• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the evaluation of health effects caused by toxic substances containing lead

Research Project

Project/Area Number 09470102
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionSaga Medical School

Principal Investigator

TOMOKUNI Katsumaro  Saga Med Sch, Dept Comm health Sci., Professor, 医学部, 教授 (40032891)

Co-Investigator(Kenkyū-buntansha) IYADOMI Minako  Saga Med Sch, Dept Comm health Sci., Res. Assoc., 医学部, 助手 (40304886)
ICHIBA Masayoshi  Saga Med Sch, Dept Comm health Sci., Res. Assoc., 医学部, 助手 (60184628)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1999: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordsexposure to lead / exposure to polycyclic aromatic hydrocarbons / individual difference / polymorphism of ALAD / polymorphism of CYP1A1 / polymorphism of GST / DNA adducts lymphocytes / molecular epidemiology / 個人差 / 発がんのリスク評価 / 喫煙 / 多環芳香族炭化水素(PAH) / 薬物代謝酵素の遺伝子多型 / リンパ球DNAadducts / 多環芳香族炭化水素 / 分子疫学的研究 / ポルフィリン代謝異常 / 赤血球δーアミノレブリン酸脱水酵素 / 遺伝子多型
Research Abstract

We investigated to evaluate the individual differences of health effects caused by hazardous substances such as lead and carcinogenic polycyclic aromatic hydrocarbons (PAHs). First, we studied the relationship between polymorphism of delta-aminolevulinic acid dehydratase (ALAD) and lead-induced porphyrin metabolic disorders in about 200 workers occupationally exposed to lead. Urinary concentration of delta-aminolevulinic acid (ALA) and erythrocyte ALAD inhibition were used as biological parameters of health effect by lead. However, we could not find a significant relation between polymorphism of ALAD enzyme and urinary concentration of ALA in the lead-exposed workers.
Secondly, we investigated the relationship between genetic polymorphism of metabolic enzymes such as cytochrome P450 (CYP1A1) and glutathione s-transferase (GSTM1)and DNA adducts levels in lymphocytes of 51 cigarette smokers and 65 coke oven workers who are exposed to carcinogen PAHs. The measurement of DNA adducts is considered a useful indicator for environmental carcinogen exposure monitoring in humans. The data obtained demonstrated that the level of DNA adducts in lymphocytes can be influenced by not only level of exposure to PAHs but also genetic polymorphism of CYP1A1, indicating that DNA adducts levels were higher in Val/Val type of CYP1A1 than in I1/I1 and II/Val types of CYP1A1.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Wang Y: "relationship between plasma concentrations of carotene and -tocopherol and lifestyle factors"Nutr Cancer. 27. 69-73 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "Relation between polymorphism of -aminolevulinic acid dehydratase and some parameters in lead...."J Occup health. 40. 77-78 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ichiba M: "Lymphocytes DNA adducts and genetic polymorphism for metabolic enzymes in low dose cigarette....."Biomarkers. 3. 63-71 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pan G: "A study of multiple biomarkers in coke oven worker -a cross-sectional study in China"Carcinogenesis. 19. 1963-1968 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang Y: "effects of genetic polymorphism of metabolic enzyme nutrition, and lifestyle factors on DNA adducts....."Ind Health. 36. 337-346 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yan Y: "Different responses other than the formation of DNA adducts between the livers of carcinogen....."Jpn J Cancer Res. 89. 806-813 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kiyohara C: "Relationship between aromatic DNA adduct levels and inducibility of the drug metabolizing enzymes"Med Sci Res. 27. 651-655 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "Armatic DNA adducts in coke oven workers in relation to exposure, lifestyle and genetic poly....."Int Arch Occup Environ Health. 72 (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "The relation between aryl hydrocarbon hydroxylase activity and DNA adducts measured by 32P-post....."Biomarkers. 4 (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ichiba M: "Inter-individual variation of smoking related DNA adducts in lymphocytes-relationship to mRNA"Biomarkers. 4 (in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 山田浩司: "環境を考える"科学新聞社. 326 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 市場正良: "環境発がんのブラックボックスをさぐる"(財)労働科学研究所出版部. 195 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang Y: "Relationship between plasma concentrations of β-carotene and α-tocopherol and lifestyle factors and levels of DNA adducts in lymphocyte"Nut Cancer. 27. 69-73 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "Relation between polymorphism of delta-aminole-vulinic acid dehydratase and some parameters in lead workers"J Occup Health. 40. 77-78 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ichiba M: "Lymphocytes DNA adducts and genetic polymorphism for metabolic enzymes in low dose cigarette smokers"Biomarkers. 3. 63-71 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ichiba M: "Effect of genetic polymorphism for metabolic enzymes on the relationship between smoking dose and DNA adducts in lymphocytes"Biomarkers. 3. 425-432 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Pan G: "A study of multiple biomarkers in coke oven workers -a cross-sectional study in China"Carcinogenesis. 19. 1963-1968 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Wang Y: "Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adducts formation in lymphocytes"Ind Health. 36. 337-346 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Yan Y: "Different responses other than the formation of DNA adducts between the livers of carcinogen-resistant rat and carcinogen-sensitive rats to 3'-methyl-4-dimethyl-Aminoazobenzene administration"Jpn J Cancer Res. 89. 806-813 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kiyohara C: "Relationship between aromatic DNA adduct levels and inducibility of the drug metabolizing enzyme aryl hydrocarbon hydroxylase in lymphocytes"Med Sci Res. 27. 651-655 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "Aromatic DNA adducts in coke oven workers in relation to exposure, lifestyle and genetic polymorphism of metabolic enzymes"Int Arch Occup Environ Health. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Zhang J: "The relation between aryl hydrocarbon hydroxylase activity and DNA adducts measured by 32P-postlabelling assay in lymphocytes of lung cancer patients"Biomarkers. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Ichiba M: "Inter-individual variation of smoking related DNA adducts in lymphocytes- relationship to mRNA levels for CYP1A1 and DNA repair enzymes"Biomarkers. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chikako Kiyohara: "Relationship between aromatic-DNA adduct levels and inducibility of the drug metabolizing....."Medical Science Research. 27. 651-655 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jiusong Zhang: "Aromatic DNA adducts in coke oven workers in relation to exposure,lifestyle and qenetic polymor...."International Archives of Occupational and Environmental Health. 72(in press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jiusong Zhang: "The relation between aryl hydrocarbon hydroxylase activity and DNA adducts measured by 32P-post...."Biomarkers. 4(in press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Masayoshi Ichiba: "Inter-individual variation of smoking related DNA adducts in lymphocytes- relationship to mRNA...."Biomarkers. 4(in press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 市場正良: "環境発がんのブラックボックスをさぐる"(財)労働科学研究所出版部. 195 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Jiusong Zhang: "Relation between polymorphism of -aminolevulinic acid dehydratase and some parameters in lead workers" Journal of Occupational Health. 40. 77-78 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masayoshi Ichiba: "Lymphocytes, DNA adducts and genetic polymorphism for metabolic enzymes in low dose cigarette smokers" Biomarkers. 3(1). 63-71 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Ying Yan: "different responses other than the formation of DNA adducts between the livers of carcinogen-resistant..." Japanese Journal of Cancer Research. 89. 806-813 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yanping Wang: "Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct......" Industrial Health. 36. 337-346 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Masayoshi Ichiba: "Effect of genetic polymorphism for metabolic enzymes on the relationship between smoking dose and DNA...." Biomarkers. 3. 425-432 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] G.Pan: "A study of multiple biomarkers in coke oven workers- a cross-sectional study in China" Carcinogenesis. 19. 1963-1968 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Zhang J: "Relation between polymorphism of δ-aminolevulinic acid dehydratase and some parameters in lead workers" Journal of Occupational Health. 40. 77-78 (1998)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1998-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi