• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genetic mapping of the disease gene causing dyschromatosis symmetrica hereditaria

Research Project

Project/Area Number 09470188
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNagoya University

Principal Investigator

TOMITA Yasushi  Nagoya University, School of Medicine, Professor, 医学部, 教授 (70108512)

Co-Investigator(Kenkyū-buntansha) MORI Hijiri  School of Medicine, Assistant Professor, 医学部, 講師 (60260593)
MIYAMURA Yoshinori  School of Medicine, Research Associate, 医学部, 助手 (50272034)
小野 博紀  名古屋大学, 医学部, 助手 (50224275)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥13,700,000 (Direct Cost: ¥13,700,000)
Fiscal Year 1999: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1998: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1997: ¥11,700,000 (Direct Cost: ¥11,700,000)
Keywordsdyschromatosis symmetrica hereditaria / linkage analysis / autosomal dominant inheritance / Idiopathic torsion dystonia / 優性遺伝
Research Abstract

Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary disorder, first reported by Toyama, Japanese Dermatologist in 1910. It is characterized by a mixture of hypopigmented and hyperpigmented macules of various sizes on the backs of the hands and feet. The disease gene of DSH and its chromosomal localization have not yet been identified. We therefore tried to determine the locus of the disease gene.
We performed linkage analysis between DSH and microsatellite markers in three Japanese DSH families (36 patients in total). More than 200 microsatellite markers from Linkage Mapping Set (Perkin-Elmer, Foster City, CA) were used for linkage analysis. DNA fragment length analysis was carried out using personal computer, Macintosh Centris 650 with 672 Genescan software and Genotyper Ver. 1.1. The allele size of each marker was rounded using the GAS package Ver. 2.0. Calculations for linkage analysis were performed with the FASTLINK software package Ver. 4.0.
The result of two-point and five-point analyses showed the regions with a LOD score of <3. We now try to specify the region.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Kono, et al.: "Exclusion of linkage between dyschromatosis symmetrica---"J. Dermatol. Sci.. 22. 88-95 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsunaga, et al.: "A splicing mutation of the tyrosinase gene cause yellow--"Dermatology. 199. 124-129 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fuse, et al.: "Molecular cloning of cDNA encoding a novel microphthalmia-"J. Biochem.. 126. 1043-1051 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 富田靖: "チロジナーゼと白皮症"日本皮膚科学会雑誌. 109. 1905-1907 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 富田靖: "チロジナーゼ関連型眼皮膚白皮症"日本皮膚科学会雑誌. 109. 1974-1976 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 富田靖: "色素脱失症"日本皮膚科学会研修委員会. 12 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kono, et al.: "Exclusion of linkage between dyschromatosis symmetrica hereditaria and chrosome 9"J Dermatol Sci. 22. 88-95 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Matsunaga, et al.: "A splicing mutation of the tyrosinase gene causes yellow oculocutaneous albinism in a Japanese patient with a pigmented phenotype"Dermatology. 199. 124-129 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Fuse, et al.: "Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus"J Biochem. 126. 1043-1051 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomita, Yasushi: "Tyrosinase and albinisms"Jap J Dermatol. 109. 1905-1907 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomita, Yasushi: "Tyrosinase-related oculocutaneous albinisms"Jap J Dermatol. 109. 1974-1976 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomita, Yasushi: "Hypopigmentary disorders"Published by The Japanese Dermatological Association. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kono,et al.: "Exclusion of linkage between dyschromatosis symmetrica---"J Dermatol Sci. 22. 88-95 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsunaga,et al.: "A splicing mutation of the tyrosinase gene cause yellow--"Dermatology. 199. 124-129 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Fuse,et al.: "Molecular cloning of cDNA encoding a novel microphthalmia--"J Biochem. 126. 1043-1051 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 富田 靖: "チロジナーゼと白皮症"日本皮膚科学会雑誌. 109. 1905-1907 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 富田 靖: "チロジナーゼ関連型眼皮膚白皮症"日本皮膚科学会雑誌. 109. 1974-1976 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 富田 靖: "色素脱失症"日本皮膚科学会研修委員会. 12 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsunaga J,他: "Sequenced-based diagnosis tyrosinase-negative oculocutaneousu albinisms : successful sequence analysis of the tyrosinase gene from blood spots dried on filterpaper." Dermatoogy. 196. 189-193 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Tomita Y,他: "Oculocutaneous albinism and analysis of tyrosinase gene in Japanese patients." Nagoya J.Med.Sci.61. 97-102 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Demitsu T,他: "Erythema induced by intraarterial infusion chermotherapy on the buttock presenting GVHD-like features with marked cellular atypia in histology." Dermatoogy. 197. 88-89 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Hieaiwa A,他: "Specific distribution patterns of hCDC47 expression in cutaneous diseases." J Cutan Pathol. 25. 285-289 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中村えり子、他: "Hermansky-Pudlak症候群 -遺伝子異常と肺線維化-" 呼吸. 17. 1314-1321 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 富田 靖、他: "色素異常症" 現代医学. 45. 423-430 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 富田 靖: "色素異常症。日本皮膚化学会総会教育コース(4)テキスト" 日本皮膚化学会, (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] K.Yasumoto 他: "Funcctional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes." J.Biol.Chem.272. 503-509 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] J.Matsunaga 他: "Sequence analysis of the human tyrosinase promoter from a patient with tyrosinase-negative oculocutaneous albinism." Pigment Cell.Res.10. 64-67 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] K.Maeda 他: "Comparison of the melanogenesis in human black amd light brown melanocytes." J.Dermatol.Sci.14. 199-206 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 富田 靖: "尋常性白斑" 臨床科学. 33. 1357-1359 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 富田 靖: "白皮症" 皮膚科の臨床. 39. 1055-1060 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 富田 靖: "白皮症と白斑" 小児科診療. 60. 627-631 (1997)

    • Related Report
      1997 Annual Research Report

URL: 

Published: 1997-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi