| Project/Area Number |
09470108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ISO Hiroyasu University of Tsukuba, Institute of Community Medicine, Associate Professor, 社会医学系, 助教授 (50223053)
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| Co-Investigator(Kenkyū-buntansha) |
IIDA Minoru Osaka Medical Center for Cancer and Cardiovascular Diseases, Director, 集検工部, 部長
KOIKE Kazuko Ibaraki Prefectural University of Health Science, Professor, 保健医療学, 教授 (60110508)
TANIGAWA Takeshi University of Tsukuba, Institute of Community Medicine, Professor, 社会医学系, 講師 (80227214)
SHIMAMOTO Takashi University of Tsukuba, Institute of Community Medicine, Professor, 社会医学系, 教授 (50143178)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1997: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | Platelet aggregation / Serun fatty acid composition / Fish intake / Risk factors / Cardiovascular disease |
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| Research Abstract |
To investigate the contribution of the platelet aggregation in the development of cardiovascular diseases, we examined the relation of constitutional and lifestyle variables with platelet aggregation for a total of 306 males aged 50 to 70 in Ikawa town of Akita prefecture (n=163), Noichi town of Kochi prefecture (n= 143) and Kyowa twon of Ibaraki prefecture (n=142). Mean logarithmic transformed PATI (log PATI) was higher in Ikawa than in Noichi and Ibaraki. Thus platelet aggregation was lower in Ikawa than in the other populations. According to multiple regression analysis, age, platelet count in platelet rich plasma, mean platelet volume in platelet rich plasma, and white blood cell count serum arachidonic acid composition were inversely associated with log PATI.Serum n3 polyunsaturated fatty acid composition and log gamma-GTP were positively associated with log PATI.
Maximum aggregation rate under ADP lmuM was found to be a comparable indicator to PATI (r = 0.9). A study of 465 men an
… More
d women aged 50-74 in Ibaraki showed that this indicator had similar correlates to PATI.
To investigate changes in platelet function, count and metabolism following fish intake among Japanese, we conducted an experimental intervention study of seven healthy Japanese volunteers (4 males and 3 females) aged 28-58 years. We supplemented their diets with an approximate daily intake of 200-400g fish which is equivalent to about 10g n3-polyunsaturated fatty acids during the 17 days. The study continued until the 23rd day after returning to an ad lititum diet. The proportion of serum n3-polyunsaturated fatty acids three-fold during the fish supplementation, and returned to the level before fish supplementation on the 12th day after returning to an ad lititum diet. Platelet counts decreased and the mean platelet volume increased during fish supplementation. Platelet aggregation by collagen tended to decrease during fish supplementation. Mean serum triglyceride level declined and mean plasma fibrinogen tended to decline during the fish supplementation. Habitual fish intake may attenuate the development of atherosclerosis and prevent ischemic heart disease through suppression of platelet activity, and by reducing platelet counts and serum triglyceride levels.
This study demonstrated feasibility of platelet aggregation test in health examination. For persons with enhanced platelet aggregation, habitual fish intake may be recommended to attenuate the development of atherosclerosis and prevent ischemic heart disease. Less
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