| Project/Area Number |
09470261
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Akita University |
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Principal Investigator |
KOYAMA Kenji AKITA UNIV,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (80004638)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masanao AKITA UNIV,SCHOOL OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (80282169)
SATO Tsutomu AKITA UNIV,SCHOOL OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (90235367)
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| Project Period (FY) |
1997 – 1998
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| Project Status |
Completed (Fiscal Year 1998)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 1998: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1997: ¥11,300,000 (Direct Cost: ¥11,300,000)
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| Keywords | Hepatic cirrhosis / hepatoma / hepatic vascular exclusion / hepatic metabolism / heat shock protein |
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| Research Abstract |
1. Arrangement of the new system for measuring hemodynamic and metabolism of the liver : Blood flow and oxygen tension of the hepatic artery, portal vein and hepatic vein are imputed simultaneously in the computer, from which oxygen consumption of the liver can be measured continuously.
2. Hepatic damage caused by total hepatic exclusion is more serious than that by hepatic inflow occlusion, in Which back flow from hepatic vein can supply oxygen to the hypoxic liver. however.
3. Induction of heat shock protein using warm water immersion is useful in the cirrhotic rats as is observed in normal. In cirrhotic animals, however, too long immersion is so harmful that gentle warming is necessary. Earlier detection of induction of heat shock protein can be achieved by measuring m-RNA of the heat shock protein.
4. Intra hepatic or superior mesenteric arterial infusion of PG-E1 increases hepatic blood flow and oxygen delivery in the hepatic tissue, which is effective for prevention and improvement of hepatic failure after hepatic arterial occlusion. The effect of the treatment can be realized in patients of hepatic arterial embolisation for the rupture of hepatic arterial pseudoaneurysm.
Conclusion : Preconditioning of heat shock protein induction before operation, and infusion of PGE1 via hepatic or superior mesenteric artery around operation can improve the safety of total hepatic vascular exclusion in cirrhotic.
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