prognostic significance."Oncology,. 54. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yasui N., Ochiai A., et al.: "Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors."Invesion and Metasatsis. 17. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] nakanishi Y., Ochiai A., et al.: "Clinicopathological significance of small Lugol's Iodine Unstained areas in the mucosa surrounding resected esophageal cancer."Cancer. 82. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Akimoto S., Ochiai A., et al.: "Expression of Cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers."Jpn. J. Cancer Res.. 89. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Inomata M., Ochiai A., et al.: "Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer."Jpn. J. Clin. Oncol.. 28. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kanai Y., Ochiai A., et al.: "DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis."Cancer Letters. 122. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurisu Y., Ochiai A., et al.: "Histlogic and immunohistochemical analysis of early submucosal invasive carcinoma of the colon and rectum."Pathol Int.,. 49. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Harabayashi T., Ochiai A., et al.: "Reduction of integrin b4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinoma."J Urology.. 161. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Saito A., Ochiai A., et al.: "Disruption of E-cadherin-mediated cell adhesion system in young patients with gastric cancers."Jpn. J Cancer Res.. 90. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Shimmura K., Ochiai A., et al.: "Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations."Carcinogenesis. 20. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Nakanishi Y., Ochiai A., et al.: "Clinical implications of lymph node mecrometastases in patients with colorectal cancers. A case control study."Oncology. 57. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Becker K-F., Ochiai A., et al.: "Analysis of E-cadherin in diffuse type gastric cancer using an mutation-specific monoclonal antibody."Am. J Pathol.. 156. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Konishi, K, Ochiai A., et al.: "Clinicopathlogical differences between colonic and recatl carcinomas: are they based on the same mechanism of carcingogenesis?"Gut. 45. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Emura M., Ochiai A., et al.: "Development of myfibroblasts from human bone marrow mesenchymal stem cells co-cultured with human colon carcinoma cells and TGF beta 1."In Vitro Cell Dev. Biol.. 36. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ishii. Y., Ochiai A., et al: "Integrin b4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer."Gastroenterology. 118. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasebe T., Ochiai A., et al.: "Proliferative activity of intratumoral fibroblats is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast."Am J Pathol.. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Hasebe T., Ochiai A., et al.: "New prognostic histological parameter of invasive ductal carcinoma of the breast: clinicopathological significance of fibrotic focus."Pathol. Int.. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tajima Y., Ochiai A., et al.: "Histopathological findings predicting lymph node metastasis and prognosis in patients with superficial esopahgeal cancer."Analysis of 240 surgically resected tumors-. Cancer. 88. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai, A. et al.: "Multiple genetic alterations in gastric cancer."In "Gastric Cancer" T. Sugimura and M. Sasako ed.. 87-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai A. et al.: "Genetic alterations In the precursors of gastric cancer."In "Molecular Pathology of Gastroenterological Cancer-Application to Clinical Practice". 43-54 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ochiai, A. et al.: "Multiple mechanisms for inactivation of E-cadherin cell adhesion system in cancer."In "Epithelial morphogenesis and diseases" W and C Birchmeyer. ed.. 427-444 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kurisu Y. Ochiai A et al.: "Histlogic and immunohistochemical analysis of early of early submucosal invasive carcinoma of the colon and rectum"Pathol Int.. 49. 608-616 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Harabayashi T. Ochiai A, et al.: "Reduction of integrin b4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinoma"J Urology. 161. 1364-1371 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Saito A, Ochiai A et al.: "Disruption of E-cadherin-mediated cell adhesion system in young patients with gastric cancers"Jpn. J Cancer Res.. 90. 993-999 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimmura K, Ochiai A, et al.: "Familial gastric cancer : clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations"Carcinogenesis. 20. 1127-1131 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakanishi Y, Ochiai A, et al.: "Clinical implications of lymph node mecrometastases in patients with colorectal cancers. A case control study"Oncology. 57. 276-280 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Becker K-F, Ochiai A, et al.: "Analysis of E-cadherin in diffuse type gastric cancer using an mutation-specific monoclonal antibody"Am. J Pathol.. 156. 1803-1809 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Konishi K, Ochiai A, et al.: "Clinicopathlogical differences between colonic and recatl carcinomas : are they based on the same mechanism of carcingogenesis?"carcingogenesis? Gut.. 45. 818-821 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Emura M, Ochiai A, et al.: "Development of myofibroblasts from human bone marrow mesenchymal stem cells co-cultured with human colon carcinoma cells and TGF beta 1"In Vitro Cell Dev. Biol.. 36. 77-80 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishii Y., Ochiai A. et al.: "Integrin b4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer"Gastroenterology. 118. 497-506 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hasebe T, Ochiai A et al.: "Proliferative activity of intratumoral fibroblats is closely correlated with lymph node and distant organ metastases of invasive ductal carcinoma of the breast"Am J Pathol.. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hasebe T, Ochiai A, et al.: "New prognostic histological parameter of invasive ductal carcinoma of the breast : clinicopathological significance of fibrotic focus"focus. Pathol. Int.. (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tajima Y, Ochiai A, et al.: "Histopathological findings predicting lymph node metastasis and prognosis in patients with superficial esopahgeal cancer. Analysis of 240 surgically resected tumors-"Cancer. 88. 1285-1293 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ochiai, A. Kanai Y. et al.: "Epithelial morphogenesis and diseases"W and C Birchmeyer. 489 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kanai.Y.,Ochiai,A.,et al.: "DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis." Cancer Letters. 122. 135-141 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Nakanishi Y.,Ochiai,A.,et al.: "Clinicopathological significance of small Lugol's Iodine Unstained areas in the mucosa surrounding resected esophageal cancer." Cancer. 82. 1454-1459 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inomata,M.,Ochiai,A.,et al.: "Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer." Jpn.J.Clin.Oncol.28. 123-128 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Akimoto,S.,Ochiai,A.,et al.: "Expression of Cadherin-catenin cell adhesion molecules,phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers." Jpn.J.Cancer Res.89. 829-836 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yasui,N.,Ochiai,A.,et al.: "Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors." Invesion and Metasatsis.17. 259-269 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Kurisu,Y.,Ochiai,A.,et al.: "Histlological and Immunohistochemical analvsis of early submucosal in vasive carcinoma of the colon and rectum." Pathol International. (in press). (1999)

    • Related Report
      1998 Annual Research Report
  • [Publications] Inomata,M., Ochiai,A., et al.: "Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer." Jpn. J. Clin. Oncol.(in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] kanai,Y., Ochiai,A., et al.: "DNA hypermethylation at D17S5 locus is associated with gastric carcinogenesis." Cancer Letters. 122. 135-141 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Minamoto,T., Ochiai,A., et al.: "Combined analysis of microsatellite instability and K-ras mutation incease detection incidence of normal samples from colorectal cancer patients." Clin.Cancer Res.3. 1413-1417 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Emura,M., Ochiai,A., et al.: "In vitro reconstitution of human respiratory epithelium." In Vitro Cell.Dev.Biol.33. 602-605 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kanai,Y., Ochiai,A., et al.: "The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas." Int.J.Cancer. 71. 355-359 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Nakanishi,Y., Ochiai,A, et al.: "Expression of E-cadherin,α-catenin,β-catenin and plakoglobin in esophageal carcinomas and its prognostic significance." Oncology. 54. 158-165 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ochiai,A., et al.: "Gastric Cancer" Oxford University Press,Oxford New York Tokyo., 309 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Ochiai,A., et al.: "Molecular Pathology of Gastroenterological Cancer:Application to Clinical Practice" Springer-Verlag,Tokyo, 259 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-03-31   Modified: 2016-04-21  

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