| Project/Area Number |
09470284
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
KAWAZOE Kohei SCHOOL OF MEDICINE, IWATE MEDICAL UNIVERSITY, PROFESSOR, 医学部, 教授 (50075561)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
CHIBA Naoki SCHOOL OF MEDICINE, IWATE MEDICAL UNIVERSITY, ASSISTANT PROFESSOR, 医学部, 助手 (80254754)
KAMATA Junya SCHOOL OF MEDICINE, IWATE MEDICAL UNIVERSITY, ASSISTANT PROFESSOR, 医学部, 助手 (10254765)
IZUMOTO Hiroshi SCHOOL OF MEDICINE, IWATE MEDICAL UNIVERSITY, ASSISTANT PROFESSOR, 医学部, 助手 (10265150)
NASU Masataka SCHOOL OF MEDICINE, IWATE MEDICAL UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 講師 (20180531)
|
|---|
| Project Period (FY) |
1997 – 1999
|
| Project Status |
Completed (Fiscal Year 1999)
|
| Budget Amount *help |
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1999: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1998: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Keywords | ATRIAL FIBLILATION / MAZE OPERATION / MITRAL VALVE DISEASE / ATRIAL TACHYCARDIA / MACRO REENTRY / Elecro-Anatomical Mapping system / 心房能動収縮機能 / 血中心房性Na利尿ペプチド / 最高酸素摂取量 / 左房能動駆出分画 / 嫌気性代謝閾値 / マクロリエントリ-回路 / 心房表面マッピング / 左房径 / f波高 |
|---|
| Research Abstract |
(1) Clinical results of Maze procedure for chronic atrial fibrillation combined with other cardiac surgery. The Maze procedure was safely combined with other cardiac surgery without adding undue operative morbidity and mortality. Seventy-three of 100 patients regained sinus rhythm, 21 patients were in atrial fibrillation and 6 patients underwent pacemaker implantation. Ambulatory electrocardiographic monitoring revealed that atrial fibrillatory wave in leads II or VI and left atrial diameter by echocardiography were independent predictors of sinus rhythm restoration early after the Maze procedure. The preoperative left atrial dimention may also be useful in predicting the restoration of postoperative atrial contractile function. In the follow-up period, some patients who regained sinus rhythm after procedure converted back to atrial fibrillation. The probability of sinus rhythm maintenance was 88.8 ± 3.7% at on year and 64.8 ± 7.5% at five years. It was suggested that gradual but constant attrition in the rate of sinus rhythm maintenance continued after the Maze procedure combined with mitral valve surgery.
(2) Modification of the original Cox/Maze procedure We made left atriotomy line in Cox/Maze procedure into the simple isolation of four inlet orifices of pulmonary vein from left atrium. Because left atrial epicardial mapping study during operation showed that the firing potential usually located around the orifices of pulmonary vein. Although atrial tachyarrhythmia disappeared after the modification of left atrial incision, the rate of regaining sinus rhythm decreased. The further evaluation will be necessary to prove the efficacy of the modification.
|
