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New indicies of manganese ; Magnetic resonance imaging(MRI) findings and T1 values on brain in relation to plasma and whole blood manganese levelsin patients receiving total parenteral nutrition

Research Project

Project/Area Number 09470249
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

TAKAGI Yuji  OSAKA UNIVERSITY MEDICAL SCHOOL, PROFESSOR, 医学部, 教授 (40154760)

Co-Investigator(Kenkyū-buntansha) HIRABUKI Norio  OSAKA UNIVERSITY MEDICAL SCHOOL, LECTURER, 医学部, 講師 (00189862)
SANDO Kinya  OSAKA UNIVERSITY MEDICAL SCHOOL, ASSISTANT, 医学部, 助手 (40252671)
OKADA Akira  OSAKA UNIVERSITY MEDICAL SCHOOL, PROFESSOR, 医学部, 教授 (40028569)
Project Period (FY) 1997 – 1998
Project Status Completed (Fiscal Year 1998)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 1998: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1997: ¥7,300,000 (Direct Cost: ¥7,300,000)
Keywordsmanganese / total parenteral nutrition / plasma panganese level / whole blood manganese level / brain magnetic resonance imaging / high intensity on TィイD21ィエD2 weighed images / TィイD21ィエD2 relaxation time (TィイD21 ィエD2value) / globus pallidus on basel ganglia / マンガン / 静脈栄養 / 脳MRI
Research Abstract

Manganese (Mn) metabolism and kinetics in patients on total parenteral nutrition (TPN) still remain unclear. There is no establish standard for daily Mn requirement parenterally, nor are any indicies reflecting Mn concentration in tissue reliable. Although Mn accumulation in brain could be verified by magnetic resonance imaging (MRI) in TPN patients with Mn supplementation, no attempts have been made to investigate the relationship between the degree of high intensity (HI) and T1 relaxation time (I. E. T1 value) by brain MRI and blood Mn level. TPN patients with daily 20 μmol of Mn supply parenterally were participated in this on-off study of Mn. Before the discontinuation of Mn administration, plasma Mn level was within normal range, but whole blood level was higher than normal value and high intensity (HI) and shortened T1 value of basal ganglia by MRI, were noted in all patients. Discontinuation of Mn supply was followed in one month by lowering of plasma Mn below normal level. Whole blood Mn level also declined to return to normal in 2 months post discontinuation. The HI findings of the brain by MRI became less conspicuous to disappear completely by 11 months after discontinuation.
After re-supply of Mn, plasma Mn level did not increase so much. Whole blood Mn level increased to above normal value after 2 months of re-supply. The HI findings of the brain were again observed by 3 months after re-supply. T1 value was correlated to the changes of whole blood Mn level and MRI findings during Mn on off study. Daily administration in the dose of one μmol of Mn should be recommended during TPN rather than the dose of 2 or 20 μmol judging from MRI findings and T1 value and whole blood Mn level.

Report

(3 results)
  • 1998 Annual Research Report   Final Research Report Summary
  • 1997 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 高木洋治: "高カロリー輸液とマンガン"現代栄養療法のポイント. 3(2). 14-17 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 高木洋治: "在宅静脈栄養(HPN)患者の血中マンガン(Ma)値と脳MRI所見T_1値の緩和"Biomed Pes Trace Elements. 9(3). 159-160 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takagi: "magnetic resonarce imaging (MRI) findings and T_1 relaxation time of the hain in relation to blood mangarese levels in prtients receiving HPN."J.Trace Elements Exp.Med.. 11(4). 484-485 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 高木洋治: "バイオメタル-生体調節の多彩な役割と病態"山口正義編 黒船出版. 232 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takagi Y, Li Cui, Wasa M, Sando K, Okada A, Hirabuki N: "Changes of findings and T1 value of brain by magnetic resonauce imaging (MRI) in relation to blood manganese level in patients on home parenteral nutrition during on-off study of manganese"Biomed Res Trace Elements. 9(3)(in Japanese). 159-160 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takagi Y, Li Cui, Wasa M, Sando K, Okada A, Hirabuki N: "Magnetic resonance imaging (MRI) findings and T1 relaxation times of the brain in relation to blood manganese (Mn) levels in patients receiving home parenteral nutrition (HPN) during on-off study of manganese"J Trace Elements Exp Med. 11(4). 484-485 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] Takagi Y: "Deficiency of biometal as nutritional factor""Biometal" ed. By Yamauti M, Kurobune Printing Company, Shizuoka, Japan (in Japanese). 205-228 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1998 Final Research Report Summary
  • [Publications] 高木洋治他: "在宅静脈栄養(HPN)患者の血中マンガン(Mn)値と脳MRI所見、T_1値の推移" Biomed Res Trace Elements. 9(3). 173-174 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 高木洋治: "高カロリー輸液とマンガン" 現代栄養療法のポイント. 3(2). 14-17 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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