| Project/Area Number |
09470124
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
FUKAI Yuko Professor, Graduate School of Medicine, Kyoto University, 医学研究科, 教授 (10025588)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hiroshi Instructor, Graduate School of Medicine, Kyoto University, 医学研究科, 助手 (60263092)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1998: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1997: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Alcohol / DNA injury / NF-kappaB / Signal transduction / Signal transcription / Pharmacokinetics / AP-1 / 転写制御因子 / 情報伝達系 / サイトクローム P450 2E1 |
|---|
| Research Abstract |
1. Nuclear DNA injuries occurred in the rat liver after acute ethanol administration
2. Cytochrome P450 2E1 played an important role in increase of hepatic DNA injuries by ethanol.
3. Ethanol rapidly activated NF-kappaB in perfused rat livers
4. Dual properties of ethanol-stimulated NE-kappaB activation
5. Kupffer cells played an important role in hepatic NF-kappaB activation
6. Ethanol activated AP-1 as well as NE-kappaB
7. MEKK1 played a key role in celluar NF-kappaB activation by ethanol
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