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Induction of long-term remission in advanced malignant abdominal tumors with percutaneous isolated organ chemoperfusion

Research Project

Project/Area Number 09470267
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKobe University

Principal Investigator

GU Eisei  Kobe University, School of Medicine, First department of Surgery, Associate Professor, 医学部, 助教授 (40195615)

Co-Investigator(Kenkyū-buntansha) IWASAKI Takeshi  Kobe University, School of Medicine, First department of Surgery, Medical staff, 医学部・附属病院, 医員
TOMINAGA Masahiro  Kobe University, School of Medicine, First department of Surgery, Assistant Professor, 医学部・附属病院, 助手 (70188796)
KURODA Yoshikazu  Kobe University, School of Medicine, First department of Surgery, Professor, 医学部, 教授 (70178143)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1999: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1998: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1997: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsPercutaneous isolated organ chemoperfusion / Venous isolation and charcoal hemoperfusion / High-dose chemotherapy / 経皮的肝灌流 / adriamycin / 大腸癌肝転移 / cisplatin / 肝細胞癌
Research Abstract

We have already established a new system for high-dose intraarterial chemotherapy with complete venous isolation and charcoal hemoperfusion in an attempt to maximize tumor drug delivery and at the same time, to minimize systemic toxicity. The purpose of this project was to develop multimodal treatment strategies for malignant abdominal tumors in the liver, the pancreas, and the pelvis. As for the liver tumors, from the clinical trials using percutaneous isolated hepatic perfusion (PIHP), we have confirmed that repeated treatments on the same patient further expand the therapeutic index of this treatment compared with single treatment. In patients with advanced hepatocellular carcinoma (HCC-stageIVA), the results indicated that complete plus partial response rates reached 63% and that 5-year survival rate increased to 30%. Moreover, based on our findings, we initiated randomized study of the preventive utility of PIHP for the patients with high risks of recurrence after resection of HCC … More . Now, our data showed that PIHP after resection remarkably reduced the recurrence rate and improved the tumor free survival. In addition, we have performed reduction surgery of HCC combining with PIHP for the patients who had unresectable tumors until now. The reduction surgery combining PIHP has resulted in increasing resection rate and survival rate of advanced HCC. While, we have also treated 8 patients with colorectal hepatic metastases using PIHP. We have introduced a new treatment protocol combining repeated PIHP as the inductive for these patients and have intermittent infusions as the maintenance therapy for these patients and have shown the efficacy of PIHP for the disease. Relating to the pancreatic cancer, in which multiple liver metastases were common, we have initiated a new trial of PIHP as the prophylactic treatment against liver metastases. On the other hand, we have initiated clinical trial of pelvic chemoperfusion with infrarenal inferior vena caval isolation and charcoal hemoperfusion (IVCI-CHP) for advanced uterine cancer. A protocol with pelvic chemoperfusion as a neoadjuvant chemotherapy was designed to achieve down-staging of advanced uterine cancer and those results confirmed us the effectiveness of this treatment for pelvic tumors. Recently we have also tried PIHP with peripheral blood stem cell transplantation for the purpose of super high dose chemotherapy. Based on these results, we concluded that our methods offers an effective therapeutic option for patients with malignant abdominal tumors. Less

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Y. Ku: "Single catheter technique of hepatic venous isolation and charcoal hemoperfusion for malignant liver tumors"American Journal of Surgery. 173. 103-109 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M. Tominaga: "Pharmacologic evaluation of portal venous isolation and charcoal hemoperfusion for high-dose intraarterial chemotherapy of the pan"British Journal of Surgery. 84. 1072-1076 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Ku: "Induction of long-term remission in advanced hepatocellular carcinoma with percutaneous isolated liver chemoperfusion"Annals of Surgery. 227. 519-526 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y. Ku: "Efficacy of repeated percutaneous isolated liver chemoperfusion in local control of unresectable hepatocellular carcinoma"Hepato-Gastroenterology. 45. 1961-1965 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 具 英成: "StageIV肝細胞癌に対する経皮的肝潅流化学療法(PIHP)のQOLと遠隔成績"日本消化器外科学会雑誌. 32. 1075-1079 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 具 衛生: "肝細胞癌外科治療の展開ー多発進行肝細胞癌に対する肝切除と経皮的潅流化学療法(PIHP)の2段階治療"臨床外科. 53. 1457-1461 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Ku: "Single catheter technique of hepatic venous isolation and extracorporeal charcoal hemoperfusion for malignant liver tumors"American Journal of Surgery. 173. 103-109 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Tominaga: "Pharmacological evaluation of portal venous isolation and charcoal haemoperfusion for high-dose intra-arterial chemotherapy of the pancreas"British Journal of Surgery. 84. 1072-1076 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Ku: "Efficacy of repeated percutaneous isolated liver chemoperfusion in local control of unresectable hepatocellular carcinoma"Hepato-Gastroenterology. 45. 1961-1965 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Ku: "Induction of long-term remission in advanced hepatocellular carcinoma with percutaneous isolated liver chemoperfusion"Annals of Surgery. 227. 519-526 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Y.Ku: "Percutaneous isolated liver chemoperfusion for treatment of unresectable malignant liver tumors : Technique, pharmacokinetics, clinical results"Recent Results in Cancer Research. 147. 67-82 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 具英成: "経皮的肝潅流による高用量化学療法の現状"肝胆膵. 39. 869-876 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎武: "進行肝細胞癌に対する高用量肝動注化学療法:endovascular interventionを応用した低侵襲性外科治療としての経皮的肝潅流システムの有用性"日本血管外科学会雑誌. 8. 399-405 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 具英成: "StageIV肝細胞癌に対する経皮的肝潅流化学療法(PIHP)のQOLと遠隔成績"日本消化器外科学会雑誌. 32. 1075-1079 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Ku: "Induction of long-term remission in advanced hepatocellular carcinoma with percutaneous isolated liver chemoperfusion" Annals of Surgery. 227・4. 519-526 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] T.Iwasaki: "Regional pharmacokinetics of doxorubicin following hepatic arterial and portal venous administration" Cancer Research. 58・8. 3339-3343 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] M.Tominaga: "Resection of pheochromocytoma under inferior vena caval isolation and axtracorporeal charcoal hemoperfusion" Archives of Surgery. 133・9. 1016-1018 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 具 英成: "肝癌の低侵襲性外科治療-経皮的肝灌流による高用量化学療法" 日本醫事新報. 3865. 26-32 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 具 英成: "多発進行肝細胞癌に対する肝切除と経皮的肝灌流化学療法 (PIHP) の2段階治療" 臨床外科. 53・11. 1457-1461 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Y. Ku: "Single catheter technique of hepatic venous isolation and charcoal hemoperfusion for malignant liver tumores" American Journal of Surgery. 173・2. 103-109 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] M. Tomonaga: "Pharmacologic evaluation of portal venous isolation and characoal hemoperfusion for high-dose intraarterial chemothoerapy of the pancreas" British Journal of Surgery. 84. 1072-1076 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y. Ku: "Efficacy of repeated percutaneous isolated chemoperfusion in local control of unresectable hepatocellular carcinoma" Hepatao-Gastroenterology. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Y. Ku: "Induction of long-term remission in advanced hepatocellular carcinoma with percutaneous isolated liver chemoperfusion" Annals of Surgery. (in press). (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] 具 英成: "高度進行肝癌に対する肝切除の位置付け一経皮的肝潅流の併用による減量肝切除の新しい展開" 外科治療. 77. 157-164 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 楠 信也: "シスプラチンを用いたHVI・CHP肝潅流におけるチオ硫酸ナトリウム併用の意義" 癌と化学療法. 24. 1781-1784 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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