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Studies for clinical use of olfactory evoked potentials by electrical stimulating olfactory mucosa

Research Project

Project/Area Number 09470299
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionFukushima medical university

Principal Investigator

KODAMA Namio  medicine, Fukushima medical university, professor, 医学部, 教授 (40004999)

Project Period (FY) 1997 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordsevoked potentials / olfactory function / electrical stimulation / intraoperative monitoring / olfactory mucosa
Research Abstract

Following surgeon near the anterior fossa, some patients experience loss of olfactory functions. However, objective methods for evaluating olfactory functions, which are also important for daily living, have not yet been developed.
The olfactory evoked potential (OEP) obtained by electrical stimulation of the olfactory mucosa was recorded in dogs and humans to develop an objective method for evaluating olfactory functions. In dogs, OEPs were recorded from the olfactory tract and the scalp. The latency of the first negative peak was approximately 40 msec. A response was not obtained following stimulation of the nasal mucosa and disappeared following sectioning of the olfactory nerve. With increasing frequencies of repetitive stimulation, the amplitude was reduced, suggesting that the response was synaptically mediated. These results demonstrate that evoked potentials from the olfactory tract and the scalp following electrical stimulation of the olfactory mucosa originate specifically from the olfactory system. In humans, a stimulating electrode with a soft catheter was fixed on the olfactory mucosa. The OEP from the olfactory tract was recorded with a negative peak at approximately 27 msec, similar to characteristics found in dogs. The OEP from the olfactory tract in humans also originates specifically from the olfactory system. The OEP obtained by electrical stimulation of the olfactory mucosa may prove useful for intraoperative monitoring of olfactory functions.

Report

(5 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • 1997 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Sato M: "Olfactory evoked potentials : Experimental and clinical studies"Journal of Neurosurgery. 85. 1122-1126 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 佐々木達也: "上位脳神経の術中モニタリング"脳神経外科ジャーナル. 10. 99-103 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 児玉南海雄: "脳腫瘍手術術中のモニタリング"末梢神経(脳神経)のモニタリング(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sato M: "Olfactory evoked potentials : Experimental and clinical studies."J Nuerosurg. 85. 1122-1126 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Sasaki T: "Intraoperative monitoring of the upper cranial nerves."Jpn J Neurosurg. 10. 99-103 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kodama N: "Intraoperative monitoring of the cranial nerves."Intraoperative monitoring on brain tumor surgery. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 佐々木達也,児玉南海雄 他: "上位脳神経の術中モニタリング"脳神経外科ジャーナル. 10・2. 99-103 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 1997-04-01   Modified: 2016-04-21  

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