| Project/Area Number |
09470299
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Fukushima medical university |
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Principal Investigator |
KODAMA Namio medicine, Fukushima medical university, professor, 医学部, 教授 (40004999)
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| Project Period (FY) |
1997 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1998: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1997: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | evoked potentials / olfactory function / electrical stimulation / intraoperative monitoring / olfactory mucosa |
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| Research Abstract |
Following surgeon near the anterior fossa, some patients experience loss of olfactory functions. However, objective methods for evaluating olfactory functions, which are also important for daily living, have not yet been developed.
The olfactory evoked potential (OEP) obtained by electrical stimulation of the olfactory mucosa was recorded in dogs and humans to develop an objective method for evaluating olfactory functions. In dogs, OEPs were recorded from the olfactory tract and the scalp. The latency of the first negative peak was approximately 40 msec. A response was not obtained following stimulation of the nasal mucosa and disappeared following sectioning of the olfactory nerve. With increasing frequencies of repetitive stimulation, the amplitude was reduced, suggesting that the response was synaptically mediated. These results demonstrate that evoked potentials from the olfactory tract and the scalp following electrical stimulation of the olfactory mucosa originate specifically from the olfactory system. In humans, a stimulating electrode with a soft catheter was fixed on the olfactory mucosa. The OEP from the olfactory tract was recorded with a negative peak at approximately 27 msec, similar to characteristics found in dogs. The OEP from the olfactory tract in humans also originates specifically from the olfactory system. The OEP obtained by electrical stimulation of the olfactory mucosa may prove useful for intraoperative monitoring of olfactory functions.
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