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Prediction of durability of artificial organs using an accerelated fatigue tester

Research Project

Project/Area Number 09470288
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionWaseda University

Principal Investigator

UMEZU Mitsuo  Waseda University, School of Science and Engineeing, Professor, 理工学部, 教授 (90132927)

Co-Investigator(Kenkyū-buntansha) AKUTSU Toshinosuke  Kanto Gakuin University, School of Engineering, Professor, 工学部, 教授 (90231852)
KITAMURA Nobuo  Kyoto Prefectural University of Medicine, School of Medicine, Professor, 医学部, 教授 (70075513)
KAWAZOE Kohei  Iwate Medical College, School of Medidne, Professor, 医学部, 教授 (50075561)
UCHIYAMA Akihiko  Waseda University, School of Science and Engineering, Professor, 理工学部, 教授 (50063615)
FUJIMOTO Tetsuo  Waseda University, Advanced Research Inst for Sci.and Eng.Assoc.Professor, 理工学総合研究センター, 助教授 (50267473)
富岡 淳  早稲田大学, 理工学部, 助教授 (40217526)
Project Period (FY) 1997 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 1999: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1998: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 1997: ¥6,900,000 (Direct Cost: ¥6,900,000)
Keywordsaccerelated fatigue tester / ISO standard / Polymer valve / Jellyfish valve / FEM / load / temerature / fracture / 人工弁 / 負荷 / リム / ポリウレタン弁 / 回転型成形機 / 膜厚 / 偏差係数 / 弁葉 / 水力学特性
Research Abstract

In order to predict a durability of heart valve prostheses, two types of commercially available (ISU-Standard) accerelated fatigue tests were employed, while improving a life time of Jellyfish polymer valve.
A chronic animal experiment of Jellyfish valves incorporated into conventional sac-type blood pumps for over 300days exhibited that there were a fracture and calcification on this flexible membrane. Therefore, a long durability (approx. 1 year guarantee) of Jellyfish valve has been developing. while clearing a cause of the problems.
First of all, design improvement of Jellyfish valve was attempted. Results of finite element analysis during closed phase of Jellyfish valve indicated that mechanical strain generated on valve membrane fracture and calcification in the animal experiment. Moreover further analysis suggested that an additional circular rim located at 7.0mm in radius was quite effective to avoid strain concentration. In vitro steady and pulsatile tests demonstrated that a modified valve with 0.5mm width rim located at 70mm in radius had a comparable hydrodynamic performance to the original Jellyfish valve.
For the next step, commercially available two types of accelerated fatigue tests were employed. Fatigue tests successfully revealed that a durability of the modified valve was much more extended than the original Jellyfish valve by 7 times.
Thus, chronic animal experiment with conventional sac-type blood pumps in which the modified valves were incorporated was performed for months. Hemolysis related to the application of the modified valve was not observed. This would be owing to the tapered configuration of the additional rim with 0.1mm width of inflow side.
From the data above, the modified polymer valve showed great promise for clinical artificial heart application, and it was also clarified that our prevent fatigue tester could provide comparative durability data of polymer valves.

Report

(4 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] M.Umezu: "Application of rotational moulding for the development of artificial organs"Rotation (The magazine of the Int.Rotation Molding Industry). 7(3). 24-31 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎清隆,梅津光生 他: "医療用高分子材料の疲労が血液適合性に与える影響の検討"第14回ライフサポート学会講演予稿集. 106-107 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Iwasaki, M.Umezu, et al.: "Development of a durable polymer valve based on finete element analysis"APCMBE, Proc.. 252 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 岩崎清隆,梅津光生 他: "高分子製人工弁の加速耐久試験確立に向けての力学的検討"人工臓器. (掲載予定). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Umezu: "Development of a mechanical circulatory simulator to evaluate hemodynamics of artificial organs"9^<th> International Conference on Biomedical Engineering. 3(6). 153-155 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Umezu, T.Fujimoto, et al.: "Three types of in-vitro evaluation test system for blood pump performance"Proc.Of 4^<th> Int.Conf.on BME. 1-2 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] M.Umezu: "Mock circulatory system (in Japanese)"SICE. 38(5). 312-316 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] T.Fujimoto, M.Umezu, et al.: "Effects of cardiac function on an arterial vascular graft implantation"Artif Organs. 23(7). 685 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] K.Iwasaki,M.Umezu et al.: "Dvelopment of a durble polymer valve based on finete element analysis"APCMBE. Proc.. 252 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 岩崎清隆,梅津光生ほか: "高分子製人工弁の加速耐久試験法確立に向けての力学的検討"人工臓器. (掲載予定). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] M.Umezu: "Application of rotational moulding for the development of artificial organs" Rotation(The magzine of the Int.Rotation Molding Industry). VII-3. 24-31 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 岩崎清隆,梅津光生他: "医療用高分子材料の疲労が血液適合性に与える影響の検討" 第14回ライフサポート学会講演予稿集. 106-107 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 長久大地,井内康浩,藤里俊哉,辻 隆之,梅津光生: "ポリウレタン製人工弁閉鎖不全の解析" 医用電子と生体工学. 第35巻特別号、35. 467 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 長久大地,井内康浩,藤里俊哉,辻 隆之,梅津光生,大場謙吉: "ポリウレタン製人工弁閉鎖不全の解析" 第9回バイオエンジニアリング講演会. 講演論文集、No.96-48. 111-113 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 長久大地,藤里俊哉,辻 隆之,梅津光生,大場謙吉: "ポリウレタン製人工弁閉鎖不全の温度変化による影響" 第20回日本バイオレオロジー学会. 年会抄録集. 46 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Daichi NAGAHISA, Toshia HUJISATO, Takayuki TUJI, Mitsuo UMEZU, et al.: "Quantative Evaluation Regurgitation in Polyurethane Tricuspid Aortic Valve" The Third Far-Eastern Symposium on Biomedical Materials.Abstract. 84 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] 梅津光生,Teoh Swee-Hin: "人工臓器製作用三次元回転成形機" 医用電子と生体工学. 第35巻秋季特別号. 55 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Mitsuo UMEZU, Manoja RANWAKE, John WOODARD, et al.: "Basic Study Towards the Establishment of a Fabrication Technology for a Vacuum-Formed Blood Pump" Springer-Verlag. Heart Replacement-Artificial Heart6. 353-357 (1998)

    • Related Report
      1997 Annual Research Report
  • [Publications] Msakazu Nurishi, Kazushige Iinuma, Mitsuo Umezu, et al.: "Establishment of an internal coating method of Blood Pumps with Non-Thrombogenic polymer" 9th International Conference on Biomedical Engineering. December 3-6, Singapore. 286-288 (1997)

    • Related Report
      1997 Annual Research Report
  • [Publications] Kiyotaka IWASAKI, Mitsuo UMEZU, Hideki WAKUI, Hiroyuki KAWADA, Tetsuo FUJIMOTO, Kou IMACHI: "Improvement of Dynamic conditions in the acclelerated fatigue testing for prosthetic heart valve" 9th International Conference on Biomedical Engineering. December 3-6, Singapore. 342-344 (1997)

    • Related Report
      1997 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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