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Genetic alteration, angiogenesis and stromal proliferation related to the development and metastasis of gastric cancer

Research Project

Project/Area Number 09470269
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MAEHARA Yoshihiko  Faculty of Medicine, Kyushu University, Department of Surgery II, Assistant Professor, 大学院・医学系研究科, 助教授 (80165662)

Co-Investigator(Kenkyū-buntansha) TAKEUCHI Hideya  Faculty of Medicine, Kyushu University, Department of Surgery II, Assistant, 医学部, 助手
KAKEJI Yoshihiro  Faculty of Medicine, Kyushu University, Department of Surgery II, Assistant, 医学部, 助手 (80284488)
ONO Shinji  Faculty of Medicine, Kyushu University, Department of Surgery II, Assistant, 医学部, 助手 (50203881)
TOMODA Masaaki  Faculty of Medicine, Kyushu University, Department of Surgery II, Researcher, 医学部, 医員
古賀 聡  九州大学, 医学部, 医員
蓮田 正太  九州大学, 医学部, 医員
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1999: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1998: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1997: ¥5,100,000 (Direct Cost: ¥5,100,000)
Keywordsgastric cancer / VEGF / angiogenesis / p53 / TGF-β1 / invasion and metastasis / the growth development form / 微小転移 / cyclooxygenase-2 / 血管新生 / P53 / gastric cancer / prognosis / microsatellite instability / 早期胃癌 / p53 / マイクロサテライト
Research Abstract

We examined the expression of p53 VEGF in the gastric cancer organization and the part of the various factors in relation to the angiogenesis had been explained. The rate of the presence of lymphatic and vascular involvement and lymph node metastasis was high in their cases which showed positive finding of mutant p53 and VEGF staining and were the poorest prognosis. The case that the expression of mutant p53 led the expression of VEGF, stimulated the angiogenesis, was increased the microvessel density (MVD) in the tumor and prompted the infiltration and metastasis of the gastric cancer.
It was examined about the relations between the growth development from the tumor, (which was classified as a Pen A type, a Pen B type and the unclassified type), MVD and the expression of VEGF in submucosal gastric cancer. For Pen A Type, the positive rate of VEGF and increased MVD was significantly higher than other forms. 5 years survival rate of Pen A type is lower as compared with it of Super type. All of recurrent cases in Pen A type was hyper expression of VEGF. As a result of multivariate studies, the expression of VEGF was significant prognostic factor as same as lymphatic involvement. In the initial development of the gastric cancer, Pen A type could be estimated to be easy to produce VEGF, stimulate angiogenesis and lead to vascular involvement. For that reason, it was thought that Pen A type showed high rate of recurrent due to hematogenous metastasis and poor prognosis. It was examined about relation between TGF-β1 and gastric cancer. Metastatic lymph modes of gastric carcinomas with a TGF-β1 negative primary tumor were positive for TGF-β1 staining in 54.2%. TGF-β1 is closely related to the invasion and metastasis of gastric cancer.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Maehara Yoshihike, et al.: "Lymph node metastasis and relation to tumour growth potential and local immune response in advanced gastrec cancer."Int J Cancer. 74. 224-228 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al.: "Dynamics of tumor oxygenation: CD31 staining and transforming growth factor-b levels after treatment with radiation or cyclophamide in the rat 13762 mammary carcinoma."Int J. Rad Oncol Biol Phys. 37. 1115-1123 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehara Yoshihiko, et al: "Tumor angiogenesis and micrometastasis in bone marrow of patients with early gastric cancer."Clin Cancer Res. 4. 2119-2134 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehara Yoshihiko, et al: "Role of transforming growth factor-b in invasion and metastasis in gastric carcinoma."J Clin Oncol. 17. 607-614 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehara Yoshihiko, et al: "Recurrences and relation to tumor growth potential and local immune response in nodenegative advanced gastric cancer."Oncology. 56. 322-327 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiko, et al.: "Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer"Oncology Rep. 6. 1213-216 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al: "Clinical significance of micrometastasis in bone marrow of patients with gastric cancer and its relation to angiogenesis."Gastric Cancer. 2. 46-51 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al: "Intratumoral angiogenesis and micrometastasis in bone marrow of patients with gastric cancer."Multimodality Therapy for Gastric Cancer. 177-182 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomoda Masaaki, et al: "Intratumoral neovascularization and growth pattern in early human gastric carcinoma."Cancer. 85. 2340-2346 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehata Yoshihiko, et al.: "Lymph node metastasis and relation to tumor growth potential and local immune response in advanced gastric cancer"Int. J. Cancer. 74(2). 224-228 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al.: "Dynamics of tumor oxygenation, CD31 staining and transforming growth factor-βlevels after treatment with radiation or cyclophamide in the rat 13762 mammary carcinoma"Int. J. Rad Oncol. Biol. Phys. 37(5). 1115-1123 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehata Yoshihiko, et al.: "Tumor angiogenesis and micrometastasis in bone marrow of patients with early gastric cancer"Clin Cancer Res.. 4(9). 2129-2134 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehata Yoshihiko, et al.: "Role of transforming growth factor-β in invasion and metastasis in gastric carcinoma"J. Clin Oncol. 17(2). 607-614 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehata Yoshihiko, et al.: "Recurrences and relation to tumor growth potential and local immune response in nodenegative advanced gastric cancer"Oncology. 56(4). 322-327 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al.: "Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer"Oncology Rep.. 6. 1213-1216 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al.: "Clinical significance of micrometastasis in bone marrow of patients with gastric cancer and its relation to angiogenesis"Gastric Cancer. 2(1). 46-51 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kakeji Yoshihiro, et al.: "Intratumoral angiogenesis and micrometastasis in bone marrow of patients with gastric cancer"Multimodality Therapy for Gastric Cancer. 177-182 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Tomoda Masaaki, et al.: "Intratumoral neovascularization and growth pattern in early human gastric carcinoma"Cancer. 85(11). 2340-2346 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Maehara Yoshihiko, et al.: "Role of transforming growth factor-β1 in invasion and metastasis in gastric carcinoma."J Clin Oncol. 17. 607-614 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maehara Yoshihiko, et al.: "Clinical implications of serum anti-p53 antibodies for patients with gastric carcinoma."Cancer. 85. 302-308 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maehara Yoshihiko, et al.: "Prognostic value of p53 protein expression for patients with gastric cacner-a multivariate analysis-"Br J Cancer. 79. 1255-1261 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Maehara Yoshihiko, et al.: "Recurrences and relation to tumor growth potential and local immune response in node-negative advanced gastric cancer."Oncology. 56. 322-327 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Yoshihiko Maehara ,et al: "Prognostic value of p53 protein expression for patients with gastric can cer-A mult ivariate analvsis" Br.J.Cancer. inpress.

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshihiko Maehara ,et al: "Clinical implications of serumanti-p53antibodies for patients withgastric cancer" Cancer. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshihiko Maehara ,et al: "Tumorangiogenesis and micrometastasis in bone maitow of patients with earlygastric" Clin Cancer Res. 4. 2129-2134 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshihiko Maehara ,et al: "Atumor-associated cellsurface glycoprotein accompanying p53 overexpres sionand higher growth potential for gastric cancer" Br.J.Cancer. 75. 999-1002 (1995)

    • Related Report
      1998 Annual Research Report
  • [Publications] Eiji Oki.et al: "Mutated gene-specific phenotype of dinucleotide repeal instability in h uman colorectal carcinoma cell" Oncogene. in press.

    • Related Report
      1998 Annual Research Report
  • [Publications] Yoshihiko Maehara,et al.: "Surgical treatment and outcome for node-negative gastric cancer" Surgery. 121. 633-639 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Shinya Oda,et al.: "Precise assessment of microsatellite instability using high resolution fluorescent microsatellite analysis" Nucleic Acids Research. 25. 3415-3420 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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